Dhis005665.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila histrio
Gene Symbol
su(Hw)
Assembly
GCA_958299025.2
Location
OY282581.2:18876569-18879724[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00068 0.054 14.2 2.2 1 20 226 245 226 247 0.94
2 12 2.8e-06 0.00022 21.7 0.4 3 23 298 319 296 319 0.93
3 12 0.02 1.6 9.6 0.1 1 23 325 347 325 347 0.95
4 12 7.7e-07 6.1e-05 23.5 2.5 1 21 354 374 354 375 0.95
5 12 3.3e-06 0.00026 21.5 0.6 2 23 387 408 386 408 0.96
6 12 0.00011 0.0084 16.8 5.3 1 23 419 441 419 441 0.99
7 12 8.3e-05 0.0065 17.1 0.9 1 23 447 469 447 469 0.97
8 12 1.7e-05 0.0013 19.3 0.8 1 23 475 497 475 497 0.99
9 12 2.1e-06 0.00016 22.2 3.1 1 23 503 525 503 525 0.98
10 12 8.7e-05 0.0069 17.1 2.2 1 23 529 551 529 551 0.97
11 12 0.00018 0.014 16.1 0.1 1 21 559 579 559 583 0.91
12 12 9.2e-05 0.0072 17.0 0.3 3 23 603 624 601 624 0.96

Sequence Information

Coding Sequence
ATGAGCGCCAACAAGGAAGTCAAAGTGACCGACGTCCCAAAAGCGACTACCGTTCCCAGTACCAATGATGAGGGAACAGTGATCAAAATACTGGACGTCGAGCAAATCGTGTCTCCCAAGGAAAAGCGACCTGGCACTCGCATGAAATTGCTCAACGATGTGGTGGCAAAGGGCGGGGGGAAGACTGCATCCGTCTCGCCTCGTGTTAAGCAGGAGAAGCGTACGagcattaaaatacttaacaatGATGAAACCACGAGCGGAGCTCTTAAAAACGACAAACGATCGGCAACCAAAACCGTAAGTCCCACCGGAAGCGTCAAGATATTGAACGAGAAGCGTACTGCGTCTGTTACCACTCCGGTTGAAACCGCCAAGATAAAAACATCGCctagcaagaagaagaaaatggATCACTATGTGCTGCAGGCCATAAAAAGCGAAAGCAGTAAAGCGGACAACAACACAACCAGCATAGAGATCGAGGATGAAGATACCATTGACTTTATACTGGCCGAGAATGATGACATCGAGCTGGGAGCGGCCAAAGCTAATGAAGATGAGTTTGTGGTTTCGGGGGTTGAGgaagatgacgatgatgaggaCGAAGCATTGGGTGACGGCAGTCCGAACCGCACAAGCGGCACAAATAGCGACCTCAAGGAAATGGTCGAGCACGTGTGCGGCAAGTGCTACAAGACATTCCGACGCGTCAAGAGCCTGAAGAAACACTTGGAATTCTGTCGCTACGACAGTGGTTATCATCTGCGCAAGGCGGACATGCTGAAGAATCTGGAGAAGATCGAGAAGGATGCTGTGGTCATGGAGAAGAAAGACATTTGCTTCTGCTGCAGCGAAAGCTACGACACTTTTCATCTCGGTCACATTAATTGTCCGGATTGCCCAAAGTCGTTTAAGACACAGACAAGCTATGAGCGTCACATCTTCATCACTCACTCGGAGCTCAATGATTACCCCTGCTCCATTTGCAATGCGAAACTGCGCAGCGCTGCCCTGTTGAAGTTGCACGAGGAACAGCATCAGTCGCGTGGCAAGCCCTTCGCCTGCAAGATCTGTGGCAAGGACTTTACTCGCTCCTACCATCTGAAGCGACACCAGAAGTACTCGTCGTGCTCGGCCAACGAGAATGACACCATGAGCTGCAAGGTGTGCGATCGTGTCTTCTATCGCCTGGACAATCTACGAGCTCATCTCAAGCAGCATTTGGGCACTCAGGTGGTAAAGAAGCCGGAGTACATGTGTCATGTGTGCAAGAACTGCTTCTACAGCCTGTCAACACTAAACATTCACATACGTACTCACACTGGCGAGAAGCCCTTCGACTGTGATCTGTGTGACAAGAAGTTCTCCGCCTTGGTGGCTCTGAAAAAGCATCGTCGTTATCATACGGGAGAGAAACCCTACACTTGCACAGTGTGCAGTCAATCGTTTGCTGTGAAGGAGGTGCTTAATCGCCACATGAAGCGTCACACTGGTGAGCGCCCACACAAGTGCACCGAGTGCGGTAAGAGCTTCATTCAGGCAACCCAGCTACGCACGCATTCCAAGACGCATCTGCGTCCCTTTTCCTGCTCCATGTGCACCCAAAAGTTTAAGACAGAGAAGCAACTTGAGCGCCACGTTAAGGAGCATACACGTCAGAAACGTCCCTGCTTCGCATGCTTGGATTGCTCTCGCAGTTTCCGCACCAGCGCACTGCTCAAGGAACACATTGAGGCCGGCGATCATTCGCCTGTTAAACCAACTCGGGCCAAGCGCACTACTAAGATGATCGAGCGCACAGATTGCGCCATCTGTGACAAGAACTTTGACAGTACAGAAACCCTGAGAAACCATATACGTAACGTGCATGAATGCGATCCGGATGATATCTTTGGCACAGAGCCACCAGCCAAGCGCAAAGCTAAAAAGACCGTTGTGTTGGAGGAAGTTGTGGAAgtggaagaggaagaggagaacgaggaggaggatgaggaaGTGGCGCCAGCAAACACTTCAGCCGGTTCGCTGATCTCTAGCAAAACAGATGGCAATGGTGTTGTGGTGCGTGAGTTCTTGGTAGATGAGGGAGACGGCAGTGCACAGACAATTATGCTGGAGAATGAGGTCTACACCATTCTGCCTTTGGAGGGAGCCAACGCTAGCGAGACACCAGCTGCAAGTGATGTCAAACCCGAGTCCAAGGAGAAACAATCCCCGGCTGCCTCGCAAGTGGTTAAAAAGGAGCAGCGCAAATCTCTAGCTGCCAGTTTGGCAGCTGCCATTGCCGATAATCTGGAGGAGCCGTCAAGCGATGATGAGTTCACTGGCGAAGTGCTCACCGAGGAGGATTTGAAGCTCAAGGAGAACATTGCCAAGTTAATCGACATGCTCGTCGATCCGCAGACACTTAAGAAATACGGCTGGCCCAACAGCTCCGAGGAGACGGTACTGTGCAAGGTCATCGAGAACTGTGGCCACGATTTGACCAAGGGAGGCGAGAACTATGCCGAGTTGGATTACGGCAGTCGCATGCGTGAATATTGCAAGCTGCTGTTCACAGTTGTTATCCACAATGATTCGATCAAGTCGCTGCTAAATAACTTTCCAATTGACGATGTTATCGAGTATGTGCTGGGTGATGAAGATCAGGATCAGGAGctcgaaatggaaatgggcAAAGGCAAAGAAACGGAGAAGGAGCCGGAAAAGTCCGATACGGAGACCGGACTGGATGCCGATGAAGCTGAGGCTTAA
Protein Sequence
MSANKEVKVTDVPKATTVPSTNDEGTVIKILDVEQIVSPKEKRPGTRMKLLNDVVAKGGGKTASVSPRVKQEKRTSIKILNNDETTSGALKNDKRSATKTVSPTGSVKILNEKRTASVTTPVETAKIKTSPSKKKKMDHYVLQAIKSESSKADNNTTSIEIEDEDTIDFILAENDDIELGAAKANEDEFVVSGVEEDDDDEDEALGDGSPNRTSGTNSDLKEMVEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSELNDYPCSICNAKLRSAALLKLHEEQHQSRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRAHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCTVCSQSFAVKEVLNRHMKRHTGERPHKCTECGKSFIQATQLRTHSKTHLRPFSCSMCTQKFKTEKQLERHVKEHTRQKRPCFACLDCSRSFRTSALLKEHIEAGDHSPVKPTRAKRTTKMIERTDCAICDKNFDSTETLRNHIRNVHECDPDDIFGTEPPAKRKAKKTVVLEEVVEVEEEEENEEEDEEVAPANTSAGSLISSKTDGNGVVVREFLVDEGDGSAQTIMLENEVYTILPLEGANASETPAASDVKPESKEKQSPAASQVVKKEQRKSLAASLAAAIADNLEEPSSDDEFTGEVLTEEDLKLKENIAKLIDMLVDPQTLKKYGWPNSSEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDQELEMEMGKGKETEKEPEKSDTETGLDADEAEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00569117;
90% Identity
iTF_00510679;
80% Identity
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