Dhel014505.2
Basic Information
- Insect
- Drosophila helvetica
- Gene Symbol
- MBD-R2
- Assembly
- GCA_963969585.1
- Location
- OZ018403.1:10043512-10047420[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.2e-22 9.8e-19 67.2 0.1 3 76 445 516 443 517 0.93
Sequence Information
- Coding Sequence
- ATGGGACGACGTTGCTGCGTTGCAAAGTGCCCGTCGACGTCGCGTCTCTTGGAGCACCACGGCGTCACATACCACTCCTTTCCCCTCGACCCGATAATCCGCACAATTTGGATCAAAAACTCTCGCATCAGCCTGGACAGGCAGATTACCAAGAGCGTTTTGGTGTGCTCGCGCCATTTTCGGCGAGTCGATTTCAATACCATACGCAATGGGAAATATTTGCTGAAGCCACGCGTCTTCCCGACGGTTTTCCCATGGGGAAAAATGGATGCCGCTGAAATAGAGGCCGACCATCGTGCTCTACAGCAGGTGAATGTGGATGGTACAGCCGCACACGGCGCTTCCACGAGCTCGGGCAATGAGGATGTGATCAAGGCGACTGTGGACCAAATCGTTTCGCAGATCATGGCAGAGACAGCGGAGCGCAATGCCACGGCAGCTGTCGAGGCAGCTGGCAATGCGGAAAAGGAGAAGGAAGTGGCCAAAGCAGCCGTCGCCGAAGAAGCTGAGAGCGCGGCAAAAGAAGGTGGCTCCATTGGAGAAGATTCGGCCGAAACTCCAACAACTGAAGGAGGCGAATCTGCAGCGGCTGCCGAATCAAGTGCCGACTCTCCAGTGCCTTCCGCAAGCAACCAACCGAAGTACAGCAGTCCCCATAATTTGATAATAGGAGCACGACTCGAGGCCAAGAGCGTGGATGGCTCTTGGCTGCCCGCTCGCATTGTGGAGGTCAATGAAACGGAGCAGACGATCCTCATCCGTTTTGAACGTAACAATAAGATAAAGGTGATGCCCTCCAGCATGGGCACCTATCAGGAGTGGATGGCCGTCAAATCGGATCGCGTCCGACAACGCGTCAGCAACCGAATCCTGCCCGTGTTCGAATTGGAGGAGAAATGCATGGCACGCTGGTCGGGGCCGCGCAAATTTCCGGGTACCATCAAGAAGCTGCTTGGCCACGACACCTACGAGGTACTCTTTGACGATGGCTACTCCAAGAACGTACGTGCCGTCCACATGAACAAGCTGCCCAAGCCAGCTGCCGTAGAGGAAGTGGAGACTGCTCCAGCCAGTACGACGACGGCTCTGAAGAGGGCCAGCACTGGCACTGCCCCTGGCACtgccagtggcagcagcactGGTGCCTCGAGCAGCAAGAAGAGCAAAAACTCACAGCGCAAGGATTGGCCACTGCTCGACATGTCTACCTTGGATATTGATTCTCTGGGATTGCCGGAGATACCGCACGACGGGGAGTGGACCTGCCACTGGGTCAATGATCAGCCCATTGGCACCGAAGGTTTTCTGATTGTGGGCGAGCACCAAAAGCCGACCGTGATTGTTCAGGACTGGCGTCTGCCCACGGGCTGGATCAAACACATGTATCAGCGCTCGAATGTCCTCGGAAAGTGGGATGTCATTTTGGTCTCGCCCAACGGCAAACGATTCCGCTCCAAGTCGGATCTGAAATTGTTTCTCGAGTCGCAGGGCTTGGTCTACAATCCGGATGTCTACGACTTCAGCATTCATCGTCGTCGCGCCAAAGACATCAATGCGTATGTGTACACTGGCGACTACAGTCCCCAGCCGCCGCACAAGCCCAAGACAATGAATGTCTCTGCGCTGGACACCACCGTGGACCAGAGCAACACAACATTGCCAGCCATTAGCACCCCCTCGACACCCATTTCAGCAGCTGGGCCGCCCCATCCCGGGGACATTCAGTATATGGAGACACCCGTAGCCTCATTAATGCCACCAGCAGAGCTGATGTCGCCACCGTCGCATCAAACGGATGACGGCCATCCAACCGCCGATATGCCAGAGGTCACTGGAAGTGTCGCCTCTCTGAACGTTCCTGTGGACGAGCAGGGAACGGTTCTGGTCGAGAACGGTTACGCTTTTATCGGCGGCTTGAAGGTTTCCATCGTTGACAATTTGTTCGTTTGCCCGGGCGAGGGATGCGGCAAAACGTATCGCAAGGAAGATGTTCTGCTCATACACATCCGACACTACCACAAGGAGTTTGCCGAATATGTCAGCCACTGTCCCAAGATGCAGGAACTGGCTGTCAAGCGGACACATGCCTCTTCGATTGACCAGGGCGATGCTGTGCCGAAGAATCAAATACCCAATCAGCAGTTCTTTGCTAAGATGCATCAGCAAGACATGCAGCAATCGCGATCCTTTAAGCGTCTGGGAGCGACACCGGGAGCGACGCCATCGCCAAAAACTCCAGGGACTCCAGCCGGTGTTTCACCTACGAAATCGCAGGCCTCGCCCATTGTAGACAAACCGGCCACGCCCTTGGCAGCGGCTGAGAGCACAGTGACCCCAGAGGCGGTCATTAGTCCCAAAACgagtggtgctgctgctgctggtgctgctgctactggtgctgctgatgctgctgctgctgctgctgctgctgctactactactactgcGACAGCAATCTCCTCTCCAACAGTGTCGCAGGACTCGCCACTTGGTCGCTCAAACAAGCGACCACGGTATTCGTCCTCAAGACGCTCGTCTGGATCCCGCAAAAGCAATCGGCAGAACTCACGCCGTCGTCCTGCCAATGCCACACCTGCTGGAGCAATCACTGCTGACGCGGACTCCGAGGAGATGCGTCCGTCTTTGAAAACTACTACGCCGGAGGGTCGCCCTGATGCCAAGAGGCGTCGAATGATGGCGGGAACGACGCCAAGCAGCTCCCCAGCCGCAGCGGACACAGCCGTGTCGACGCCCTCGTCAAATGATCAACCAGATATCAACGCGGCTGTGGCTCCGCCTCAAACGGATGCGCATGGCGGCAAGGCGCCGCAGTACATCAATGAGAATGGACAACTGATTCGAATTGTCCGTATGCGTCaggaggagatcatcaactgCCTCTGTGAGTACGGCGAGGAGGATGGCCTGATGATCCAGTGCGAGCTGTGCCTGAGCTGGCAGCATGGCGGCTGCAATGGCATTGTTAACGAGTCCCAGGTGCCGGACAAGTATGTCTGCTATATCTGCCGCAATCCGCCACGAGTGCGCAAGTCGATGCGGTACAAGCACGATCAGGAGTGGCTGTTCGATGGCAAGCTGCCAGCGGCCGCGTATCACACAACGAGCCTATTTACCGGCAAGCAGTCTGAGCTGCTCAAGCGCTCCCACACGCTCACTGGAAATCTGCTGGATGCCAAACGCGCGATGCACTCGCTGCGCGTGAAGATGAACATTTCCCGCAATCGCTGCCATCCCAAGCTGTACCTGTGGGCCAAGAAGTGGGATGAGGACCAGGGTGAAGCCTCAACGACACCATTGAAGCGCCCCAAGCCAGAGCAACCCGGTTTTCCCAATATCCCACAGCCCGAGGCCGCCATCGATCCCGAGGAGTGCCAGTTTCGCTTAATCGAGCATGTAAAAGTGCAGCAGTCCCTGGTCATGAATCGTCTCAACGAAATCGAGGCCGAAATGGATGAGCTAGAAAGGGAGGATATACTTAGTGATCTGAAGGACGCGGACATCTCAGTGACCAAAGAGGCCGTGGCCACATTTGTCAAAGAGCTGGAGACGCTGAAGCGTCTGGCTCGCCTCAACTATGTGGGCAATGAGAACAGTCTTAAAGACAAGGAAGCAGGAGCCACGGCCAATTAA
- Protein Sequence
- MGRRCCVAKCPSTSRLLEHHGVTYHSFPLDPIIRTIWIKNSRISLDRQITKSVLVCSRHFRRVDFNTIRNGKYLLKPRVFPTVFPWGKMDAAEIEADHRALQQVNVDGTAAHGASTSSGNEDVIKATVDQIVSQIMAETAERNATAAVEAAGNAEKEKEVAKAAVAEEAESAAKEGGSIGEDSAETPTTEGGESAAAAESSADSPVPSASNQPKYSSPHNLIIGARLEAKSVDGSWLPARIVEVNETEQTILIRFERNNKIKVMPSSMGTYQEWMAVKSDRVRQRVSNRILPVFELEEKCMARWSGPRKFPGTIKKLLGHDTYEVLFDDGYSKNVRAVHMNKLPKPAAVEEVETAPASTTTALKRASTGTAPGTASGSSTGASSSKKSKNSQRKDWPLLDMSTLDIDSLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPTGWIKHMYQRSNVLGKWDVILVSPNGKRFRSKSDLKLFLESQGLVYNPDVYDFSIHRRRAKDINAYVYTGDYSPQPPHKPKTMNVSALDTTVDQSNTTLPAISTPSTPISAAGPPHPGDIQYMETPVASLMPPAELMSPPSHQTDDGHPTADMPEVTGSVASLNVPVDEQGTVLVENGYAFIGGLKVSIVDNLFVCPGEGCGKTYRKEDVLLIHIRHYHKEFAEYVSHCPKMQELAVKRTHASSIDQGDAVPKNQIPNQQFFAKMHQQDMQQSRSFKRLGATPGATPSPKTPGTPAGVSPTKSQASPIVDKPATPLAAAESTVTPEAVISPKTSGAAAAGAAATGAADAAAAAAAAATTTTATAISSPTVSQDSPLGRSNKRPRYSSSRRSSGSRKSNRQNSRRRPANATPAGAITADADSEEMRPSLKTTTPEGRPDAKRRRMMAGTTPSSSPAAADTAVSTPSSNDQPDINAAVAPPQTDAHGGKAPQYINENGQLIRIVRMRQEEIINCLCEYGEEDGLMIQCELCLSWQHGGCNGIVNESQVPDKYVCYICRNPPRVRKSMRYKHDQEWLFDGKLPAAAYHTTSLFTGKQSELLKRSHTLTGNLLDAKRAMHSLRVKMNISRNRCHPKLYLWAKKWDEDQGEASTTPLKRPKPEQPGFPNIPQPEAAIDPEECQFRLIEHVKVQQSLVMNRLNEIEAEMDELEREDILSDLKDADISVTKEAVATFVKELETLKRLARLNYVGNENSLKDKEAGATAN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00480891;
- 90% Identity
- iTF_00473813;
- 80% Identity
- iTF_00517742;