Basic Information

Insect: Drosophila kikkawai
Gene Symbol: pax6a
Assembly: GCA_018152535.1
Location: NW:158922-186039[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.3e-72 6.2e-69 229.4 0.6 1 125 30 154 30 154 0.99

2 2 1.1 1.6e+03 -1.3 0.0 53 77 391 415 370 419 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.3e-72	6.2e-69	229.4	0.6	1	125	30	154	30	154	0.99
2	2	1.1	1.6e+03	-1.3	0.0	53	77	391	415	370	419	0.73

Sequence Information

Coding Sequence: ATGATGCTAACGACGGAACACATCATGCACGGCCACCACCCGCATTCGTCCGTCGGTCAGAGTTCACTTTTTGGGTGTTCGACGGCGGGTCACAGTGGCATTAATCAATTGGGCGGCGTCTATGTTAACGGAAGGCCGTTGCCCGATTCAACGCGTCAGAAAATAGTGGAATTGGCCCATTCAGGTGCTCGTCCATGTGATATTTCAAGGATTTTACAAGTATCCAACGGGTGTGTTAGCAAAATTCTTGGCAGatattatgAAACAGGATCAATTAAACCACGAGCGATAGGTGGTTCAAAGCCACGCGTAGCCACGACTCCTGTCGTACAAAAAATTGCTGACTATAAACGGGAATGCCCAAGTATATTCGCGTGGGAAATCCGGGATCGTCTTCTATCGGAACAAGTTTGCAATAGTGATAATATACCAAGTGTTTCATCTATAAATCGAGTATTACGGAATTTAGCCTCTcaaaaggagcagcaggcgCAGCAACAAAGTGAATCAGTTTATGAGAAGCTTCGAATGTTTAATGGCCAGACCGGTGGATGGGCCTGGTATCCAAGTAATACAACGACGGCCCATTTAGCATTACCACCAGCGACATCATCAGTGTCAGTATCAACCCCCACAAATTTATCTGGACAAATTAATCGAGAGGATATCCAGAAAAGagaTTTACAATACTCTGCGGACGTATCTCATCCAAACTCCCATGATAGTACGTCCGATGGCAATTCTGATCATAATTCATCGGGTGACGAGGACTCGCAAATGCGACTAAGgctaaaaagaaaattgcaaCGAAATCGAACATCATTTTCAAATGAACAAATTGATAGTTTGGAAAAAGAATTTGAACGAACACACTACCCGGATGTTTTTGCCCGAGAAAGGCTTGCAGATAAAATTGGTTTGCCAGAGGCACGTATTCAGGTCTGGTTTTCCAACCGACGAGCTAAATGGCGACGGGAAGAAAAAATGCGAACACAGAGAAGGCCGACGGAAAATGCTGGAAGTGGAAGAGGCAGCACAgggcaaaataataataatccttCGGGAACGGGAGCATCGGTATCAGCCACCGTTGTCACGTCAAATAATTCCCCATCTGGTATTGGTAGCTTAGCAGTCAACAGTTCGGAGCGTGCATCGTCGTCAGCAATAATTAGCAATAACCTTTCCGAGACAACAACAAGTGCACCAACCGTTCTCGGAGGTGACGCCAATACGCATACGACTTCTGAAAGTCCACCACTTCAAGCAGTAGCACCACGGATACCCTTAAATAGTGGATTTAATGCCATGTACTCATCTATTCCGCAACCAATTGCAACAATTGCAGAAAATTACAATTCATCATTAAGCTCGATGACGCCTACCTGTTTGCAACAACGAGATGCCTATCCCTATATGTTTCACGATCCCTTATCGCTAGGATCCCCATATGCTCCACCCCACCATCGAAATACCAGTTGTAATCCTGCCGCGGCGCATCAACAGCCACCTCAGCATAGTGTTTATGGCAATAGCACTGCAATGCCGTCATCAAGTACAgGTGTCATTTCTGCTGGTGTTTCAGTCCCCGTACAAATTTCAACGCAAAATGTATCTGATTTAACCGGAAGTAATTACTGGCCGCGTCTTCAGTGA
Protein Sequence: MMLTTEHIMHGHHPHSSVGQSSLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQSESVYEKLRMFNGQTGGWAWYPSNTTTAHLALPPATSSVSVSTPTNLSGQINREDIQKRDLQYSADVSHPNSHDSTSDGNSDHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRPTENAGSGRGSTGQNNNNPSGTGASVSATVVTSNNSPSGIGSLAVNSSERASSSAIISNNLSETTTSAPTVLGGDANTHTTSESPPLQAVAPRIPLNSGFNAMYSSIPQPIATIAENYNSSLSSMTPTCLQQRDAYPYMFHDPLSLGSPYAPPHHRNTSCNPAAAHQQPPQHSVYGNSTAMPSSSTGVISAGVSVPVQISTQNVSDLTGSNYWPRLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00594492;
90% Identity: iTF_00594492;
80% Identity: iTF_00527144;