Basic Information

Insect: Drosophila hydei
Gene Symbol: ZNF423
Assembly: GCA_003285905.2
Location: NW:2956284-2961213[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 26 0.0011 0.065 13.3 1.4 1 23 241 263 241 263 0.97

2 26 0.028 1.6 8.9 1.9 1 23 269 291 269 291 0.97

3 26 0.00091 0.052 13.6 0.4 2 23 323 344 323 344 0.97

4 26 0.0051 0.29 11.2 1.6 1 23 417 440 417 440 0.94

5 26 0.56 32 4.8 0.4 2 22 451 471 450 471 0.95

6 26 0.42 24 5.2 1.3 1 23 480 502 480 503 0.95

7 26 0.68 39 4.5 1.3 2 23 515 536 514 536 0.97

8 26 0.16 9.3 6.5 1.9 1 23 616 639 616 639 0.96

9 26 0.00023 0.013 15.5 0.1 1 22 648 669 648 669 0.96

10 26 8.4 4.8e+02 1.1 6.7 1 23 678 701 678 701 0.95

11 26 0.0041 0.23 11.5 1.3 2 23 733 754 732 754 0.96

12 26 0.00016 0.0091 16.0 7.5 1 23 762 784 762 784 0.98

13 26 0.0051 0.29 11.2 1.7 1 23 929 952 929 952 0.95

14 26 0.96 55 4.1 1.6 3 22 961 980 960 980 0.92

15 26 0.21 12 6.2 0.7 1 23 989 1012 989 1012 0.90

16 26 3.4e-05 0.0019 18.1 3.9 1 23 1037 1059 1037 1059 0.97

17 26 0.00096 0.055 13.5 2.4 1 23 1066 1088 1066 1088 0.98

18 26 0.2 12 6.2 0.0 2 21 1115 1134 1114 1135 0.93

19 26 0.035 2 8.6 4.0 1 23 1180 1203 1180 1203 0.96

20 26 0.0025 0.14 12.2 0.7 1 23 1240 1263 1240 1263 0.96

21 26 0.013 0.71 10.0 3.1 1 23 1288 1311 1288 1311 0.97

22 26 1.2e-05 0.00068 19.5 0.1 2 23 1340 1361 1339 1361 0.95

23 26 4.1e-05 0.0023 17.8 2.9 1 23 1367 1389 1367 1389 0.99

24 26 2e-06 0.00011 22.0 2.0 1 23 1395 1417 1395 1417 0.97

25 26 1.7e-07 1e-05 25.3 2.4 1 23 1423 1445 1423 1445 0.99

26 26 0.00015 0.0088 16.0 0.5 1 23 1451 1473 1451 1473 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	26	0.0011	0.065	13.3	1.4	1	23	241	263	241	263	0.97
2	26	0.028	1.6	8.9	1.9	1	23	269	291	269	291	0.97
3	26	0.00091	0.052	13.6	0.4	2	23	323	344	323	344	0.97
4	26	0.0051	0.29	11.2	1.6	1	23	417	440	417	440	0.94
5	26	0.56	32	4.8	0.4	2	22	451	471	450	471	0.95
6	26	0.42	24	5.2	1.3	1	23	480	502	480	503	0.95
7	26	0.68	39	4.5	1.3	2	23	515	536	514	536	0.97
8	26	0.16	9.3	6.5	1.9	1	23	616	639	616	639	0.96
9	26	0.00023	0.013	15.5	0.1	1	22	648	669	648	669	0.96
10	26	8.4	4.8e+02	1.1	6.7	1	23	678	701	678	701	0.95
11	26	0.0041	0.23	11.5	1.3	2	23	733	754	732	754	0.96
12	26	0.00016	0.0091	16.0	7.5	1	23	762	784	762	784	0.98
13	26	0.0051	0.29	11.2	1.7	1	23	929	952	929	952	0.95
14	26	0.96	55	4.1	1.6	3	22	961	980	960	980	0.92
15	26	0.21	12	6.2	0.7	1	23	989	1012	989	1012	0.90
16	26	3.4e-05	0.0019	18.1	3.9	1	23	1037	1059	1037	1059	0.97
17	26	0.00096	0.055	13.5	2.4	1	23	1066	1088	1066	1088	0.98
18	26	0.2	12	6.2	0.0	2	21	1115	1134	1114	1135	0.93
19	26	0.035	2	8.6	4.0	1	23	1180	1203	1180	1203	0.96
20	26	0.0025	0.14	12.2	0.7	1	23	1240	1263	1240	1263	0.96
21	26	0.013	0.71	10.0	3.1	1	23	1288	1311	1288	1311	0.97
22	26	1.2e-05	0.00068	19.5	0.1	2	23	1340	1361	1339	1361	0.95
23	26	4.1e-05	0.0023	17.8	2.9	1	23	1367	1389	1367	1389	0.99
24	26	2e-06	0.00011	22.0	2.0	1	23	1395	1417	1395	1417	0.97
25	26	1.7e-07	1e-05	25.3	2.4	1	23	1423	1445	1423	1445	0.99
26	26	0.00015	0.0088	16.0	0.5	1	23	1451	1473	1451	1473	0.97

