Basic Information

Insect: Drosophila hamatofila
Gene Symbol: zfh1
Assembly: GCA_035045345.1
Location: JAWNPA010000020.1:11898121-11902269[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4.8e-05 0.0035 17.9 1.7 1 23 150 172 150 172 0.97

2 15 0.00088 0.065 13.9 1.2 3 23 180 200 178 200 0.94

3 15 9.6e-05 0.0071 16.9 0.1 1 23 364 386 364 386 0.98

4 15 0.012 0.91 10.3 0.9 1 23 392 414 392 414 0.98

5 15 3.6e-05 0.0027 18.2 2.2 1 23 445 468 445 468 0.95

6 15 0.00014 0.01 16.4 0.5 1 23 494 516 494 516 0.95

7 15 0.019 1.4 9.7 1.3 1 23 522 545 522 545 0.97

8 15 0.028 2.1 9.2 0.5 3 19 554 570 553 571 0.95

9 15 0.00017 0.012 16.2 5.6 1 23 580 602 580 602 0.97

10 15 0.043 3.2 8.6 1.2 2 23 608 629 607 629 0.96

11 15 9.8e-06 0.00072 20.0 1.0 1 23 638 660 638 660 0.98

12 15 0.00023 0.017 15.7 0.5 3 23 668 688 666 688 0.97

13 15 5.9e-05 0.0044 17.6 0.5 1 23 694 716 694 717 0.95

14 15 0.057 4.2 8.2 0.4 1 23 727 749 727 749 0.97

15 15 0.0006 0.044 14.4 0.5 1 23 1256 1278 1256 1278 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4.8e-05	0.0035	17.9	1.7	1	23	150	172	150	172	0.97
2	15	0.00088	0.065	13.9	1.2	3	23	180	200	178	200	0.94
3	15	9.6e-05	0.0071	16.9	0.1	1	23	364	386	364	386	0.98
4	15	0.012	0.91	10.3	0.9	1	23	392	414	392	414	0.98
5	15	3.6e-05	0.0027	18.2	2.2	1	23	445	468	445	468	0.95
6	15	0.00014	0.01	16.4	0.5	1	23	494	516	494	516	0.95
7	15	0.019	1.4	9.7	1.3	1	23	522	545	522	545	0.97
8	15	0.028	2.1	9.2	0.5	3	19	554	570	553	571	0.95
9	15	0.00017	0.012	16.2	5.6	1	23	580	602	580	602	0.97
10	15	0.043	3.2	8.6	1.2	2	23	608	629	607	629	0.96
11	15	9.8e-06	0.00072	20.0	1.0	1	23	638	660	638	660	0.98
12	15	0.00023	0.017	15.7	0.5	3	23	668	688	666	688	0.97
13	15	5.9e-05	0.0044	17.6	0.5	1	23	694	716	694	717	0.95
14	15	0.057	4.2	8.2	0.4	1	23	727	749	727	749	0.97
15	15	0.0006	0.044	14.4	0.5	1	23	1256	1278	1256	1278	0.98

