Basic Information

Insect: Drosophila littoralis
Gene Symbol: zfh1
Assembly: GCA_018903485.1
Location: JAEIGF010000593.1:12019250-12023422[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.4e-05 0.0022 18.2 1.1 1 23 150 172 150 172 0.97

2 15 0.00082 0.051 13.8 1.2 3 23 180 200 178 200 0.94

3 15 8.9e-05 0.0056 16.9 0.1 1 23 356 378 356 378 0.98

4 15 0.00031 0.019 15.2 0.9 1 23 384 406 384 406 0.98

5 15 3.4e-05 0.0021 18.2 2.2 1 23 437 460 437 460 0.95

6 15 0.00056 0.035 14.4 1.9 1 23 494 516 494 516 0.95

7 15 0.017 1.1 9.7 1.3 1 23 522 545 522 545 0.97

8 15 0.026 1.6 9.1 0.4 3 19 554 570 553 571 0.95

9 15 0.00015 0.0097 16.1 5.6 1 23 580 602 580 602 0.97

10 15 0.04 2.5 8.5 1.2 2 23 608 629 607 629 0.96

11 15 9.1e-06 0.00057 20.0 1.0 1 23 638 660 638 660 0.98

12 15 0.001 0.064 13.5 0.1 3 23 668 688 666 688 0.97

13 15 5.5e-05 0.0034 17.5 0.5 1 23 694 716 694 717 0.95

14 15 0.052 3.3 8.2 0.4 1 23 727 749 727 749 0.97

15 15 0.0016 0.097 13.0 0.3 1 23 1286 1308 1286 1308 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.4e-05	0.0022	18.2	1.1	1	23	150	172	150	172	0.97
2	15	0.00082	0.051	13.8	1.2	3	23	180	200	178	200	0.94
3	15	8.9e-05	0.0056	16.9	0.1	1	23	356	378	356	378	0.98
4	15	0.00031	0.019	15.2	0.9	1	23	384	406	384	406	0.98
5	15	3.4e-05	0.0021	18.2	2.2	1	23	437	460	437	460	0.95
6	15	0.00056	0.035	14.4	1.9	1	23	494	516	494	516	0.95
7	15	0.017	1.1	9.7	1.3	1	23	522	545	522	545	0.97
8	15	0.026	1.6	9.1	0.4	3	19	554	570	553	571	0.95
9	15	0.00015	0.0097	16.1	5.6	1	23	580	602	580	602	0.97
10	15	0.04	2.5	8.5	1.2	2	23	608	629	607	629	0.96
11	15	9.1e-06	0.00057	20.0	1.0	1	23	638	660	638	660	0.98
12	15	0.001	0.064	13.5	0.1	3	23	668	688	666	688	0.97
13	15	5.5e-05	0.0034	17.5	0.5	1	23	694	716	694	717	0.95
14	15	0.052	3.3	8.2	0.4	1	23	727	749	727	749	0.97
15	15	0.0016	0.097	13.0	0.3	1	23	1286	1308	1286	1308	0.98

