Dleo011661.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
hang
Assembly
GCA_035045365.1
Location
JAWNPC010000481.1:3360788-3376106[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.4 30 5.5 1.0 3 23 533 554 532 554 0.93
2 18 1.1 86 4.1 3.2 3 22 661 680 659 680 0.89
3 18 0.00086 0.064 13.9 3.3 1 22 782 803 782 805 0.90
4 18 0.099 7.4 7.4 0.1 2 21 817 836 816 837 0.93
5 18 0.00099 0.075 13.7 0.2 2 23 974 996 973 996 0.95
6 18 0.023 1.7 9.4 0.2 1 23 1004 1027 1004 1027 0.96
7 18 0.00022 0.016 15.8 0.2 2 23 1113 1134 1112 1134 0.97
8 18 0.00041 0.031 14.9 2.9 2 23 1232 1254 1231 1254 0.97
9 18 0.032 2.4 9.0 0.2 2 23 1263 1285 1262 1285 0.95
10 18 0.34 25 5.8 0.8 1 23 1298 1321 1298 1321 0.97
11 18 0.00018 0.013 16.1 1.1 1 23 1362 1384 1362 1384 0.99
12 18 0.0028 0.21 12.3 0.9 1 23 1392 1415 1392 1415 0.96
13 18 0.097 7.3 7.5 0.4 2 19 1423 1440 1423 1441 0.94
14 18 3.8e-05 0.0028 18.2 0.4 3 23 1551 1571 1550 1571 0.98
15 18 0.0072 0.54 11.0 0.1 1 23 1606 1628 1606 1628 0.97
16 18 0.00085 0.064 13.9 0.6 2 23 1717 1739 1716 1739 0.93
17 18 0.0092 0.69 10.7 0.3 3 23 1795 1815 1795 1815 0.98
18 18 5.4e-05 0.0041 17.7 2.3 1 23 2287 2309 2287 2309 0.99

Sequence Information

Coding Sequence
ATGTGCGACGCTGtcgcaactacaacaacaacaacaacagcagcaatggcaacgaTCCCAGCAGCAGGATCCGGATCTGGAGTGGCTGCGGGCGATACCACATTGACAGCAATGGAGGAGCGTACGCGACAAAGTTGCTGTCGCCTGTGCATTGCGCCCGCCAGCGAATGCATTTCGATCATTAACAGTTATGCGGCCGATAAGGAACCGTTGGCCACTAAAATACACAACTGCGTAAATATCAAGatcaCGCCATTGGATCGTCTATCGCTGCATATTTGTCATGCCTGCATCAGCTATTTGAACTCTTGGCAGAGCTTTAAAAATCGCTGCCTCAGCTCACAGTCCAAGCAGCGGCAATGGCTGGACGGCGATAAAAGCAAGCAGCAGACGCTTTTGGGATATTTGGATTTGAACAAAACGGAGAATGGCAGCTCCattgaacagcagcagcagcagcagcagcagcagcacgaatCGAATATCGATTCGGCAACGATTGCAGCTGAAAAGGCGTCCGCCAACATTTTGGATGGCATTCCTTCGTTGAAGAAACGCAAATCGTTAACAGTCTATGTGAGTCCAAAGCAACAgcttcaacagcaacaacaacaacaacagcaacagctacaacaacagcagcagcagcaacaacagcagcagcagcaggtgcagcatgcagcaagaGCAACGAGCGCGGCGGCGGAATCACAGCAAACGTTGCAGACCCTTTTATTGCAGGTGcccccaacagcaacagcagcagcagcaggagcagcaatggcagcgacatcaacccagcagcagcaacagcaacagcgcaaatatcaacagcagcagcaacgtgtCAAGCAACAACActaccaacagcaacatcaacaaagtcaacaacaacaacaacagccgcagcagcagcagcgcttgAGTCGCATTCGTCAGCCGAGACGCCAGCAACAAGCGACAATGTCTGCCCAGCGTATGGTCAAATTTAAGCCGAAAGTGTATTTGCCACTGGATATATCGGTGCctccgctgccgccgctgttgCCGACACCGTCACAGCCGCTGgacactgttgctgctggtgctaaGTTGGCgccgttgcctttgccgttgccgttgccgttgccactTGATTTTAGCCAGAGTCAGTGTCAGCATCCGAATCCGAATCCGAGTCAGCAGAAACATGGCAAcgtgttgccgttgccgttgccattgccgccgTCGACGCCGCTGCCAGCTGCAACAATGACCAGCAACGCCGCTGCCTCTagctctgcctctgccgctgccgcagccgcagccgtcACGACTCCTCTACTCATGCCGCCGCTGCCTGCCGTCCCGATCAAGGATGAGCCCATTGATGATACGGACGATGACTTTCAAATGAAGTGCATAGACGAATCCGATGATATGATGGATCCCACAATGTTCCTAGAGCGCTCCGAGCATGAGGGCGATGTGCCACTAATGACCTCCGACTATGATTACACGGCGCAACACGGCGTGACGGCAGTTGTGGCGGCGGCATCACTGCCCGCCAGCGCGGTTGCAAACGTGGCCGCCGCTGGCGACTCAAAGGTGGCCAGCTGTCGGGCGTGCAGTCTGCAGTTTTCGACGCGCGCGAATGCCCGACGCCACGAACGCAATCTGCATCCGAATCTGTTTCAACTGTCGACAGATTCACCAAATAATACGCCAATCACAAAACCAACGCCGGCCCTGGCCGCCGCACTGGAAATTCAACGTGCCGCcgcggcggcagcagccacCGCCGAGGCAACCAAAGCCGCCGCCGGCGGCAACATATCAGCGCAAAAGTATCGCCAGGTGGTCATGAATACGTTCATCAAATGCGAGAATGGCGGCTTCGACTACGACAATCCGGAACAATATCAGCAGCTGCTCACCAGCGACAAGGTGGAGTTCATCCAAGAGAACAATGAGTTTCTGGAGCAATACCAGACGATGACGTGTCGCTGCTGCAACAAATACTTCAACACCTACAAGAACTTCATGGCGCATGTGCGCAAAAAGTATCCGCTGCTGCCGCGCAATCTGTGCTTCAACTGCCTCAAGATGAACGACTCGAAGGCGCTGTTCATATCGCATCTGAAGAAGCGCAACTGCATCAATTTGTATCGCGTGCTGAACGCTTTGCGCTTGAAGCAGCCATACTTTCTGCATGCCAATGCAGCTGGTGTGGCTGTCTCGGCCGACTTGAGTGTTggccaggcagcagcaggagtagcagcagcagcagcagctgctgctgctgatacaTCCATGGAGCGGCCAGAGAAGCTGCGTGCCAAGGAGCTGCTGGTGAACAAGCTGTATGAGTGCAAGCTGTGCCCGAAGGGTTTTCGCACCAAGCACGAGTTCCGCACCCATGTGTATGACAAGCATGCGGATGTGCAGCGCAAGGATAACAACTCGATACAGtgcagcttttgtggcttggaCTTTGCCGATCCCGTGGATCGTCGGCGCCACTACAACAATATGGCCTGCATTGTGCGATTGCGCTGTATGACCTGCGACGCCAAGCTGGAGACGCATCAGCGCTTTCTCGATCACGTCTACCAGGATCATCTGGGCGGTGTGAGCAGCGATAATGCGTCTACAGCCAACAGCGGCATGGATCATTCACCGGGCAAGCGTAGCCTGCTGGgtggcatgggcatgggcatgggcatgggcgttGGTATGAGTCAGTCATCGAATGATGAGTCACGTAGCAGcacacacaacaataacaatgctaTGGAATTGCCGTTCACCTCAACACCGAAGCCAGCTGGACAAGCAGGTGGAGCAGCGACcagtggcggcggtggcggtggcggcggcggctccACAACGGGCAGTCGCGATGCACCCAAATCGCAGTATTTTTCCCGCATGCCACAGGTGTGCCCCATATGTGGGCAACagtacaacaactacaacaacgtGCTGCGCCACATGGAATCGAAGCATCCCAATAAGCTGCCCGAGACATACAAGTGTGTGCGCTGCAGCCTGGGCTATCCGCGAATCTCATATCTGCGCGAGCACATGATCAATGTGCATGGCGTGGACAAGAATCGGCATTCGGGCGGCTTCGAGTATATTGTGAATGCGGACGCAGTCAAATTGGCGGATGGCAGTACGCCGAACGTCTATACGGGTCGCTATGATTATGTGATGAAGGATCTGATGTCAATAACAAATGGTGGGACACTCGatgatgatgaggaggaCACTGGCAGCGTTGCCAAAAAGATGCGACTCgatgacagcagcaacaatagcagcatCAACATGAGCATGGCCAACCAGCAGAAGGAGTGCCTCATCTGCAATGCGGTGTTTAGCAACAACATTGGCTTATCGAATCACATGCGCTCGCATTATACAGCCTCGACGGCAACGAATGCAGCGCTGGCGGCTGCCAATCGCATGACGCCCAAATCTTTGACAATTACTGCAACGCCGCCATTGGAaacgactgcagcagcagcaccagcagcagcaacaacatctgcGGCGCCCGCcacaagtgcagcagcagccgctggagtagcaacgacaacaaccgGCGTTGGCGGCTTGCCACCAGCCATGGCGCATCAGACGCCACAGGAGCAGGCCGTGTTCCGGCGCAGCTTGGATCAGGCAGCCGATCGTCGCTTTCGACGCATGCGCTGTCGCATCTGTCAGCGCAGATTCAGCTCTAAGAAATCATATCGCTATCACATGCTCACCGACCATCAGGTGCAGAACGTGCAGTTCATCAAGTGCAAGCTCTGCAATGCAGAGTTTGCCTACGAGAAGGGCCTCAAAGTGCATCTCTTCAAGGTGCACGGGCGGGCCATTAAGGACGAGATGATTGTGAAGCAATTCGAGTGCGATATCTGCTCCATTGTCTACAGCTgtgagctggagctgcagcagcacaagcgcagCGTTCACAAATCCCAACTGGGCGCCAATGATGCCTCGAAAGCAGCAACCAAATCATCTACCGCTACCTCAGCTGCTGAACTGGCCGACACTGCGGGCACGCCTGTGGCGGTCCTGCCGCTCTACTGGTACCAGTGCAAGTACTGCCCATCCAACTTCAATACCAACAAGAAGCTGGCCATTCACATCAATTCGCACGACGAGTTCGACTCGAATGATTATTCGTGCAAGGATTGCGGCAATGTCTACAGCGGACGTAAGAGCCTCTGGgtGCATCGCTATAAGAAACATCCGCAGGTGCCAGATCCCGCGGAGTGTACGCTGTGCCGCAAGATGTTCTTTGATCGACAGATGCTGGAGAATCATACGCCCACCTGCAATCGGAAGCCCATCACTGCCACCGGCGCCCATCAGCAggaccagcagcaacaccagcaacagcagcagcagcagcagcaacaacagcagcagcaacagctgcaattgcaacatCAGCGCGCCATATTCAAGCACAAGACGggcgatgatgacgatgaggaggaggatgatAAGCTAATGCTGCTGGACGATAGTGCACTTGGCAGCGATAGCAACGGTGGCCATGTGATCCATGCGCccgccaccaccagcagcagcaacagcaatccaAATACCATAACTGCGAGCACATTGAAGATACGCATACCGGAGGTGGCGTGCACCATTTGTGGTGCTCGCTTCACCGACCAGGAGATGTTCACCAAGCATATACAGAAGCATGAACAGGATCTGTATGTGGACAATCCGTTGGCGGCCATGTTCGATGATGGGCCAGCCGATGCTGGCCAATTTCAGGTGGAGCGACAGAACGAGAATGGGGAATATGCGTGCGATTTGTGCGCGAAGACGTTCCCCCAGGTGATTGCGCTCAAGGTGCATCGCAAGTGGCATTTCAGAGGTGATAGCAAGCAGAATCTCATCATCGACGGCGAAGCGACAACgctgaacaacagcagcaacaacaacaacaacaattcgctGAGCTCCTCATCGATGCTGCGCGAGCTACATGCAGTGGGCCTGATGcccaaccaacaacagcaccagaagcaactacaacagcagcaacaacaacagcagcaacagcaacaacaacaacaacggaaCAACACATCGAGCGGGTCGAGCAAGTCGATGAAACGAAAACGTGAACTGAAATGCGAATATTGCGCCTCCACATtcattagcaacaacaacctgcGACGCCACATGTACGAGCTGCACAAGCACGAGGTCAGCAATCTGCCAGAGCCGCCAGTTATTGAAGTGGATGAGCCGCTGACGTGTCGTCGTTGCGGCGATAAACGCTTCGATACCAAAGAGCTGTGGATCGAGCATAAGCTGGCGGACGCCAAAGTGGTGCGTCCCTTCTGTCCATTCCAATGGGGCTGTGATCTCTGCGGCGAGTACTTGTCGCGCAAAGAGAAGCTCATCAATCACATTAACAATCATCTCAAAGAGGATGTGATAGTGCCCGTGGCAACGGTGGCGACAGCCAACAAGGCGACGCCACCAGCTTCCGTGCTAACCAACAAGAATGCAACAGCGAAACCAACAGCTggaacaccaacaacaacaacaacaacagcaacgacaaagGGCATAATGCGAGCGGCGGCACCAGCTGGCGGTAGAGTTAATAAGAGTAAACAACTGGAGGAGGAGCAGCTGACAATGAAGGTGGcaacaaaacagcagcagcagcaacaacagcaacaatcgtCAAATGATGCTAATGCTGAGCAAGATGATGAGGAGGATGACAGTGAtatggatgatgatgatgatgatgatgatagcGATAGTGGCGATGCGGATAGCATAagtgctgatgatgatgatgatgatgacgacgacgaggaggaggatgatgacgatgaggGCGACgttgatgacgatgatgatgatgacgatgaggaTGTGGATGGTGATGTTgttcaacaacaattgctgcaacaaaaacaacagcagcaacaacaacaacagcagcaacaacaacaaccacaaaccctcaacagcaacagcaatagcgtAGCTGCAaacgatgatgacgatgatctCATTGAGGAAGTCATCGAGGATGATGGCATTGTCGAGGAGTtggacgatgatgatgaggaggaTGAGGACGATGACGATGGTAATACAACCGTTGAGAACTATCAGCTGACATCAGCCAatacaaagcagcagcaacagcagcagcagcagcaggggaGACGCCTCAACTTTGACTACTCGCGCTCCGACAGCGCCAAGCtgaatggcaatggcaaacaGACGCCACAGCAGCTGGCCAAGTCGAAGGGGCAGCCGGCGGTGCTGGTTATGCACAGCTCCgaggaggatgaggatgaggatgcgAATGATGGTGTTGGTCATGTCGACaatgatgaggatgaggagggcgtgggcgtgggcgaaGCAATGACCATTGATGATATTATTGAAGAAGATGATGGGgaggatgaggatgacgaTGTGGTCGGTGTCGGCGGTGGTGTTGTtgaggatgatgatgacgatgatgatgatgatgatgttgaggAAGACATGGATgaggatgatgacgatgatgatgatgaggacgacgacgacgacgacgatggtAACGGCGTCAATATTGGCAAGAACAATCGTCGTCGCGACGGTGCTGTGATGGTCAGCGGCATCGGCATTGGCGATGGTGAGGCTGATGATggtgttgctgatgctgatggtgATGGTGATGGCGATGCTGATGCTACATCATCATCGGAGAGcgagtcaacaacaacaacatcgcatTCAATTGGTGAGCGGCGTAAAAAATCAGTAGTTAAATCAGCGGCACATGGCGCTGCCGCTGATCAGTCTAATTCCATCTATACGTGTGATCTATGTCAACTTTGTTTCGATTCTCAGGAGCAACTGCAGTCACATATTAAAAGTCATTTTCTGAATGGGCCGTCGgcgggtggtggtggtggtggcagcagcagcagcagcaacaacagcaacagcagcagtgccGCCAGCAATTGCAGAAGAATTGGTGCCagcgctggcagcagcagcagcagcagtagcagcagcagcaggaccaacaacaacaacaacaataataataacaataacaataagaataataataataataataacagcaaaagcaaaaccaaaaagtCTGGCTTGGATGCAACGAAAGGTgatagtgctgctgctgcaacagcagcaacaacaacaacaacaacggcaacaatggcaacaacacgagcaacaacagcagcaacgacaacagcaacagttgccgctgaggcagctgcagcaacagcagctgctgaggCAGCAAACAGCTTGAACTga
Protein Sequence
