Basic Information

Gene Symbol
TRERF1
Assembly
GCA_035042345.1
Location
JAWNLM010000015.1:7133366-7147990[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.00013 0.0091 16.3 0.2 2 23 359 380 358 380 0.97
2 6 4.1e-06 0.00028 21.1 1.3 1 23 386 408 386 408 0.98
3 6 0.0013 0.091 13.2 2.4 1 23 414 438 414 439 0.93
4 6 0.00062 0.043 14.2 0.8 2 23 710 731 709 731 0.97
5 6 0.0019 0.13 12.7 0.1 1 23 1823 1847 1823 1847 0.98
6 6 9.1e-05 0.0063 16.9 0.8 1 23 1990 2012 1990 2012 0.98

Sequence Information

Coding Sequence
ATGGCTGCCATAAATACGGTATCCAAAAGCATACATCTGCCTCTGACGAATCTCAGCGCTCAGCGTGTGTTGATGTGCAGCGCCTCTCTGGGCAGCGAGGGATCCGTGACACTGCAACTGAGAGATGCGAGTACCTTGGAGACAGCCGATAGTacaacaccaccaacagcaacaacatcgacatcagcaacagcagcaacaacaacatcgcaTCCAATAGCAACATCGTCACTAGGCAGCCAATCAAATGGCGTCACAGTGCTTGGGACATCGTCATCAGCGACGTCAGGAATAACGTCAGCATTGGAAATTGCGCTGACCGTTGGCTATCCGGATCCGGAAATGCTTGCTGATGTTTTAGGCACAATACAGACAGCCTCTCTTAAAAACAAGcatagcagcaacagtaataatagcaacaacagcaacaccagcatcaaaagatgcaacaacaacaagagcagcagcactgCAGCGACAATTCTGAACAATTCAGGAATACATCTGAATAGTCCCAACAAAATAACGATAACACGTCGCAGTGCCAGCAACAAGATTAGCGTGCAGACTGTGAGCACATCGACGAACACGACGATTAGCAGCATTGGTGGTAGCAAGACCAACTACATTAAGAACTGTCTAATacggagcagcagctgcagcaatacGGCAACCAATGTCACAACGCTGGCACAGATtctgagcaacagcagcaccagcagcgcaGCCAGTTTACTCAgtcagcacaacaacaatagcaactgcagcaacagcagcaactttaGCATCGCCTCCTCTGTGGGCAGCATTGGCAGCGttagcagcatcaacagcaacaccagcaacaccagcagcagcagcacttgtagcagcagcaatagcaacgatagcaacagcagcatcggTCAAAGCATAAGCTTCAAGAGCAACAATGTTCAAAATGTTGCTGGCATAGTAACTGCGTCAACAACATCCACgagcacagcagcaaccagcatTGGCATTGTCCACGTCGACAACGCACCCAGAAAGAGTCGACCCAAATTATCTTCCCCAACGCGTCACGGACCTCAGCAGTGTCagATTTGTAGCAAGATTTTTGGAAATGCCTCGGCGTTGGCCAAGCACAAACTGACGCACAGCGACGAACGGAAATACATTTGTGCGCTTTGCTCGAAGGCATTCAAGCGGCAAGATCACTTAAACGGACACATGATGACGCATCGCAACAAGAAGCCTTACGAGTGTCGGGCGGATGGCTGTGGCAAATCATATTGCGATGCGCGCTCCCTTCGTCGTCATTCAGAGAATCACCATAATTGCGTGCCCGCCAGCGAATCACTCTCGCCCACGGCCAGCGTCAGCAACGGCACCGGCATtatcagtggcagcagcattggcaacagcaacggcatcGGAGTCGCCACCAGTTCCCTGAGTCTGTCGCCGGCTACGGCCAGCGGGGATGCCAGCTCACCAGATGGCGCCACCTGCATTCGCACATATATTTCCACTGGCAGCTCCATTGTGGATGCGGCCACTGGAATTGCGCTCTCTGATGAGCAAATCAGAGCAATGAATTTACCCATTAAAACGGGCGTTACTCTGCTCTCGCCCACCACATCGACATGCTCGACAACATCTTCCACCGCATCTTCTGTGTCATGCTCGACATCGGGCAATGTCAGCGGCAGCTCCTTTGTGGCCAGTTCACCCACCATAACGCTCTGTGATGGCGCCACGCTGGAGGCCGAAGGACTCACCCGCGAGCAACTCGATCTGATCAGCAAGATCATGCAGCAGACGAAGCAAACCAGTGCCCAAGTCACAGTCTCCTCGCCCACCAGCGTTAGCTCCTACAAAATCAATACGGAATCGGCCCAGACCTCAACCCGACCAAGGACCTGGAACATGCAATTGCTCAATAATGTGCAAAATGTGACGCTAACCGTGGACGATGGCCCCGAACTGGTTACCTCCGCATCCAGCCCACCCGACGAGGTAAAGGACGATGAGCtaggccagcagcagcagcagctgggccagcaacaactgaaccagcaacaacagctggtCACAGCCATAAATCCCCACCTGCTCAACATTGTGAAGGTCGACAAGCCAGTTGAGTGTAATCTCTGTCACCGTAAGTTCAAAAATGTACCGGCCCTCAATGGGCATATGCGTCTGCATGGAGGCTACTTCAAAAAGGATCCGGAGACAAAGCGCAGCGAGAAGAAGGACTCCGGCGGACCACCACTGCAGACGGCCAGCATTGGAGTGCGCGCCCTCATCGAGGAGAAGATTATAAGCAAGCGCAAGGAAATCAATAAGGGCGCCTTTGCAGTTCCGGCACCACCCAGCAGTGCTGTTAATAGTGGAGTCGTcagctgcaacaataacaataacaacagcagccacaacaacaacaataacaataggaATTCCCATCTGCGTCGCTCCATCAGCGACTTGGAGAGCTTTCTCAGTCCGAAAAATAACGGGAACAGTAGCCTGAGCCAAGCGCTAGCCAACACTTGCAGCACCACCACAACCACAGCGGTGCTGCCGGCTGCAACCACCATTAAGAGCAGCAGTGGTCTGAGTATTCAGCAGATTGGTCTGCCGCAAAGCATCGAGATCTTCAGCGGAGGGCAGAGACAGCCGAAAACTCTGAGTTTGGGCAGTGGTGCAAATACGATTACGATAACCACCAACAATGTGCCAACGACGACCACAATGAGTGCTCTGTCGGCGCTGAAGGGAGCCAGCAGCATTGGCAGTGTCTCTGGCCATGCGGATCACAAGGATTCCACATTGATTGAGCTGCTCAAGCGTGGCACGCGGATTGCCGTCACCTCGAAGAAGGCACAAAACACAAGTACAAATCTGCTGCTCAGCAATGCGGCCAACGCGGAGCTCATTGGGAACAGTGTCCAGGCAGCGACCAGTCGACAGATTATCACCAATAACAATCGCACAGTGATTATACCCTCGGATGTGCATGTCGTGTCCACAAAGTCCAACAAGTTGGCCAGCAACGCCGTAAGCAATGGGAACAGCATCTCTCTGCCGGATGGCACCCCACTCTCACTGACCATTGGAGGCAACCAGGAGAGCATTGGACCAAGCAGCATCTCGGGTGGTGTCAATGGGGTTTATGCGGTCACCTACACGACCAATACGGACGCAGTCGATCTGTTTGGCAACGCCGAGGTGTTCAATGTCTCGGACACTGAAATGCTGTTGCAAACTGTGGACACAATGGAACTGCTTAACAATGAGGAAGAGAATGAGGATGAGGGGCACAAGCAAAGCGAACATTCCGAGAACTTTCCGCTGCTCAGCAATGTTGAGGACGATGTGCTGATCAAACTGGAGCCAGAGTCGGGCACACCCAATACCAACACGAACACCAACCCAAGTCAGACAACAACGCCGTTGCCCACGTTTCAGCAATTCCATTCCAAGGAGCTCATCATGGAGAACAGCTCACAGATTCAGGCGATTGCCAACATGCGAGCAGGTGTTCTCACATCACCATTGCATTCGCCATTGGCTTATCCGACTCCGCCGTCCAGTCACGAGAATGTCGCCCAATCCTCGCCCTTTATCGAAGATGCTGCGGCTCAGTTTGTGGACGCCAGCCACACGTTCTTCGGGGACAAGACAGATTTCTCGCAGGTCTATTTCAAGACGGATGACGAgtgcatgcagcagcagctcaatgAGAATGACAATGAGAAGATACTCAAATTGAAGACGGTGCTGGAGGAGAGCGCTTTTGATGCTTCGATCAAGGTGGAGGATCTCCTAAATGGCACGGAGGATGATGCTGAGTGTGATCTGCGAGAGTTTGCGGAGACTAATTTGTCGTTTCTTGATGAGGATCAGGAGTTCCTGAATGACTCACGCAATGTCACCTCGCCTCTCTCGGAGTCCTTCTTCACCAGTGGCATCGGTTCCGCCGAGGATGTTAAGCAGGTGCTTCGCGAGGTTCTTCCGGATGAGAATATGCAATTGCAGCTGAGCAGCGAACAGATGGCTGAGAATATCATCGATCTCTACTATTTGCCCGGATTGGGTCTGCAATCGCAAATGATGGCCAACTCAGATGATCCGCTCTTGTCCTCTTCCCCCCGAGATTTTGGCCTCCAGCGTCAGGTGGTCCATGCGGCAACTTCTGTGACTTCATCAATGGTACCATCCATGGAGCAGTTGCAGGCTTCCGGGATCATGTTTGAGCAACAGCCGCAAGAGCAGcaaaaccagcagcaacaactgcaacctcagcagcagcagcaacaattgcagatCGGCCAaaatccgcagcagcagcaacagtcggaCTTCATGCTGTCCAACTTTACTCCGGACTCCTGTCAAACGCAGTATTTAAATGCCAATCAGCAGTCGATGACGATGCAGCCACTCAACAATCTGCTGCAGCCATTGCTATtcggcagcaacaatagcagcaaccacatcgacaacaacagcatcgatAAGCAACAAGAGTTTGGAACGCTTCTCCAAACAACAAATGGACAAACATCCGCTCTGGATGCTAGCCTGATCTTTACCTGCGGCGAGGGAATCAAAAGTAATTCCAACAGCAACCAGTCGCTGATTAGCAACTTACCCGCAGCAGCATCTGTGTCGACACCAACATCCAGCTTCTCCAATCTGCAACCGTTGTCCAATCAAACGAATTCCATATTGAAGCGTCGACTGCGCTCAAATGGTGCACAGGATGTGCACAAGTTCTCCAAATTCCATACGCTGTCGCCACATCGCTCCAAGCTGCGAAAACCCTCGCGCACCCACTACACTCCATCGCCAATATTGAATCCGGATCGGAAGGGCACTGGACTCTATTATAATGTTCGCAACCAGATTGGTCAAAACATTTTCGATGTCTTTGATGATGATTTTGGTGATCCCGTGGGCCTGGTGGACTTCTCCGATGATTCGAAAGTGAATCTGGGCTCGACGTATCAGGCGCAGATCCCCTCCTGCAAGCCACTCGAAGAGGCCATCAAGGAGACAATGTGCGCGGACATGATGTGGGATCCTAGCGTACAGATCGACGAGAAGATACTGATGCGCTACATAGATCTCAGCAAATCCTCGGCCGTGCCCATGGGCAGCCATTCCGAGGAGGTAGCCCTCCAAGCACTGCTTGAGGCGCAGGGTAACTCGGCGGCCGCCGTGTTGACCCTTCTGCAGACGCAGTCCAGCGCATTCCAAATGAAATGGACAGCCTACGAACTGGAACACTTTCTACGTGGCCTGGAAAGGCATGGCAAAGACTTTGGCAAAATAGCCAGCGAGcTGCTCACGAAGACATCGGGCGAATGTGTgcaaatgtattatttttggaaGAAACTCTGTGTTGATTACAAGGTATCCCACCTAAAAATGGAGCCAGTGCAGCCCAGCACCCCAGTCGTGGAGCAGAAGCCCTACGTTTGCGAGATTGCTGATTGCTCGGCGAGCTTCAGCTCAAAGGCGGCGCTGCACGGTCATGTTCGCATACACGCTTATGGTAGaaatgccagcaacagcaacaacagcaacaacagcagcaatagcaacaacagcaacaacaacaacaatcagcatGCCACGGCAATTAGttccaacaacagcaacaacaacaacaccaataacaGCAACGCATGCGCGCCCCAGCCTTGTAGCAATAGCAATCAATGCAACagtgcaacaataacaacagcaacatcaacagtaGCGCACACAAAtggcaataacagcaacaacatcaatgccaatgccaatgccaacaacaataacagcaacaacaatatgaacaacaacagcaacaacaactccaatGCAACTGGCAATTCCTTAAACCCAACAttgctgccagcagcagcgacaacaacaacagcaacaaaagacaacaacagcaacaattccAATATTGCAAAGGACACCGAGTTCCCCTGCAAAGTGTGCGGCAAAGTCTTTAATAAGGTGAAAAGTCGCAGCGCCCATATGAAAACGCATCGAGTGCAAGAATCAGAACAATCAACCAATTCCAAACAGCAATCGGCAACCAATGCGAATCTATctgctgttgcagtggcagtggcactggcagcagcgtcagcatcggcagcatcagcagcagcagcagcaacagcatcagcagcagcagcatctgtggcatccacagcagcaacagcaacagcatcagcagcacccTCTGCTTTATCGGTTGCGGCATCCACCTCGTCGTAG
