Dleo010734.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
bin
Assembly
GCA_035045365.1
Location
JAWNPC010000454.1:8942280-8946805[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.8 3.3e+03 -1.5 3.5 13 68 157 210 156 231 0.73
2 2 2.3e-34 2.7e-31 107.7 0.0 1 87 331 418 331 419 0.95

Sequence Information

Coding Sequence
ATGATCAAAAGCGAGGAAGGGGCATCGGAGCTGAACAGCCGCACAATGGTTGTGGATCCACTGGGTGGCTTTGTCAGTGGCTCGCACTATCATCCCCATCACACGCATCATCCACTGGGCAGCGGTGCCCAGCATCTGCATGCTCACACCTTTGCGCATCACACACCTTCGCACCTGTATCGCGGTGGGAATGCGCTGCCCGCTGGCAATTTCCAATTGATGGGCGGCGACTCGCCCACAGAGCTGGTGGATGAGAAGCCAAACATTAGCTATATGGAGCGCAAGTACTATGCGCCCACGttggatgccacgcccaccgcaCAGCACTATGGGCTGAGTGCGCTGCACAGCATGGGCACGCCGCCGGCATCGTCGAGTCCGATTCCGCCATATGGCGTGCTGATGCAAGCCCATTCCGTTGGCTCCGTGTCGCCCAATTCCAGCTCCAAGACGCCCACCGATCAGGATATGTGCATCAGCTCCTCAGTGGTGAAGCCGTTGCAGCTTCAGCACATTAACCATCAATATGCCTCCACCATCAAGTACTGCACCAACAATACCATAGTCAGTGCCAATGACTACCATCAGCTGGCACTGCATGAATccgaacaacagcagcagcagcaacaacagcaacagcaacaacagcagcaacaacaacagcaacaacagcaacagcaacaacagcagcagcaacatcagcagcagcagcagcagcaacaacaacactctCCCGGCGGCTACTTGCCACGCCACTCCGCCTCACCCACCCAGGCCATTGCGAATACCCACGGACATGGCATGCCTGTGCTGAACTACTCGAGTGCCAGCTCCTCGCCACGCCTCGCCAAGTCACTCAATGGCACCGAGACGACAGCCACCAGCGCAGCTCACGAAAGTGTCAGCGCTCAGCAGGCGAAGGTGAACGGCTCCAGTGCTCAAGAGAGCAACACGCCGGATACCACCAAGAAATCCGGTACGCGTCGTCCCGAGAAACCAGCTTTAAGCTACATCAACATGATCGGGCATGCCATCAAGGAGTCGCCCACTGGCAAGCTGACGCTCAGCGAGATCTACGCATATCTACAGAAGAGTTATGAATTCTTTCGCGGCCCCTACGTGGGCTGGAAGAACTCGGTGCGTCACAATCTCAGCCTGAACGAGTGCTTCAAGAAACTGCCCAAGGGCATGGGCGTCGGCAAGCCCGGCAAGGGCAACTACTGGACCATCGATGAGAATTCGGCGCACTTGTTCGAGGATGAGGGCAGCCTGCGACGTCGTCCTCGCGGCTATCGCTCCAAGATCAAGGTCAAGACATATGCGGTCAATGCGAACAGCTTCTACAGCGGCAGCTATGGCGATGCGGGCATGGACAATGCCAACTTCTATGCAACGCCCGCCTATGGCAGCTATGATTacagcgcagcagctgcaggtcCCTCGGCTGGGCAGGGCTTCAGCGATGCCTGGAACGTGCATGCGGCTCACAGTGGAGCGCCATCTGTTGGCGTCGGCACGCTGCCGCAGTACTCCAACATCACCTGCCTCACGGCTGTGGGCAACAATCTGAATGGCTCTCCCACTCCCCCGTTGGCACACACGACTCTTGGCATGTCCTCGACGGTGGGCCCCTCCAGCTCGCCAGTGGCGGCGCTTCAAAGTGATTATGCGCCAGCCGCCAGCCTCGTGGCTGCTGGCTACTCCTATACAACAAGTGGCAGCGGCTTGGATAACGGTCTGCGCTCCAtgtcgctgcagcagctgccagcatTGTCCTCCATACAGACGgggcagtcgcagtcgcatcatcatcatcatcatcattcacATCATTCGCACCACCCGCATCATGGAAGCATGACGCCGCCGCCATCTCAATCGGGCAACCATGCAACCGATCGCTCGCCAATCGATTTCAAACCGGTTTACCTGCCCATGACTCCGCCTCCGACTGCGGTCAATGGCGGCTACTATGAGacaatcaaatattcaaattag
Protein Sequence
MIKSEEGASELNSRTMVVDPLGGFVSGSHYHPHHTHHPLGSGAQHLHAHTFAHHTPSHLYRGGNALPAGNFQLMGGDSPTELVDEKPNISYMERKYYAPTLDATPTAQHYGLSALHSMGTPPASSSPIPPYGVLMQAHSVGSVSPNSSSKTPTDQDMCISSSVVKPLQLQHINHQYASTIKYCTNNTIVSANDYHQLALHESEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQQQHSPGGYLPRHSASPTQAIANTHGHGMPVLNYSSASSSPRLAKSLNGTETTATSAAHESVSAQQAKVNGSSAQESNTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKTYAVNANSFYSGSYGDAGMDNANFYATPAYGSYDYSAAAAGPSAGQGFSDAWNVHAAHSGAPSVGVGTLPQYSNITCLTAVGNNLNGSPTPPLAHTTLGMSSTVGPSSSPVAALQSDYAPAASLVAAGYSYTTSGSGLDNGLRSMSLQQLPALSSIQTGQSQSHHHHHHHSHHSHHPHHGSMTPPPSQSGNHATDRSPIDFKPVYLPMTPPPTAVNGGYYETIKYSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00476434;
90% Identity
iTF_00516068; iTF_00479302; iTF_00545033; iTF_00472876; iTF_00493458; iTF_00540179; iTF_00544282; iTF_00572412; iTF_00554207; iTF_00551397; iTF_00573127; iTF_00476434; iTF_00568066; iTF_00599394; iTF_00559305; iTF_00519729; iTF_00502335; iTF_00509629;
80% Identity
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