MCDAVATTTTTTTAAMATIPAAGSGSGVAAGDTTLTAMEERTRQSCCRLCIAPASECISIINSYAADKEPLATKIHNCVNIKITPLDRLSLHICHACISYLNSWQSFKNRCLSSQSKQRQWLDGDKSKQQTLLGYLDLNKTENGSSIEQQQQQQQQQHESNIDSATIAAEKASANILDGIPSLKKRKSLTVYVSPKQQLQQQQQQQQQQLQQQQQQQQQQQQQVQHAARATSAAAESQQTLQTLLLQVPPTATAAAAGAAMAATSTQQQQQQQRKYQQQQQRVKQQHYQQQHQQSQQQQQQPQQQQRLSRIRQPRRQQQATMSAQRMVKFKPKVYLPLDISVPPLPPLLPTPSQPLDTVAAGAKLAPLPLPLPLPLPLDFSQSQCQHPNPNPSQQKHGNVLPLPLPLPPSTPLPAATMTSNAAASSSASAAAAAAAVTTPLLMPPLPAVPIKDEPIDDTDDDFQMKCIDESDDMMDPTMFLERSEHEGDVPLMTSDYDYTAQHGVTAVVAAASLPASAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAAAAATAEATKAAAGGNISAQKYRQVVMNTFIKCENGGFDYDNPEQYQQLLTSDKVEFIQENNEFLEQYQTMTCRCCNKYFNTYKNFMAHVRKKYPLLPRNLCFNCLKMNDSKALFISHLKKRNCINLYRVLNALRLKQPYFLHANAAGVAVSADLSVGQAAAGVAAAAAAAAADTSMERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMACIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVSSDNASTANSGMDHSPGKRSLLGGMGMGMGMGVGMSQSSNDESRSSTHNNNNAMELPFTSTPKPAGQAGGAATSGGGGGGGGGSTTGSRDAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCSLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDDEEDTGSVAKKMRLDDSSNNSSINMSMANQQKECLICNAVFSNNIGLSNHMRSHYTASTATNAALAAANRMTPKSLTITATPPLETTAAAAPAAATTSAAPATSAAAAAGVATTTTGVGGLPPAMAHQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIVKQFECDICSIVYSCELELQQHKRSVHKSQLGANDASKAATKSSTATSAAELADTAGTPVAVLPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPAECTLCRKMFFDRQMLENHTPTCNRKPITATGAHQQDQQQHQQQQQQQQQQQQQQQLQLQHQRAIFKHKTGDDDDEEEDDKLMLLDDSALGSDSNGGHVIHAPATTSSSNSNPNTITASTLKIRIPEVACTICGARFTDQEMFTKHIQKHEQDLYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNLIIDGEATTLNNSSNNNNNNSLSSSSMLRELHAVGLMPNQQQHQKQLQQQQQQQQQQQQQQQRNNTSSGSSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIEVDEPLTCRRCGDKRFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLINHINNHLKEDVIVPVATVATANKATPPASVLTNKNATAKPTAGTPTTTTTTATTKGIMRAAAPAGGRVNKSKQLEEEQLTMKVATKQQQQQQQQQSSNDANAEQDDEEDDSDMDDDDDDDDSDSGDADSISADDDDDDDDDEEEDDDDEGDVDDDDDDDDEDVDGDVVQQQLLQQKQQQQQQQQQQQQQPQTLNSNSNSVAANDDDDDLIEEVIEDDGIVEELDDDDEEDEDDDDGNTTVENYQLTSANTKQQQQQQQQQGRRLNFDYSRSDSAKLNGNGKQTPQQLAKSKGQPAVLVMHSSEEDEDEDANDGVGHVDNDEDEEGVGVGEAMTIDDIIEEDDGEDEDDDVVGVGGGVVEDDDDDDDDDDVEEDMDEDDDDDDDEDDDDDDDGNGVNIGKNNRRRDGAVMVSGIGIGDGEADDGVADADGDGDGDADATSSSESESTTTTSHSIGERRKKSVVKSAAHGAAADQSNSIYTCDLCQLCFDSQEQLQSHIKSHFLNGPSAGGGGGGSSSSSNNSNSSSAASNCRRIGASAGSSSSSSSSSSRTNNNNNNNNNNNNKNNNNNNNSKSKTKKSGLDATKGDSAAAATAATTTTTTATMATTRATTAATTTATVAAEAAAATAAAEAANSLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00476771;
90% Identity
-
80% Identity
-