Basic Information

Insect: Drosophila leonis
Gene Symbol: zfh1
Assembly: GCA_035045365.1
Location: JAWNPC010000456.1:518764-522907[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.0002 0.015 15.9 2.6 1 23 150 172 150 172 0.97

2 15 0.00091 0.068 13.9 1.2 3 23 180 200 178 200 0.94

3 15 0.00025 0.019 15.6 0.1 1 23 356 378 356 378 0.98

4 15 0.013 0.94 10.3 0.9 1 23 384 406 384 406 0.98

5 15 3.7e-05 0.0028 18.2 2.2 1 23 437 460 437 460 0.95

6 15 0.00062 0.046 14.4 1.9 1 23 491 513 491 513 0.95

7 15 0.019 1.4 9.7 1.3 1 23 519 542 519 542 0.97

8 15 0.029 2.2 9.1 0.4 3 19 551 567 550 568 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 577 599 577 599 0.97

10 15 0.03 2.3 9.1 1.1 2 23 605 626 604 626 0.96

11 15 1e-05 0.00075 20.0 1.0 1 23 635 657 635 657 0.98

12 15 0.0011 0.085 13.5 0.1 3 23 665 685 663 685 0.97

13 15 6.1e-05 0.0046 17.5 0.5 1 23 691 713 691 714 0.95

14 15 0.058 4.3 8.2 0.4 1 23 724 746 724 746 0.97

15 15 0.00061 0.046 14.4 0.5 1 23 1279 1301 1279 1301 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.0002	0.015	15.9	2.6	1	23	150	172	150	172	0.97
2	15	0.00091	0.068	13.9	1.2	3	23	180	200	178	200	0.94
3	15	0.00025	0.019	15.6	0.1	1	23	356	378	356	378	0.98
4	15	0.013	0.94	10.3	0.9	1	23	384	406	384	406	0.98
5	15	3.7e-05	0.0028	18.2	2.2	1	23	437	460	437	460	0.95
6	15	0.00062	0.046	14.4	1.9	1	23	491	513	491	513	0.95
7	15	0.019	1.4	9.7	1.3	1	23	519	542	519	542	0.97
8	15	0.029	2.2	9.1	0.4	3	19	551	567	550	568	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	577	599	577	599	0.97
10	15	0.03	2.3	9.1	1.1	2	23	605	626	604	626	0.96
11	15	1e-05	0.00075	20.0	1.0	1	23	635	657	635	657	0.98
12	15	0.0011	0.085	13.5	0.1	3	23	665	685	663	685	0.97
13	15	6.1e-05	0.0046	17.5	0.5	1	23	691	713	691	714	0.95
14	15	0.058	4.3	8.2	0.4	1	23	724	746	724	746	0.97
15	15	0.00061	0.046	14.4	0.5	1	23	1279	1301	1279	1301	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGACTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTGGATTCCGAGACGGATCTACTGGAAAACGGCGCCACTGACAGCGAGGTAACGTCCGCCTACTTGGTCAATGGCAATGCAACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATATTCATGGCACGCGATGGCCAGCTAAGTGAGATAATTGCAGCCAACGAAAACGGCGGCGGCACCGTCTTAATTACGGACAGTGGAACTGTTGCCTATGCCGACTCGTTCGATGAGGATGCCCAGGTGGTCACCGAGGAGATCATCACAGATGACTGGGTGCAGCATCAGGGCGCCGAGCGTGTGGAAATCGCTGCGGAGCAAATTGCGGGCAATAACAGCTCGCAGGAGCTGCTGGACATGGAGCAGGACGAGTATACGGCACTGCGACCCTATCCTTGTGACTTCTGCAGCCGGCGCTTTCGCAAAAAGGCCAGCCTGCACAATCATATGCTGGCGCATCAGAACGATCGTTCGCATCTGTGTAAATTGTGTGGAGCTCGGTTCTCGCGGCGCGCTGAGCTCATCAGCCACTTCAAGGCGCATGCCGAGGCACAGGTGGCGGCAGATGCGGCGGCAGCAATTAAATTCGAGCAGccacaactgcagcagctgcagcaacgcCAAATGGACGATCATTTCTATGAGCAGGAATGGCCCTTGTACCAGGAACAGGACGACGATCAAGTgcagcaggagctgcagcaactggagcaggagcaggagcagctggTGCTGCCACAGGCTAGCTATGCAGCCATCAGCGATGTGCCCGCACCAACAGCCACGCGCGGCCGCATCAGCCGCCTCAAGCCCAAAGAGGAGAGCACTCAGTATATTGTGATTGCCGAGAAGCAGCCAGCGGATGACCTGCAGCAGTACATGGAGTGCGAGGAGCTGCCGCCAACGCTAACGAGCACGTCCATCGAGGCGCCCCAGTTGGCAGCTGGCGCACCCGCTGCTGATGCGGCACAGCCTCAACGCTTTCCGGTGATAGACGACAGCAAACCCTTTGTGTGCCAGCAATGCGGCTTGGCATTTGCGCGCGAGAAGGCACTGGACTCACACATTAAGAATCATCGCGATGACTCTCCATTCGAATGCAATCAGTGCCAGGATATGTTCTGGGACAATTACAGCCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAGTATGATCCGGCCTCGGCTGGCGAGGACAGCGCCAGCGAATCGGAACCAGAGCAGCTGTACGGCGAATTCTACTGCAGCGAATGTGGCATCTCGTTCCACAGGCAGGACCTGCTGCGGCGCcatgccaagcagcagcacaagcagctgGCCACGGATGTGGAGAGCGTCGCTggcgatgctgctgctgatgccgcGGCGCATGCCGAGAGTGCCAAAGATGCAGCGCAGCATTGTTGTCATACATGCGGGAAGTCGTTTCCCAGCGCCCTGGAGCTGCTCGCCCATGCCGAGGTGCATGCGCGCTTCCCGCCCTTCAAATGCGTTCTGTGTGGTGTTAGCTTCTACGAGGAGCAGGCTATCAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAGGAGTGCCGAGATCGCAAAGCCCTGATCAAGCATGCCTGGGATCACTCGCGCGAGAAGTGCCACTCGTGCTCGAAGTGTGGCAAGAACTTCCACAACAAGGCTCGACTGAAGCGACACATGGCCTCGCATCGCGACAAGTCAGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGACGATCCCTGTCCAATCATCGACATTCGCACAGCACCACCTCGCCGGGCAAGCTCTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGTTCGCGCAGCTCCCAGCAGATCCATGTGCGCATCCACACGGGCGAGCGACCCTATGGCTGTCGCTATTGCTGGAAGGCGTTCGCGGATGGCGGAACGTTGCGCAAACACGAGCGCATTCACACAGGCGAGAAGCCCTATGCCTGTTCCGTCTGTCCGCGCGCCTTTAACCAGCGCGTGGTGCTGCGTGAGCACATACGCTCGCACCACTCGGGCCTGGATGTTGTGCGCGGCACGTATCACTGCACCGTCTGCTCGGCCGACCTGTCCTCATCCAATGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACCGccaagcagcggcagccaaTTACTGGTCCGCGCAAGTACAAGCGACGCAGGAAACTGCAGCCGCATGAGATTGCGCACATGCGTGCGGGGCACAAGGATGGCGAGGACTATCCCAGCGACATAGACTTCTGCGACTTGGATGTGGAGAATGTGGATGATCTGCTGGAAGGGGCGGAGCCATTGCCAACTAAAAAGGAGAAGCGCAAGCGTGCAGCTGCCCATCAAGCTAAGGCCGTGACAAATGGGGGCGGGAATAGCAACGCCTCCccctccgcctccgcctcggCCTCAGCTAAGTCCGTCAACAGCAGCTGGGATGAAAAGTTCCTTCAAACGaatagcaatggcaacggTGCCAATGCTGATGAGAGCTTCAAGAGCATCTTTCAAATTGATTCGCTCGTGGTGGTCAATGATACCACATTGCCGGCCATCAGCTCATCCAGCAATGCTCAAGGTGCTGCCAAATCTCGGCGAGGCGGGGGCAAGCAGGCCGAGCATAGCGTCAAAGCAGAAGGCGGAGCAGGCACAGCTGGTGCGGAGTCTCGCAAAACCAatcgcagcagcaaccgcaagAAGTCAACTAAGTCGGCCAAGAGTGCAGCCactgcagcagccacagcagcaacagcagctgcaggatCACCCACGGCGAGTAGCTCGCGTCCACGCATGATACACACGGAAAAGTCGCGTGCGGGGCCAGAGAATGCAGCGAAGAAGTCGCGTGGTCGCAGCTATGTAACgcgcaccagcagcagcgaggccagcagcagccagcagctgagCAGTCACCATGGTCAGCTGGTGAAGTCGAGCGGCGTGTCCAGTTCGCGTATTGTCGATGACTACGAGATTATATCACCTGCCACCCAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACATcaagcaggagcaggagcagcagcagcagcgcgtcCAGTTCATGTACGATGACACCCATCTGATGATCCATACGTCACACATGTTGCGGGAGAAGACCTACGACAAATTCAATCCGAGCATTGTGAATGATCTCGAGGAGATTTTGCGCAGTCCGCTCAAGCATGATCGCAATGCGCGGCTGCGTTTCATCAGCGAGTCGTCGACGACGCCACAGTTCCTGCCCGAGGAGGAGCAAAATCTGATTAAGATTGAGCCCACATCGCCGGATCTGCGGGATATGGTGGAGAGCCGGCAGCAGCGTGTCCATGCCACAAGTGGACAaccggccacgcccacctcgTCATGCTCGTCGTCGGCGGCGCGCACCTCGCGCCATCTGCGGCAGCTGACGGCCAATGGCTCGGGCAGCCGAGCGGCGTCCAAGCGAAGCGTTGCCAAATCTTTAACTACCGCCACGAAATCCAGCAGCCACACATCCTCCACGGAAGCTGACAGCAAATCGTACCTCAGCTATGGTGTGGACTCCTACAATGTGAGTGTGGCAGCGAGTGCCAATGCGTCGGATGTCAGCTCCGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCTGCCCATGCAGCCGATGCGgccaaggcagcagcagcgagcaaAACGCAGCGCCGGACCCGTTGCTTCGAGTGCGAAATGTGCTCATCCATATTTTCCGATCGGGCTCAGCTGCTGGagcacatgcacatacacatcTAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGATDSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANENGGGTVLITDSGTVAYADSFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLHNHMLAHQNDRSHLCKLCGARFSRRAELISHFKAHAEAQVAADAAAAIKFEQPQLQQLQQRQMDDHFYEQEWPLYQEQDDDQVQQELQQLEQEQEQLVLPQASYAAISDVPAPTATRGRISRLKPKEESTQYIVIAEKQPADDLQQYMECEELPPTLTSTSIEAPQLAAGAPAADAAQPQRFPVIDDSKPFVCQQCGLAFAREKALDSHIKNHRDDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESEPEQLYGEFYCSECGISFHRQDLLRRHAKQQHKQLATDVESVAGDAAADAAAHAESAKDAAQHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRSLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGHKDGEDYPSDIDFCDLDVENVDDLLEGAEPLPTKKEKRKRAAAHQAKAVTNGGGNSNASPSASASASAKSVNSSWDEKFLQTNSNGNGANADESFKSIFQIDSLVVVNDTTLPAISSSSNAQGAAKSRRGGGKQAEHSVKAEGGAGTAGAESRKTNRSSNRKKSTKSAKSAATAAATAATAAAGSPTASSSRPRMIHTEKSRAGPENAAKKSRGRSYVTRTSSSEASSSQQLSSHHGQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQFMYDDTHLMIHTSHMLREKTYDKFNPSIVNDLEEILRSPLKHDRNARLRFISESSTTPQFLPEEEQNLIKIEPTSPDLRDMVESRQQRVHATSGQPATPTSSCSSSAARTSRHLRQLTANGSGSRAASKRSVAKSLTTATKSSSHTSSTEADSKSYLSYGVDSYNVSVAASANASDVSSGFFSISEVVSAAHAADAAKAAAASKTQRRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: -
80% Identity: -