Dinc000039.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Drosophila incognita
Gene Symbol
KLHL5_15
Assembly
GCA_035042225.1
Location
JAWNLQ010000014.1:234739-236556[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.6e-27 4e-25 88.2 0.1 2 109 52 159 51 160 0.95
2 2 2.5 3.7e+02 1.4 0.1 84 104 178 198 171 202 0.90

Sequence Information

Coding Sequence
atgtcatccGTAAATGGACACCAAGAAGAGAGCCGCAGTGGAGAGCCGACAGCGTCCACATCGATGAATATGGCGGAGAATAAGCTggagtctttgtctttgtcgagGGATTCCAGTGTGGGTAGCCATGCAGACGCCTTActgaagcgaatgcaacaatttgtggaagaGAAGCAGCTGTTCGATGTGGTTCTGatcgctggcattgatggcaagagggtgtccgctcatcgcttggtgctcgcagcttcgagtgaatatttttcggcaatgtttaccggacagatgcgcgagagcaaggagcacgagGTGACCGTTGGCGAGGTGCGTGGCGATCCGTTGCATCTGCTCGTCCAGCACTGTTACACCGGAAGCATTGAACTGCACGAGGACACTGTcgagacgctgctggccaccgccgacctgctgcagctgatccctgtggtgacggcatgctgcaattttctcgcCCGCCACCTGCACCCATCCAATTGTTTGGGATTCGCATTCTTGGCGGATCAGCATGGCTGCACAGAGCTGCTGCGATTGGCGCAGGAGTACATCTGCCAGCACTTTATGGAGGTGTGCCACAATGAGGAGTTCTTTCAGCTAAACGCGAATCAGCTGGGCAAGCTGCTATCCAGCGATGATCTCTGTGTGCCAACCGAGCGGGATGTCTTCCACTCGATGATGTCGTGGGTGCGCCACGATGCGCCCACTCGTGAGCAGCACATGCCCGAGCTGCTCGCTAAGGTGCGTCTGCCCCTGTTGGATTTATCCTTCATTGCGCATCACGTGGAGAAGGTGTGCAGTGCCAGCATCGAgtggctgcaactgctgttggagGCCTTCAAGTGGCATTCACTTCCCTCCCAGCGTCGTTCTCTCATTGCTGCCACTGAACGAACCAAGCCCCGCAAATACACTGCTGTCGGCCAATTGCTGGTTATGGGTGGCCGCAATAATGGCCGCTGGGTCCCCACCATTGAGAGCTACTGTCCGCGGCTGAACAAGTGGACGACTTGGCAGCACACGATCGATGGGCGTGAGGATTTTGGCGCCGCTGTCTTggacaacaaactgattttggtagGCGGATTCAATGGTGGGGAAGCATTGTGCTCTGTGGAGAGCCTCGACCAACACACGATGGCCTGCGTGCCACTCAATCCAATGGGAACGGCACGTTATAACCCAGGTGTTGCAGTGCTGGATGGACACCTCTATGCGGTCGGCGGACAGTCTGGTCTCCAGTTGCTGAACACGGTTGAACGCTATGATCCCATTGCGCGCACCTGGAGCTATGTGTCGCCGATGTCCGAGAAGCGTTCGAAGCCTGGTGTTGCAGTGTTGGGCAACCGCCTCTATGCCATTGGCGGAAGAGACCTATACTCAGTCGAAAACTATGATCCGCGAACAAACGAGTGGAGTTTTCGGGCGCCAATGAATCGCAATAAATTTAacgttggtgtcgctgttgcaaatggatacatctatgccTTGGGTGGCCATGACCGGAACTATAGTCCCACAGCAACCGTGGAACGTTATGATCCAGCTACTGATACGTGGACACTGATTTGCTCTCTGACAGTGGGACGCTATGGGATTGGTTGTGCTCAGCTTGCAGatcgtttgattgccgttggAGGATATGATAGGCATCGTAGTCTCAACATTGTCGAGGAGTACGATCCGGTGCGCAATGCCTGGAATGAACTGGCGCCAATTTCGAGTCCTAGATACAACGTCCTTGTCTTTGCCATTCCGAACAtaacaccaccaccagcagccaagTATGGATCCAAACCAGCTTAA
Protein Sequence
MSSVNGHQEESRSGEPTASTSMNMAENKLESLSLSRDSSVGSHADALLKRMQQFVEEKQLFDVVLIAGIDGKRVSAHRLVLAASSEYFSAMFTGQMRESKEHEVTVGEVRGDPLHLLVQHCYTGSIELHEDTVETLLATADLLQLIPVVTACCNFLARHLHPSNCLGFAFLADQHGCTELLRLAQEYICQHFMEVCHNEEFFQLNANQLGKLLSSDDLCVPTERDVFHSMMSWVRHDAPTREQHMPELLAKVRLPLLDLSFIAHHVEKVCSASIEWLQLLLEAFKWHSLPSQRRSLIAATERTKPRKYTAVGQLLVMGGRNNGRWVPTIESYCPRLNKWTTWQHTIDGREDFGAAVLDNKLILVGGFNGGEALCSVESLDQHTMACVPLNPMGTARYNPGVAVLDGHLYAVGGQSGLQLLNTVERYDPIARTWSYVSPMSEKRSKPGVAVLGNRLYAIGGRDLYSVENYDPRTNEWSFRAPMNRNKFNVGVAVANGYIYALGGHDRNYSPTATVERYDPATDTWTLICSLTVGRYGIGCAQLADRLIAVGGYDRHRSLNIVEEYDPVRNAWNELAPISSPRYNVLVFAIPNITPPPAAKYGSKPA