Basic Information

Insect: Drosophila innubila
Gene Symbol: zfh1
Assembly: GCA_004354385.1
Location: NW:21562843-21568513[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.5e-05 0.0014 18.5 1.0 1 23 149 171 149 171 0.97

2 15 0.00078 0.044 13.8 1.2 3 23 179 199 177 199 0.94

3 15 8.5e-05 0.0048 16.9 0.1 1 23 368 390 368 390 0.98

4 15 0.00079 0.045 13.8 2.2 1 23 396 418 396 418 0.98

5 15 3.2e-05 0.0018 18.2 2.2 1 23 449 472 449 472 0.95

6 15 0.00013 0.0074 16.3 0.5 1 23 507 529 507 529 0.95

7 15 0.01 0.57 10.3 1.3 1 23 535 558 535 558 0.97

8 15 0.025 1.4 9.1 0.4 3 19 567 583 566 584 0.95

9 15 0.00015 0.0083 16.1 5.6 1 23 593 615 593 615 0.97

10 15 0.038 2.2 8.5 1.2 2 23 621 642 620 642 0.96

11 15 8.6e-06 0.00049 20.0 1.0 1 23 651 673 651 673 0.98

12 15 0.00098 0.055 13.5 0.1 3 23 681 701 679 701 0.97

13 15 5.2e-05 0.003 17.5 0.5 1 23 707 729 707 730 0.95

14 15 0.048 2.7 8.2 0.4 1 23 740 762 740 762 0.97

15 15 0.0028 0.16 12.1 0.1 1 23 1294 1316 1294 1316 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.5e-05	0.0014	18.5	1.0	1	23	149	171	149	171	0.97
2	15	0.00078	0.044	13.8	1.2	3	23	179	199	177	199	0.94
3	15	8.5e-05	0.0048	16.9	0.1	1	23	368	390	368	390	0.98
4	15	0.00079	0.045	13.8	2.2	1	23	396	418	396	418	0.98
5	15	3.2e-05	0.0018	18.2	2.2	1	23	449	472	449	472	0.95
6	15	0.00013	0.0074	16.3	0.5	1	23	507	529	507	529	0.95
7	15	0.01	0.57	10.3	1.3	1	23	535	558	535	558	0.97
8	15	0.025	1.4	9.1	0.4	3	19	567	583	566	584	0.95
9	15	0.00015	0.0083	16.1	5.6	1	23	593	615	593	615	0.97
10	15	0.038	2.2	8.5	1.2	2	23	621	642	620	642	0.96
11	15	8.6e-06	0.00049	20.0	1.0	1	23	651	673	651	673	0.98
12	15	0.00098	0.055	13.5	0.1	3	23	681	701	679	701	0.97
13	15	5.2e-05	0.003	17.5	0.5	1	23	707	729	707	730	0.95
14	15	0.048	2.7	8.2	0.4	1	23	740	762	740	762	0.97
15	15	0.0028	0.16	12.1	0.1	1	23	1294	1316	1294	1316	0.97