Sequence Information

Coding Sequence: ATGAACAACCAGGACTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCGGTTGATTCCGAAACAGATATGCTGGAAAACGGCGCTGCTGACAGCGAGGTGACTGCCGCCTATTTGGTAAATGGCAATGCAACAGACGAGGATCTTGATCATATGGCGGCCGAGAATCTAATCTTCATGGCGCGCGATGGTCAGCTAAGCGAAATCATAGCCGCCAACGAAGCCGGCGGCGGAACTGTATTAATCACGGACAGCGGCACCGTTGCCTATGCCGAGTCATTTGATGATGATGCACAGGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCATCAGGGTGCCGAGCGCGTGGAAATCGCCGCGGAGCAAATAGCGGGCAACAACAGCTCGCAGGAGCTGCTGGACATGGAACAGGATGAATATACGGCGCTGCGCCCCTATCCCTGCGACTTTTGCAGCCGACGCTTTCGCAAAAAGGGCAGCCTCAATACTCACATGCTGGCGCACCAAAACGATCGTCCACATCTGTGTAAATTGTGCGGCGCTCGTTTTTCAAGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCACAGGTTGCGGCAGATGAGGCGGCTGCAATTAAATTTGAGCCGCAGCAACAGCAACGCCAAGCGGATGATCATTATTACGAACAGGATTGGCCTTTGTACCAGGAACAGGAAGAGGATCAGGTGCAAGACCAGATGCAGCAAATGGAGCAGGAGCAGCTGGTGGAGCCGCAGGCCAGCTATGCAGCGGTTAGCACTGTGTCCGCTCCAACAGCCACGCGCGGCCGCATTAGCCGCCTCAAGCCCAAAGAAGAGAGCACGCAGTACATTGTGATTGCCGAGAAGCAGACAACTGACGATTTGCGCCAGTACATGGATTGCGAGGAGCTGCCGCTGCAGCCGCCGCTCACTGGCAGCACGTCAATCGATGCATCGCATTCGACAGAGTGCCCAGACGGCCCAGTCGCAGTCGGTGGGGCAGAGACGCTACGCTTTCCGGTGCTGGACGAGAGCAAGCCCTTTGTGTGCCAGCAGTGTGGACTCGCATTTGCGCGCGAAAAAGCGCTCGTCTCGCATATCAAGAACCATCGCGTGGACTCGCCCTTCGAATGCAATCAGTGTCAGGAGATGTTCTGGGATAATTACAGCCTGCAGGAACATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCTTCGGCGGGCGAAGATAGCGCCAGCGAATCGGAGCCGGATCAGCTTTACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCCTTTCACAGGCAGGACCTGCTGCGTCGTCATGCCAAGCAACAGCACAAGCTGACACCAGACATGGAGGGCGGTGATGGCGGTGGTGGCGGCGAAGGTGACGGCGACGGCGGCGATGCTGATGCCGAAAATGCCAAAGACGCAGCGCACTGTTGTCACACATGCGGTAAATCGTTTCCCAGCGCACTGGAGCTGCTCGCCCATGCCGAAGTCCATGCACGCTTCCCGCCATTCAAATGCGTCCTGTGCGGTGTTAGCTTTTACGAGGAGCAGGCTATCAAGCGGCATTTGCATACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAAGAGTGTCGCGATCGCAAGGCACTGATCAAGCACGCCTGGGATCACTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGTCTGAAGCGACACATGGCCTCACATCGGGACAAGTCGGTGGTTTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGACGCACGCTTTCCAATCATCGGCATTCACATAGCACCACATCGCCGGGCAAGCTGTTTCCCTGCCACGAGTGCGGCAAGACCTTTGGCTCGCGCAGCTCACAGCAGATACATGTCCGCATCCATACGGGCGAACGACCATATGGCTGTCGCTACTGCTGGAAGGCGTTCGCCGATGGCGGTACGCTGCGCAAGCACGAACGCATTCACACGGGCGAGAAGCCCTATGCCTGTTCCGTGTGTCCGCGTGCCTTCAATCAGCGCGTTGTGCTGCGCGAGCATATACGCTCGCATCACTCGGGTCTGGATGCAGTACGTGGCACCTATCATTGCACCGTCTGCTCGGCCGATTTGTCCTCGTCCAATGAGCTTATACAGCATCTCATCCAGCACAGTGACACGAACACCGCCAAACAGCGACAGCCAATTACTGGTCCGCGCAAGTACAAGCGACGTAGGAAACTGCAGCCACACGAGATTGCCCACATGCGTGCGGGGAACAAGGATGGCGAGGAGTATGCCAGCGATATGGAACTATGTGACTTTGATGTTGAGAACGTGGATGATCTCCTGGACAGGACGGAGCCATTGCCAACCAAAAAGGAGAAGCGCAAGCGATCAGCTGCAAATCAAGCTAAGGCCGTGACCAATGGCGCCGCACACAATAGTTCCAGTTCTGCCAAATCCGTCAATAGCAGCTCGGAACGTCTGTGGGATGAGAAATTCCTGCCGGCAAACAGCAATGGCAATGTTGGCCACGCAGATGATGCCTACAAAAACTTCTTTCAAATTGATTCGTTGGTGGTGGTAAATGATACCACTCTGCCGCCTGTAAGCTCATCCAGCAGCACACCAAGCGCCCCTAAGTCGCGACGCGGCGGCAAGCAGCCACCGACGCAAACGCAGACCGAGAGCATTGACAAGTCTGGAGGTGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAAAGAAGTCTAGCAAGGCGGCCAAGAATACAGGCACAGCAGCTGCCACATCAAGCAGTTCACGTCCCCGCATGATACACACAGAAAAGGCACGAGTGCCGCCAGAGAATGCCAGCAAAAAGTCGCGTGGGCGCAGCTACATAACGCGCACCAGCACCAGCGAGAGCAACCAGCTGGGCCTGGTCAAGTCGAGCGGCGTGGCCAGTTCGCGGATTGTCGATGACTACGAAATTATATCACCTGCCACACAGCCGCCAAACCAGATCAGCTCCAGTCCGCTGCACATCAAGCAGGAGCAGGAGCAGCAACAGCAGCGGGTCCAGCTCATGTACGATGACACCCATTTGCTGATCCATGCGGCCATGTTGCGCGATAAGCCCTACGACAAGTTCAATCCGAGCATTGTCAATGATCTGGAGGAGATATTACGCAGTCCGCTCAAGCATGATCGGAATGCGCGCCTGCGTTTCACTAGCGAATCGTCCACAACGCCACAGTTTCTGCCCGAGGAGGAGCAGAACCTTATTAAAATTGAGCCCACGTCCCCGGATCTGCGCGAAATGGTGGAGAGCCAGCAACGTGTAACTGCCACAGGACACACAGCCACGCCCACATCATCATCATCATCCTCATCGGCGGCGCGCACATCGCGCCATCTGCGCCAGATCACTGCCAACTCGGCCACCCGCTCGGCAGCCAAGCGACACATGGACAAAAACTCATCCGAATTCAGCGCCAAGAAATCGACAACATCTTCGCCCGTTGCAGTCAGTAAGCCGGCCGCCAACTCGTACCTCAGCTATGGCGTGGACTCGTACAATGTGAATGTGGTGGCCAGTGCCAACTCTTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTGGTATCCGCTGCACATGCCGCCGATGCAGCGGCCAAGGCAGCAGCGGCCAGCAAAACGGAGCGTCGGACGCGCTGCTTTGAGTGTGAAATGTGCTCATCCATATTTCCGGATCGCGCCCAGCTGCTGGAGCACATGCATATACACATCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDMLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKGSLNTHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEAAAIKFEPQQQQRQADDHYYEQDWPLYQEQEEDQVQDQMQQMEQEQLVEPQASYAAVSTVSAPTATRGRISRLKPKEESTQYIVIAEKQTTDDLRQYMDCEELPLQPPLTGSTSIDASHSTECPDGPVAVGGAETLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHKLTPDMEGGDGGGGGEGDGDGGDADAENAKDAAHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGNKDGEEYASDMELCDFDVENVDDLLDRTEPLPTKKEKRKRSAANQAKAVTNGAAHNSSSSAKSVNSSSERLWDEKFLPANSNGNVGHADDAYKNFFQIDSLVVVNDTTLPPVSSSSSTPSAPKSRRGGKQPPTQTQTESIDKSGGGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKSSKAAKNTGTAAATSSSSRPRMIHTEKARVPPENASKKSRGRSYITRTSTSESNQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQLMYDDTHLLIHAAMLRDKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTATGHTATPTSSSSSSSAARTSRHLRQITANSATRSAAKRHMDKNSSEFSAKKSTTSSPVAVSKPAANSYLSYGVDSYNVNVVASANSSDVSSGFFSISEVVSAAHAADAAAKAAAASKTERRTRCFECEMCSSIFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00563313;
80% Identity: -