Basic Information

Gene Symbol
-
Assembly
GCA_035042345.1
Location
JAWNLM010000177.1:1034213-1035064[-]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 9.2e-08 6.8e-05 22.9 5.3 3 69 27 84 25 85 0.80
2 2 9.8 7.3e+03 -2.9 0.3 13 21 138 146 135 149 0.60

Sequence Information

Coding Sequence
ATGACCAACGTGGAGCCGCAAGTGATTTCCATTAGCATCTCCAGCGGCAAGTCCACCTTGGGCCACCTGCAAACGGTGTCTACCAGGGTCAATTGTCCCGCCTGCGAGCATTTTGAGATGAGCATTGTGGAACACGAGGCGGTCACTTCGCTGCAGTGGCTGCTGAGTCTAACAAAGCTATTcAAGAAATGGTCTGAACGTGTAGATATCAATCATTATTGTGCCCACTGCGGCTGTTATATTGGACGCTATGTGCCCATTGGATGTTACGAGCACTGTATATCCCGATCTGCGCGACAACAGGCAGTCGTGGATGAGATGCGGCTAAAGACGAAACCAAAGGATTGTGCAGTGCGCGCCCAAAAGTCGAGGGAAAACATAATGGCCAAACGGGCCGAGCAGCGTGCCAAGAAACAGacccaaacacaaacacaaaagcaattaaaaataacagaatAA
Protein Sequence
MTNVEPQVISISISSGKSTLGHLQTVSTRVNCPACEHFEMSIVEHEAVTSLQWLLSLTKLFKKWSERVDINHYCAHCGCYIGRYVPIGCYEHCISRSARQQAVVDEMRLKTKPKDCAVRAQKSRENIMAKRAEQRAKKQTQTQTQKQLKITE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00499266;
80% Identity
-