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATTCAGCAGCACGCATCTGCGGTCGACTCCGAGTCCGATATGCTGGAAAACGGTGCTGGCGACAGTGAGGTGACTGCAGCCTATTTGGTAAATGGCAACGCCACCGACGAAGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCGCGAGATGGTCAGCTGAGCGAGATTATAGCTGCCAACGAATCGGGTGGCGGCACAGTTTTAATCACTGACAGCGGCGTCGCATATGCCGAGTCATTCGATGATGACGCACAGGTGGTCACCGAGGAGATCATTACCGATGATTGGGTGCAGCATCAAGGCGCCGAACGGGTCGAAATCGCTGCAGAGCAAATTGCAGGAAATGTCAATTCGCTGGAGCTACTGGATATGGAGCAGGATGAGTATACGGCCCTGCGTCCCTATCCTTGTGATTTCTGTAGCCGGCGATTCCGCAAGAAGGCAAGCCTCAACAATCACATGCTGGCACATCAAAACGATCGTCCGCATCTGTGTAAATTGTGTGGTGCACGATTCTCACGTCGCGCCGAGCTCATCAGTCACTTTAAGGCACATGCCGAGGCGCAGGATGCAGCCGATGCGGAGGCAGCAGCGGCggcttcaattaaatttgagccACCGCAGCACAGACAAGTGGATGATCATTTCTACGAACAGGAATGGCCATTGTATCAGGATCAGGAGCACGAACAAAtacaagagcagcagcaacaacaactggagcAGGAGCAAGAGCAGGAACAGTTGGCCGTTGCCAGCCAGGTGATGCAACAGGCCAGCTATGCAGCAGTGTCAGATGTGGCCGCACCAACAGCTGCCCGGGGTCGCATAAGTCGCCTCAAGCCCAAGGAGGAGAGCACGCAGTATATTGTGATTGCTGAGAAGCAGACATCGGACGACTTGCAACAGTTTGTGGACTGTGAGGAGTTggcgccaccgccaccactgACAAATACCAATGTCAATGCAACGTCAACTCAATGCGATGCCAACAGCTCAACAGACAACAGTCAGGCCATGAATGCATCACGTTTCCCAGTGCTGGATGAGAGCAAACCCTTTGTGTGTCAACAATGTGGATTGGCATTTGCACGAGAGAAGGCGCTTGTCTCCCATATCAAGAATCATCGCGTGGACTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATCACAGCCTGCAGGAGCATCAGAAGACACATCAGTTTGAGGAGAGCAATTCAGAGTACGATCCTGCCTCGGCGGGGGATGACAGTGCCAGCGAATCGGAGCCAGATCAGCTCTATGGTGACTTCTATTGCAGTGAGTGCGGCATCTCATTTCATAGGCAGGATCTGCTCCGTCGTCATGCCAAGCAGCAGCATAAATTGGCCGTGACATCAGCCGTCAACTCTGTCGATGTGGAGGGCAGTGCAGATCtggatgcagatgcagatggtGATACCGACAATACCAAAGATGCGCCGCATTCTTGTCACACGTGTGGCAAGTCATTTCCCAGCGCATTGGAGCTGCTCGCCCATGCCGAGATTCATGCCCGTTTCCCGCCATTCAAATGTGTCTTGTGCGGCATTAGCTTTTACGAGGAACAGGCCATTAAAAGGCATTTGCACACTCGTCATCCGCACGAGTTGAAGCCAAATTCGTGTGTGCTCTGTGGCAAGGAGTGTCGGGATCGCAAGGCGTTGATTAAACATGCGTGGGATCATTCCCGTGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCACAACAAGGCGCGTCTGAAGCGACACATGGCCTCGCATCGTGATAAGTCGGTGGTGTGCGAGGTGTGCCACGAGGAGTTCCCCGACGGACGCACCCTTTCCAATCATCGTCATTCGCATAGCACCACGTCGCCGGGCAAACTGTTTCCCTGCCATGAATGCGGCAAGACCTTTGGCTCCCGCAGCTCACAGCAGATACATGTGCGCATCCACACGGGCGAACGGCCCTATGGATGCCGGTATTGCTGGAAGGCCTTTGCCGATGGAGGTACGCTGCGCAAGCACGAAAGGATTCACACTGGCGAGAAGCCATATGCCTGCTCCGTCTGTCCGCGTGCGTTTAATCAGCGTGTTGTGCTCAGGGAACACATACGCTCCCATCATTCAGGACTGGATGCAGTGCGTGGAACGTATCATTGCACCGTCTGCACTGCGGATTTATCCTCATCCAATGAGCTTATACAGCATCTCATCCAACACAGCGACACGAACACAGccaaacaacgacaaccaaTTACGGGTCCACGTAAATACAAGCGTCGAAGGAAACTGCAGCCTCATGAAATTGCACACATGCGTGCTGAGAACAAGGATGGCGATGGTGATGGCGATGATTATGTCAGTGATATGGATCTCTGCGATCTGGATGTGGAAAATGTGGACGATCTCTTTGACGCGGCAGAAACAACGCCACCCAAAAAAGAGAAGCGCAAACGGAATGCCGCCAGTCAAGGGAAACCAGTGTCAAATGGCGTCTCAACATCCGCGCTAAATAACAATACAACTCCATCAGCCAAATCCGCCAATGGGAATCCGGATCGCCTGTGGGAGGAGAAATTTCTGCAGtccaatggcaatggcaatgccagCAATCAGTTAAATGATGATGCGTTCAAAAGCTTCTTTCAAATTGACTCTTTGGTGGTGGTTAATGATACCACACTGCAACCTATAAGCTCATCCAGTGTTGTCACTGCGCCCAAGACACGACGTAGTGCCAAACACACGCCACAGTTGCCGACgagcaccagcaacagcaacaagtcaacaacagcagcaggaacaacaacaactggtgATGATTGTAGCAAGTCCAGTGCCTCAGTATCGTCAAGCAGTCGCAGCAGCCGTAAGAAATCATCCAAGTCCACTAAGAACTCGACCAACACGGCGTCCACTTCGAGCAGCTCGCGTCCTAGGATGATACACACAGAAAAGTCACGTGTGCCGCCGGAGAATGTGTCGAAGAAGACACGAGGAAGGTCCTATGTGACGAGGACGAGCACCAGCGAGAGCAGCCAGCTGGGTCTGGCTAAGTCGCGCATTGTGGATGACTATGAGATAATATCACCTGCCACACAGCCACCGAATCAGATAAGCTCCAGTCCGTTGCACATCaagcaggaacaggagcagcagcaacaacgagtgCCTCTCATGTATGATGATACGCATCTGTTGATCGATGCGGCTTTGTTGCGTGAGAAGACCTATGAAAAGTTTAATCCCAGCATTGTCAATGATCTGGAGGAGATTCTACGTAGTCCACTCAAGCATGATCGCAATTCGCGTCTGCGTTTCACCAGCGAATCATCGACAACGCCCCAGTTTCTGCCCGAGGAGGAGCAGAATCTGATTAAAATAGAGCCAACGTCACCGGATTTGCGTGAAATGGTGGAGAGCCAGCAGCGTGTCAGCTCAACGGGACATGCAACCACAccctcatcatcatcctcgtcAGCGGCGCGAACTTCACGTCACCTGCGACAGCTCACTGCCAATTCCAGTTCACGGGCGGGAACGAAAcgacacagcagcagcagtaacaaaACAGTTTCCGCCTCCAGCTCCAAGAAATCCGCATCATCCGGATCATCCGTTGCTGTGAGCAAAGCCAACTCGTACCTCAGCTATGGCGTGGACTCTTACAATGTGAGTGTTGCTGCCAATGCCAACTCATCGGATGTCAGCTCTGGATTCTTCTCAATCTCGGAGGTTGTGTCCGCTGCAGATGCCGCCGATGCAGCTGCCAAAGCGGCAGCGGCCAATAAACCGGAGCGTCGTGCCCGTTGCTATGAGTGTGAAATGTGCTCCGCCAATTTTCCGGATCGAGCTCAGCTGCTGGAGCATGTGCATATACACATCTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSESDMLENGAGDSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNVNSLELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAASIKFEPPQHRQVDDHFYEQEWPLYQDQEHEQIQEQQQQQLEQEQEQEQLAVASQVMQQASYAAVSDVAAPTAARGRISRLKPKEESTQYIVIAEKQTSDDLQQFVDCEELAPPPPLTNTNVNATSTQCDANSSTDNSQAMNASRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNHSLQEHQKTHQFEESNSEYDPASAGDDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHKLAVTSAVNSVDVEGSADLDADADGDTDNTKDAPHSCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDGDGDDYVSDMDLCDLDVENVDDLFDAAETTPPKKEKRKRNAASQGKPVSNGVSTSALNNNTTPSAKSANGNPDRLWEEKFLQSNGNGNASNQLNDDAFKSFFQIDSLVVVNDTTLQPISSSSVVTAPKTRRSAKHTPQLPTSTSNSNKSTTAAGTTTTGDDCSKSSASVSSSSRSSRKKSSKSTKNSTNTASTSSSSRPRMIHTEKSRVPPENVSKKTRGRSYVTRTSTSESSQLGLAKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVPLMYDDTHLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRNSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSTGHATTPSSSSSSAARTSRHLRQLTANSSSRAGTKRHSSSSNKTVSASSSKKSASSGSSVAVSKANSYLSYGVDSYNVSVAANANSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00575748;
80% Identity: -