Basic Information

Insect: Drosophila lacicola
Gene Symbol: zfh1
Assembly: GCA_035045355.1
Location: JAWNPB010000347.1:11925427-11929619[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4e-05 0.0027 18.2 1.1 1 23 150 172 150 172 0.97

2 15 0.00095 0.064 13.8 1.2 3 23 180 200 178 200 0.94

3 15 0.0001 0.007 16.9 0.1 1 23 355 377 355 377 0.98

4 15 0.00035 0.024 15.2 0.9 1 23 383 405 383 405 0.98

5 15 3.9e-05 0.0026 18.2 2.2 1 23 436 459 436 459 0.95

6 15 0.00064 0.044 14.4 1.9 1 23 495 517 495 517 0.95

7 15 0.02 1.4 9.7 1.3 1 23 523 546 523 546 0.97

8 15 0.03 2 9.1 0.4 3 19 555 571 554 572 0.95

9 15 0.00018 0.012 16.1 5.6 1 23 581 603 581 603 0.97

10 15 0.046 3.2 8.5 1.2 2 23 609 630 608 630 0.96

11 15 1e-05 0.00071 20.0 1.0 1 23 639 661 639 661 0.98

12 15 0.0012 0.081 13.5 0.1 3 23 669 689 667 689 0.97

13 15 6.4e-05 0.0043 17.5 0.5 1 23 695 717 695 718 0.95

14 15 0.06 4.1 8.2 0.4 1 23 728 750 728 750 0.97

15 15 0.0018 0.12 13.0 0.3 1 23 1289 1311 1289 1311 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4e-05	0.0027	18.2	1.1	1	23	150	172	150	172	0.97
2	15	0.00095	0.064	13.8	1.2	3	23	180	200	178	200	0.94
3	15	0.0001	0.007	16.9	0.1	1	23	355	377	355	377	0.98
4	15	0.00035	0.024	15.2	0.9	1	23	383	405	383	405	0.98
5	15	3.9e-05	0.0026	18.2	2.2	1	23	436	459	436	459	0.95
6	15	0.00064	0.044	14.4	1.9	1	23	495	517	495	517	0.95
7	15	0.02	1.4	9.7	1.3	1	23	523	546	523	546	0.97
8	15	0.03	2	9.1	0.4	3	19	555	571	554	572	0.95
9	15	0.00018	0.012	16.1	5.6	1	23	581	603	581	603	0.97
10	15	0.046	3.2	8.5	1.2	2	23	609	630	608	630	0.96
11	15	1e-05	0.00071	20.0	1.0	1	23	639	661	639	661	0.98
12	15	0.0012	0.081	13.5	0.1	3	23	669	689	667	689	0.97
13	15	6.4e-05	0.0043	17.5	0.5	1	23	695	717	695	718	0.95
14	15	0.06	4.1	8.2	0.4	1	23	728	750	728	750	0.97
15	15	0.0018	0.12	13.0	0.3	1	23	1289	1311	1289	1311	0.98