Protein Sequence
MAAINTVSKSIHLPLTNLSAQRVLMCSASLGSEGSVTLQLRDASTLETADSTTPPTATTSTSATAATTTSHPIATSSLGSQSNGVTVLGTSSSATSGITSALEIALTVGYPDPEMLADVLGTIQTASLKNKHSSNSNNSNNSNTSIKRCNNNKSSSTAATILNNSGIHLNSPNKITITRRSASNKISVQTVSTSTNTTISSIGGSKTNYIKNCLIRSSSCSNTATNVTTLAQILSNSSTSSAASLLSQHNNNSNCSNSSNFSIASSVGSIGSVSSINSNTSNTSSSSTCSSSNSNDSNSSIGQSISFKSNNVQNVAGIVTASTTSTSTAATSIGIVHVDNAPRKSRPKLSSPTRHGPQQCQICSKIFGNASALAKHKLTHSDERKYICALCSKAFKRQDHLNGHMMTHRNKKPYECRADGCGKSYCDARSLRRHSENHHNCVPASESLSPTASVSNGTGIISGSSIGNSNGIGVATSSLSLSPATASGDASSPDGATCIRTYISTGSSIVDAATGIALSDEQIRAMNLPIKTGVTLLSPTTSTCSTTSSTASSVSCSTSGNVSGSSFVASSPTITLCDGATLEAEGLTREQLDLISKIMQQTKQTSAQVTVSSPTSVSSYKINTESAQTSTRPRTWNMQLLNNVQNVTLTVDDGPELVTSASSPPDEVKDDELGQQQQQLGQQQLNQQQQLVTAINPHLLNIVKVDKPVECNLCHRKFKNVPALNGHMRLHGGYFKKDPETKRSEKKDSGGPPLQTASIGVRALIEEKIISKRKEINKGAFAVPAPPSSAVNSGVVSCNNNNNNSSHNNNNNNRNSHLRRSISDLESFLSPKNNGNSSLSQALANTCSTTTTTAVLPAATTIKSSSGLSIQQIGLPQSIEIFSGGQRQPKTLSLGSGANTITITTNNVPTTTTMSALSALKGASSIGSVSGHADHKDSTLIELLKRGTRIAVTSKKAQNTSTNLLLSNAANAELIGNSVQAATSRQIITNNNRTVIIPSDVHVVSTKSNKLASNAVSNGNSISLPDGTPLSLTIGGNQESIGPSSISGGVNGVYAVTYTTNTDAVDLFGNAEVFNVSDTEMLLQTVDTMELLNNEEENEDEGHKQSEHSENFPLLSNVEDDVLIKLEPESGTPNTNTNTNPSQTTTPLPTFQQFHSKELIMENSSQIQAIANMRAGVLTSPLHSPLAYPTPPSSHENVAQSSPFIEDAAAQFVDASHTFFGDKTDFSQVYFKTDDECMQQQLNENDNEKILKLKTVLEESAFDASIKVEDLLNGTEDDAECDLREFAETNLSFLDEDQEFLNDSRNVTSPLSESFFTSGIGSAEDVKQVLREVLPDENMQLQLSSEQMAENIIDLYYLPGLGLQSQMMANSDDPLLSSSPRDFGLQRQVVHAATSVTSSMVPSMEQLQASGIMFEQQPQEQQNQQQQLQPQQQQQQLQIGQNPQQQQQSDFMLSNFTPDSCQTQYLNANQQSMTMQPLNNLLQPLLFGSNNSSNHIDNNSIDKQQEFGTLLQTTNGQTSALDASLIFTCGEGIKSNSNSNQSLISNLPAAASVSTPTSSFSNLQPLSNQTNSILKRRLRSNGAQDVHKFSKFHTLSPHRSKLRKPSRTHYTPSPILNPDRKGTGLYYNVRNQIGQNIFDVFDDDFGDPVGLVDFSDDSKVNLGSTYQAQIPSCKPLEEAIKETMCADMMWDPSVQIDEKILMRYIDLSKSSAVPMGSHSEEVALQALLEAQGNSAAAVLTLLQTQSSAFQMKWTAYELEHFLRGLERHGKDFGKIASELLTKTSGECVQMYYFWKKLCVDYKVSHLKMEPVQPSTPVVEQKPYVCEIADCSASFSSKAALHGHVRIHAYGRNASNSNNSNNSSNSNNSNNNNNQHATAISSNNSNNNNTNNSNACAPQPCSNSNQCNSATITTATSTVAHTNGNNSNNINANANANNNNSNNNMNNNSNNNSNATGNSLNPTLLPAAATTTTATKDNNSNNSNIAKDTEFPCKVCGKVFNKVKSRSAHMKTHRVQESEQSTNSKQQSATNANLSAVAVAVALAAASASAASAAAAATASAAAASVASTAATATASAAPSALSVAASTSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00485798;
90% Identity
iTF_00498811;
80% Identity
iTF_00511213;