Dhet009618.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila heteroneura
Gene Symbol
-
Assembly
GCA_035042245.1
Location
JAWNLO010000887.1:28768-35282[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.05 3.2 8.3 0.2 1 23 1382 1405 1382 1405 0.94
2 13 4.5 2.9e+02 2.1 0.2 1 23 1575 1597 1575 1597 0.91
3 13 0.00018 0.012 16.0 2.7 2 23 1600 1621 1600 1621 0.97
4 13 7e-05 0.0044 17.3 0.2 3 23 1629 1649 1627 1649 0.98
5 13 5.8e-07 3.7e-05 23.8 4.1 2 23 1656 1677 1655 1677 0.97
6 13 5.5 3.5e+02 1.9 0.4 5 23 1690 1708 1688 1708 0.96
7 13 1.4 87 3.8 5.4 3 23 1715 1736 1713 1736 0.93
8 13 0.15 9.3 6.8 0.2 2 23 1747 1767 1746 1767 0.96
9 13 5.6e-05 0.0035 17.6 0.4 1 19 1773 1791 1773 1795 0.95
10 13 1.6e-05 0.001 19.3 0.5 1 23 1803 1825 1803 1825 0.98
11 13 0.0001 0.0066 16.7 7.6 1 23 1831 1853 1831 1854 0.96
12 13 0.0002 0.013 15.8 5.9 1 23 1859 1881 1859 1881 0.98
13 13 0.029 1.8 9.0 8.2 1 23 1887 1909 1887 1910 0.95

Sequence Information

Coding Sequence
atggtGGACAGTGTGCAGTGCCCCGTGTGCACCTTGTATCTGCATGCGGGCATGAATCTCTCCGATCACTTGGAGACACATCCCAAGGAGCAGGTCATCAAGGCACTGGTGCAAATGACCAttgctggcaacaacaatggtggTCTGGACAGCGCCCTGGCGGCAGCTGTCATCTCCAGCAGCAGTCGCTGCAGCGTTGCCTCAACCGAAAGCGTCGCCTCAACGCCGCCTGCTGTTGATGTCAAACCAGATGTGGCATCAGTaccaacagcgacagcaacacaACCGCCACAGCCACCACAACCACCCcaaccaacaccaccaccagcagcaacaacaacaacagcagcagcatcaacaacaacaagcacatcGCAATCAGCAGCACCCAAAGCTGTCGCATTGCTggacaacaccagcagcagcagtagcaacaacagcagcagcaacaacaacaataacaacaaattgagcaATCCACCGATTAAGGCAGTTAAGAGTGCGCCACCCACGACTGAGGCGCCAGCCACCacatccaacaacaacacacccACCATAAGCAACGTGTCTGCTGTCTATCCGGCAACCCTGGCAACCGACTATCGCtacgaacagcagcaacagcaacagccacagctacagcaccagcagctgcaTGGCTTTCCACgtggcaccaccaccacactGGTGATACCACAAGCGCCGCCGCAACAGCACCACAATTTTCTGGCCAACCAACAGCCGCCTGCGCACTTTGcccatcagcaacagcagccgcagtcgaCCATGAAGTTCACGTATGCAACAGCGGCGTTGCCTCCGCCTCCTTTGCAGCTTTTTGCACAGCAGCCGACAGCAACGCAGCCGCATCAGAAGCCTCCACCCGCCTATGGCGCCGCCATCAGTCAAATTCGATCTCAGCATAaccaaaacaagcaacaacaccaccaacaacagcaacaacaacaacaaccacaacacgTAAACGTACAGCAGcataatgcaaatgcagcacCACCGagtggcaaacaacaacacaatagCAAAATCCATGCGGATATCTTTCTGAatccaccgccaccgccacagCTCACAATTCCatcgtcggcgtcggcgtcatcattgtcgttgtcgctgtccCTGTCGTCATCGACCTCCTCAAGACTGCAACATCCccaacagcaccaccaacaatCCCATGctgctagcagcagcagcagtagcagtagcagcagcaactatgcAGCAACCAGCTGCGCTCCCAGCTCCTCGGTTGCTCTGATGTCCGGCACATCGTCGGCACGCACCAGCAGTCGCCAATCGAGCAATTCGCCCTTTGGTGCCCTGCTGAATGCGGCTGCGCACGCTGCCTGCTCCTCGCCCGCTTCGACTGGGGCGTCTGTGCTGCGCTATGCCGAGTCGCCAGTGGCCCACTATCTGGAGCGGGATAATGGTGATTTCATAGTGCAGGAGACGCCCAAACACATTGTGGAGTGTGTCGAGAAGGACGACGGTGAATTCTCCGTGATTGAACGCATCTATCAATCGCCACCCAGCGTTCTCCACAtacacgacgacgacgaagaggaggaggaggacgaggatgATCAGCAGGGTTGGGCAAACAGCGATGAGGAAGATCACGTCAAGGTGCCACACGAGCATGTCGAGGATGGCGATGATGAGCACGAGGATAGTCGCAGCCGAGTTGCACCCAAAACGACAACGAAAAAGTCACGCAAGACAAAATCGAGTGGCAGATTGCACAAGCGCGCCTCCAAGCAACAGCTGGCCACGACGACGGAGGACGAGGACGACTTCATGAGCATAGGCAGCAGTTGTGCCGAAAGCGAACATCATCCagaggagcagctgcagcaacagcagccgcagcaacagcatccgcAGCAATTAGCATCGGCTGGGGGGGCAGCACAGTTGGCGGCGAGCTCATCGCCAGCTCAACTTTGCACTGCGCCCTCCACGAGCAgtggagctgctgttgctgctgttgctgccgccagTGGTGGTAAATTCATGGCCAGCGGCACCATCAAGTCCAAAAAGAATCGGGTAACGGTGCTCAGCGATGTGCCGCTCAACATGAACGAGTATCTGGATCTGGTGGGCAACATTGTTGCCTCGAGCCGCATTGGCGCAGCGCGTTCCTTTGCCGCTGTAGCGCCCATACCGCTCGTCAAGGTGGAAAAGGAGGAACCCATGGATGAATATGATGCCGTTGAGGTCGAGATGCAGTTGGAGCAAAAGCCGAGCCTAGAGCATGctagtggcagcagcagtagcagcagcagtagcagcaacagtagtagcagcagcagcagtggacaTGGCACCACCAGCGTGATACGCATGGCTAGCACCAGTGCGGCGAACGTTGCCGCCGAGGATCTCACACAGCCGCTACCGATGAAGGTGGAGGTGGAGCCAACGGCGCTGCTGCCGCAACGCTTTTCGGCACCGGGGCAGCTGCGTGGACCCAAGAAATTAGTCATCAAACCAAAGGCCACAgcgacggcaacggcgacgtcAACGACGAAAAAGACTGAGaacaacgctgctgctgttgctactggcagcaacagtagcaattGCGCCGAATCCCATAGCATATCAGTGAATACGCCCGCCGAGCTTGTGCAGATCAAGAGCGAGAATGTGGAGGCGTCCACAtccagcagtggcagcatATTGGAAAAGCATCTGACTACCAGCTATGCGGCACAGCAGGCGGCACGCAAGCACTCCGCCGTCAACGATGACGATGCACGTGTCCTGCTCGAGTTTGCCAACTCGAAGCAGTTGCCGATGCCTGGCAATAGCAATCATACCACGTTTGTGGTGAACGCGGCCAGTTTTGCGTCAGCGGGTTCCGTATttgccagcggcagcagcagcagcggtggaAATGTGCAAAAGTCAACCAAGCCGGGCTGTGGCGATGAGTACATTCTGCCCGATGACACCAAACTGGAGGTGGATGAAATTGTGATATCCTCCTCGTCTTCCTATGCCTCCAcctcgcagcagcaacagcagcatctccaacaacaaacacaacagcagcagcagcaacaacaatctttGCAGCAGGCGCAACCATCCGCTTTCACTGAGTTTAGTTTTCTGTACCAccaaaacacaacagcaacaacagcagcagcagcagcagcagcggcaacaacggcGACATCTACTACTTCCAACTTTGCACCGTTTGGcattcagcaacagcaacaacagctgcagttgcaacatCATCCGCAGCATGGGTCCAGCGAGGCAACCAATGCCGCAACGCTTGCATCCTCGTCGAGCAATTCGTCTGTATTGGATCAGGAGTGCTCGATGTTTCGCGTGGCAAAGCCACAATCAATGCTGGGCGCCTGGTATCAGCCACATCAGGCGCAGCATCAGGTGACATCTTCGCACAGTCCACAACATGTGGATCAGCCGAGCAATTTTATTGCGGCTCTGTCTGCCGTCGACTGCTGCAGTGCAGCCGTCGATAGCGATATGAGTGAGGCTAAATACTTGGATCTGGATGCCTGCAAGCGGGAACAgctgagcaacagcagcagccatatGCCCTCCGCTTCGACATCAACCACATCGTCATCGTTTGCTGCCGCAGCAACGGAGAGCAGTCTCGTCGGCGGCCTGGGTCTGAATATACGCACCGATGAGAAGATGCCCGCCAAGGGTGAGATTTCCGAGCAGGAAAGCAACTGCGACATAGAGAACTCTTGGAGTCAATCGATGTATGGCGACATATCACAGCGTTACTTTAGGAATCAGTTCACGGATGGCTACAATCAGCAGCTGGCCGATTGGCGTCACGACTACTATCCGGCGCAGGATCTCAgtggccagcagcaacagcagcgagagCAAAAACGATTTGACTTCAATGCGGTCGCCTCGGAGTACGCACAGCCGGGCGAGCTGGAAGCTTCCTCGAGCTCAACGAGGAACAATCATTTGTTGGATGCACAGCCCACCACTTCCTCGTCGTCATCGGCTTTGTTGGCTGGTCCACCAATAGCCTCGACATCCCGCGCTGCCGCCGAAGCGGAGGCGGTTGCAGCAGCGCTGGCTCAACGGAAGCCAGCACGTCGCAAGATCTACAAGTGTCCACACTGTGTGGCCATCTTCGAGAAGCTAAAAGAGCGCAATGCGCACATGATTGGCGAGCACAACTATGTGCGCCAGAATCGGCGTCTCATCTGCACGCAGGCGTTGGCGATACTGACCCAGCCGCTGGCTCAGCAGCCAGAGCAGCAaatggagctggagctggagcagcagcagcagcagcatcagttgcTGCAGGTGGGCCACAGCACGGGCGGCGCCGAGCACGAAGATTCCAAGGATGGTATTGTGAAGATTAAGCAGGAACACTGTCAGGACAAGCACGATCCAGCATCGGAGCAATTGCTTGGCCACTTGGAGCTGCCGGATGTGAAGGATGCTGGCCTGCTCGAAGCCAGCGGTGAAAACGGACGCGATGCGGACATGAAGCCACCAACCACTGTTGCTGAGCTGGACGAAAAGCCGACCATAGCACCGCTGGCCATGACGACGCCCGCTGCCAAACTGGCTGCTCTTTATCGCATGCTAATTGCCTACAACGAATCAAAGCTGGGCCAGGAGCGCAATAATCTGAGCGAACTGGAGCAAAAGGCCATGGAGAAATCTATATTCTTGTGCTACATTTGCCGCACCGATTTCCCCTCTGTGAAGCTGTACGATGCGCATCTAACCGAGCATCCCGCCGAGTGTTTCACCTGTGGCAAGAAATTCTATCGCTGGAAGAACTTCTCGCTGCACCTGAAACGCCATCTGGGCTGGAAGGAGTTCGGCTGCTATGTCTGCGACAAGAAGTTTGTGGTGCGCAGCGCTCTCGTCGAGCACATGCGGATGCACACTGGCCAGACGCCACTTAAGTGCAAGATATGCGGCAAGAAGTTCAAGCGATACTCGAACTTGACGCAGCATCGCAAGCGCCACACTAAGATGACGGTGCGCAAAAAGGAATATGTGTGCCACTGTGGCGAAGTGCTGCCCTCAAAGGCGCGCTTCCTGTGGCACAAGGAGACGCACGACTTGAAGCCCAAATGCTGTCCGTACTGCTGCGATCGCTTCGTGCATGCGAACTCGCTTCGTCGACACATCCGGCTGGCGCATTCGGACAAGTTCGACTATGCCGAGCCGATGGAGTGTCCCATGTGCAAGCAGATCTTTGCCAAGACATCGATTAAGGCACACATGGCGACGCACTCGACGGATCCGCAATACGATTGCGCCATCTGCAACAAGAGCTTCTCCACCAAATGGAATCTCAAGATACATTCGTGGGTGCATGCGAATCGAACGGCCAAACCGTTTAAGTGCGAGTACTGCCCCAAGGCGTTCGTGCGCGAGTTGGACTTCAAGAATCATATGAATGCGCACAAGCAGATTAAGCCGTACACCTGCGAATATTGCGGTTGCAAGTTCATACGCAAGTACAACTATATGCGGCATAGGCGGGAGCATCATGGTAACAAGAAGTTCACGTGCGACCAATGCGACAAGTCTTTCCATCGCCATTACTATCTGATTGAGCATCGGCGCATTCACACTGGCGAGCGACCCTTCCACTGCACCATCTGTGGCAAGAGCTCCACCACAAAGACCAATCACAACAAGCATCTGAAGATTCATCATTCGCGCGATCCCTTCACTGTGGAGGTCTAA
