Basic Information

Insect: Drosophila kokeensis
Gene Symbol: lz
Assembly: GCA_035042145.1
Location: JAWNLT010000194.1:214725-222692[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.9e-17 8.4e-14 51.2 0.1 93 129 21 57 16 57 0.94

2 2 1.6 4.6e+03 -2.9 0.0 68 91 426 450 418 455 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.9e-17	8.4e-14	51.2	0.1	93	129	21	57	16	57	0.94
2	2	1.6	4.6e+03	-2.9	0.0	68	91	426	450	418	455	0.75

Sequence Information

Coding Sequence: ATGTACACCAAAATGAAGACGGCGCTGTCAGCAGGCGCAGTGGAGTGTGCCAGCAACATGTGGAAGAGCTTCACATTAACCATCACCGTGTCAACGAATCCACCACACATAGCCACCTACAACAAGGCGATCAAAGTAACCGTCGATGGGCCACGTGAGCCGCGCTCCAAGACAATGTTATCCCTTTtagggcaacaacaacaatttcacttCGCCTTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCACTGTCCGGCTTCCGCATGCCACCGATTGGCAACTGTCAGAGTGCCAGCAATACGCATTGGGGCTACGGATCGGCGGCCTCTGCCTACTCTCCGTACTTGGCCAGCAGCGGACTCTCCTCGTGCACCACGCCCACTTCAGCGCAGTTTAACAATCCCGCGTTGGGCTTCACCTGTTCTTCAAACGATCAGAGCAACAATCAGGACTTCGGCGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCCGACTCGACGGCCAGTGACTTGGATCAGCATCTGAGCAGTCTGGTTGGATCCACCAGTGGCCAGATGTCGCATCATAGCCTGTTGGGCGCCAGCGGACAGACGTCCATCACATCGACGGTGAATGGAGCGAGCGCCGGCAGCGGGGCAACAGCCGGGAGTGCAGCGGGTGCTGGGAGCGGAGGCGGTGGCAACTCGATATTGGTGCCACGATATCACACCAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAGAACGGGCCGCGCAGCCTGAGCGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGATCTGCTGTCAACCAATACTCCAAATTTGGGCAGCGGTAGCGGCGGCGGTGCAACAAATGGTGGTGCTGccaatggcagtggcagtgcTGCCGTCGCTGGCAGCGTTGCATCATCGGTGGCATCCGCTGGCGCTGGCAATCCCGGCATGCTAGGCACCAACCAGAATTTTCCGGGCATTGTCAATCAGGCCCAGCATGCGTCTGCCTCGGCCTATGGCGGCGGCGtaggcgtcggcgtcggcgtcggtgGTGGGCATGGTGGTGGTGCCGGTGCGACAGCCGCCGGCTGCAATGGATCACTGTATCCGGTTCTGCCCGCCAGCCTGCTCTACTCGCAGCTGTATACCGCAGCCAATCAGTCGGCGCACGGATTCCACTCGCACACATTGCCGGCGCATGCGTCACCCAACTCCTCGGTGCATGGTGAGCTGCAGAGCGTGATGGATCACATCAGCAATGTGGGTGTGCGGCAGCAGCATAACATAATGGCTGGCGGGGGCGTGGCGCATCCAGGTGATCTGACGCTGATCGGCAACTGCGGTGCGTCGGTGAGGAACATTGAGGATGGGAACACCAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCGGTCACCACAACCCAACTGACAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence: MYTKMKTALSAGAVECASNMWKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASAGSGATAGSAAGAGSGGGGNSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGATNGGAANGSGSAAVAGSVASSVASAGAGNPGMLGTNQNFPGIVNQAQHASASAYGGGVGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00498646;
90% Identity: iTF_00521941;
80% Identity: -