Basic Information

Insect: Drosophila heteroneura
Gene Symbol: L
Assembly: GCA_035042245.1
Location: JAWNLO010000105.1:367050-376805[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 1e-05 0.00066 19.9 2.9 1 23 173 195 173 195 0.98

2 17 0.36 23 5.6 6.2 1 23 201 223 201 223 0.97

3 17 1.7e-07 1.1e-05 25.5 3.2 1 23 229 251 229 251 0.99

4 17 1.3e-05 0.0008 19.6 0.4 1 23 257 279 257 279 0.99

5 17 0.12 7.7 7.1 0.1 2 23 353 378 352 378 0.92

6 17 0.00042 0.027 14.8 0.4 2 23 411 433 410 433 0.96

7 17 0.028 1.8 9.1 0.7 1 23 498 520 498 520 0.97

8 17 0.0052 0.33 11.4 0.1 2 23 528 549 527 549 0.91

9 17 0.00021 0.013 15.8 0.1 1 23 557 581 557 581 0.93

10 17 5.2 3.3e+02 2.0 1.7 2 23 617 639 616 639 0.95

11 17 0.0026 0.16 12.3 1.1 1 23 689 712 689 712 0.97

12 17 0.0065 0.42 11.1 1.6 2 23 886 908 885 908 0.96

13 17 0.12 7.4 7.1 0.1 1 23 914 936 914 936 0.92

14 17 0.56 36 5.0 0.4 2 23 944 965 943 965 0.93

15 17 0.65 42 4.8 0.6 2 23 1064 1085 1064 1085 0.94

16 17 0.024 1.6 9.3 0.0 1 23 1095 1117 1095 1117 0.96

17 17 0.00022 0.014 15.7 1.2 1 23 1122 1144 1122 1144 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	1e-05	0.00066	19.9	2.9	1	23	173	195	173	195	0.98
2	17	0.36	23	5.6	6.2	1	23	201	223	201	223	0.97
3	17	1.7e-07	1.1e-05	25.5	3.2	1	23	229	251	229	251	0.99
4	17	1.3e-05	0.0008	19.6	0.4	1	23	257	279	257	279	0.99
5	17	0.12	7.7	7.1	0.1	2	23	353	378	352	378	0.92
6	17	0.00042	0.027	14.8	0.4	2	23	411	433	410	433	0.96
7	17	0.028	1.8	9.1	0.7	1	23	498	520	498	520	0.97
8	17	0.0052	0.33	11.4	0.1	2	23	528	549	527	549	0.91
9	17	0.00021	0.013	15.8	0.1	1	23	557	581	557	581	0.93
10	17	5.2	3.3e+02	2.0	1.7	2	23	617	639	616	639	0.95
11	17	0.0026	0.16	12.3	1.1	1	23	689	712	689	712	0.97
12	17	0.0065	0.42	11.1	1.6	2	23	886	908	885	908	0.96
13	17	0.12	7.4	7.1	0.1	1	23	914	936	914	936	0.92
14	17	0.56	36	5.0	0.4	2	23	944	965	943	965	0.93
15	17	0.65	42	4.8	0.6	2	23	1064	1085	1064	1085	0.94
16	17	0.024	1.6	9.3	0.0	1	23	1095	1117	1095	1117	0.96
17	17	0.00022	0.014	15.7	1.2	1	23	1122	1144	1122	1144	0.97

