Basic Information

Insect: Drosophila kuntzei
Gene Symbol: zfh1
Assembly: GCA_035042165.1
Location: JAWNLU010001128.1:65298-70035[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0022 18.5 1.0 1 23 149 171 149 171 0.97

2 15 0.0009 0.067 13.8 1.2 3 23 179 199 177 199 0.94

3 15 9.8e-05 0.0073 16.9 0.1 1 23 356 378 356 378 0.98

4 15 0.00091 0.068 13.8 2.2 1 23 384 406 384 406 0.98

5 15 6.1e-05 0.0046 17.5 4.2 1 23 437 459 437 460 0.95

6 15 0.0026 0.2 12.4 1.8 1 23 498 520 498 520 0.95

7 15 0.012 0.87 10.3 1.3 1 23 526 549 526 549 0.97

8 15 0.029 2.1 9.1 0.4 3 19 558 574 557 575 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 584 606 584 606 0.97

10 15 0.044 3.3 8.5 1.2 2 23 612 633 611 633 0.96

11 15 1e-05 0.00074 20.0 1.0 1 23 642 664 642 664 0.98

12 15 0.0011 0.084 13.5 0.1 3 23 672 692 670 692 0.97

13 15 6e-05 0.0045 17.5 0.5 1 23 698 720 698 721 0.95

14 15 0.056 4.1 8.2 0.4 1 23 731 753 731 753 0.97

15 15 0.0032 0.24 12.1 0.1 1 23 1293 1315 1293 1315 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0022	18.5	1.0	1	23	149	171	149	171	0.97
2	15	0.0009	0.067	13.8	1.2	3	23	179	199	177	199	0.94
3	15	9.8e-05	0.0073	16.9	0.1	1	23	356	378	356	378	0.98
4	15	0.00091	0.068	13.8	2.2	1	23	384	406	384	406	0.98
5	15	6.1e-05	0.0046	17.5	4.2	1	23	437	459	437	460	0.95
6	15	0.0026	0.2	12.4	1.8	1	23	498	520	498	520	0.95
7	15	0.012	0.87	10.3	1.3	1	23	526	549	526	549	0.97
8	15	0.029	2.1	9.1	0.4	3	19	558	574	557	575	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	584	606	584	606	0.97
10	15	0.044	3.3	8.5	1.2	2	23	612	633	611	633	0.96
11	15	1e-05	0.00074	20.0	1.0	1	23	642	664	642	664	0.98
12	15	0.0011	0.084	13.5	0.1	3	23	672	692	670	692	0.97
13	15	6e-05	0.0045	17.5	0.5	1	23	698	720	698	721	0.95
14	15	0.056	4.1	8.2	0.4	1	23	731	753	731	753	0.97
15	15	0.0032	0.24	12.1	0.1	1	23	1293	1315	1293	1315	0.97

