Basic Information

Insect: Drosophila kambysellisi
Gene Symbol: L
Assembly: GCA_035042185.1
Location: JAWNLS010000039.1:2402560-2412760[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 1.1e-05 0.00074 19.9 2.9 1 23 169 191 169 191 0.98

2 17 0.36 26 5.6 6.2 1 23 197 219 197 219 0.97

3 17 1.8e-07 1.2e-05 25.5 3.2 1 23 225 247 225 247 0.99

4 17 1.3e-05 0.00091 19.6 0.4 1 23 253 275 253 275 0.99

5 17 0.12 8.7 7.1 0.1 2 23 349 374 348 374 0.92

6 17 0.00043 0.03 14.8 0.4 2 23 407 429 406 429 0.96

7 17 0.029 2 9.1 0.7 1 23 494 516 494 516 0.97

8 17 0.0054 0.37 11.4 0.1 2 23 524 545 523 545 0.91

9 17 0.00022 0.015 15.8 0.1 1 23 553 577 553 577 0.93

10 17 5.3 3.7e+02 1.9 1.6 2 23 613 635 612 635 0.95

11 17 0.0026 0.18 12.3 1.1 1 23 686 709 686 709 0.97

12 17 0.0067 0.47 11.1 1.6 2 23 884 906 883 906 0.96

13 17 0.12 8.3 7.1 0.1 1 23 912 934 912 934 0.92

14 17 0.57 40 5.0 0.4 2 23 942 963 941 963 0.93

15 17 0.67 47 4.8 0.6 2 23 1065 1086 1065 1086 0.94

16 17 0.05 3.5 8.3 0.0 1 23 1096 1118 1096 1118 0.94

17 17 0.00023 0.016 15.7 1.2 1 23 1123 1145 1123 1145 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	1.1e-05	0.00074	19.9	2.9	1	23	169	191	169	191	0.98
2	17	0.36	26	5.6	6.2	1	23	197	219	197	219	0.97
3	17	1.8e-07	1.2e-05	25.5	3.2	1	23	225	247	225	247	0.99
4	17	1.3e-05	0.00091	19.6	0.4	1	23	253	275	253	275	0.99
5	17	0.12	8.7	7.1	0.1	2	23	349	374	348	374	0.92
6	17	0.00043	0.03	14.8	0.4	2	23	407	429	406	429	0.96
7	17	0.029	2	9.1	0.7	1	23	494	516	494	516	0.97
8	17	0.0054	0.37	11.4	0.1	2	23	524	545	523	545	0.91
9	17	0.00022	0.015	15.8	0.1	1	23	553	577	553	577	0.93
10	17	5.3	3.7e+02	1.9	1.6	2	23	613	635	612	635	0.95
11	17	0.0026	0.18	12.3	1.1	1	23	686	709	686	709	0.97
12	17	0.0067	0.47	11.1	1.6	2	23	884	906	883	906	0.96
13	17	0.12	8.3	7.1	0.1	1	23	912	934	912	934	0.92
14	17	0.57	40	5.0	0.4	2	23	942	963	941	963	0.93
15	17	0.67	47	4.8	0.6	2	23	1065	1086	1065	1086	0.94
16	17	0.05	3.5	8.3	0.0	1	23	1096	1118	1096	1118	0.94
17	17	0.00023	0.016	15.7	1.2	1	23	1123	1145	1123	1145	0.97