Sequence Information

Coding Sequence: ATGTCAATCAATTCACCAAGTACACAAAATAGTCGAAGGTTTCGGTGTGGCCACACTGatttattaaataaagttaaaagcATGTTGCCGATGGATATTTGCCGCACTTGCACGCAACATGATGATAGCTTACTGCCGCTTGCGACGTGCACagataaatatgcaaataaaagctTAAATGATATGTTGCACGAATTGACACAAAATGATCCCCTGCAGGAACATACGGACGACAGTCTGCCTCAGCACTTGTGTATCGGTTGCCTGCACAAGCTGGAAGCGGCCTATGCGTTTGTGTTGCAGGCTCGACAGGCTCAGGAGCAATTGTTGTTACGGCTGCATAAAGGCTTGCAAACACAGTGCCTAGATGAGATGCCTATAGACATTAACTTGCAGCAAATCAAAATCGAAACGATTGTTGATATGCAACTACCTAGCAAAACCAAGAGTGATGACGAGAGGGAACAAGACATGGCTGCAGTATCTATTCCAGTCCTGAAATGGCAACCAGAAAGCGATAATGAGAGTGATCAGACTGCAGTTGACCAGGACGAAGACTTGAAGCCCACGCAAGTAAGGCGCAGCGCACGTAAATTCAGAACCAACATTGACAACGAAAATGAAGCAGCATCTGGCCAAGCGAATCCGTTGCCTAACAAGCGGCGTCGCGGTCGCCCAGCACATCTAATCAAAAAGGAAACTGTCAACGAAGAAGGACGGCATGTATGCGATGTTTGTGGAAAGACATTTTCGTGGTACCGCGATATGCAGCGCCACTCGCGCATACACTTCGAACAGGCGACTTACGTGTGTGACAGTTGTGGCAAGAGCTTCTTGCGGAAAGACAAATACATGTTCCATCTTCGTTCGCACGAAAAACGTGCGGCCAAATCCCAGGCCATGCTACTGAGCAGCGAATGGCGCTTCGCTGAACGTCTCTACAGCTCTAGCCGACTCAAACGTGCGGAGTGTAAGCTGTGCGGCTTAAAATATCGGCGTATAGGGGAATTGCGCCAGCATCTGTCTTCCCATAACAACATTGAGACTTTGTCCAATCTGAGTTTGGAGAGTGACGTTATTAAGGAACAGTTTGATAGAGACCAGCGGCAGCTAGATTTGGCGCTGATAAAGCAACAATTGTGTGCAGACATTGCAAAGGGACGTGCTGAGCTAGACAAATACTGCGCTGTGGTCAATGCGTATGGCTATGAGCTCAGTCTTAGCGATTCAGACGAAGAGGTAGCTCAATATCAGTGCCAGCCGTGCAATACCAACTTCTCGCGCAAATATCGCCTTATGCGACACACTCTGGAggaacacacacaggcggagaCTGCTTTTTCTTTGCAGCGCTGTGATGTTTGCCAAATTGGTTTTGTGTGTGCCAATATGTTGGAGCAACATCAACGCACACAGTGCTTCAACAAGCTGAAGCGTTACAACTGTCCCAACTGCCCAGGTAAATTTATTTGGCTGCAGAATTTGGAGCAGCATGCGTGCTCGCATCACATCAAGCAGCTCGACGGGGAACATCAAATAAAGCAGTGTTGTCTTTGTGATGCCCAATTGAACAGCATGATCGAATTACGCACTCATTTGCTCACCCATCAAGATGGACGCTGTGGCATATATCCAGAGCAGCAGGCGACCTTCTTTCGCACCTACTATCCCAACGGCCTTGACTGCAGTTTGTCAGACCTAAGCACAGTCATTGCTGCCGATTTTAAGGCGGAGAATTATGGACGATACTTCAATGCCAGAACGAAAAACGGCGAGGAGCTCGATTTCTTTGCTTCTGACTCTGATTTGAGTGATGCGGACCAGCAAAGTTCAGAAACTACCCTACATATATGTTCTGTGTGTGGCGAAACGAAAAGGCGCCTGTCTCGGCTGCTTGAGCATCAGAAAAGCAAGCATAGTCAGGAGCAGAAAAGTCTGCCATACGTCTGTGGCGATTGCGATTTGAGTTTTGTAGCCAATTCACTGCTCCAACAGCACCGCCGACGTGTTTGTGACAAGCAGCATGCCAAGTACCATTGCCAGCAATGTAGTCAGCGCTTTTACTGGTTTTCCAATTACAAGCTGCATATGCATCTGCAACACGAGACACAAGCTGAGGCGCAGACAGACGCTATCGATGAATACGAGCAGGAGTCCACGATGAGAAGCAAGCGCCAGTCAGCAGATGCCAAGTTGCAGTGCGGCGAGTGCGAAAAGGTGTTCATCTGGCACAAGGATCTGACGCGTCACAAGCGCCTGCACCAACCACAAGCCTTGGCGCAATACcattgtgtgcactgtgaccGCAAGTTCCATCGCAAGGATGGCCTTAAATCGCATATGCGTGTACATGGCGAACATGAGGTGGATGAAGCGGTCGCCAGGGAACCAATTCCACCCGCGCTACTGCCAGTGTTGCTAGCCCAACTGTGTCGGCCTAATGGctgcaaacaaattcaatgcATGATATGTCTCTCGCAGCATACCAAGATATCTGATCTACGTACTCATTTGCTTCAACATCAGTATACGGTCAAATTTGCAGAGGAGCGGGGCCAGCCAGAAAGCATTGCGAGCATTTCACGCTCCCTATATCCAGAACTAAGCACACcattggagcagcagcaactaatcGAGCGCATTCAAAGTGATGTGGCAAAAGGTGTGGAGCTGGAGAGATTCATATCCATTACCAACGAGGCAGGTATTGAGCTTAGCCTGGACAGCAGCGAAACAGAAACTGATTCCGACTCTACCGAGACAGTCGGAAGTAACAGTGGACTCTACAGCTGTGAGCTGTGCCAGCTGAAGGTCTCGCGCAAGCATCAGCTCTACGCCCATCAGCTGGAGCAGCATTCGTGGCAGCAGGCAACACGTGtttgcaactgttgccagGCGAGATTTGTGAATGAGCAACTATTAGAGCATCATTATCGGACACTCTGTCGCAACGTTCAGCGACGCTTCTTTTGTCGCAAATGTCCGTTGCGTTTCCGCTGGCGCGAGAATCTGAAACTGCACTCAGACGTGGCACACAACGAAACCAGAGGCGAGCAATCGAACTTGGGCATTCATTTAAACGGATCGCGCCTGTTGCCTATTGCTAGCTACGACTGCACCGAATGCCATCGTagttttaaaatgcaaaaggaTCTCACCAGGCACACTCTGATGCACGCTCAGGAGTCGAGCATTTATCGTTGTCGATGGTGTGCACGACGTTTCTATCGCCATGCCAATCTTCTGCAGCATATTGAGCGTCATGGAATTATCGCGGAACAGCTGCCCTATGCTGAGGCACTGCTGAATGCTAGCCGAAATCCGCATGGCCAAAAGTGCATCCAGTGCATGGTGTGCAACGTGACCTACCCCACCATTGCTGCACTGCGCAGCCATCTTCTATCAGCACCAACAGGCACACATCATGAGTTTAGCTCGTTGCTCAATTACTCCATTACCAACCAGTTGGGATACGAGCTGCTGCTTGACGACTCGGAAACGGATGAGGAAGCAAAGCCACCAGGTACGCCCGCGCACTACACATGCGGTATGTGCCAACTGCGCTGTGTGCGCAAGTTTGagctgcatcagcatcagcaagcGATGCATCGGCTGGAGCGTATAAATGAGGGTTGTGATGTCTGCATCTTTAAGAGTGTCTCCCCAGATATCGTAGCCTATCATCGCCGCGTCTTATGCGACAACACGGAAAAGCGCTTCAAATGCTCAAAGTGTGGCTACAAGTTTATGTGGGAGGCGAATTTACTGCAGCACATGCAGTTGCAGCATCCAAGCAGCGAAACGCAGCAGGATGCAAGTTCTATTTCTGCACAAGAATTACCCAGCGCAGATTCCCAAATTTTTCAGTGCGGTCAGTGTCCTAGTAAATATAATCGCAAGGATCGCCTTACAGCACATGTAAAGAAATGTCATATGGCGGGAACTACAGGCGCCACGGCTGCAACAGATGCAAAGGCTATGAAAAATTCAACTGGCgccaagcagcaaaaaagttttctttgtgCCTTCTGCGGCAAGGCGGTCAGCTCCTCTTCCAATCTGATTATACACATACGTCGACATACTGGCGAGAAGCCTTTCAAGTGTGACTACTGCGATATGGCTTTCCCACGTTCCTCCGATCTACAGTGTCATCGACGCACCCACACGGGAGAGCGGCCGCACGTCTGCACCGTTTGCCAGAAGGGCTTTGCTCGATCCTACAAGCTGCAACAACATATGCGCATCCACAATGGCGAACGACCATACAAGTGTACCTATTGTGAAAAGAGTTTTACTCAGTCGAATGACCTGACGCTTCACATACGACGGCACACAGGCGAGCGTCCCTATCAGTGCAATACGTGCGGCGAACGCTTCATTCAGGGCACAGCCCTGAAAAATCATCGCCTGCAACATGGACACCACGATATGGAACTAGAGCAAATCAAAGATAACTAA
Protein Sequence: MSINSPSTQNSRRFRCGHTDLLNKVKSMLPMDICRTCTQHDDSLLPLATCTDKYANKSLNDMLHELTQNDPLQEHTDDSLPQHLCIGCLHKLEAAYAFVLQARQAQEQLLLRLHKGLQTQCLDEMPIDINLQQIKIETIVDMQLPSKTKSDDEREQDMAAVSIPVLKWQPESDNESDQTAVDQDEDLKPTQVRRSARKFRTNIDNENEAASGQANPLPNKRRRGRPAHLIKKETVNEEGRHVCDVCGKTFSWYRDMQRHSRIHFEQATYVCDSCGKSFLRKDKYMFHLRSHEKRAAKSQAMLLSSEWRFAERLYSSSRLKRAECKLCGLKYRRIGELRQHLSSHNNIETLSNLSLESDVIKEQFDRDQRQLDLALIKQQLCADIAKGRAELDKYCAVVNAYGYELSLSDSDEEVAQYQCQPCNTNFSRKYRLMRHTLEEHTQAETAFSLQRCDVCQIGFVCANMLEQHQRTQCFNKLKRYNCPNCPGKFIWLQNLEQHACSHHIKQLDGEHQIKQCCLCDAQLNSMIELRTHLLTHQDGRCGIYPEQQATFFRTYYPNGLDCSLSDLSTVIAADFKAENYGRYFNARTKNGEELDFFASDSDLSDADQQSSETTLHICSVCGETKRRLSRLLEHQKSKHSQEQKSLPYVCGDCDLSFVANSLLQQHRRRVCDKQHAKYHCQQCSQRFYWFSNYKLHMHLQHETQAEAQTDAIDEYEQESTMRSKRQSADAKLQCGECEKVFIWHKDLTRHKRLHQPQALAQYHCVHCDRKFHRKDGLKSHMRVHGEHEVDEAVAREPIPPALLPVLLAQLCRPNGCKQIQCMICLSQHTKISDLRTHLLQHQYTVKFAEERGQPESIASISRSLYPELSTPLEQQQLIERIQSDVAKGVELERFISITNEAGIELSLDSSETETDSDSTETVGSNSGLYSCELCQLKVSRKHQLYAHQLEQHSWQQATRVCNCCQARFVNEQLLEHHYRTLCRNVQRRFFCRKCPLRFRWRENLKLHSDVAHNETRGEQSNLGIHLNGSRLLPIASYDCTECHRSFKMQKDLTRHTLMHAQESSIYRCRWCARRFYRHANLLQHIERHGIIAEQLPYAEALLNASRNPHGQKCIQCMVCNVTYPTIAALRSHLLSAPTGTHHEFSSLLNYSITNQLGYELLLDDSETDEEAKPPGTPAHYTCGMCQLRCVRKFELHQHQQAMHRLERINEGCDVCIFKSVSPDIVAYHRRVLCDNTEKRFKCSKCGYKFMWEANLLQHMQLQHPSSETQQDASSISAQELPSADSQIFQCGQCPSKYNRKDRLTAHVKKCHMAGTTGATAATDAKAMKNSTGAKQQKSFLCAFCGKAVSSSSNLIIHIRRHTGEKPFKCDYCDMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCNTCGERFIQGTALKNHRLQHGHHDMELEQIKDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00509945;
90% Identity: iTF_00502659;
80% Identity: -