Basic Information

Insect: Drosophila eohydei
Gene Symbol: ZNF423
Assembly: GCA_035045825.1
Location: JAWNOT010000069.1:4558116-4562725[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 26 0.0044 0.3 11.6 3.7 1 23 214 236 214 236 0.96

2 26 0.032 2.2 8.9 1.9 1 23 242 264 242 264 0.97

3 26 0.001 0.069 13.6 0.5 2 23 296 317 296 317 0.97

4 26 0.0058 0.4 11.3 1.6 1 23 390 413 390 413 0.94

5 26 0.64 44 4.8 0.4 2 22 424 444 423 444 0.95

6 26 0.47 32 5.2 1.3 1 23 453 475 453 476 0.95

7 26 1.3 92 3.8 2.7 2 23 488 509 487 509 0.97

8 26 0.12 8.4 7.1 1.6 1 23 589 612 589 612 0.96

9 26 0.00026 0.018 15.5 0.1 1 22 621 642 621 642 0.96

10 26 0.43 29 5.4 4.8 1 23 651 674 651 674 0.96

11 26 0.0047 0.32 11.5 1.3 2 23 706 727 705 727 0.96

12 26 0.00018 0.012 16.0 7.5 1 23 735 757 735 757 0.98

13 26 0.0058 0.4 11.2 1.7 1 23 902 925 902 925 0.95

14 26 0.0035 0.24 11.9 0.4 2 22 933 953 933 953 0.96

15 26 0.23 16 6.2 0.7 1 23 962 985 962 985 0.90

16 26 3.9e-05 0.0026 18.1 3.9 1 23 1010 1032 1010 1032 0.97

17 26 0.0011 0.075 13.5 2.4 1 23 1039 1061 1039 1061 0.98

18 26 0.034 2.3 8.9 0.0 2 21 1088 1107 1087 1108 0.93

19 26 0.039 2.7 8.6 4.0 1 23 1153 1176 1153 1176 0.96

20 26 0.0028 0.19 12.2 0.7 1 23 1213 1236 1213 1236 0.96

21 26 0.014 0.97 10.0 3.1 1 23 1264 1287 1264 1287 0.97

22 26 1.4e-05 0.00093 19.5 0.1 2 23 1316 1337 1315 1337 0.95

23 26 4.6e-05 0.0032 17.9 2.9 1 23 1343 1365 1343 1365 0.99

24 26 2.3e-06 0.00015 22.0 2.0 1 23 1371 1393 1371 1393 0.97

25 26 2e-07 1.4e-05 25.3 2.4 1 23 1399 1421 1399 1421 0.99

26 26 0.00018 0.012 16.0 0.5 1 23 1427 1449 1427 1449 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	26	0.0044	0.3	11.6	3.7	1	23	214	236	214	236	0.96
2	26	0.032	2.2	8.9	1.9	1	23	242	264	242	264	0.97
3	26	0.001	0.069	13.6	0.5	2	23	296	317	296	317	0.97
4	26	0.0058	0.4	11.3	1.6	1	23	390	413	390	413	0.94
5	26	0.64	44	4.8	0.4	2	22	424	444	423	444	0.95
6	26	0.47	32	5.2	1.3	1	23	453	475	453	476	0.95
7	26	1.3	92	3.8	2.7	2	23	488	509	487	509	0.97
8	26	0.12	8.4	7.1	1.6	1	23	589	612	589	612	0.96
9	26	0.00026	0.018	15.5	0.1	1	22	621	642	621	642	0.96
10	26	0.43	29	5.4	4.8	1	23	651	674	651	674	0.96
11	26	0.0047	0.32	11.5	1.3	2	23	706	727	705	727	0.96
12	26	0.00018	0.012	16.0	7.5	1	23	735	757	735	757	0.98
13	26	0.0058	0.4	11.2	1.7	1	23	902	925	902	925	0.95
14	26	0.0035	0.24	11.9	0.4	2	22	933	953	933	953	0.96
15	26	0.23	16	6.2	0.7	1	23	962	985	962	985	0.90
16	26	3.9e-05	0.0026	18.1	3.9	1	23	1010	1032	1010	1032	0.97
17	26	0.0011	0.075	13.5	2.4	1	23	1039	1061	1039	1061	0.98
18	26	0.034	2.3	8.9	0.0	2	21	1088	1107	1087	1108	0.93
19	26	0.039	2.7	8.6	4.0	1	23	1153	1176	1153	1176	0.96
20	26	0.0028	0.19	12.2	0.7	1	23	1213	1236	1213	1236	0.96
21	26	0.014	0.97	10.0	3.1	1	23	1264	1287	1264	1287	0.97
22	26	1.4e-05	0.00093	19.5	0.1	2	23	1316	1337	1315	1337	0.95
23	26	4.6e-05	0.0032	17.9	2.9	1	23	1343	1365	1343	1365	0.99
24	26	2.3e-06	0.00015	22.0	2.0	1	23	1371	1393	1371	1393	0.97
25	26	2e-07	1.4e-05	25.3	2.4	1	23	1399	1421	1399	1421	0.99
26	26	0.00018	0.012	16.0	0.5	1	23	1427	1449	1427	1449	0.97