Protein Sequence
MVDSVQCPVCTLYLHAGMNLSDHLETHPKEQVIKALVQMTIAGNNNGGLDSALAAAVISSSSRCSVASTESVASTPPAVDVKPDVASVPTATATQPPQPPQPPQPTPPPAATTTTAAASTTTSTSQSAAPKAVALLDNTSSSSSNNSSSNNNNNNKLSNPPIKAVKSAPPTTEAPATTSNNNTPTISNVSAVYPATLATDYRYEQQQQQQPQLQHQQLHGFPRGTTTTLVIPQAPPQQHHNFLANQQPPAHFAHQQQQPQSTMKFTYATAALPPPPLQLFAQQPTATQPHQKPPPAYGAAISQIRSQHNQNKQQHHQQQQQQQQPQHVNVQQHNANAAPPSGKQQHNSKIHADIFLNPPPPPQLTIPSSASASSLSLSLSLSSSTSSRLQHPQQHHQQSHAASSSSSSSSSSNYAATSCAPSSSVALMSGTSSARTSSRQSSNSPFGALLNAAAHAACSSPASTGASVLRYAESPVAHYLERDNGDFIVQETPKHIVECVEKDDGEFSVIERIYQSPPSVLHIHDDDEEEEEDEDDQQGWANSDEEDHVKVPHEHVEDGDDEHEDSRSRVAPKTTTKKSRKTKSSGRLHKRASKQQLATTTEDEDDFMSIGSSCAESEHHPEEQLQQQQPQQQHPQQLASAGGAAQLAASSSPAQLCTAPSTSSGAAVAAVAAASGGKFMASGTIKSKKNRVTVLSDVPLNMNEYLDLVGNIVASSRIGAARSFAAVAPIPLVKVEKEEPMDEYDAVEVEMQLEQKPSLEHASGSSSSSSSSSNSSSSSSSGHGTTSVIRMASTSAANVAAEDLTQPLPMKVEVEPTALLPQRFSAPGQLRGPKKLVIKPKATATATATSTTKKTENNAAAVATGSNSSNCAESHSISVNTPAELVQIKSENVEASTSSSGSILEKHLTTSYAAQQAARKHSAVNDDDARVLLEFANSKQLPMPGNSNHTTFVVNAASFASAGSVFASGSSSSGGNVQKSTKPGCGDEYILPDDTKLEVDEIVISSSSSYASTSQQQQQHLQQQTQQQQQQQQSLQQAQPSAFTEFSFLYHQNTTATTAAAAAAAATTATSTTSNFAPFGIQQQQQQLQLQHHPQHGSSEATNAATLASSSSNSSVLDQECSMFRVAKPQSMLGAWYQPHQAQHQVTSSHSPQHVDQPSNFIAALSAVDCCSAAVDSDMSEAKYLDLDACKREQLSNSSSHMPSASTSTTSSSFAAAATESSLVGGLGLNIRTDEKMPAKGEISEQESNCDIENSWSQSMYGDISQRYFRNQFTDGYNQQLADWRHDYYPAQDLSGQQQQQREQKRFDFNAVASEYAQPGELEASSSSTRNNHLLDAQPTTSSSSSALLAGPPIASTSRAAAEAEAVAAALAQRKPARRKIYKCPHCVAIFEKLKERNAHMIGEHNYVRQNRRLICTQALAILTQPLAQQPEQQMELELEQQQQQHQLLQVGHSTGGAEHEDSKDGIVKIKQEHCQDKHDPASEQLLGHLELPDVKDAGLLEASGENGRDADMKPPTTVAELDEKPTIAPLAMTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAMEKSIFLCYICRTDFPSVKLYDAHLTEHPAECFTCGKKFYRWKNFSLHLKRHLGWKEFGCYVCDKKFVVRSALVEHMRMHTGQTPLKCKICGKKFKRYSNLTQHRKRHTKMTVRKKEYVCHCGEVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRLAHSDKFDYAEPMECPMCKQIFAKTSIKAHMATHSTDPQYDCAICNKSFSTKWNLKIHSWVHANRTAKPFKCEYCPKAFVRELDFKNHMNAHKQIKPYTCEYCGCKFIRKYNYMRHRREHHGNKKFTCDQCDKSFHRHYYLIEHRRIHTGERPFHCTICGKSSTTKTNHNKHLKIHHSRDPFTVEV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00583141;
90% Identity
iTF_00564835;
80% Identity
-