Basic Information

Insect: Drosophila leonis
Gene Symbol: ey
Assembly: GCA_035045365.1
Location: JAWNPC010000824.1:159697-186473[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4e-72 3e-69 230.9 0.9 2 125 96 219 95 219 0.99

2 2 3 6.3e+03 -2.7 0.0 67 91 714 738 674 747 0.57

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4e-72	3e-69	230.9	0.9	2	125	96	219	95	219	0.99
2	2	3	6.3e+03	-2.7	0.0	67	91	714	738	674	747	0.57

Sequence Information

Coding Sequence: ATGTTTACGCTTCAAACAACGCCTGCAGCCATTGGAACAGTGCCTTGGTCAACAGGAGCACTGATTGAACGACTACCAACTTTGGATGATATGAACCATAAGGACAATGTTCTTGCTATGAGAAATCTGCCCTGCTTGGGCGTGGCTAGTGGCAACGGACTGGGCGCAAAGGCTTCTGCAACAGCTGCGATGGAAGCTGCGGATGTAACTGCAGCACCACAGCCACCACACTCAACATCCTCGTACTTTACCACCACCTACTACCACTTAACAGATGATGAATGTCACAGTGGAGTAAATCAATTGGGTGGGGTCTTTGTTGGAGGAAGGCCATTACCAGACTCGACTCGCCAGAAAATCGTCGAGCTCGCCCACTCCGGAGCACGACCATGTGATATTTCGCGAATCCTGCAAGTTTCCAATGGATGCGTTAGCAAAATTTTAGGCAGatattacGAAACAGGAAGTATTCGACCACGTGCGATTGGAGGCTCCAAGCCACGAGTAGCCACCGCAGAAGTCGTTAGCAAAATCTCGCAATATAAACGGGAATGTCCCAGCATATTTGCATGGGAAATCCGCGATAGATTATTGCAGGAGAATGTATGCACAAATGATAACATTCCAAGTGTATCTTCGATAAACAGAGTTTTAAGGAACTTAGCGGCACAAAAGGAGCAGCAAAGTGCTGGAACAAGCAGCTCCAACACAAATCTAAATCCTAATTCAAACACAAGCCAAGGCAATGGTAACAGCAATGGTAATGGTAGCACTAATGGTAACAGCATGAGTGGTGCAAGTGGGGTTGGTGTTGGCACCACAAGCACCACAAATGATATGATACAAACAGCAACACCATTAAACTCTTCGGAAAGTGGTGGTGCTAGCAATTCGGGTGAGGGCAGTGAACAGGAGTCTATTTATGAGAAGATACGCCTGTTGAACACCCAACATGTCCCGACGATCGATCCGGCGTTATCGAcaccagctgcagctccagttAGTCATGAACAGCTGATGACGAGTGTCCCCAGTCATTTTAGTCCGCATCCCCACTCCAGCCACTCGATCCCGATCCACGCTCATggccaccaccagcagcaacataaccagcaccagcagcagagTTGGCCATCACGACATTATCCCACTGGTTCCTGGTATGCGGCTCCTTTGAATAGCAGCGAAATGGTGTCATCTACAGGGGTGATATCGGTTACAGGATATGGAAATGGAGGCTCGTCAGCTGCTCCAACTCTGCTTTCGGGGCATCCCTTGACACCGCCAAGTGATCTTATCAACATTGGTGCCCCAACTGTTCGCTTGGACAATTGTTCCATTACAGGAGTTGACGAAGTAATGCTAAAAAAGGAGCTCGATGGGCACCAATCAGACGAAACTGGTTCCGGCGAGGGAGAGAATTCAAATGGTGGTGGCTCTAATATAGGAACGAGCGAAGATGACCAGGCCAGATTAATTTTGAAGAGAAAACTCCAGAGAAATCGAACATCGTTTACAAATGATCAGATCGATAGCCTAGAAaaagAGTTTGAAAGAACGCATTACCCCGACGTATTTGCACGAGAACGGTTGGCTGGGAAAATAGGATTGCCTGAAGCCAGGATACAGGTGTGGTTTTCGAATAGACGTGCCAAATGGCGTCGTGAGGAAAAGTTACGAAGTCAAAGGCGAACGCCAAACTCAACCAGTACAAATGGAACTTCATCCTCGACTTCGGCCACAACTTCTTTAACTGACAGTCCCAATAGTTTGGGTGGCTGCTCATCCTTATTAATCGGATCGGCAGGAAGTGGGTTGAACAGCTTGTCTTCGCCCAATCCAATAACCACGCCCACTAGTGGCCTTGAGACATCCGAGGCACACCACCCAGCTGGTGGaggcggaggaggaggaaaCGCACAGATTCGAAGTGGAATGCATGACGTTGGTAATGAATGCACATCGGGACTGGGGATTTCGGATCAtcggcatcagcatcatcaacatcatcatcacgTTCCCCACACTCTTGTCCCGTCCATTTCTCCGCGGCTCAACTTTAACAATGGCTTTAGCAGCTCAATGAGTGCCATGTACACGAATATGCATCATAACGCGTTATCGATGAGTGAGGGTTATGCtGCGGTTTCGTCGATACCAAGCTTTAGTCATCCTACTGTTGGTTCGTCAATTGCACAACAAAGAGATGTGACCCCGCCCTCAATGTACCCGTGTCACATGCCACTACGGCCGCCGCCCCTTGGGCCACATCAGCTGGTTTGCGTTGGAAGTGCTACAAACGAAACCACCAGTGTCAGCAGCAGTCCCACAGTGAACATCACCAATCCATCTAATAACAATTCAACTGGATACGAGTCTCTATCAGCTTATGGTTTGCCGCCCCCGccaccagctccagcttcgGCACTGGGAACACCTACCGCTGCAAATACTGTTATTGCCGCTGTGCATCATCAGAGCATGGAGGCTCGCCCACCCACGTGCAGTCCAAGTCAAATGGGGCATGGGTCGGCATTTGGGAGCGATAGTATTACACCGGCTATGCCTTCTTACGCACACATGAGCTACAACTACGCCAACAGTGTGGCGTCTTCTGGAAGCGCGAATCCGGCTGGCGCTCTTAATTCGCATGGTTCGGGAAAGCAACAGTTTTTCGCGTCTTGCTTCTACTCGCCTTGGGCCTAA
Protein Sequence: MFTLQTTPAAIGTVPWSTGALIERLPTLDDMNHKDNVLAMRNLPCLGVASGNGLGAKASATAAMEAADVTAAPQPPHSTSSYFTTTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSAGTSSSNTNLNPNSNTSQGNGNSNGNGSTNGNSMSGASGVGVGTTSTTNDMIQTATPLNSSESGGASNSGEGSEQESIYEKIRLLNTQHVPTIDPALSTPAAAPVSHEQLMTSVPSHFSPHPHSSHSIPIHAHGHHQQQHNQHQQQSWPSRHYPTGSWYAAPLNSSEMVSSTGVISVTGYGNGGSSAAPTLLSGHPLTPPSDLINIGAPTVRLDNCSITGVDEVMLKKELDGHQSDETGSGEGENSNGGGSNIGTSEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRSQRRTPNSTSTNGTSSSTSATTSLTDSPNSLGGCSSLLIGSAGSGLNSLSSPNPITTPTSGLETSEAHHPAGGGGGGGNAQIRSGMHDVGNECTSGLGISDHRHQHHQHHHHVPHTLVPSISPRLNFNNGFSSSMSAMYTNMHHNALSMSEGYAAVSSIPSFSHPTVGSSIAQQRDVTPPSMYPCHMPLRPPPLGPHQLVCVGSATNETTSVSSSPTVNITNPSNNNSTGYESLSAYGLPPPPPAPASALGTPTAANTVIAAVHHQSMEARPPTCSPSQMGHGSAFGSDSITPAMPSYAHMSYNYANSVASSGSANPAGALNSHGSGKQQFFASCFYSPWA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00512663;
90% Identity: iTF_00476568;
80% Identity: iTF_00532214;