Sequence Information

Coding Sequence: ATGTTGCCGATGGATATTTGCCGCACTTGCACGCAACATGATGATAGCTTACTGCCGCTTGCGACGTGCACtgataaatatgcaaataaaagcttaaatgATATGCTGCACGAATTGACACAAAATGATCCCCTGCAGGAACATACGGACGACAGTCTGCCTCAGCACTTGTGTATCGGTTGCCTGCACAAGCTGGAAGCGGCCTATGCGTTTGTATTGCAGGCTCGACAGGCTCAGGAGCAATTGTTGTTACAGCTGCACAAAGGCTTGCAGACACAGTGCCTAGATGAGATGCCTATAGACATTAACTTGCAGCAAATCAAAACCGAAACGATCGTTGATATGCAACTACCCAGCAAAACCAAGAGTGATGACGAGAGGGAACAAGACATGGCTGCAGTATCTATTCCAGTCCTGAAATGGCAACCAGAAAGCGATAGTGAGAGTGATCAGACTGCTGTTGACCAGGATAAGGAATTGAAGACCATGCAAGTGAGGCGCAGCGCACGTAAATTCAGAACTAACATTGACAACGAAAATGAAGCAGAATCTAGCCAATCGAATCCGCTGCCTAACAAGCGGCGTCGTGGTCGCCCAGCACATCTAATCAAAAAGGAAACTGTTAACGAAGAAGGACGGCATATATGCCATGTTTGTGGAAAGACATTTTCGTGGTACCGCGATATGCAACGCCACTCGCGCATACACTTCGAACAGGCGACTTACGTGTGTGACAGTTGTGGCAAGAGCTTCTTGCGGAAAGACAAATACATGTTCCATCTTCGTTCGCACGAAAAACGTGCGGCCAAATCCCAAGCCATGCTACTGAGCAACGAATGGCGCTTCGCTGAACGTCTCTACAGCTCTAGCCGACTCAAACGTGCGGAGTGTAAGCTGTGCggcttaaaatataaacgtATAGGCGAATTGCGCCAGCATCTGTCTTCCCATAAAAGCATTGAGACTTTGTCCAATCTGAGTTTGGAGAGTGATATTATAAAGGAACAGTTTGATAGAGACCAGCGACAGCTAGATTTGGCGCTGATAAAGCAACAATTGTGTGCAGACATTGCAAAGGGACGTGGTGAGCTAGACAAATACTGCGCTGTGGTCAATGCGTATGGCTATGAGCTCAGTCTTAGCGATTCAGACGAAGAGGTAGCTCAATATCAGTGCCAGCCGTGCAATACCAACTTCTCGCGCAAATATCGCCTTATGAGACACACTCTGGAGGAACACACACAGGCGGAAACAGATTTTTCCTTGCAGCGCTGTGATGTTTGCCAAATTGGTTTTGTGTGTGCCAATATGTTGGAGCAACATCAACGCACACAGTGCTTCAACAAGCTGAAGCGTTACAACTGTCCCAATTGCCCAGGTAAATTTATTTGGCTGCAGAATTTGGAGCAGCATGCGTGCTCGCATCACATCAAGCAGCTCGACGGGGAACATCAAATAAAGCAGTGTTGTCTTTGTGATGCCCAATTGAACAGCATGACCAAATTACGCACTCATTTGCTCACCCATCAAGATGGACGCTGTGGCATATATCCAGAGCAGCAGGCGACCTTCTTTCGCACCTACTATCCCAACGGCCTTGACTGCAGTTTGTCAGACCTAAGCACAGTCATTGCCGCTGATTTTAAGGCGGAGAATTATGGGCGATACTTCAATGCCAGAACGAAAAGCGGCGAGGAGCTCGATTTCTTTGCTTCTGACTCTGATTTGAGTGATGCGGACCAGCAGAGTTCAGAAACTACCCTACATATATGTTCTGTGTGTGGCGAAACGAATAGGCGTCTGTCTCGGCTGCTTGAGCATCAGAAAAGCAAACATAGTCAGGAGCAGAAAAGTCTGCCATACGTCTGTGGCGATTGCGATTTGAGTTTTGTAGCCAATTCACTGCTCCAACAGCATCGCCGACGTGTTTGTGCCAAGCAGCATGCCAAGTACCATTGCCAGCAATGTAATCAGCGCTTTTACTGGTTTTCCAATTACAAGCTGCatatgcagctgcaacacGAGACACAAGCTGAGGCGCAGACAGACGTTATCGATGAATACGAGCAGGAGTCCACGATGAGAAGCAAGCGCCAGTCAGCAGATGCCAAGTTGCAGTGCGGCGAGTGCGAAAAGGTGTTCATCTGGCACAAGGATCTGACGCGTCACAAGCGTCTGCACCAACCACAAGCCTTGGCGCAATACCATTGTGTGCACTGTGACCGCAAGTTCCATCGCAAGGATGGCCTTAAATCGCATATGCGTGTACATGGCGAACATGAGGTGGATGCAGCGGTCGCTAGTGAACCAATTCCACCCGCGTTACTGCCAGTGCTGCTAACACAACTGTGTCGGCCTAATGGctgcaaacaaattcaatgcATGATATGTCTCTCGCAGCATACCAAGATATCTGATCTACGTACGCATTTGCTTCAACACCAGTATACGGTCAAATTTGCAGAGGAGCGGGGCCAGCCAGAAAGCATTGCGAGCATTTCACGCTCCCTATATCCAGAACTAAGCACACcattggagcagcagcaactaatCGAGCGCATTCGAAGTGATGTGGCAAAAGGTGTGGAGCTGGAGAGATTCATATCTATTACCAACGAGGCAGGCATTGAGCTTAGCCTGGACAGCAGCGAAACAGAAACTGATTCCGACTCTGCCGAGACAGTCGGAAGTAACAGTGGACTCTACAGCTGTGAGCTGTGCCAGCTGAAGGTCTCGCGCAAGCATCAGCTCTACGCCCATCAGCTGGAGCAGCATTCGTGGCAGCAGGCAACACGTGTTTGCAACTATTGCCAGGCGAGATTTGTGAATGAGCAGCTATTAGAGCATCATTATCGGACACTCTGTCGCAACGTTCAGCGACGTTTCTTTTGTCGTAAATGTCCGTTGCGTTTCCGCTGGCGCGAGAATCTGAAGCTGCACTCAGACGTGGCACACAACGAAACCAGAGGCGAGCAATCGAACTTGGGCATTCATTTAAACGGATCGCGCCTGTTGCCTATTGCTAGCTACGACTGCACCGAATGCCATCGTagttttaaaatgcaaaaggaTCTCACCAGGCACACTCTGATGCACGCTCAGGAGTCGAGCATTTATCGTTGTCGATGGTGTGCACGACGTTTCTATCGCCATGCCAATCTTCTGCAGCATATTGAGCGTCACGGAATTAGCGCGGAACAGCTGCCCTATGCTGAGGCGCTGCTGAATGCTAGCCGACATCCGCATGGTCAAAAGTGCATCCAGTGCAAGGTGTGCAACGTGTCCTACCCCACCATTGCTGCACTGCGCAGCCATCTTCTATCAGCACCAACAGGCACACATCATGAGTTTAGCTCGTCGCTCAACTACTCCATTACCAACCAGTTGGGatatgagctgctgctggacgACTCGGAAACTGATGAGGAAGCAAAGCCACCAGGTACGCCGGCGCACTACACATGCGGTATGTGCCAACTGCGCTGTGTGCGCAAGTTTGagctgcatcagcatcagcaagcGATGCATCGGCTGGAGCGTATAAATGAGGGTTGTGATGTCTGCATCTTTAAGAGTGTCTCCCCAGATATCGTAGCCTACCATCGCCGCGTCTTATGCGACAACACGGAAAAGCGCTTCAAATGCTCAAAATGTGGCTACAAGTTTATGTGGGAGGCGAATTTACTGCAGCACATGCAGTTGCAGCATCCAAGCAGTGGAAGCAGCGAATCGCAGCAGGATGCAAGTTCTATTTCTGCACAGGAACTACCCAGCGCAGAGTCCCAAATTTTTCAGTGCGGTCAGTGCCCTAGTAAATATAATCGCAAGGATCGCCTTACAGCACATGTAAAGAAATGTCATATGGCGGTAACTACAGGCGCCACGGCTGCAACAGATGCAAAGGTTATGAAAAATTCAACTGGCgccaagcagcaaaaaagttttctttgtgCCTTCTGCGGCAAGGCGGTCAGCTCCTCTTCCAATCTAATTATACACATACGTCGACATACTGGCGAGAAGCCTTTCAAGTGTGACTACTGCGATATGGCTTTCCCACGTTCCTCCGATCTACAGTGTCATCGACGCACCCACACGGGAGAGCGGCCGCACGTCTGCACCGTTTGCCAGAAGGGCTTTGCTCGATCCTACAAGCTGCAACAACATATGCGCATCCACAATGGCGAACGACCATATAAGTGTACCTATTGTGAAAAGAGTTTTACTCAGTCGAATGACCTGACGCTTCACATACGACGGCACACAGGCGAGCGTCCGTATCAGTGTAATACGTGCGGCGAACGCTTCATTCAGGGTACAGCCCTGAAAAATCATCGCCTGCAACATGGACATCACGATACGGAACTAGAGCAAATCAAAGATAACTAA
Protein Sequence: MLPMDICRTCTQHDDSLLPLATCTDKYANKSLNDMLHELTQNDPLQEHTDDSLPQHLCIGCLHKLEAAYAFVLQARQAQEQLLLQLHKGLQTQCLDEMPIDINLQQIKTETIVDMQLPSKTKSDDEREQDMAAVSIPVLKWQPESDSESDQTAVDQDKELKTMQVRRSARKFRTNIDNENEAESSQSNPLPNKRRRGRPAHLIKKETVNEEGRHICHVCGKTFSWYRDMQRHSRIHFEQATYVCDSCGKSFLRKDKYMFHLRSHEKRAAKSQAMLLSNEWRFAERLYSSSRLKRAECKLCGLKYKRIGELRQHLSSHKSIETLSNLSLESDIIKEQFDRDQRQLDLALIKQQLCADIAKGRGELDKYCAVVNAYGYELSLSDSDEEVAQYQCQPCNTNFSRKYRLMRHTLEEHTQAETDFSLQRCDVCQIGFVCANMLEQHQRTQCFNKLKRYNCPNCPGKFIWLQNLEQHACSHHIKQLDGEHQIKQCCLCDAQLNSMTKLRTHLLTHQDGRCGIYPEQQATFFRTYYPNGLDCSLSDLSTVIAADFKAENYGRYFNARTKSGEELDFFASDSDLSDADQQSSETTLHICSVCGETNRRLSRLLEHQKSKHSQEQKSLPYVCGDCDLSFVANSLLQQHRRRVCAKQHAKYHCQQCNQRFYWFSNYKLHMQLQHETQAEAQTDVIDEYEQESTMRSKRQSADAKLQCGECEKVFIWHKDLTRHKRLHQPQALAQYHCVHCDRKFHRKDGLKSHMRVHGEHEVDAAVASEPIPPALLPVLLTQLCRPNGCKQIQCMICLSQHTKISDLRTHLLQHQYTVKFAEERGQPESIASISRSLYPELSTPLEQQQLIERIRSDVAKGVELERFISITNEAGIELSLDSSETETDSDSAETVGSNSGLYSCELCQLKVSRKHQLYAHQLEQHSWQQATRVCNYCQARFVNEQLLEHHYRTLCRNVQRRFFCRKCPLRFRWRENLKLHSDVAHNETRGEQSNLGIHLNGSRLLPIASYDCTECHRSFKMQKDLTRHTLMHAQESSIYRCRWCARRFYRHANLLQHIERHGISAEQLPYAEALLNASRHPHGQKCIQCKVCNVSYPTIAALRSHLLSAPTGTHHEFSSSLNYSITNQLGYELLLDDSETDEEAKPPGTPAHYTCGMCQLRCVRKFELHQHQQAMHRLERINEGCDVCIFKSVSPDIVAYHRRVLCDNTEKRFKCSKCGYKFMWEANLLQHMQLQHPSSGSSESQQDASSISAQELPSAESQIFQCGQCPSKYNRKDRLTAHVKKCHMAVTTGATAATDAKVMKNSTGAKQQKSFLCAFCGKAVSSSSNLIIHIRRHTGEKPFKCDYCDMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCNTCGERFIQGTALKNHRLQHGHHDTELEQIKDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00509945;
90% Identity: iTF_00520051;
80% Identity: -