Dfun016108.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila funebris
Gene Symbol
PAX6
Assembly
GCA_018901825.1
Location
JAEIFK010000219.1:359694-372856[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.2e-72 7e-69 229.4 0.6 1 125 33 157 33 157 0.99
2 2 6.6 1.1e+04 -3.8 0.0 28 52 512 536 509 541 0.69

Sequence Information

Coding Sequence
ATGATGCTAACAACGGAACACATCATGCATGGACATCCCCACTCGTCTGTGGGCGTGGGGGTGGGCCAAAGTGCACTCTTCGGATGCTCAACTGCAGGGCACAGCGGAATTAACCAACTTGGGGGAGTTTATGTTAACGGTAGACCCCTACCGGATTCTACACGCCAAAAAATAGTCGAATTGGCTCACTCCGGCGCACGCCCTTGTGATATTTCCCGAATACTTCAAGTTTCCAACGGATGTGTTAGTAAAATATTAGGCAGATATTACGAAACAGGATCAATAAAGCCTCGAGCCATAGGAGGTTCAAAACCCCGAGTAGCTACAACGCCCGTCGTACAAAAAATTGCCGATTACAAAAGGGAATGTCCCAGCATATTTGCTTGGGAAATTCGGGATAGATTGCTATCGGAGCAAGTATGCAATAGTGATAATATTCCAAGTGTTTCATCTATTAATCGGGTGTTGCGCAATTTAGCTTCACAGAAGGAACAGCAGGCGCAACAACAAAATGAGTCTGTGTATGAAAAGCTTAGGATGTTCAATGGACAATCTGGTGGTTGGGCCTGGTACCCTGGCAATACGACGACGGCCCATTTGACGCTTCCACCAACTCCCACGGCTGTACCATCGAATTTATCTGGTCAGATTGTTCGAGAGGAAATCCAAAAACGCGATCTTTACCCAGGTGATATTTCTCACCCAAATTCACACGAAAGTACATCAGATGGTAACTCCGATCATAACTCATCCGGGGATGAAGACTCGCAGATGAGACTACGGCTAAAACGTAAGCTTCAACGGAACCGCACATCTTTTACCAATGAACAAATTGATAGCTTAGAAAAAGAATTTGAACGGACGCATTATCCTGACGTTTTCGCTCGTGAGCGGCTTGCAGAAAAAATTGGTTTGCCAGAGGCACGTATTCAGGTTTGGTTCTCAAATCGAAGGGCTAAATGGCGAAGGGAAGAAAAATTGCGTACTCAAAGACGTTCGGTTGATACTGTGGGTGGTAATAGCGGACGGGCAAGCACAAATAATCCCTCCGGAGGCACTGCACCCACTAATGCAACAGCCGCAAACAATTCCACACCCGGGATTGTTAGCTCAGGTGGTTCTGAGGGAGCCTCAGCAGCCCATCCAGGTAACAACAACAATAACCTGACTGAGACTTCGAATGGGCCAACAATACACGGAGGAGATGTTAGTACCGCACATACAAATTCCGAGAGCCCGCCCCTGCAAGCCGTTGCACCCCGTTTGCCCTTAAACACAGGTTTCAACACAATGTACTCATCTATCCCGCAACCCATCGCAACTATGGCTGAAAATTATAACTCAATGACATCGTCATTAAGTTCAATGACGCCCACATGTCTACAACAAAGGGATAGTTATCCATACATGTTTCATGATCCACTATCTTTGGGGTCTCCCTATGCGACTCACCCCAGAAATGCAGCCTGTAACCCAGCAGCAGCTCATCAGCAGCCACCACAGCACGGAGTCTATGGAAACAGCTCTACAGTGACAACAGCCAATACAGGCGTTATTTCTGCCGGCGTATCGGTACCTGTACAAATATCGACACAAAATGTTTCTGATTTGGCTGGTAGTAATTATTGGCCGCGTCTTCAGTGA
Protein Sequence
MMLTTEHIMHGHPHSSVGVGVGQSALFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQSGGWAWYPGNTTTAHLTLPPTPTAVPSNLSGQIVREEIQKRDLYPGDISHPNSHESTSDGNSDHNSSGDEDSQMRLRLKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRTQRRSVDTVGGNSGRASTNNPSGGTAPTNATAANNSTPGIVSSGGSEGASAAHPGNNNNNLTETSNGPTIHGGDVSTAHTNSESPPLQAVAPRLPLNTGFNTMYSSIPQPIATMAENYNSMTSSLSSMTPTCLQQRDSYPYMFHDPLSLGSPYATHPRNAACNPAAAHQQPPQHGVYGNSSTVTTANTGVISAGVSVPVQISTQNVSDLAGSNYWPRLQ