Basic Information

Insect: Drosophila limbata
Gene Symbol: ftz-f1
Assembly: GCA_963924055.1
Location: OZ001354.1:18042819-18056027[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 2.8e+04 -7.4 23.3 39 166 22 149 4 155 0.44

2 3 6.2e-20 8.7e-16 59.0 0.4 1 80 323 401 323 467 0.80

3 3 1.5e-72 2.2e-68 232.2 0.9 157 408 538 782 507 784 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	2.8e+04	-7.4	23.3	39	166	22	149	4	155	0.44
2	3	6.2e-20	8.7e-16	59.0	0.4	1	80	323	401	323	467	0.80
3	3	1.5e-72	2.2e-68	232.2	0.9	157	408	538	782	507	784	0.90

Sequence Information

Coding Sequence: atgttatTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCGCCGTTTAGCATGCAGctcgagcagcagcagccagcgAGTCCAGCgcacagcaacaccaacaacaacaccagcaacaacaacaacaacaacagtagcaacaataacaataacaacgataACGATACAAATGCATTGAGCAACTCTGATAATGATTACAGCGCATACACGTTGCAATTGAGcaatcatcagcagcagcaacaacaacaacagcaacatcacacgcatcatcagcaacaacaacagcaacattaccaacagcaacaacaacagaatatTGCCAACAATAATGCAAATGCAGCGAATCAATTCAATGCCTCCTCCTATTCGTATATATACAATTTCGATTCACAGTATATATTCCCGACAGGCTATCAGGAGACCAACTCATCCCATTCACAACAAAGTGGCAATGGCGGTGCCGCTGGCAACTCTGGCCAGCTACTAAATGGCGGCGCAGGTGGCAACTCTGGCGGCAATGGTTACATGTTGCTGCCACCAGTTGGCAACTCTGTTGCTGGCGGCGCCGCTGCCCACATGTCCGGCAATATTGGCGGCGGCAATGCGGCAGGCGGTGGTGCAGGTGGTGCGGGGGGCACAAGCGCTGctggtggcggtggtggtggaCATCATGGTGGCACCAGTGCCACATCCGGCAGTGGCGAGGCCATCGATTTCAAGCATCTGTTCGAGGAGCTGTGCCCCGTGTGCGGGGACAAGGTAAGCGGCTATCATTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGATTCTTCAAGCGCACCGTTCAGAACAAAAAGGTCTACACATGCGTCGCGGAGCGTTCCTGCCACATCGATAAGACGCAGCGCAAACGTTGTCCATACTGTCGATTCCAAAAGTGCCTCGAGGTGGGCATGAAACTGGAGGCTGTTCGAGCGGATCGCATGCGTGGCGGACGGAACAAGTTTGGACCGATGTACAAAAGGGATCGGGCGCGAAAGCTGCAGGTGATGCGTCAACGGCAATTGGCGCTTCAGGCGCTGCGCAGTTCCATGGGAACGGACATAAAGACGACGCCGCTGTCGCCGGGCTATCAGCAAGCATATCCAAATATGAATATTAAGCAAGAAATACAAATACCTCAGGTATCCTCACTCACACAGTCGCCGGATTCGTCGCCTAgtcccattgccattgccttgGGTCAGGTGAATGCGAGCGGGGGCGGTGTGATAGCCACGCCCATGAATGCCGGCAATGTGAGTGgcggcaatggcaacggcagCTCCTCATTGGGCgttggcaacaacagcaacaacaacaataccaacaacaacagcagcagcagcagcagcacaggCAGCGGTGGCAGTGCaggtggaggaggaggtggCGGAGGTGGCAACAACGCTGGCggtggcaacagcaacagcaacaacaatgccgaTGGCCTGCAACGCAACGGAAACGGcggcaatggcaacagcaacagcagctgccacgAAACCGGAACTGGATCTCTGCAGAACACGGCCGAATCGAAATTGTGCTTCGATTCTGGCACACATCCATCGAGCACAGCTGATGCGCTCATCGAGCCACTGAGGGTATCGCCAATGATACGTGAATTCGTGCAATCGATCGATGATCGGGAATGGCAGACACAGCTTTTTGCGCTGCTGCAGAAGCAGACGTACAATCAGGTTGAAGTGGATCTCTTTGAGTTATTGTGCAAAGTGCTCGATCAGAATTTGTTCTCGCAAGTCGATTGGGCAAGAAACACCGTCTTCTTTAAGGATTTGAAGGTGGACGACCAGATGAAGCTGCTGCAGCATTCGTGGTCCGACATGCTTGTGCTTGATCATCTGCATCATCGCATACATAACGGTCTGCCCGATGAGACGCAGCTGAATAACGGTCAGATCTTCAATCTAATGAGCCTCGGCCTGTTGGGCGTACCCCAGTTGGGCGACTACTTCAATGAGTTGCAGAATAAGCTGCAGGACCTGAAGTTCGATATGGGCGATTATGTGTGCATGAAATTCCTAATACTGTTAAATCCAGATGTGCGCGGCATTGTCAACAAGAAGACCGTCTTGGAGGGGCACGAGCGGGTGCAGGCAGCGCTGCTGGATTACACGCTCACGTGTTATCCCTCAGTCAATGACAAATTCAGGAGGCTATTAAACATACTACCGGAAATCCACGCCATGGCCGCACGGGGCGAGGAGCATCTTTATTCGAAGCACTGTGCGGGCAGCGCGCCAACGCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAA
Protein Sequence: MLLEMDQQQATVQFISSLNLSPFSMQLEQQQPASPAHSNTNNNTSNNNNNNSSNNNNNNDNDTNALSNSDNDYSAYTLQLSNHQQQQQQQQQHHTHHQQQQQQHYQQQQQQNIANNNANAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSGNGGAAGNSGQLLNGGAGGNSGGNGYMLLPPVGNSVAGGAAAHMSGNIGGGNAAGGGAGGAGGTSAAGGGGGGHHGGTSATSGSGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSMGTDIKTTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGVIATPMNAGNVSGGNGNGSSSLGVGNNSNNNNTNNNSSSSSSTGSGGSAGGGGGGGGGNNAGGGNSNSNNNADGLQRNGNGGNGNSNSSCHETGTGSLQNTAESKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELLCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQIFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHERVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00562522;
90% Identity: iTF_00585997;
80% Identity: iTF_00533856;