Basic Information

Gene Symbol
-
Assembly
GCA_035042345.1
Location
JAWNLM010000204.1:4239379-4242791[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.3e-05 0.0016 18.8 5.5 1 23 167 190 167 190 0.97
2 15 0.00073 0.05 14.0 1.5 1 23 242 265 242 265 0.97
3 15 0.001 0.072 13.5 3.8 1 23 331 354 331 354 0.94
4 15 0.015 1 9.9 0.2 2 23 406 427 405 427 0.96
5 15 0.019 1.3 9.6 0.6 1 23 570 592 570 592 0.94
6 15 0.00027 0.018 15.4 2.1 1 23 599 621 599 622 0.95
7 15 0.00043 0.029 14.7 1.4 2 23 630 651 629 651 0.96
8 15 0.014 0.96 10.0 0.1 2 21 678 697 677 701 0.88
9 15 0.11 7.5 7.2 0.9 1 23 739 762 739 762 0.95
10 15 0.37 26 5.5 2.6 1 22 769 790 769 790 0.96
11 15 0.0037 0.25 11.8 0.5 2 23 800 822 799 822 0.95
12 15 1.5e-05 0.001 19.3 0.5 1 23 842 865 842 865 0.97
13 15 0.092 6.3 7.4 0.2 1 23 875 897 875 897 0.94
14 15 2.3e-05 0.0016 18.7 3.3 1 23 903 925 903 925 0.99
15 15 4.9e-05 0.0034 17.7 0.9 1 23 931 953 931 953 0.98

