Dkan003857.1
Basic Information
- Insect
- Drosophila kanekoi
- Gene Symbol
- foxn4
- Assembly
- GCA_037075305.1
- Location
- JBAMCE010000131.1:810955-819766[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 9.6 1.2e+04 -3.5 0.9 36 56 406 425 398 433 0.72 2 3 3.2e-34 4e-31 107.0 0.0 2 83 443 525 442 530 0.93 3 3 0.63 7.9e+02 0.3 0.0 15 42 719 746 710 754 0.85
Sequence Information
- Coding Sequence
- ATGTTCGAATTGGAGGATTATTCAAGCAGTATACACGAGGGTTTCTTCAGTAAATATGCAGAAGCGGCGGGTCCTTCGCTGGAGTTTTATGTATCCGACTCCATGCAGGATATGTTGGATGTGGACATAAGGGCAGAGATTGCGAATGTTGTGGGCAGCTCAAGTGACTTGACCTCCTCGCTAGATCACGCACTGGAAGCTATTTCGGCTATAAACaatagtaacaacaacagcagcaatataTCATCGTCGAcacacaatgcaaatgcaaatttgctgGCCAGCAGCGCGCTGCACGCCTCTCCCACAGCCAAGTGGATGGGCTCTTGCGCCAATTTCTGGTCCACAGCTGATTATTATGCGGATGTTGGGGCATGTGTCAATCCCATTTCCGTGATGCCGCTAATCAACTCAAACTCCGGCTCGAATTCATTGCTTGGCTCTGGATCGCCCCAAAAGTCGCGTGGTGCGCAGTCGACGCAGAGCAGAGCGGGATCTGCGGCTGGACAGGTGCCGCCCGCCTCTCCATGCGATCAGCACAAATCGCATTTGACCTTCTCCCCAGCACAGATGAAAGTAAGCGCCGGTTCAATGCGCAGAGAGCAAGTGATGGCTCACATACCGAAGCAAATTTCGGCTCTGCCAATCTCGTCGTCGGCTTCGACCGGCGGTGGTACCACAGCGCCGGCTACAATGGCAACCAATTCTGCACTGCAGCGTCGCAATTCGTCGGCAGTGGATGCTGTGCGCAAGGATCTGGGCACTGAGCTGCGCAAGGTGCAGTCCGGCTTGGAAGAGACAAAAGCCACTGCCAAAAACACTAGCCTGCTAACGGTTGGTTGCGCTACCAACACCATTAAGCTGGGTCCCGGCATTGGTGGCCTGACCTTTGCCAACAGCGCCACATACAACAAGCTAAAGCATCAAACGTCGGCAAAGTCCCCCAACGGCGCACCGCTCACCTCCAATGGCAACATCGTGCTCAAGCGGGATCGTGAAGCGAGTCCGCTGCATAACATTGCGACGCTACACGCGGGCGGTGTCCAGAAACGGGGCAATGCGCCAAAAAGCATTGCATCGGCGGCCCACTCGCCGCATCATCAGATGCATGTGCAGAGCAGCATTGGGTCGCCCTCGTCCATTTGCTCCTCTTCTATTGGCCGTCCCACAACGTCATCCTCGCCCTTGTCCTTTGCGGCgctgagcaacaacagcttcaacagcaacaataacaacaacaataccaacaacaacagcattagTAACAATGTCAAGCCACTGCAACAGAAGGCGAAGCTGCCGGCGGCCATGAACAGCGCTTTTCCGAAGCCCGCTTACTCCTATTCCTGCCTCATCGCGCTGGCGCTCAAGAATTCGCGTGCAGGCTCACTGCCCGTATCGGAAATCTACAGTTTCTTGTGCCAGCACTTTCCCTATTTTGAGAATGCCCCTAGCGGCTGGAAGAACAGCGTGCGCCACAATTTGTCGCTGAATAAGTGCTTTGAGAAGATTGAGCGGCCGGCAACGAACGGAAATCAACGCAAGGGATGCCGCTGGGCCATGAATCCAGAACGTATCTGTAAGATGGATGAGGAGGTGCAAAAGTGGTCACGCAAGGATCCAAGCGCAATACGTGGCGCCATGGTCTATCCCGAGCATTTGGAGGCCCTGGAGCGTGGCGAAATGAAGCATGGATCGGCCGATTCTGACGTGGAGCTGGATTCTCAATCTGAGATTGAGGAATCTTCTGATTTAGAGGAGCACGACTTTGATGACACTATGATCGATACGATGCTCGTCGAAGAAGAGGACAATGATAATGTTGaCTGGATGAACAGCGATGATGAAGATAACGTTCAGGAGGACCACGTGCTTCATGAGTATGAGCCAAGTAACCAATCTGTCAATCACCTGCAAACTGATCATCAGCTGCTGGTCGCGCAGAAGAGCGCCGAATTCGACATTGAGGTTGACGAGCTGTACGGTGCCATCGACATTGAGGATGACAAGCAGGCAGTGCGTCACGCTATTGCCCACGGTCAAACATCGAACATCATTGAGCTTAACCCAGCCGATCTGAATGCGAATGATGGCTATCGGTCACCCAAGCGCGCACGGCTTGACATTAACTATGCCATCGGTCCTGCCGGTGAGCTCGAACAGAAATATGGCCAGAAAGTTAAGGTGCAGCAGGTGCACCAAgtgatgcagcagcagccgcccacGTACAATCGTCGAAAGATGCCTCTGGTTAATCGCATTATATAA
- Protein Sequence
- MFELEDYSSSIHEGFFSKYAEAAGPSLEFYVSDSMQDMLDVDIRAEIANVVGSSSDLTSSLDHALEAISAINNSNNNSSNISSSTHNANANLLASSALHASPTAKWMGSCANFWSTADYYADVGACVNPISVMPLINSNSGSNSLLGSGSPQKSRGAQSTQSRAGSAAGQVPPASPCDQHKSHLTFSPAQMKVSAGSMRREQVMAHIPKQISALPISSSASTGGGTTAPATMATNSALQRRNSSAVDAVRKDLGTELRKVQSGLEETKATAKNTSLLTVGCATNTIKLGPGIGGLTFANSATYNKLKHQTSAKSPNGAPLTSNGNIVLKRDREASPLHNIATLHAGGVQKRGNAPKSIASAAHSPHHQMHVQSSIGSPSSICSSSIGRPTTSSSPLSFAALSNNSFNSNNNNNNTNNNSISNNVKPLQQKAKLPAAMNSAFPKPAYSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFENAPSGWKNSVRHNLSLNKCFEKIERPATNGNQRKGCRWAMNPERICKMDEEVQKWSRKDPSAIRGAMVYPEHLEALERGEMKHGSADSDVELDSQSEIEESSDLEEHDFDDTMIDTMLVEEEDNDNVDWMNSDDEDNVQEDHVLHEYEPSNQSVNHLQTDHQLLVAQKSAEFDIEVDELYGAIDIEDDKQAVRHAIAHGQTSNIIELNPADLNANDGYRSPKRARLDINYAIGPAGELEQKYGQKVKVQQVHQVMQQQPPTYNRRKMPLVNRII
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00804997;
- 90% Identity
- iTF_00560852;
- 80% Identity
- -