Sequence Information

Coding Sequence: ATGATGGCCTTAAAGATGTTATATCGCGGTCCCAGTTCGCGCTTGGAGAATTTGATTGAAAAGATTCAGGCCACAAAGGAGATTACAAATAACGaCATGTACAGCACGCACACCTCGTCGAGCTACTCGCCCAGCATCTCGGATGGCACATTGACGCCCAACtcggtgcagcagcagcagcagctgcccaagGCTGCCTCCGAGGACAATCATTGCGGAGAGTCGAAGGCAAATGGTGAGGGTCCTGCTGCGGAGCAACAGGATCTGGCCAAACCGAAGCGACCCGCTCatttgcatcatcatcatcatcatcattatcatcatcagcaggcgctgaaaattgccaacaagctgcgcaaaatcaataaagaaGCCAAGTTGGCAACCGCAGGAGCAGCACATGGAACAGgcgcagcaggagcagcaggtgGCGGAGGTGGCGGAGGTGGAGGAGTTGCCGCCAGCAAGTTTGATAAGTTGACAGGCGAAAGCATTAAAAGTCGCGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGCTACTTGAAGCATCACGTCCAGAGCCATGCCGAACATTTGCCTTTCAAGTGCGAATACTGCGCCAAGCTGTTCAAGCACAAGCGATCCCGAGATCGCCACAAGAAGCTGCACACAAACGAGAGGAACTACAAGTGTCCGCACTGCGAGGCTGCTTTCTCCAGAAGCGATCATTTAAAGATTCACATGAAGACGCACGACATACAGAAGCCGTTCCAGTGCAGCATGTGCAATCGTGGCTATAATACTGCTGCCGCTTTGACCTCGCACATGCAGAAGCACAAGAAGAATGCGGCAATACTGGCAGCTGGTGGCAATCCCAATGCTTTGAATTACAGTCCACGCTCGACGGGATCGGCGTCCATCTCGAGCAATGGCAGTTTGCACAAGCGACGCTATGCTTTGGCACTCGCCTCCGACAGCAGTCCGAGTCGTCTGGAGTTCCCCAAGCGGGCACGCGGTGTTACCGTGCCGACCACGCCCACCCCAACGCCCCTGCTGCGCTGCAGTTACTGCAGTCCCAAGGTGACCGAGTTTAGCAGCCTGGAACAGTTGAATGCCCATCTGCAGGCGGCAcacgaacagcaacagcagccgggCGCAAGGAGTTCGACGGCCACCAGCAGAGAGACCACAGTGGAGACAGTGGAGCCTCCGACGAATGGTTTCCAGCTCAGCTGCGAATATTGCACAATGAAATTCGGAAATATTGCAGCACTCTTCCAGCACATGCGCACCACGCACTTGGATCGCCTGAGCAGTCCCAATTCTTATTACGAGCACTTTAATCGTTTGGCCACAGCGGGCACATTCAGTCCACGCTTGGATATGCCCAAGATCAAGCAGGATTTGCCGAGTCCGCCGGCGGAGGAGCTGCCAACGGATCTGAGCAGCAATAAGCGACGAGCGTTGACGCCGCCAGCGCCACCTGGCGTTTTCTTTTGCAATCAGTGCAACGCAGGGTTGCCAGACTTTGAGAGCTTTCGCAATCATCTAAAGACGCACATCGCGGAAGGCATGCAACTGATATGCCCCCACTGCGGATTGAGTCTGCCGGAGCAGAGTGAATTCGAGCGACATGTTGTCGCCCATTTCCTGATCAGCAGCTCCGAGTTCAATTGCGGCGCCAGTTGTGGCAAATCGTTTGCCAAATCGGAGGAACTGCAACAGCATCTGATCAGCGAACATGTCCAGACGCTGCTCAAGTGTGTGATCTGCTCGGAGCTGTGCGAGAATCGCATGTCCATGCAGCTCCACTTGGCCTGTGCCCACAGCCAGGAGACGAAGCTGCTCCGTTGCAGCGCCTGCTTGGAACTCTTTCGCACCGATACGGATTTCCATGTGCATGTCAAGACGCGTCATCAACTGGTGGGCGGTAGTGCTGCTGGCGGAGCAGTTGGCGGACCACCCACTGCGCCACCTGCCAATCCGTTGCAGTGCATGTTCTGTCGCGCTGTTTGCGCCTCGGAGCTGGAAATGCACTTCCATTTGGCGGCGCATGCTCGCCAATTCCGTTGTCCCAGTTGCCCGGAAACGTTCCACGTCGAATTCCTGCTCGATCGGCACATGCAGAGCCAGCATGGCGGCGTCAAGGATGgcaaacaggagcagcagggtGCCAACAATTCGATGGGCAGTCTTTATGTGAATGCCTTGTTGCCACCgttggcggcggcagcagcggctgcggcagctgccacaaacaataacagtaatCTGCATATTGATTACAATGTGGCGTTCAAGGGTCTGTTTGGAGGCggcaatgccacgcccaccaacACACAGCCAGCCAACAAGTTCTACAGTCCTTTGCAGGTGGATACAAGTGCGCTGAAGCCCCAACAGACGCCGCATCCCGCTCTGATGTACGGTCTCAGTCAGCGCTATTTGATGGAGATGTATGCGGCGAAGGCAACCTCGCCGGCGGCCAGTGCACCCGAGCTGCCGGCACAGGCAACCCAAGCGGCAAATGCGACGGCATCCAGCACGggcagcagctacagctgtGGCATGTGCGAGCGCCAGGATTTGCGCAGCGAGGCCGAACTGCATTCGCATCGCAAGTTGGCGCACAATCTGAAGACGGGCGTCAGTTTGAGATGTGCCTACTGTTCGGGTAACTACAAGTCGCGGgcggagctggagcagcacaTGAAGAGCTGCCACAATTCGAGTGGCAAGCACAAGTGTCTCATTTGCGACGAGATCTTTCCGTCGCCGGCGATACTCGCCGAGCACAAGTTGCAGCACTCGAAGGTGGGCCAGTCGGGCAAGTGTGCCCACTGtggccagcagctggagcatGTCGCCGCATTCCGTGCCCATCTCGGCGAGCATGGCAACGATGGCAATTTGCCCATGGCCTGCATTTGTTGCCGTCAAACTTTGCACTCGGAATTCGAGTTGAGTTTGCATGCGAAATTCCACACAAAATCACCGAGTTGTGGCAGCCTCCAGGAGCCCGTCTGTGCTCTGTGCCTGGAACCCTTGCCGGGTGCGGGCGAAACCGCCAAGCTGTGTGAGAAATGTTGTCGCAAACACAACCTGAATGGCAAACGCAACAAGGACGCAGCTgtgccaccaccagcaccagcccCACCAGCAGCCAGCACAGTGGGCTATCTCGAGAATCGTTGCAATCTGTGCAAACTGATATTGCCGCATGCCAAGAAACTGCAGGAGCATCTCGTGGAGCACACGTTTGCCGGCACCGAGCAGCGTGGCTTCAATTGCTACATTTGCTCGGCGGTTTTTACGGCACCCGGTGGCCTTTTGGCCCACATTGCGGAGCACGGTGCTCGTCCCTACGATTGCAATTTGTGCCCGGAAAAGTTTTACTTTCGTGCCGAGCTCGAGCATCATCAGCGTGCCCACGAACTAAGGCAAATCCCaacagccgctgctgctccgACACGGCCCACAACCAAGCAGGAGACTCAGCACAGCTCGTCGGCCAGTTCACCCGTGCTCACGCTCAGTCCCAGTCATGTGAAGCAGGAGCTCTACGAATCGGAGGCGGCTAACTCACCACAGCCCGACGAGCAGTCACCCGcccaggaggaggaggagtacATTGAGGTCGAGCAGATGCCACATGAGACCCGCTCCAACGAACTGGTCACCACGGAACGCTCCAGCAACAGCGCCTGA
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSVQQQQQLPKAASEDNHCGESKANGEGPAAEQQDLAKPKRPAHLHHHHHHHYHHQQALKIANKLRKINKEAKLATAGAAHGTGAAGAAGGGGGGGGGVAASKFDKLTGESIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLEFPKRARGVTVPTTPTPTPLLRCSYCSPKVTEFSSLEQLNAHLQAAHEQQQQPGARSSTATSRETTVETVEPPTNGFQLSCEYCTMKFGNIAALFQHMRTTHLDRLSSPNSYYEHFNRLATAGTFSPRLDMPKIKQDLPSPPAEELPTDLSSNKRRALTPPAPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEQSEFERHVVAHFLISSSEFNCGASCGKSFAKSEELQQHLISEHVQTLLKCVICSELCENRMSMQLHLACAHSQETKLLRCSACLELFRTDTDFHVHVKTRHQLVGGSAAGGAVGGPPTAPPANPLQCMFCRAVCASELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDGKQEQQGANNSMGSLYVNALLPPLAAAAAAAAAATNNNSNLHIDYNVAFKGLFGGGNATPTNTQPANKFYSPLQVDTSALKPQQTPHPALMYGLSQRYLMEMYAAKATSPAASAPELPAQATQAANATASSTGSSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGNLPMACICCRQTLHSEFELSLHAKFHTKSPSCGSLQEPVCALCLEPLPGAGETAKLCEKCCRKHNLNGKRNKDAAVPPPAPAPPAASTVGYLENRCNLCKLILPHAKKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLAHIAEHGARPYDCNLCPEKFYFRAELEHHQRAHELRQIPTAAAAPTRPTTKQETQHSSSASSPVLTLSPSHVKQELYESEAANSPQPDEQSPAQEEEEYIEVEQMPHETRSNELVTTERSSNSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538445;
90% Identity: iTF_00514332;
80% Identity: -