Sequence Information

Coding Sequence
ATGACAAGAACGTGTAGAATCTGCGGTGGCGCAGATGGACGCTTCTCGATCGAGACGCCAGTTGATAAATACGCGCAGAAAACATTTAATCACTTGCTGCTGGAGCTAACAAAACTTGAGGTCTCTGTGGATCAAGCAGATAAGCTGCCGCCATGGATTTGTCGCAACTGTGTGCACAGATTAGAGAACGCATATGACTTAGTATTGCAGGCGAGAGAAACGCACGAGCTTTGGCTGCTCAAGCTGCAAACAGAATCTCTATCGGAGGACACTGAAACTGGCACGTTGGAGTGCCTGCGAGAGACACCCATTCAATTGCTAGAGATTGAGGGCGTCACAATTAAAATGGAGGCGACATCCGAACCAGTCGTGCCCCAAACAGATTCAGTCAGCTCGATTGATCCGCTAATTAAAAAGAACCTAGAAGATGATGCTAGTGACGATGATGATATGCCGCTCAAGAAGCGGCGGATTGCATACACAAAACTGACGACGATGCATAAGTGCAATAAGTGCGATAAGGTGTTCAAATATGTAACGAATCTATTTAGGCACAAGCGACGAGATCACAGTCCAAAACGCAGCCAAACCAAAAATCAAGCAGCAGTGGAGAGTGAAAAGACTGATGGCATGAAACCATTCCTAAACGATGTAATCAAGAATTCTAGTGCAACAACACGCAGCAGCGAGGCAGACTTGGAAAGCGGATCTGAGGATAACTACTACAAGTGCGATCAATGCGACAAATCCTACGAATACATAATGCTGCTGATCAAGCACAAGCAAAAGACGCACGCTTCTAGCCAGCGTCCAGCAGAGCCCAGACCCATTAGAAAAAGCGGTTCTAGTTCAGAGCAAACTAATACTATACTAGGATCACCGTCTCAGCGTTCTAAACCGACCAGCACAGATTCCCTGGTGCACAGCATCATCAAAGAAATCAACTTACCGGATGAAGAAGATGCAGACAGTTCAAGTGCCGACAATTACTACAAGTGCGATCAGTGTGACAAGTCGTTCAAATACATTGTGAGTTTCATCAAGCACAAGCACAACGAGCACAAGGAGTACGGGGATTCCGATGAGGACGAGGATGAGGCAACATCTTCCAGATATGCAGCAGATGTCACTGCCATGTCGAAGCCCTCGCGCATTGATCGTCGCGTCAAGGGCTTTGATTTGAATCGCTGCCGGCCGAACGGTTCCAAGGCGATTCAGTGCATGATCTGTCTGCGAATATTCATCAAGTTGCGCGAACTGCGCGATCATCTAAAGGCCCATCCCACAGACTTTACATTTGATGCTCATGGCGAGCCGATTGAACGCATTGCCGAGGGCTTCTATAAAACAGCCGTAGAGTCCACAGTTGTGGGCTTGAAGCGACGCATATTTCATGATCTCAAGGTGGGCTTGCTCGGACGCTACTATTCCATAACAAATGAGGCACGCTATGAGATGAATCTGGACAGCTCGGACACGGACAGCGACGGCGAAGCGGATGTTGTGCAGCGGCATTCGTATGCCTGCGAACTGTGCGACTCCGCCGATGCGGTATGGCCACGCAAATATCAATTGCACGAGCATCATCGGCAGCATCATACCTGGCTGGAGGCGCCGCACGTCTGCCAGCGATGTGACTCTCGTTTTCTGAGCGCCCAACTGCTGGACCACCATACGCACAAATTGTGCCAGAACACCCTGAAGCGTTTCATGTGCGACAAGTGTCCACAGCGCTTCTTCTGGCGACGCAATCTACGTGCGCATCTTGTCGAGCACAAAAACAAGcAGGAGACGTATCCGTGTGATCAGTGCTCGCGCAGTTTTCAGGACAAGAGCGCCGTGACGAAGCACAAGTTGATGCACCACGATGTCCACAACGAGCTGCTGCCCTGCCGTTGGTGCACGCGCACATTCTATCGTCCGGCGCTGTTGCACAAGCATGTGCAGCGTCACGGCTTTAGTGGGGAGGATCTGCCTCTGGCAGAGACACTGCTAGCGGATGCCGCCAAACCATCCGGTACAAAGACGATTGTCTGCAAGTTGTGCGACATGCAGTTTATTAGCATTGCCGATCTCCGGCGACACAACTCGATGCAGGCGCACGGTGAGCAGATATCAAACTATATGATAAGCACCGAGGAGGGATTCGAGCTGCAGCTAGATGAAACGGACGAGAGTGATGAGGAGCCTACGAGTACTACGGCCAGCCGATCTTATCGGTGCGATCTGTGTGAGATGAGCTTCCTACGAAGACGCGACATGAGCGAACATCAGTATTCGTTGCACACCTTCGACAAACTGCCACATTCCTGTGAGCATTGCATTTACAAGACAGTCGATAAGACCATGCTGGAGCATCATCTACGCACACAGTGTCttaacaaagaaaagaaattaaagtgTTCGCGTTGCGGCTACAAATTCATGTGGCGTGAAAATTTGGAGCAACACATGAGCATTCTGCATCCCAAGTCATCATCTAGTCAGACGGCCGTTGCGGCAAAGAGAAGCCGACGTTTCCGATACCAGTGTCCACACTGCTGGCGCTCGTTTGTTGTACAACCCAGCTTGGACAAGCACATTCGGGACATGCATGTGGCGAAAAAGAATCCCGGCAAGAAGTATCTCTGCTCGCTGTGCGGCCTGGAGTCGCTTACCCCGAATAAGCTCAGCATACACATGCGGCGGCACAACGGCGAGAAGCCATTTAAATGTGATCTCTGCGATATGTCCTTCACCGTGCACTACGAACTGAAGGTCCATCGCCGCAAGCATACCGGTGAGCGACCCTATCAGTGCACATTCTGTGCCAAGGATTTTGCCCGGCCGGATAAGCTAAGACGGCATGTTTACATGCATAGCGTTAAGCGTTAA
Protein Sequence
MTRTCRICGGADGRFSIETPVDKYAQKTFNHLLLELTKLEVSVDQADKLPPWICRNCVHRLENAYDLVLQARETHELWLLKLQTESLSEDTETGTLECLRETPIQLLEIEGVTIKMEATSEPVVPQTDSVSSIDPLIKKNLEDDASDDDDMPLKKRRIAYTKLTTMHKCNKCDKVFKYVTNLFRHKRRDHSPKRSQTKNQAAVESEKTDGMKPFLNDVIKNSSATTRSSEADLESGSEDNYYKCDQCDKSYEYIMLLIKHKQKTHASSQRPAEPRPIRKSGSSSEQTNTILGSPSQRSKPTSTDSLVHSIIKEINLPDEEDADSSSADNYYKCDQCDKSFKYIVSFIKHKHNEHKEYGDSDEDEDEATSSRYAADVTAMSKPSRIDRRVKGFDLNRCRPNGSKAIQCMICLRIFIKLRELRDHLKAHPTDFTFDAHGEPIERIAEGFYKTAVESTVVGLKRRIFHDLKVGLLGRYYSITNEARYEMNLDSSDTDSDGEADVVQRHSYACELCDSADAVWPRKYQLHEHHRQHHTWLEAPHVCQRCDSRFLSAQLLDHHTHKLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKNKQETYPCDQCSRSFQDKSAVTKHKLMHHDVHNELLPCRWCTRTFYRPALLHKHVQRHGFSGEDLPLAETLLADAAKPSGTKTIVCKLCDMQFISIADLRRHNSMQAHGEQISNYMISTEEGFELQLDETDESDEEPTSTTASRSYRCDLCEMSFLRRRDMSEHQYSLHTFDKLPHSCEHCIYKTVDKTMLEHHLRTQCLNKEKKLKCSRCGYKFMWRENLEQHMSILHPKSSSSQTAVAAKRSRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLSIHMRRHNGEKPFKCDLCDMSFTVHYELKVHRRKHTGERPYQCTFCAKDFARPDKLRRHVYMHSVKR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00567692;
90% Identity
iTF_00570569;
80% Identity
-