Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.18 1.8e+02 2.2 0.5 52 67 7 23 2 26 0.60

2 3 1.4e-12 1.5e-09 37.8 14.7 5 70 171 235 167 235 0.93

3 3 5.2 5.4e+03 -2.5 1.2 6 11 248 253 243 256 0.56

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.18	1.8e+02	2.2	0.5	52	67	7	23	2	26	0.60
2	3	1.4e-12	1.5e-09	37.8	14.7	5	70	171	235	167	235	0.93
3	3	5.2	5.4e+03	-2.5	1.2	6	11	248	253	243	256	0.56

Coding Sequence: ATGTCCATGTGCTCAGCTTCGAAAGATGTGGACTTCATGCGCTGTATGCATTGCCAGAAGGTGATCCGCATGTCCCGCTGCGATCCCAGCTGTCTGCTGCGCCACGTCGAGTTGGAGCACCCGAGTAAATGCACTTTGACCAGCAGGAAGTGCGCGGGCAGCTGCGAAGTCAAGTCGGAGCCATGCAGCGGGAACAGAAGTAATGCTGGCGAGAACGACCAAATCAGCGAGAAGATCAAGAGAATGCACATGCTGGCCGCAGAGCATGGGATCAGCGAGGAACGCCTCTCGCAGATCAGCAAGAAGACGGGCCTTTCCGAGGAAGAGATGGCCGAAAAGGCAGAGGCATATATGAAGAAAAAGGGTTATTCCGTTTCTACACCAGTCTCTGGAAGTGGCGAAAAAGGTGCATGCCAGCAAAACGACCCCTGCCCGTGCTCGGAAAAGGAGCAGGCTCAGCGCAGGCAGTGCTACAGGCTCTCCATCAGGCGCTGGGCGCCGGCGGATGGTTGCATCTACTGTCCGTGCTGTGGCTGCCAGCGCCGTCCGATGATTAAGGCCGCCTCAGATATCGTGACCACCAAATGCTGTGCCGCCTGGATCGTGGTCTGCTGGCCGTTGTGCCTGCTGCCCTGCTTGGACTCCTCGGATAACAAGGAGTATCTGTACTGCTCGAACTGTAATGCCTTTCTGGGCATTTACAATCGTGAAAATCGCTGCATCAGGCCCAGCAAGGAGTTCGTGACCTGTTGCAACTGTGCCACGCCACCACCAGCGCAAAAGTAG
Protein Sequence: MSMCSASKDVDFMRCMHCQKVIRMSRCDPSCLLRHVELEHPSKCTLTSRKCAGSCEVKSEPCSGNRSNAGENDQISEKIKRMHMLAAEHGISEERLSQISKKTGLSEEEMAEKAEAYMKKKGYSVSTPVSGSGEKGACQQNDPCPCSEKEQAQRRQCYRLSIRRWAPADGCIYCPCCGCQRRPMIKAASDIVTTKCCAAWIVVCWPLCLLPCLDSSDNKEYLYCSNCNAFLGIYNRENRCIRPSKEFVTCCNCATPPPAQK

Sequence clustering based on sequence similarity using MMseqs2