Basic Information

Insect: Drosophila insularis
Gene Symbol: Ibtk
Assembly: GCA_018903935.1
Location: JAEIFP010001798.1:6050303-6054178[-]

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 9.7 2.6e+03 -1.4 0.0 23 42 247 266 232 284 0.78

2 4 8.3e-08 2.3e-05 24.6 0.1 6 78 559 627 554 646 0.84

3 4 2.2e-14 5.9e-12 45.8 1.0 9 107 692 794 686 797 0.84

4 4 0.058 16 5.8 0.4 57 109 778 828 771 829 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	9.7	2.6e+03	-1.4	0.0	23	42	247	266	232	284	0.78
2	4	8.3e-08	2.3e-05	24.6	0.1	6	78	559	627	554	646	0.84
3	4	2.2e-14	5.9e-12	45.8	1.0	9	107	692	794	686	797	0.84
4	4	0.058	16	5.8	0.4	57	109	778	828	771	829	0.86

Sequence Information

Coding Sequence: ATGTCAGCTGCCAAACACCAGGAGTACGATTGCACTATCAAGTGCAGATTACCCCAACATGGAAACTGTATCGTAGCCGCGCTTACTAAACGATCCATAGAGAGTCAAGCATTGGCCACGTTCATATACAAGACCTGTGCCAATTTTGCCAATATTCAAGATGATCTGGGTCGCTCTGCCGTGCACATGTCTGCTTCAGTGGCTCGCTATGATATTCTAGAATGGCTTTTGAATCATGGCGCCTACATTAATGGCAGGGACTACGAGTCGGGCAGCACTCCTTTGCATCGTGCCCTCTACTATGGTGCCATAGATTGTGCTGTTCTACTAATGAGATATGGTGCCAGCTTGGATATGTTGGACGAGAACACTCTTTGCCCATTGCAGGCAATTTGCCGGAATTGCGACGATTTTAATTTCGCCAGGAATACAAACACCCAGAACGATATTCTAGTCTGGGGATCAAATAAGAACTACAATCTAGGCATAGGCACTGAGCAGAGCTCAACTAGTGCTCCTCAGGCTGTGGATTTCTTTCGCAAAGCCAACATTTGGATTGAAAAGGTATCATTGGGAGCCTATCATAGTCTATTCCTGGATAAAAAGGGTCATCTCTACGCTGTGGGCCATGGCAAAGGTGGAAGATTAGGCAATGGCAATGAGAATAGTTTGCCAGCACCTAAGCGTGTAAAATTATCTAGCAAAATTCAAGATGACTCAATCATATGCATCAGCACATCACGTCAGCATTCCCTTGTGTTGACTCAGCGTTCAATGGTTTTCGCCTGTGGCATTAATACTGACCATCAGTTGGGTGTAAGAGATGCTCCCGAGCAACTGAATCAATTCAAAGAAGTTGTCAGTTTAAGAGACAAGGGAGCTAGTGATCTATTAAAGGTTATAGCCTGTGATCAGCATTCCATAGCATATAGCTCAAAGTGTGTATATGTGTGGGGTGCCAATCAGGGACAGTTCGGTCTGGGACCAAATCAGCAATCAATAGTAGTTCCGGTTCAAATGAAATTGCCAGCAAAAACTGTCATACGCTTTGTAGAAGCCAATAATGCAGCCACTGTGATTTATAATGACGAGAAGATCGTTTCCCTGTACTATGGAGAAAAGACAAAATATATCAAGACACCAGACTATGAGGATCTAAAGAGCATTGCCGTGATGGGTGGAAATATAAAAAGTTCTGCTAAAGGATCAGCAGCAGCTTTAAAACTACTTATGCTTACAGAAACTAATGTGATTTATCTTTGGTATGAGAACACCCAACAATTCTACAGATGCACATTATTACCCATACGTCTTCCAAATATCAAAAAAGTTCTATATAAATGTAATCAAGTCTTAATTCTCTCCCTCGATGGTTGTGTCTATCGAGGCAAATGTAATCAAGTAACTCTGCCCCCCACTTTGGGCAAGAATAATTCGAAAACAACAATAGACAATTGGACCAACAATGATCAGAATCGTACGGAAATTTCGCGGGAACATATTGTACGCATTGAGCTGACGCGTTTGCCCAACATTGATCGTGCAGTTGACATATGTTGTGATGAGAGTTTCTCATCATTTGCTGTGCTGCAGGAAGCACCCACTAAATATTTTAAGAAACCTCCACTTGCCAGAAGGGAACATAATTTTAAAAAGCTCTATCATGACACCAGCGATACGGATGCTGTCCACGATGTGATCTTTCATGTTGATGGGGAATTCTTTGCGGCTCACAAGTTTATCATCTATTCGCGAGCAAATGGACTAAGAGAATTGATGATGAATTATTTGGACAAAGATATCTATTTGAATTTCAAAAATTTGACTGGCAAAATATTTGAATTAATATTAAAAATTATTTATACCAATTATTCGCCAGCTGAAGATGATATTGACTGCATTCAACAGAGTTTGGATCCAAATTTGAGAACGAGAACTGAAGCAATTAAAATATTTCTTCATTATATTAAGAAATTTGGAATAAGTCATCTATCCAATATGCAGGTGCTTGGTATAGAAACAATATCACAGGGCAAACAAAAACCCCAGCGGATACATCGTTGTGATTATCCAGAGCTCTATGATGTTCGCGTTATCTGTGATGATGGCAAGATTCTAGAGGCACATAAATGCATTTTGGTTGCGCGTTTGGAATACTTTGAAATGATGTTTATGCATTCAACGTGGATGGAGCACTCTACAGTTACCATGGAGGGTGTTCCTTTGGAGTATATGGAACCAATTCTAGATTATCTCTATGATATGGACACAGAGGCATTTTGCAAGCAAAATTATACAGAGACTTTTCTGTATAATATGATTATCATATGCGATCAATATTTTATTGAATCACTGCACAATTTATGTGAATCATTGATTCTCGATAAGATTAGCATACGAAAATGTGGCGAACTGTTGGAATTCGCTACCATGTACAATTGCAAGCTGCTGGAGAAGGGTTGCCTTGATTATATATGCCAGAATTTGGCCAGAGTGCTCAGTTATCGAAGTATTGAGCAATGCGAACCGGCTACATTGAAACTTGTTAATATTCATTATCAGAAAATGTTTAATTGCATTTTTGACTATCGTCAAATAACACCCTTTAACGAGGCCGTAAAGGATGAGTTGCTATTCAGCTTCATTGAGGGTTGTGAAGTTGATCTAAAGTCCACAATGAGATTTGAAGAGTCCTCAGCCAAGCAGAATAAACAAAAGGAAATACGTAAACAAGATGCACGTCATCAATATGAACAACAGGCCATAACAAGCATGATGAGATCGTTGAGTACCAGTGAAGGAGGTGAGACAGCAGCTTCTGTTGCTTCAGGTACAATTAACCAGGCCACAAATGAGGCTAAAAATTGGTCCAAAGTAAAGGATAAAAAAGAGAAAACACGCAAACTAAGTGAGAAACAGGAGCAGGTGCAAGTTCCTGCTCCACCTATCAAAGAACAAACGCCACCTCCCCAACAATCAAAGCCAATTGAAGCTATTCCCACGTCGCCCCAAGATGAGGCGGCTTCTCCCTTAAATAAAAGTTACAATCTTGATCTCAGTTCCTGGACACCGCAACCTTCACAGAAATTATCACAAAAAGAACGCAAACGTCTTTCCTCAGAGTCAAAAACTTGGCGCTCAGCAGCACCCAGCGCACAGATTGCAACTCCACCGCAGCCGGTGCCCAATGCTTGGGGATTACCTTCAACACCTTCGAGTAGTTCGTTCAACGATTCTTTAAACTCACCGCCAACCGGTAGTTCAACGGATCCCACGTCCTTTGCCAATATGATGAGAGCTCAGGCAACGGGAGCCACCGCTAGTTCACCATTGGAACAGCAACCAAATAGCTTTTCACGCATTTTAGCCGACGAACGACGACAACGGGAATCCTATGAACGTATGCGTAATAAATCACTTTACCATACCCAAATCGAAGAGACAGCCATTGCGGAACTTCGAGAGTTCTATAATGTGGACAATGTGGATGATGAGTATATCACAATTGAGCGGGTATCCAGGCCCGCAGATATTAATTTTAGCACTTGGTTTAAGCATTAA
Protein Sequence: MSAAKHQEYDCTIKCRLPQHGNCIVAALTKRSIESQALATFIYKTCANFANIQDDLGRSAVHMSASVARYDILEWLLNHGAYINGRDYESGSTPLHRALYYGAIDCAVLLMRYGASLDMLDENTLCPLQAICRNCDDFNFARNTNTQNDILVWGSNKNYNLGIGTEQSSTSAPQAVDFFRKANIWIEKVSLGAYHSLFLDKKGHLYAVGHGKGGRLGNGNENSLPAPKRVKLSSKIQDDSIICISTSRQHSLVLTQRSMVFACGINTDHQLGVRDAPEQLNQFKEVVSLRDKGASDLLKVIACDQHSIAYSSKCVYVWGANQGQFGLGPNQQSIVVPVQMKLPAKTVIRFVEANNAATVIYNDEKIVSLYYGEKTKYIKTPDYEDLKSIAVMGGNIKSSAKGSAAALKLLMLTETNVIYLWYENTQQFYRCTLLPIRLPNIKKVLYKCNQVLILSLDGCVYRGKCNQVTLPPTLGKNNSKTTIDNWTNNDQNRTEISREHIVRIELTRLPNIDRAVDICCDESFSSFAVLQEAPTKYFKKPPLARREHNFKKLYHDTSDTDAVHDVIFHVDGEFFAAHKFIIYSRANGLRELMMNYLDKDIYLNFKNLTGKIFELILKIIYTNYSPAEDDIDCIQQSLDPNLRTRTEAIKIFLHYIKKFGISHLSNMQVLGIETISQGKQKPQRIHRCDYPELYDVRVICDDGKILEAHKCILVARLEYFEMMFMHSTWMEHSTVTMEGVPLEYMEPILDYLYDMDTEAFCKQNYTETFLYNMIIICDQYFIESLHNLCESLILDKISIRKCGELLEFATMYNCKLLEKGCLDYICQNLARVLSYRSIEQCEPATLKLVNIHYQKMFNCIFDYRQITPFNEAVKDELLFSFIEGCEVDLKSTMRFEESSAKQNKQKEIRKQDARHQYEQQAITSMMRSLSTSEGGETAASVASGTINQATNEAKNWSKVKDKKEKTRKLSEKQEQVQVPAPPIKEQTPPPQQSKPIEAIPTSPQDEAASPLNKSYNLDLSSWTPQPSQKLSQKERKRLSSESKTWRSAAPSAQIATPPQPVPNAWGLPSTPSSSSFNDSLNSPPTGSSTDPTSFANMMRAQATGATASSPLEQQPNSFSRILADERRQRESYERMRNKSLYHTQIEETAIAELREFYNVDNVDDEYITIERVSRPADINFSTWFKH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00501150;
90% Identity: iTF_00618513;
80% Identity: -