Basic Information

Insect: Drosophila demipolita
Gene Symbol: lz
Assembly: GCA_035042405.1
Location: JAWNLI010000476.1:1251724-1259727[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.4e-17 8e-14 51.3 0.1 93 129 21 57 16 57 0.94

2 2 1.2 4.2e+03 -2.8 0.0 68 91 419 443 411 449 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.4e-17	8e-14	51.3	0.1	93	129	21	57	16	57	0.94
2	2	1.2	4.2e+03	-2.8	0.0	68	91	419	443	411	449	0.75

Sequence Information

Coding Sequence: ATGTACACCAAAATCAAGACGGCGctggcagcagccgcagtGGAGTGTGCCAGCAACATGTgGAAGAGCTTCACATTAACCATCACCGTGTCAACGAATCCACCACACATAGCCACCTACAACAAGGCGATCAAAGTAACCGTCGATGGGCCACGCGAGCCGCGCTCCAAGACAaggcaacaacaacaatttcacttCGCCTTTGGCCAGCGACCGTTCCACTTCTCCACGGATCCACTTTCCGGCTTCCGCATGCCACCGATTGGAAACTGTCAAAGTGCCAGCAATACGCATTGGGGCTACGGATCGGCGGCCTCTGCCTACTCACCGTACTTGGCCAGCAGCGGACTGTCCTCGTGCACCACGCCCACTTCAGCGCAGTTTAACAATCCGGCGTTGGGCTTCACATGTTCTTCGAATGATCAGAGCAACAATCAGGACTTCGGCGGCGCCACCAATCGCGACTGTGTGCCAATGCTGCCCGACTCGACGGCCAGTGACTTGGATCAGCATCTGAGCAGTCTGGTTGGGTCAACCAGTGGCCAGATGTCGCATCATAGCCTGTTGGGCACCAGCGGACAGACGTCAATCACATCGACTGTGAATGGAGCGAGCGCAGGCAGCGGGGCAACCGCTGGCAGCGCAGCGGTCGCTGGGAGCGTAGGCGGTGGCAACTCGATATTGGTGCCACGATATCACACTAATACCAGCAACGAGTACAATGTCCATTCCAGCCAGAACGGGCCGCGTAGCCTGAGCGATAGCTCGCAGGCCGAGTCACCGGTGCAGGAGGATTTACTGTCAACCAATACACCTAATttgggcagcggcagcggcggcggtgCAACGAATGGTGCAGccaatggcagtggcagtgctGCCGTCGCTGGAAGCGTTGCCTCATCGGTGGCATCTGCGGGCGCTGGCAATCCCGGCATGCTGGGCTCCAATCAGAACTTTCCGGGCATTGTCAATCAAGCCCAGCATGCGTCAGCCTCCGCCTATGGCGGTGGCGTAGGCGTCGGAGTCGGTGGTGGacatggtggtggtggtgccgGTGCGACAGCCGCGGGCTGTAATGGATCACTGTATCCGGTTCTGCCCGCCAGCCTGCTCTACTCGCAGCTTTATACCGCTGCCAATCAGTCGGCGCACGGATTCCACTCGCACACATTGCCGGCGCATGCGTCACCCAACTCCTCGGTGCATGGGGAGCTGCAGAGCGTTATGGATCACATCAGCAATGTGGGTGTGCGGCAGCAGCATAACATAATGGCTGGCGGGGGGGTAGCGCATCCGGGAGATCTGACGCTAATTGGCAACTGCGGTGCGTCGGTGAGGAACATCGAAGATGGGAACACCAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACTGACAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence: MYTKIKTALAAAAVECASNMWKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGTSGQTSITSTVNGASAGSGATAGSAAVAGSVGGGNSILVPRYHTNTSNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGATNGAANGSGSAAVAGSVASSVASAGAGNPGMLGSNQNFPGIVNQAQHASASAYGGGVGVGVGGGHGGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00530732; iTF_00513957; iTF_00582042; iTF_00548580; iTF_00916004; iTF_00527822; iTF_00564430; iTF_00484914; iTF_00613289; iTF_00612593; iTF_00552084; iTF_00511049; iTF_00576122; iTF_00543519;
90% Identity: iTF_00497928;
80% Identity: -