Dlow005099.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila lowei
Gene Symbol
rdx
Assembly
GCA_008121275.1
Location
CM017777.1:33408867-33421702[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.5e-34 4.5e-32 110.3 0.4 2 109 266 371 265 372 0.97

Sequence Information

Coding Sequence
ATGTTTGAGCCCTATGTGAAAATCAAGAAAAAGCGAAATGTCCATGAAATTTATCAACAAAACAACGAGAATTTAGAAAGGGAACGGGACCAACCACAACAGGAGCCGCAGGAGTCGCAGGAGGATACCGCCGCAAATTTCTGTGATAAAAGATTGCCGGTGAACGAATGTCAGGCAAGCCAAACAGCTAGAGTCACCTCGAACCTGCACGCATCCAGTAGCACGATGGCGGTCAGCCGTGTACCCTCGCCGCCCTTGCCGGAAGTTAATACGCCAGTTGCCGAGAACTGGTGTTATACGCAGGTTAAAGTGGTTAAATTTAGTTATATGTGGACCATAAATAACTTTAGTTTTTGTCGGGAAGAGATGGGTGAGGTACTCAAATCGTCCACATTCTCAGCCGGTGCTAATGACAAACTGAAATGGTGTTTACGGGTTAATCCAAAGGGCCTCGACGAGGAGAGCAAGGATTACTTATCATTATATTTACTATTAGTTTCGTGTAATAAATCAGAAGTCAGAGCCAAGTTCAAATTTTCCATACTGAATGCGAAGCGTGAGGAGACCAAAGCCATGGAATCCCAAAGAGCTTACCGTTTTGTGCAGGGCAAAGATTGGGGCTTCAAGAAATTCATACGACGCGACTTCCTGCTGGACGAGGCCAACGGCCTGCTGCCGGAGGACAAGCTAACGATCTTCTGTGAGGTTAGCGTCGTGGCGGACAGTGTTAACATCTCCGGACAATCCAATATTGTGCAGTTCAAAGTGCCCGAGTGCAAGCTCTCCGAGGATCTTGGCAATCTCTTTGACAATGAGAAATTCAGCGATGTGACGCTCTCAGTGGGCGGTCGAGAGTTTCAGGCGCACAAGGCCATACTGGCAGCGCGCAGCGATGTCTTTGCGGCCATGTTTGAGCATGAAATGGAGGAGCGTAAGCTGAATCGTGTCGCCATAACCGATGTGGATCATGAGGTTCTTAAAGAAATGCTGCGATTCATATACACGGGCAAGGCGCCCAATTTAGAAAAAATGGCTGATGATCTCCTAGCGGCTGCTGATAAGTATGCACTCGAAAAGCTGAAAGTGATGTGCGAGGAGGCGCTGTGCGTCAATCTCTCTGTTGAAACAGCAGCCGAAACATTAATATTAGCTGATCTCCATAGTGCGGATCAATTGAAAGCACAAACGATAGATTTCATAAATACTCATGCCACCGATGTGATGGAAACCTCTGGATGGCAAAATATGATCACAACACATTCACATTTGATAGCAGAGGCATTTCGTGCACTCGCAACACAACAAATCCCACCAATTGGACCACCAAGGAAACGCGTGAAAATGAGCTGA
Protein Sequence
MFEPYVKIKKKRNVHEIYQQNNENLERERDQPQQEPQESQEDTAANFCDKRLPVNECQASQTARVTSNLHASSSTMAVSRVPSPPLPEVNTPVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSVNISGQSNIVQFKVPECKLSEDLGNLFDNEKFSDVTLSVGGREFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDHEVLKEMLRFIYTGKAPNLEKMADDLLAAADKYALEKLKVMCEEALCVNLSVETAAETLILADLHSADQLKAQTIDFINTHATDVMETSGWQNMITTHSHLIAEAFRALATQQIPPIGPPRKRVKMS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00628449; iTF_00082212; iTF_01461252; iTF_01356998; iTF_01563848; iTF_00192880; iTF_01562974; iTF_00366569; iTF_00188235; iTF_01322767; iTF_01023089; iTF_01196051; iTF_00528865; iTF_00555905; iTF_00580033; iTF_01165602; iTF_01364002; iTF_00473123; iTF_00480227; iTF_00531715; iTF_00550947; iTF_00593891; iTF_00904803; iTF_00612132; iTF_00832228; iTF_01165604; iTF_00516325; iTF_00533861; iTF_00601861; iTF_00338406; iTF_00587462; iTF_00612870; iTF_01554022; iTF_00517767; iTF_00556583; iTF_00595303; iTF_00817511; iTF_01326471; iTF_00483752; iTF_00549608; iTF_00579336; iTF_00606376; iTF_00914568; iTF_01055304; iTF_01195336; iTF_00475273; iTF_00504745; iTF_00544553; iTF_00554441; iTF_00561097; iTF_00916297; iTF_00569034; iTF_00609226; iTF_00488075; iTF_00539019; iTF_00541131; iTF_00582315; iTF_00617707; iTF_00803659; iTF_00806027; iTF_01551787; iTF_00336812; iTF_00476684; iTF_00540428; iTF_00890188; iTF_01259276; iTF_01324972; iTF_01374156; iTF_00510605; iTF_00512781; iTF_00534637; iTF_00594605; iTF_00493710; iTF_00500366; iTF_00816622; iTF_01486286; iTF_00614959; iTF_00716783; iTF_00491568; iTF_00501104; iTF_00538288; iTF_00586736; iTF_01194480; iTF_01327952; iTF_01548912; iTF_01551056; iTF_00470929; iTF_00475985; iTF_00506929; iTF_00532433; iTF_00919121; iTF_01231665; iTF_00199954; iTF_00258962; iTF_00509874; iTF_00572659; iTF_00624819; iTF_01557619; iTF_00490836; iTF_00507668; iTF_01235828; iTF_00251413; iTF_00480917; iTF_00498933; iTF_00519221; iTF_01237749; iTF_01556181; iTF_01570293; iTF_00524470; iTF_00557974; iTF_00590295; iTF_00997815; iTF_00339224; iTF_00478072; iTF_00545304; iTF_00568312; iTF_01378456; iTF_01470584; iTF_01559096; iTF_00490137; iTF_00581593; iTF_01175193; iTF_01323449; iTF_01324185; iTF_00561818; iTF_01132986; iTF_01261082; iTF_00259835; iTF_00543163; iTF_00548123; iTF_00559547; iTF_00565435; iTF_00583739; iTF_00802907; iTF_00917275; iTF_00471676; iTF_00487356; iTF_00584476; iTF_01236796; iTF_01549628; iTF_00613565; iTF_00616253; iTF_00805245; iTF_01550333; iTF_00257918; iTF_00512062; iTF_00551646; iTF_00575646; iTF_00972286; iTF_00335967; iTF_00533151; iTF_00918207; iTF_01552511; iTF_00550304; iTF_00891040; iTF_00600375; iTF_01382999; iTF_01382167; iTF_00793593; iTF_00402843; iTF_00474556;
90% Identity
iTF_00082212; iTF_00334247; iTF_00190024; iTF_01055304; iTF_01563848; iTF_00192880; iTF_01562974; iTF_01196051; iTF_01195336; iTF_01426739; iTF_01023089; iTF_01200958; iTF_00251413;
80% Identity
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