Basic Information

Insect: Drosophila histrio
Gene Symbol: ey
Assembly: GCA_958299025.2
Location: CATQJB020000004.1:27769-47815[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.6e-72 3.2e-69 230.9 0.9 2 125 95 218 94 218 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.6e-72	3.2e-69	230.9	0.9	2	125	95	218	94	218	0.99

Sequence Information

Coding Sequence: ATGTTTACGCTTCAACCCACTCCGGCGACCTTGGGGGCAGTTCCTTGGTCGGCGGGCGCACTAATTGAACGATTGCCGACCTTGGATGATATGAATCACAAGGACAATGTCCTTGCTATGAGAAATTTGCCCTGTCTGAGTGTCGCAAGTGCCACCGGACTAAACGGAAAGGCGGCAACTGCTGCGATGGAAGCCGCTGATGGAAACACAGCACCACAGCCACCACATGCAGCATCTTCGTACTTTGCAACAACTTATTACCACTTGACAGATGATGAATGTCACAGTGGTGTCAATCAGCTGGGTGGAGTGTTTGTTGGAGGAAGGCCATTACCAGACTCGACACGACAGAAAATCGTTGAGCTAGCCCATTCCGGAGCTCGACCATGTGATATATCTCGGATTCTTCAAGTTTCCAATGGATGCGTTAGCAAAATTTTAGGCAGaTATTACGAAACTGGAAGTATTCGACCCCGCGCGATTGGAGGCTCCAAGCCAAGGGTGGCCACTGCTGAGGTCGTTAGTAAAATCTCACAATATAAACGGGAATGTCCCAGCATATTTGCTTGGGAAATTCGGGATAGATTATTGCAGGAGAATGTTTGCACAAATGACAACATACCTAGTGTGTCGTCCATAAATCGTGTGCTGAGAAACTTGGCTGCACAAAAGGAGCAACAAAGTGGAGGAACAAGCAGCTCCAGTTCCCAGCCAAATGGAAGTGGAAATGGCAACAGTATTGGCAGTAGTAACAGTAATACTTTGGGCGTGGCCAATGGGGTGGGAACAAGCACCACCAATGATCTGTTGCAAACGGCGACACCTTTGAACTCTTCGGAGAGCGGAGGTGCCAGCAATTCCGGCGAGGGGAGCGAACAGGAGTCGATATACGAGAAGCTGCGACTGCTGAACACCCAACACGCCCCGTCGCTGGAATCAACACCAACCGCAGGCGGACATGGTCAGCTCATTACCAGTGTGCCCAGCCACTTCAGCCCCATTCCCCATCCCCATTCCAACCACTCGCTTCAAGCCCATGGacaccaccagcagcagcagagctGGCCACCTCGACATTACTCCGCCGGATCTTGGTATGCAGCTCCTTTGAACGGCGGTCAAGTTCCTCCTTCTCCCGACGGACTATCTGTGACTGGATACACAAACGGAGGCGTTGGCGCACTTGGTCCAGGCCCAGGCCCAGGTTCGGGTCCGGGTCCAGGTCCAGGGCATCCCCTGAGCCCACCAACTGATCTCACCAACATTGGAGGCCAAAATGTTCACTTGAGCAATTGTAACATCGAAGACGATGTTATGCTTAAAAAAGAACTTGATGGCCACCAATCGGACGAAACAGGATCCGGGGAGGGAGACAATTCAAATGGTGGAGCATCCAACATCGGAACTAACGAAGATGATCAAGCCAgattaatattgaaaagaaaattgcaGAGGAACCGCACATCATTTACAAATGAGCAAATTGATAGTTTAGAAAAAGaGTTTGAAAGAACACATTATCCAGATGTGTTTGCACGGGAACGATTAGCGGGGAAAATTGGATTACCTGAGGCGAGAATACAAGTCTGGTTTTCAAATCGACGTGCCAAATGGCGCCGTGAGGAAAAGTTGCGAAACCAACGCCGAACTCCCAACTCTACGGGTACAAATGGAACATCCTCATCGACTTCAGCGACAGCGTCCATGACAGACAGTCCTAACAGTCTCGGTGGTTGTTCGGCGCTTTTGGTCGGCTCTACAAGCAGCGGTTTAAATGGTGTGGCTTCACCAAATCCAATAGCAACCCCAACTGGCGGATCTGAGACATCTGACGTGCATCATTCAAGTTCAAGAACCGGAACTCATGGCATTGGGGGTGGTCGGCTAAATGAAGACGTGGGCAATGCATGTTCGCCAGGCCTGGGAATTGTTGATCAGCATCcgcatcaacatcagcatcaacatcagcatcagcaccaacatcagcatcagcatcatcatgtTGCTCACACTCTCGTGCAATCGATATCACCTCGCCTCAATTTCAACAGTGGGTTCAGCAGTTCAATGAGTGCCATGTATTCGAATATGCATCACAATGCGATATCCATGAGTGAGGGATATGGcTCGGTTTCATCAATGCCCAGCTTCAGCCATTCAACCGTCGGATCGCTGGCACCTCCTTCGCCGATTTTACAGCAGAGAGATCTGACGCCACCATCAATGTACCCGTGCCACATGCCACTGCGTCCACCGCCCATCGGACCACACCATATTGTGGGTGTTGGGGTTGGTGTTGGTGCCTCAAATGAAGGCGCAACTGTCAGCAGCAGTCCCACATTGAATGCCTCAAATACGCATGTCTCGAACGGGCCGAcaaatgccaatgccaatgccaatacCAATGCGAATAACGCAGCTGGGTACGAGGTGCTATCGTCCTACGGtttgccaccgccaccgccccCGCCACCGTCCCTGGCAGCATCCTCGTCCGCCCATCATACCATGGAGGCTCGCCAATCCACTTGCAGTCCCAGTCAAATGGGCGTTGGGCTGAGCCATGGACCTGGCTTTGGTAGCGATAGTATATCACCTTCCATGCCTTCCTATGCGCACATGAGCTACAACTatgcggcagcggcggcagccaATGGCGGCGTTGCCCCATCCGGTGGCACTCACAACAACTCACACGGACCCGCACACTCGCATGGGAAGCAACAATTTTTTGCATCTTGCTTTTACTCGCCATGGGTTTAA
Protein Sequence: MFTLQPTPATLGAVPWSAGALIERLPTLDDMNHKDNVLAMRNLPCLSVASATGLNGKAATAAMEAADGNTAPQPPHAASSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSGGTSSSSSQPNGSGNGNSIGSSNSNTLGVANGVGTSTTNDLLQTATPLNSSESGGASNSGEGSEQESIYEKLRLLNTQHAPSLESTPTAGGHGQLITSVPSHFSPIPHPHSNHSLQAHGHHQQQQSWPPRHYSAGSWYAAPLNGGQVPPSPDGLSVTGYTNGGVGALGPGPGPGSGPGPGPGHPLSPPTDLTNIGGQNVHLSNCNIEDDVMLKKELDGHQSDETGSGEGDNSNGGASNIGTNEDDQARLILKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGTNGTSSSTSATASMTDSPNSLGGCSALLVGSTSSGLNGVASPNPIATPTGGSETSDVHHSSSRTGTHGIGGGRLNEDVGNACSPGLGIVDQHPHQHQHQHQHQHQHQHQHHHVAHTLVQSISPRLNFNSGFSSSMSAMYSNMHHNAISMSEGYGSVSSMPSFSHSTVGSLAPPSPILQQRDLTPPSMYPCHMPLRPPPIGPHHIVGVGVGVGASNEGATVSSSPTLNASNTHVSNGPTNANANANTNANNAAGYEVLSSYGLPPPPPPPPSLAASSSAHHTMEARQSTCSPSQMGVGLSHGPGFGSDSISPSMPSYAHMSYNYAAAAAANGGVAPSGGTHNNSHGPAHSHGKQQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00518998; iTF_00585133; iTF_00585025; iTF_00537455; iTF_00537347; iTF_00533745; iTF_00533640; iTF_00510483; iTF_00510378; iTF_00506805; iTF_00506697; iTF_00522902; iTF_00522793; iTF_00583574; iTF_00583623; iTF_00608385; iTF_00557799; iTF_00608334; iTF_00557853; iTF_00585912; iTF_00585806; iTF_00575417; iTF_00575525; iTF_00610489; iTF_00610593; iTF_00601723; iTF_00601610; iTF_00528639; iTF_00528745;
90% Identity: iTF_00585912;
80% Identity: iTF_00518998;