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCGGTCGACTCCGAGTCGGATATGCTGGAAAACGGCGCTGGCGACAATGAGGTGACTGCAGCTTATTTGGTGAATGGCAATGCAACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCGCGAGATGGTCAGCTGAGCGAGATTATAGCCGCCAACGAATCTGGTGGCGGCACAGTCCTAATCACTGACAGCGGCGTTGCATATGCCGAGTCATTCGATGATGACGCACAAGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCACCAAGGCGCCGAACGTGTCGAAATCGCTGCAGAGCAAATTGCAGGAAATGTCAATTCGCTGGAGCTACTGGATATGGAGCAGGATGAGTATACGGCCCTGCGTCCCTATCCTTGTGATTTCTGTAGCCGGCGTTTTCGCAAAAAGGCAAGCCTCAATAATCATATGCTGGCGCATCAAAACGATCGTCCACATCTGTGTAAATTGTGCGGTGCACGGTTTTCCCGTCGCGCCGAGCTTATCAGTCACTTTAAGGCACATGCCGAGGCTCAGGATGCAGCCGATGCCGAGGCTGCAGCGGCggcttcaattaaatttgagcCACAGCAGCACAGACAAGTGGATGATCATTTCTACGAACAGGAATGGCCATTGTATCAGGACCAGGAACACGAGCAGatgcaggagcagcagcaacaactggaCCAGGAACAGTTAACCGTTGCCAGCCAGGTGATGCAACAGGCCAGCTATGCGGCAGTGAGTGATGTGCCCGCTCCAACTGCCGCCCGGGGTCGTATAAGTCGTCTCAAGCCCAAGGAGGAGAGCACGCAATATATTGTGATTGCTGAGAAGCAGACAACAGACgatttgcaacaatttgtggACTGTGATGGCTTGGCGCCACCGCTCGCTGCCAATGCATCGTCAAGTGATGCCAACAATTCGTCAGACAACGGTCAAGCCATGAATGCATCAAGATTTCCAGTGTTGGACGACAGCAAACCCTTTGTGTGTCAGCAATGTGGTTTGGCATTTGCACGAGAAAAGGCGCTTGTCTCCCATATCAAGAATCATCGCGTGGACTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGATAATCACAGTCTGCAGGAGCATCAGAAGACACATCAGTTCGAGGAGAGCAATTCAGAGTACGATCCCGCCTCGGCGGGGGACGACAGTGCCAGCGAATCGGAGCCAGATCAGCTCTACGGGGAATTCTACTGCAGTGAGTGCGGCATTTCATTTCACAGGCAGGACTTGCTCCGTCGCCATGCCAAGCAACATCATAAGTTGGGCACGGGCAGCGCTGTGGCATCAACAGTCGATGTGGATGGCAGTGCAGATGCTGACGCCGATGCTGATGTCGATGGCGATGCCGAGAATACCAAAGATGCGCCGCATTGTTGTCATACGTGTGGCAAGTCATATCCCAGCGCATTGGAGTTGCTCGCCCATGCCGAGATTCATGCCCGTTTCCCGCCATTCAAATGTGTCTTGTGTGGCATTAGCTTTTACGAGGAACAGGCCATCAAAAGGCATTTGCACACTCGTCATCCGCACGAGCTGAAGCCAAATTCATGTGTGCTCTGTGGTAAAGAGTGTCGCGATCGCAAGGCGTTGATTAAACACGCCTGGGATCATTCCCGTGAGAAGTGCCACTCGTGCTCAAAGTGCGGCAAAAACTTCCACAACAAGGCGCGTCTGAAGCGACACATGGCCTCGCATCGGGATAAGTCAGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGACGGACGCACCCTTTCCAATCATCGTCATTCGCATAGCACAACATCGCCGGGTAAACTGTTCCCCTGCCATGAATGCGGCAAGACTTTTGGTTCACGCAGCTCACAGCAGATTCATGTGCGCATCCACACGGGCGAAAGGCCCTATGGATGTCGCTATTGTTGGAAGGCCTTTGCCGATGGAGGTACACTACGCAAGCACGAAAGGATTCACACTGGCGAGAAGCCTTATGCCTGTTCCGTCTGCCCGCGTGCGTTTAATCAGCGTGTTGTGTTAAGGGAACATATACGGTCCCATCATTCGGGATTGGATGCTGTGCGTGGTACGTATCACTGCACTGTCTGCACAGCGGATTTGTCCTCATCCAATGAGCTTATACAGCATCTCATACAACACAGCGACACGAACACAGCCAAACAGCGACAACCAATTACGGGTCCCCGCAAATACAAGCGTCGAAGGAAACTGCAGCCCCATGAGATTGCTCACATGCGTGCTGAGAACAAGGATGGCGACGATTATGTTAGCGACATGGATCTCTGCGATCTGGATGTGGAAAATGTCGACGATCTCTTTGACGCGGCAGAAACAACGCCACCCAAAAAGGAGAAGCGCAAACGCAATACTGCAAGGCAAGCGAAATCAGTGTCAAATGGCGTTTCAACATCCTCGCTAAACAACAATACAACTTCATCATCTAAATCCGCCAATGGAAATCCGGATCGCATGTGGGAGGAGAAATTCCTGCAGGCAAATAGCAATGGCAATGCCGGCAATCAATTAAATGATGATGCGTTCAAGAACATCTTTCAAATTGACTCGCTGGTGGTGGTTAATGATACCACGCTGCAGCCTGTAAGCTCATCCAGTGGTGTCACTGCGTCCAAGACGCGGCGCAGCGTCAAACACACGCCACAGGCGCAGCTGTTGCAGCCGAGCAACACCAACAAgtcaacgacagcagcagcagcaacaacaacagctggtgATGATTGTAGCAAGTCCAGTGCCTCCGTATTATCAAGCAGTCGCAGCAGCCGTAAGAAAGCTGCCAAGTCCACCAAGAACTCGGCCAACACGGCGTCCACTTCGAGCAGCTCGCGTCCACGCATGATACACACGGAAAAGTCACGTGTGCCGCTAGAGAATGTATCGAGGAAGACACGAGGAAGGTCCTATATCACGAGGACGAGCACCAGCGAGAGCAACCAGCTGGGTCTGGTCAAGTCGAGTGGCGTTGGGAGCTCACGCATTGTGGATGACTATGAGATTATATCACCTGCCACACAGCCACCAAATCAGATAAGCTCCAGTCCGTTACACATcaagcaggaacaggagcagcagcaacagcgtgTGCCCCTCATGTATGATGATACGCATCTGTTGATCGATGCGGCCCTGTTGCGTGAGAAGACCTATGAGAAGTTCAATCCCAGCATTGTCAATGATCTGGAGGAGATACTGCGTAGTCCGCTCAAGCATGATCGCAATTCGCGTCTGCGCTTCACCAGCGAATCATCGACAACGCCACAGTTCCTGCCCGAGGAGGAGCAGAATCTTATCAAAATAGAGCCAACGTCACCGGATTTACGTGAAATGGTTGAGAGTCAACAGCGTGTCAGTTCCACAGGACACAACCATACAACCACAccctcatcatcatcctcgtcAGCGGCACGCACTTCACGTCACCTGCGACAGCTCACTGCCAATTCCAGTTCACGGACGGCAACGAAAcgtcacagcagcagcagcaacaaaacagTTTCCGCTTCCAGCTCCAAGAAATGCGCATCATCGTCATCTGCATCATCTGGTGCCGTGAGCAAAGCCAACTCGTACCTCAGCTATGGCGTGGACTCCTACAATGTGAGTGTGGCTGCCAATGCCAACTCATCGGATGTCAGCTCTGGATTCTTTTCCATCTCGGAGGTCGTGTCCGCTGCAGATGCCGCCGATGCAGCTGCCAAAGCGGCAGCGGCCAACAAACCGGAGCGTCGAGCCCGTTGCTATGAGTGTGAAATGTGCTCGGCCAATTTTCCGGATCGAGCCCAACTGCTGGAGCATGTGCATATACACATCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSESDMLENGAGDNEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNVNSLELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAASIKFEPQQHRQVDDHFYEQEWPLYQDQEHEQMQEQQQQLDQEQLTVASQVMQQASYAAVSDVPAPTAARGRISRLKPKEESTQYIVIAEKQTTDDLQQFVDCDGLAPPLAANASSSDANNSSDNGQAMNASRFPVLDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNHSLQEHQKTHQFEESNSEYDPASAGDDSASESEPDQLYGEFYCSECGISFHRQDLLRRHAKQHHKLGTGSAVASTVDVDGSADADADADVDGDAENTKDAPHCCHTCGKSYPSALELLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDDYVSDMDLCDLDVENVDDLFDAAETTPPKKEKRKRNTARQAKSVSNGVSTSSLNNNTTSSSKSANGNPDRMWEEKFLQANSNGNAGNQLNDDAFKNIFQIDSLVVVNDTTLQPVSSSSGVTASKTRRSVKHTPQAQLLQPSNTNKSTTAAAATTTAGDDCSKSSASVLSSSRSSRKKAAKSTKNSANTASTSSSSRPRMIHTEKSRVPLENVSRKTRGRSYITRTSTSESNQLGLVKSSGVGSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVPLMYDDTHLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRNSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSTGHNHTTTPSSSSSSAARTSRHLRQLTANSSSRTATKRHSSSSNKTVSASSSKKCASSSSASSGAVSKANSYLSYGVDSYNVSVAANANSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00585360;
80% Identity: -