Sequence Information

Coding Sequence: ATGAACAATCAGGACTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCGGTTGATTCCGAAACAGATATGCTGGAAAACGGCGCTGCTGACAGCGAGGTGACTGCCGCCTATTTGGTAAATGGCAATGCAACAGACGAGGATCTTGACCATATGGCGGCCGAGAATCTTATCTTCATGGCGCGCGATGGTCAGCTAAGCGAAATCATAGCCGCCAACGAAGCCGGCGGCGGAACTGTATTAATCACGGACAGCGGCACCGTTGCCTATGCCGAGTCATTTGATGATGATGCACAGGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCATCAGGGTGCCGAGCGcgTGGAAATCGCCGCGGAGCAAATAGCGGGCAACAATAGCTCGCAGGAGCTGCTGGACATGGAGCAGGATGAATATACGGCACTGCGGCCCTATCCCTGCGACTTTTGTAGTCGACGCTTTCGCAAAAAGGGCAGCCTCAATACTCACATGCTGGCGCACCAAAACGATCGTCCACATCTGTGTAAATTATGCGGCGCACGTTTTTCAAGGCGCGCTGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCTCAGGTTGCGGCAGATGAGGCggcagcaattaaatttgagccgcagcaacagcaacgccaaGCGGATGATCATTATTACGAACAGGATTGGCCTTTGTACCAGGAACAGGAAGATGATCAGGTGCAAGACCAGATGCAGCAaatggagcaggagcagctggtgGAACCGCAGGCCAGCTATGCAGCGGTTAGCGCTGTGTCCGCACCAACAGCCACGCGCGGTCGCATTAGCCGCCTCAAGCCCAAAGAAGAGAGCACGCAGTACATTGTGATTGCCGAGAAGCAGCCAACTGACGATTTGCGCCAGTACATGGATTGCGaggagctgccgctgcagccgccgcTCACGGGCAGCACGTCAATCGAGGCAGCGCATTCGACACAGTGCCCAGACGGCCCAGTCGCCGATGGCGCAGAGACGCTACGCTTCCCGGTGCTGGACGAGAGCAAGCCCTTTGTGTGCCAGCAGTGTGGACTCGCATTTGCGCGCGAAAAAGCGCTCGTCTCGCATATCAAGAATCATCGCGTGGACTCGCCCTTCGAATGCAATCAGTGTCAGGAGATGTTCTGGGATAATTACAGCCTGCAGGAACATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCTTCGGCGGGCGAAGATAGCGCCAGCGAATCGGATCCGGAACAGCTTTACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCCTTTCACAGGCAGGACCTGCTGCGTCGTCATGCCAAGCAACAGCACAAGCTGACACCAGACATGGAGGGCGGCGGCGAAGgtgacggcgacggcggcggcggcgaagGCGACGGCGGCGATGCTGATGCCGAAAATGCCAAAGACGCCGCGCACTGTTGTCACACATGCGGCAAATCGTTTCCCAGCGCTCTGGAGCTGCTCGCCCATGCCGAGGTCCATGCACGCTTCCCGCCATTCAAATGCGTCCTGTGCGGTGTTAGCTTTTACGAGGAGCAGGCTATCAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAAGCCCAACTCGTGCGTGCTGTGCGGCAAAGAGTGTCGCGATCGCAAGGCACTGATCAAGCACGCCTGGGATCACTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCACGTCTGAAGCGACACATGGCCTCGCATCGCGACAAGTCGGTGGTTTGCGAGGTGTGCCACGAGGAGTTCCCCGATGGACGCACGCTCTCCAATCATCGGCATTCACATAGCACCACATCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAGACCTTTGGCTCGCGCAGCTCACAGCAAATCCATGTCCGCATCCACACTGGCGAACGGCCATATGGCTGTCGCTACTGCTGGAAGGCGTTTGCCGATGGCGGTACGCTGCGCAAGCACGAACGCATTCACACGGGCGAGAAGCCCTATGCCTGTTCCGTGTGTCCGCGTGCCTTCAACCAGCGCGTTGTGCTGCGCGAGCACATACGCTCCCATCACTCGGGTCTGGATGCGGTACGTGGCACCTATCATTGCACCGTCTGCTCCGCCGATTTGTCCTCATCCAATGAGCTTATACAGCATCTCATCCAGCACAGTGACACGAACACCGCCAAACAGCGACAGCCAATTaCTGGTCCGCGCAAGTATAAGCGACGCAGGAAACTGCAGCCACACGAGATTGCCCACATGCGTGCGGGGAACAAGGATGGCGAGGAGTATGCCAGCGATATGGAACTATGTGACTTTGATGTTGAGAACGTGGATGATCTCCTGGACAGGACAGAGCCATTGCCAACTAAAAAGGAGAAGCGCAAGCGAGCAGCTGCAAATCAAGCTAAAGCCGTGACAAATGGCGCCGCACACAATAGTTCCAGTTCTGCCAAATCCGCCAATAGCAGCTCGGAACGTCTGTGGGATGAGAAATTCCTGCCGGCAAATAGCAATGGCAATGTTGGCAGCGCAGATGATGCCTACAAAAGCTTCTTTCAAATTGATTCGCTGGTGGTGGTAAACGATACCACTCTGCCGCCTGTAAGCTCATCCAGCAGCATACCAAGCGCCTCCAAGTCGCGACGCGGCGGCAAGCAGCCACCGACGCAAACGCAGGCCGAGAGCAGTGACAAGTCAGGAGGTGGAGCgggagcaacagcatcagcaacaacgacaataacaacagcagcagcagcagcagctggtgagGAGTCCGGCAAATCCAGCGTCGCCAACAGTCGCAGTAGCAGCAGAAAGAAGTCTAGCAAGGTGGCCAAGAATACAGGCACAGCGGCTGCCACATCAAGCAGTTCACGTCCCCGCATGATACACACAGAAAAGGCGCGAGTGCCGCCAGAGAATGCCAGCAAAAAGTCGCGTGGTCGCAGCTACATAACGCGCACCAGTACCAGCGAGAGCAGCCAGCTGGGCCTGGTCAAGTCGAGCGGCGTGGCCAGTTCGCGGATTGTCGATGACTACGAAATTATATCACCTGCCACACAGCCGCCAAATCAGATCAGCTCCAGTCCGCTGCACAtcaagcaggagcaggagcagcaacagcagcgcgtCCAGCTCATGTACGATGACACCCATTTGCTGATCCATGCGGCCATGTTGCGCGAGAAGCCCTACGACAAGTTCAATCCGAGCATTGTCAACGATCTGGAGGAGATATTACGCAGTCCGCTCAAGCATGATCGGAATGCGCGCCTGCGTTTCACTAGCGAATCGTCGACAATGCCACAGTTTCTGCCCGAGGAGGAGCAGAACCTCATTAAAATTGAGCCCACGTCTCCGGATCTGCGCGAAATGGTGGAGAGCCAGCAACGTGTAACTGCCACAGGAcacacagccacgcccacatcatcatcatcatcctcatcgGCGGCGCGCACATCGCGCCATCTGCGACAGATCACTGCCAACTCGGCCACCCGCTCGGCAGCCAAGCGACACATGGACAAAAGCTCATCCGAATTCAGCGCCAAGAAATCGACAACATCCTCGCCCGTTGCAGTCAATaagccagcagcaggcaactCGTACCTCAGCTATGGCGTGGACTCGTACAATGTGAATGCGGTGGCCAATGCCAACTCTTCGGATGTCAGTGCCGGTTTCTTTTCCATCTCCGAGGTGGTATCCGCTGCACATGCCGCCGATGCAGCCGCCAAGGCGGCAGCGGCCAGCAAAACGGAGCGTCGGACGCGCTGCTTTGAGTGTGAAATGTGCTCCTCCATATTTCCGGATCGCGCCCAGCTGCTGGagcacatgcatatacacatttgA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDMLENGAADSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGTVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKGSLNTHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEAAAIKFEPQQQQRQADDHYYEQDWPLYQEQEDDQVQDQMQQMEQEQLVEPQASYAAVSAVSAPTATRGRISRLKPKEESTQYIVIAEKQPTDDLRQYMDCEELPLQPPLTGSTSIEAAHSTQCPDGPVADGAETLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESDPEQLYGDFYCSECGISFHRQDLLRRHAKQQHKLTPDMEGGGEGDGDGGGGEGDGGDADAENAKDAAHCCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAGNKDGEEYASDMELCDFDVENVDDLLDRTEPLPTKKEKRKRAAANQAKAVTNGAAHNSSSSAKSANSSSERLWDEKFLPANSNGNVGSADDAYKSFFQIDSLVVVNDTTLPPVSSSSSIPSASKSRRGGKQPPTQTQAESSDKSGGGAGATASATTTITTAAAAAAGEESGKSSVANSRSSSRKKSSKVAKNTGTAAATSSSSRPRMIHTEKARVPPENASKKSRGRSYITRTSTSESSQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVQLMYDDTHLLIHAAMLREKPYDKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTMPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTATGHTATPTSSSSSSSAARTSRHLRQITANSATRSAAKRHMDKSSSEFSAKKSTTSSPVAVNKPAAGNSYLSYGVDSYNVNAVANANSSDVSAGFFSISEVVSAAHAADAAAKAAAASKTERRTRCFECEMCSSIFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: iTF_00563313;
80% Identity: -