Dleo018045.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
-
Assembly
GCA_035045365.1
Location
JAWNPC010000953.1:9406499-9411090[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9.2e-15 2.1e-11 43.5 0.1 8 73 398 459 392 462 0.88

Sequence Information

Coding Sequence
ATGAGTTCGCCTGATGATGCCTTGGAAGAAGGCAATAACAGCTTTCGTTCAATGAAGAAAGCAAGAGCATTTCCGAGAGGCAGGGCATCGAGCGATGATTCTGTACCCGACAACGACAATTCCAATCATTCGGTGGCTTCCATGTTCAAGTCCACTGATAGTATCAACGGTCGTAAGGTCCTGGGcgataaaattaaaaagcagAACTCATTTGAAATGGAATCAGACATCTCACAGCAGGCGGTGCAGCTGGATGCCGAGGAGAATGCTGAGGCCGCAAGCATTCGCAAGGCCAAAAAGCGTAAGgccaagaaaaacaaacagcgaCGCGGCTCGAGGGAGGATGCTTTGGTGGGTTGGAGCGGTGCTTTTCCCAATCTCTCATCCACTCACAGCTTGGAGAGTAATTCGGATGTGGATCAACAGcagctgcccgcTGACCTAAAGGCAATCTGTGCCACTGGGCTGAGCGTGTTTCCCAGAGAGGACAAGGAGCAGGGGCCGCCGCtgtcatcatcgtcgtcttCTGATTCTACTTCCCTCTCGCCAGTTTCCCAACATAAAATGcctgcaacaacgacaacaacagctttcACAATTACTACAAATTCGACTACTCCAAGTCCAAAGTCTACGCagacaaccaacaacaacaacatcaacaacaacgacaacaattcAGCGTCAATGTCACTTGCTACAAGTTGTCAACGCTCAGAACCATCATCAGAGccagaatcagaatcagaaacCCAAGCTGATCTAGCTATGCAGAAGGCCAAGCGTGTAAAGAAGAGATTGTCCGGTGGCGCTGCTGACATTGAGCCATTGATTGCAGGTTTGGTAGCGGGTGAGGAGTCGAATGCTTCCTCTAGCTCTTTACCCAACAAAAGAAGCCGAAAACGTGCCAAGAGAGGCACACCTGATAAACCGGACAAAGGGTCAAAACGCAAGAAGTCCGAAGATAAGGATTGGACCTGCAGCTTGCGCACTCGTTCAAAGTCTTTGTACGAACCAAACCCGGATATGCCACCACGTACAACACGTGCACGAAGCGTTTGTGCCGCCACCTTGCTTAATCAAACTAACAAGCCAGTCGAAATGATCACATCCAGCCTTGAAACAAAGTCTGTGGCTGCTCGCCGTCGTTCGGTCGCTGCAGTCAAACTGCCTGCAACTGATGCATTCTATCGCTTGCCGTTCAAGTACGGTTGGAAACGTCAGTTTGTGATTCGCAGCAACTCATCATCGTCGCGTCTACGCGGCGACATCATATTTATATCGCCGGATGGGAAGAGGGTACGCTCCCGTGAGGAAATTTTTACGCTACTGAAGGGCGAGTTGACCATCGATCATTTTTGCTTTCAACGAAAGCTGCAGCATGCCGGTGAGGAGTACGAGACAGTGCGTCATGCACAGCCTGCTTCTAGCCGCCGTAAGTCTGGAGCAGCAACAAAGCAACAGGCGAcactcaacaacaataagctcCAACAGTCGTCAGCGGTTGCACCTGTGCCTGGCAAACGTGTACCAAAACCCAAGGTTCCAAAGGGAGCCAGCCCTCCGCCAGAAGGATGGACCTCTACGATGGCCGTCAAGGGCAATGCGCGAGTGTTGGCAGCAAGCAATGGTAACAATAGCGCAGGCAgcggctctggctctggcaacAGCACACGTAAACGAAGcagcaatcaatcaaaacAATCAGCTAAGACAGCTCCGGAACAACCAACTGCACAGGCAAATCTCCAGATCCCGTCTTTTGTAGACAAGATGATGATCTGTGTATATTGCCTAAAACCGATCAATGAGAAACAGCAGGCTTTTCCCGTCGGTACAGCTCATGTCAACAGCTACATTTGTATGCAATGCGTTAAACCAGGCAGCAAAGTAGCCAATTTGCAGCAGGCAGCCAAAGGATTAGCAGCGGGACAAGTACAAGGACAGGCCAATGGTCTCAAGATGCAAGATCTGATCGATGAGAATGTAAACACAAATACCAAATCTGCCTCCGATGCAGGCAAGACTTCGCCGTCTGATCTAAATATTAATGGCAACAGTaatagcaatggcaatggagCCTTGCTAGAAATCGGTGGAGAGATTGAACTGCCGGGTGCACTGCCACCCGACCAGTTGCTCAGTGATGAGGCACCTGCAAGATGTGTCGGTAACAAGATCGCGCCCAAGCCACTGGAGGTTGTTGTGATTAACGGTCGCAAAGCTCTGGCCGTTGCTGGCGAGCCGCCACGCACTCGTTTACAAGTcatgcCACGAGAACCGGACTTGGAGACTTATGATAAGCATTTCAAGCGCAACACAAGGACCAAGGAGAAGCGCCAGAATTTCATTGAATGCGTTTCAGCTGGCAACTTAAGCTGCCAGGTTGTGTCAGCCGTTATGAAGACAATGGATTTGCACGACCGTGTTCGTATGTCAGAAGTGTGCAAGACTTGGGCTATGATTGCCCGTGATCGTTGCGTGTGGCGTACGTTGAAGCTGCGCGACACACACATTACCAAATGGTTGTTCCTTTTGCGTGATATGGCTCGTAATCGCACCTACGAGTTGGATATGATGGGCGTTAAAATAGATAGTCCCAAAATGCGCTTGGATGGAGATTTGCGCGTGCTAAAGTCACTGCGTATTCTGCGCACCGATCCAAGCGAGGCGGAGTTCATCCAGTCGGTTATTAAGCGCATACCACGTCTGAAGGAGCTGCGCACAACATGCACCAGTCGCACACTCAATTTGACTAATGTAGAGAAGATGGTGGAATTGCGCGTGCTGCGCATACGCATGTTAGAGCCAAAGGCTAGTATTATTTCGCTGCAGCCTCTGCAAAATATGGAACAGCTGCGGGAGCTTAGTCTGCGCGGAATTAACAATATGGCTCAGCTGGAATTGTTGCAGCTGAAAGGATTGAAACAGCTCGAAACCCTTGTGCTGGGCTCCTGCCGTGGCATGAAAGTTGTGTCGTTCGGGCAACAAGTGCTACCGAGTCTGAGTCGCCTTCGCCATCTGCGTCTCGAAAACCACCATAGCAATCGCTCCTTTAATATTAATGAGATAATGGAGGGAATCGCCGCCGGCGGGAGCGTGAAGCGTGTGGAGCTCATCAATGTGAACGTGGATGTCGAGCTCAGTCGTCAGTTGGCCGCTTGTGAATCGGTGCAGGAACTGCTGCTGATGCCAAACTTCCACAATAACACGGCCTACATGATGTATTACATTATGCAGGCCATCAATGAAAACAGCGAGCAGCTAAAGGTATTTCGTTTGGGTCTGACATACGAGCTACTGAGCGTCACTCGCGCCCTGGCCATGACTCAAGAGAAGGATTGCATTCCGGTAGCATTGCCCATACCTGGCGTCCCTGACAACGATGTACTGAACGAGTCCGACGAGCCAATCGCTTACTTGCCGGTCGATCGCCTCGAGTCCATTCTACACCACATGATGCCGCAGGCCTGGCTGACAGTTGCCAAGGTCTCCCAGAGCGAGACAACCAATCTTAAATTTCTTCCGGCTTTACCGACTGACGTAACCGGAATTTCACATAATTAA
Protein Sequence
MSSPDDALEEGNNSFRSMKKARAFPRGRASSDDSVPDNDNSNHSVASMFKSTDSINGRKVLGDKIKKQNSFEMESDISQQAVQLDAEENAEAASIRKAKKRKAKKNKQRRGSREDALVGWSGAFPNLSSTHSLESNSDVDQQQLPADLKAICATGLSVFPREDKEQGPPLSSSSSSDSTSLSPVSQHKMPATTTTTAFTITTNSTTPSPKSTQTTNNNNINNNDNNSASMSLATSCQRSEPSSEPESESETQADLAMQKAKRVKKRLSGGAADIEPLIAGLVAGEESNASSSSLPNKRSRKRAKRGTPDKPDKGSKRKKSEDKDWTCSLRTRSKSLYEPNPDMPPRTTRARSVCAATLLNQTNKPVEMITSSLETKSVAARRRSVAAVKLPATDAFYRLPFKYGWKRQFVIRSNSSSSRLRGDIIFISPDGKRVRSREEIFTLLKGELTIDHFCFQRKLQHAGEEYETVRHAQPASSRRKSGAATKQQATLNNNKLQQSSAVAPVPGKRVPKPKVPKGASPPPEGWTSTMAVKGNARVLAASNGNNSAGSGSGSGNSTRKRSSNQSKQSAKTAPEQPTAQANLQIPSFVDKMMICVYCLKPINEKQQAFPVGTAHVNSYICMQCVKPGSKVANLQQAAKGLAAGQVQGQANGLKMQDLIDENVNTNTKSASDAGKTSPSDLNINGNSNSNGNGALLEIGGEIELPGALPPDQLLSDEAPARCVGNKIAPKPLEVVVINGRKALAVAGEPPRTRLQVMPREPDLETYDKHFKRNTRTKEKRQNFIECVSAGNLSCQVVSAVMKTMDLHDRVRMSEVCKTWAMIARDRCVWRTLKLRDTHITKWLFLLRDMARNRTYELDMMGVKIDSPKMRLDGDLRVLKSLRILRTDPSEAEFIQSVIKRIPRLKELRTTCTSRTLNLTNVEKMVELRVLRIRMLEPKASIISLQPLQNMEQLRELSLRGINNMAQLELLQLKGLKQLETLVLGSCRGMKVVSFGQQVLPSLSRLRHLRLENHHSNRSFNINEIMEGIAAGGSVKRVELINVNVDVELSRQLAACESVQELLLMPNFHNNTAYMMYYIMQAINENSEQLKVFRLGLTYELLSVTRALAMTQEKDCIPVALPIPGVPDNDVLNESDEPIAYLPVDRLESILHHMMPQAWLTVAKVSQSETTNLKFLPALPTDVTGISHN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00476618; iTF_00516255; iTF_00502518; iTF_00512714; iTF_00519917; iTF_00572592;
90% Identity
-
80% Identity
-