Sequence Information

Coding Sequence: ATGAACAACCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCCGCGGTGGACTCCGAGACCGACCTACTGGAAAACGGCGCTGGCGACAGCGAGGTAACGTCCGCATATTTGGTCAATGGCAATGCCACCGACGAGGATCTCGACCATATGGCAGCCGAGAATCTCATATTCATGGCGCGCGATGGTCAGCTAAGCGAGATAATTGCTGCCAACGAGAGTGGCGGCAGCACCGTCTTAATTACGGACAGCGGAACTGTTTCCTACGCCGCGGCGTTTGACGAGGATGCCCAGGTGGTCACCGAGGAGATCATCACGGATGACTGGGTGCAGCACCAGGGCGCTGAGCGCGTGGAAATCGCTGCGGAACAAATTGCGGGCAACAACAGCTCGCAGGAGCTGCTGGACATGGAGCAGGATGAGTACACGGCACTGCGACCCTATCCCTGTGACTTCTGCAGCCGACGCTTCCGCAAGAAGACCAGCCTGAATAATCACATGCTGGCGCATCAGAACGATCGTCCGCATCTGTGTAAATTGTGCGGGGCTCGGTTCTCGCGGCGGGCCGAGCTCATCAGTCACTTTAAGGCGCATGCCGAGGCCCAGGATGCGGCCGATGCGGCGGCAGCAATCAAATTCGAgccgccacagcagcagcgccaaatGGACGACCATTTCTATGAGCAGGAATGGTCGCTGTACCAGGTACAGGAAGACGATCAAGTGCAAcaggagctgcagcaaatggagcaagagcagcaggaacagcatgagcagcaggagcaggagcaggagcagctggtGCTGCCGCAGGCCAGCTATGCAGCAATCAGTGATGTGCCCGCGCCAATAGCCACGCGTGGTCGTATCAGCCGCCTCAAGCCCAAAGAGGAGAGCACTCAGTACATTGTGATTGCCGAGAAGCAGGCAGCGGACGACCTGCAGCCCTACATGGAGTGCGAGGAGCTGCCGCCCACGCTGACGAGTAACACCTCCATCGAGGCGACGTCGGTGACGGTCAGCGTGCCAGTTGCTGAGACGGCGCAGGCTCAGCGCTTTCCGGTGATAGACGACAGCAAACCTTTTGTGTGCCAGCAATGCGGCTTGGCATTTGCGCGCGAAAAGGCGCTGGTGTCGCACATCAAGAATCATCGCGTGGACTCTCCGTTCGAATGCAACCAGTGCCAGGACATGTTCTGGGACAATTACAGCCTGCAGGAGCATCAGAAGACACACCAGTTTGAGGAGAGCAATTCGGAGTACGACCCGGCCTCGGCTGGCGAGGACAGCGCCAGCGAGTCGGATCCGGATAAGCTGTACGGTGACTTCTACTGCAGCGAGTGCGGCATTTCATTTCACAGGCAGGACCTGCTGCGTCGCcatgccaagcagcagcacaagcagcTGCCCACGGATGTGGAGGGCGTCGCTGGCGATGCGGATAGAGACGCCGCGAGTGCCAAAGATGCGCAGCATTCTTGTCACACATGCGGCAAATCCTTTCCCAGCGCCTTGGAGCTGCTCGCCCATGCCGAAGTGCATGCGCGCTTCCCGCCCTTCAAatGCGTCCTGTGCGGCGTTAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATTTGCACACGCGCCATCCGCACGAGCTGAGGCCCAACTCCTGCGTGCTGTGCGGCAAGGAGTGTCGCGATCGCAAGGCCCTGATGAAGCACGCCTGGGATCACTCGCGGGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTCCACAACAAGGCGCGACTGAAGCGACACATGGCCTCGCACCGGGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAGGAGTTCCCCGACGGGCGCACGCTGTCCAATCATCGGCATTCGCACAGCACCACCTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATCCATGTGCGCATCCATACGGGCGAGCGACCATATGGCTGCCACTACTGCTGGAAGGCGTTCGCCGATGGCGGAACCCTGCGCAAGCACGAGCGCATACACACGGGCGAGAAGCCCTACGCCTGCTCCGTGTGTCCACGTGCCTTCAATCAGCGCGTCGTGCTGCGCGAGCACATACGCTCGCACCACTCGGGCCTTGATGCAGTGCGAGGAACCTATCACTGCACGGTCTGCTCGGCCGACCTGTCCTCGTCCAATGAGCTCATACAGCATCTCATCCAGCACAGCGACACGAACACCGCCAAACAGCGACAGCCAATCACTGGTCCTCGTAAGTATAAGCGACGCAGGAAACTGCAGCCACATGAGATCGCGCACATGCGTTCGGAGCACAAGGATGGCGAGGATTATGCCAGCGACATGGAGTTCTGTGACCTGGATGTGGAGAATGTGGATGATCTGCTGGAAGGGGCGGACACGTTGCCAACCAAAAAGGAGAAGCGCAAGCGTTCAGCTGCCAATCAGACGAAGGTAGTGAGCAATGGGGCTGGAAGTAGCAACGCCTCCGCTTCGGTGAAGTctgccaacagcagctgggATGAAAAGTTCCTTCAGAcgaacagcaatggcaatggcagcggAGCCAATGCTGATGAGAGCTACAAGGGCTTCTACCAGATTGATTCGCTCGTCGTGGTTAATGATACCACTTTGCCGGCGATTAGCCCGTCCAGCAATTCACAAGGGGCTTCCAAGTCGCGTCGGGGCGGGGGCAAGCAGGCTGAGAATGGCGATAAATCCGCAGGAGgtggcacagcagcagctgcagctggcgcgGAGTCTGGCAAACCCCACGTCGctagcagtcgcagcagcagccgtaagAAGACCAGCAAGTCGACCAAgaccacagccacagcagcatcCGCATCATCCGCAGCAACATCAGCCACGTCGAGCAGTTCGCGTCCACGCATGATACACACGGAGAACACCAGcgagagcagcagccagctgTCCAGCCAGCTGGTCAAGTCGAGCGGCGTCTCCAGTTCGCGAATTGTGGATGACTATGAGATCATATCACCTGCCACCCAGCCGCCCAATCAGATCAGCTCCAGTCCGCTGCACATtaagcaggagcaggagcagcagcagcagcagcgcgtcCTCTTCATGTTCGAAGACCCCCACCTCATCCACACGGGCATGTTGCGGGAGAAGCCCTACGATAAATTCAATCCCAGCATTGTCAATGATCTCGAGGAGATATTGCGCAGTCCGCTCAAGCACGATCGGAATACCCGATTGCGCTTCACCAGCGAGTCTTCGACGACGCCACAGTTTCTGCCCGAGGAGGAGAACCTCATCAAGATTGAACCCACATCGCCAGATCTGCGCGACATGGTGGAGAGCCAACAGCGCGTCAATGCCACGGGTGGACaagcggccacgcccacatcgtCATCCTCGTCGTCGGCGCGCACATCGCGCCACCTGCGACAGCTGACGGCCAACGGCTCCGGCAGCCGGGCGGCGTCCAAGCGAAGCACTGGCAAATCCTCAACTTCCGCTGGGTCCAGCGCCACGAAACCCAGCAGCAACGCATCCTCGACAGAAGCCGTCAGTAAGTCCTACCTCAGCTACGGTGTGGACTCCTacagtgtgggcgtggcaacgaGTGCCAACTCATCGGATGTCAGTTCCGGCTTCTTCTCCATCTCCGAGGTGGTCTCCGCCGCCCACGCAGCCGACGCGgccaaggcagcagcagcgagcaaAACGGAGCGCCGGACCCGCTGCTTCGAGTGCGAGATGTGCTCCTCCATATTCTCGGATCGGGCGCAGCTGCTGGAGCACATGCACATCCACATCTAA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDLLENGAGDSEVTSAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGSTVLITDSGTVSYAAAFDEDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNNSSQELLDMEQDEYTALRPYPCDFCSRRFRKKTSLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAAAAIKFEPPQQQRQMDDHFYEQEWSLYQVQEDDQVQQELQQMEQEQQEQHEQQEQEQEQLVLPQASYAAISDVPAPIATRGRISRLKPKEESTQYIVIAEKQAADDLQPYMECEELPPTLTSNTSIEATSVTVSVPVAETAQAQRFPVIDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQDMFWDNYSLQEHQKTHQFEESNSEYDPASAGEDSASESDPDKLYGDFYCSECGISFHRQDLLRRHAKQQHKQLPTDVEGVAGDADRDAASAKDAQHSCHTCGKSFPSALELLAHAEVHARFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELRPNSCVLCGKECRDRKALMKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCSADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRSEHKDGEDYASDMEFCDLDVENVDDLLEGADTLPTKKEKRKRSAANQTKVVSNGAGSSNASASVKSANSSWDEKFLQTNSNGNGSGANADESYKGFYQIDSLVVVNDTTLPAISPSSNSQGASKSRRGGGKQAENGDKSAGGGTAAAAAGAESGKPHVASSRSSSRKKTSKSTKTTATAASASSAATSATSSSSRPRMIHTENTSESSSQLSSQLVKSSGVSSSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQQRVLFMFEDPHLIHTGMLREKPYDKFNPSIVNDLEEILRSPLKHDRNTRLRFTSESSTTPQFLPEEENLIKIEPTSPDLRDMVESQQRVNATGGQAATPTSSSSSSARTSRHLRQLTANGSGSRAASKRSTGKSSTSAGSSATKPSSNASSTEAVSKSYLSYGVDSYSVGVATSANSSDVSSGFFSISEVVSAAHAADAAKAAAASKTERRTRCFECEMCSSIFSDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00582391;
90% Identity: -
80% Identity: -