Sequence Information

Coding Sequence: ATGATGGCCTTAAAGATGTTATATCGTGGTCCCAGTTCGCGTTTGGAGAATTTGATTGAAAAGATTCAGGCCACAAAGGAGATTACAAATAACGaCATGTACAGCACGCACACCTCGTCGAGCTACTCGCCCAGCATCTCGGATGGCACATTGACGCCCAACTCGgtacagcagctgcagcagcagtcgtcCAAGGCTGCCGGCGAGGACACTCACAGCGAAGAGTCCAAGGCAAATGGTGAGGGTCCTGCTGCGGAGCAACAGGATCTGGCCAAGCCGAAGCGACCCGCTCAtttgcatcatcatcatcatcatcattatcatcatcagcaggcGCTGAAAATTGCCAACAAGCTGCGCAAAATCAATAAGGAAGCCAAGTTAGCAAACGCCGGAGCAGGAGCACATGgcacaggagcagcaggagcaggtggTGGTGGAGTTGCCGCCAGCAAGTTTGATAAGTTGACAGGCGAGGGAATTAAAAGTCGCGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGCTACTTGAAGCATCACGTCCAGAGCCATGCCGAACATTTGCCTTTCAAGTGCGAATACTGCGCCAAGCTGTTCAAGCATAAGCGATCCCGAGATCGCCACAAGAAGCTCCACACAAATGAGAGGAACTACAAGTGTCCGCATTGCGAGGCTGCTTTCTCCAGAAGCGATCATTTAAAGATTCACATGAAGACGCACGATATCCAGAAGCCGTTCCAGTGCAGCATGTGCAATCGTGGCTACAACACTGCCGCCGCTTTGACCTCGCACATGCAGAAGCACAAGAAGAATGCTGCAATTCTGGCAGCTGGTGGCAATCCCAATGCCCTGAATTATAGTCCACGCTCCACGGGATCGGCGTCCATTTCGAGCAATGGCAGTCTGCACAAGCGACGTTATGCTTTGGCGCTCGCCTCGGACAGCAGTCCGAGTCGTCTGGAGTTCCCCAAGCGGGCACGTGGTGCTACCGTaccgaccacgcccactccaacgCCCCTGCTCAGATGCAGCTACTGCAGTCCCAAGGTGACCGAGTTTAGCAGCCTGGAACAGTTGAATGCCCATCTGCAGGCGGcacacgaacaacaacagcagccgggCGCCAGGAGTTCGACAGCCACCAGCAGAGAGACCACAATAGAGTCAGTGGAGCCACCCACGAATGGTTTCCAGCTCAGCTGCGAATATTGCACAATGAAATTTGGGAATATTGCGGCACTCTTTCAACACATGCGCACCACTCACTTGGATCGCCTGAGCAGTCCCAATTCGTATTATGAGCACTTTAATCGTTTGGCCACCGCTGGAACGTTTAGTCCACGTTTGGATATGGCCAAGATCAAACAGGATTTGCCTAGTCCGCCGGCGGAGGAGCTGCCAACGGATCTGAGCAGCAATAAGCGCCGAACGTTGACACCGCCAGCGCCACCTGGCGTCTTCTTTTGCAATCAGTGCAACGCAGGGTTGCCAGACTTTGAGAGTTTCCGCAATCATCTCAAGACGCACATTGCGGAGGGCATGCAACTGATATGTCCCCATTGCGGATTGAGTCTGCCAGAGCAGAGTGAATTCGAGCGACACGTAGTCGCCCATTTCCTGATCACCAGTTCCGAGTTCAATTGCGGCGCCAGCTGTGGCAAATCGTTTGCCAAATCGGAGGAGCTGCAACAGCATCTGATCAGCGAACACGTTCAGACGCTGCTCAAGTGTGTGATCTGCTCGGAGCTCTGCGAGAATCGCATGTCGATGCAGCTCCACTTGGCCTGTGCCCACAGCCAGGAGACGAAGCTGCTCCGTTGCAGCGCCTGCTTGGAGCTCTTTCGCAATGACACCGATTTTCATGTGCATGTCAAGACGCGTCATCAACTGGTGGGTGGTGGCGGTGCGTCGGGCGGTGCAGTTGGTGGACCACCCACTGCTCCGCCTGCCAATCCGTTGCAGTGCATGTTTTGTCGCGCCGTTTGCGCCTCGGAGCTGGaaatgcatttccatttggcGGCGCACGCCCGTCAATTCCGTTGTCCCAGTTGCCCGGAAACGTTCCACGTCGAATTCCTGCTCGATCGGCATATGCAGAGCCAGCATGGCGGTGTCAAGGATGgcaagcaggagcagcagggcGCCAACAATGCGATGGGCAGTCTTTATGTGAACGCCTTGTTGCCACcgttggcggcggcggcagcggctgcggcagctgccacaaataATAACAGTAATCTGCATATTGATTACAATGTGGCATTCAAGGGTCTCTTTGGAGGCggcaatgccacgcccaccaacACACAGCCAGCCAACAAGTTCTACAGTCCTTTGCAGGTGGATACAAGTGCGCTGAAGCCGCAACAAACCCCGCATCCCGCACTGATGTACGGACTCAGTCAGCGCTATTTGATGGAGATGTATGCGGCAAAGGCAACCTCGCCGGCGGCCAGTGCACCCGAGCTGCCGGCACAGGCAACCCAAAATGCGGCAAATGCGACGGCATCCAGCACCGGCAGCAGTTACAGTTGTGGCATGTGCGAGCGACAAGATTTGCGCAGCGAGGCCGAACTCCATTCGCATCGCAAGTTGGCGCACAATCTGAAGACGGGTGTCAGTTTGAGATGTGCCTACTGCTCGGGCAATTACAAGTCGCGGGcggagctggagcagcacaTGAAGAGCTGCCACAATTCGAGTGGCAAGCACAAGTGTCTCATTTGCGACGAGATCTTTCCGTCGCCGGCGATACTTGCCGAGCACAAGTTGCAGCACTCGAAGGTGGGTCAGTCGGGCAAGTGTGCCCATTGTggccagcagctggagcaTGTCGCCGCATTCCGTGCCCATCTCGGCGAGCATGGTAACGATGGTAATTTGCCGATGGCCTGCATTTGTTGCCGGCAAACTTTGCACTCGGAATTCGAGTTGAGTTTGCATGCGAAATTCCACACAAAATCACCGAGTTGTGGCAGCCTCCAGGAGCCCGTGTGTGCGCTTTGCCTGGAGCCGTTGCCGGGTGCGGGAGAAACCGCCAAGCTGTGTGAGAAATGTTGTCGCAAACATAATTTGAATGGCAAACGCAACAAGGATGCAGCTGTTCCACctccaccagcaccaccaacagcagcagcagcagccaactcCGTGGCTTATCTCGAGAATCGTTGTAATCTGTGCAAACTGATATTGCCACATGCCAAAAAACTGCAGGAGCATCTTGTGGAGCACACATTCGCGGGCACCGAGCAGCGTGGTTTCAATTGCTACATTTGCTCGGCGGTTTTTACGGCACCCGGTGGTCTCCTGGCCCACATTGGGGAGCACGGTGCTCGACCCTACGATTGCAATTTGTGCCCGGAGAAGTTTTACTTCCGCGCCGAACTCGAGCATCATCAGCGTGCTCATGAGCTGAGGCAAATCCCAGCAGTCGCTCCGCCACGGCCCACAACCAAACAGGAGACTCAGCTCAGCTCGTCGGCCAGTTCACCCGTTCTCACGCTCAGTCCCAGTCACGTGAAGCAGGAGCTCTACGAATCGGAGGCGGAGCGAAATTCACCGCAACCCGACGAGGACTCGCCCGCCcccgaggaggaggagtacATTGAGGTCGAGCAGATGCCGCATGAGACCCGCTCCAATGAACTGGTCACCACGGAACGTTCCAGCAACAGCGCCTAA
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSVQQLQQQSSKAAGEDTHSEESKANGEGPAAEQQDLAKPKRPAHLHHHHHHHYHHQQALKIANKLRKINKEAKLANAGAGAHGTGAAGAGGGGVAASKFDKLTGEGIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLEFPKRARGATVPTTPTPTPLLRCSYCSPKVTEFSSLEQLNAHLQAAHEQQQQPGARSSTATSRETTIESVEPPTNGFQLSCEYCTMKFGNIAALFQHMRTTHLDRLSSPNSYYEHFNRLATAGTFSPRLDMAKIKQDLPSPPAEELPTDLSSNKRRTLTPPAPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEQSEFERHVVAHFLITSSEFNCGASCGKSFAKSEELQQHLISEHVQTLLKCVICSELCENRMSMQLHLACAHSQETKLLRCSACLELFRNDTDFHVHVKTRHQLVGGGGASGGAVGGPPTAPPANPLQCMFCRAVCASELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDGKQEQQGANNAMGSLYVNALLPPLAAAAAAAAAATNNNSNLHIDYNVAFKGLFGGGNATPTNTQPANKFYSPLQVDTSALKPQQTPHPALMYGLSQRYLMEMYAAKATSPAASAPELPAQATQNAANATASSTGSSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGNLPMACICCRQTLHSEFELSLHAKFHTKSPSCGSLQEPVCALCLEPLPGAGETAKLCEKCCRKHNLNGKRNKDAAVPPPPAPPTAAAAANSVAYLENRCNLCKLILPHAKKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLAHIGEHGARPYDCNLCPEKFYFRAELEHHQRAHELRQIPAVAPPRPTTKQETQLSSSASSPVLTLSPSHVKQELYESEAERNSPQPDEDSPAPEEEEYIEVEQMPHETRSNELVTTERSSNSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538445;
90% Identity: iTF_00522402;
80% Identity: -