Basic Information

Gene Symbol
RREB1
Assembly
GCA_035042425.1
Location
JAWNLL010000475.1:503402-510882[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.038 2.4 8.8 0.8 1 21 254 274 254 276 0.93
2 13 0.00036 0.022 15.2 0.2 1 23 286 308 286 308 0.98
3 13 8.7e-05 0.0054 17.1 7.3 1 23 314 336 314 336 0.98
4 13 0.074 4.6 7.9 1.8 2 20 553 571 553 573 0.93
5 13 0.033 2.1 9.0 0.2 1 23 715 737 715 737 0.96
6 13 1.3e-05 0.00082 19.7 0.7 1 23 747 769 747 769 0.99
7 13 0.00089 0.055 13.9 2.0 1 23 775 798 775 798 0.97
8 13 0.0032 0.2 12.2 2.0 1 23 1059 1082 1059 1082 0.95
9 13 9.3e-05 0.0058 17.0 0.3 2 23 1450 1471 1449 1471 0.97
10 13 0.16 9.7 6.9 6.3 1 23 1477 1500 1477 1500 0.97
11 13 4.1 2.6e+02 2.4 3.5 1 23 1609 1632 1609 1632 0.85
12 13 0.009 0.56 10.8 0.5 3 23 1685 1705 1683 1705 0.96
13 13 0.0014 0.089 13.3 4.8 1 23 1711 1733 1711 1733 0.99

Sequence Information

Coding Sequence
atgctggccacacagcagcagcagcagcagcacacaacagcaactcaagcagcagcagcaacaacaacagtaagaCAAGAGGATGCGATAATGGAGCGACAGCGTCGTGAGTCAAGCACCTCCGAATCCTCGCTGGAGCACCTGGACTTGGGTCGCACACCAAAGaaactgagcagcagcagcggagcgCCGCagccgacgtcgacgccgcACGAGGCGACGTCGCGCAAACGCAAACtgcgccaacagcagcagcagcagcagcagcaacagcagccgctcTCCGATGAGGAGGAACAGTCgcttcagcagcaacagttgcagtcgcagtcgcagctggAGCCGTCGTCGCTGCGCGCACGTCACAAGCAGCGCCGcagcgcagtcgcagtcgcagtcgctgcctctgccgctgccagCGCCAGCATCGTCGTCGACTACAGCGCCAGCGGCGACGCCAGCTCGCTGCGCAAAAAGTTTCGCCTGAATCGCAGCAGCGCGAatagcaccaacaacaacaacaacaacaatggtgaTCTCTCCGAGTCGGGCTTCGTTGATGGCAGCGCCCACAGCGGCTAtctgctgagcagcagcagcggcagcagcagcgctctcgctctcgctcagTCAGCGtcgacggcggcggcagcggcagcgcagcCAGCGTCGAGCAGCAGCTCCGGCGGCTCCTCGCCACAGGGCCTGTGCCTGTCCAGCGCCGAGTCCGGCCTCGGCGCCGGCGACGACCACATGAAATATCTCTGCCCCATCTGCGAGGTCGTCTCGGCCACGCCGCACGAGTTCACCAATCACATTCGCTGCCACAACTACGCCAATGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCGAAGGTGCTTTCGTCGGCCTCCTCGCTGGACCGGCACGTCCTGGTGCACACTGGCGAGCGTCCGTTCAACTGCCGCTACTGCCACCTGACCTTCACCACCAATGGCAACATGCATCGCCATATGCGCACCCACAAGCAGCATCAGGCgacgccgcagcagcagtcgcagcagcagtcgcagcagcagcagcagcaacagtcgcagcagcagcatcgacgCCAGCAGGGATCGGCTGGAGGATCCGGCTCGGGTTCGGGCTCGGGTTCGGGCTCCCAGTCGCTGCCGACGCGCGCCGAGAGCTATGAGAGCGATGCGAGCAGCTCGACGGATGTGTCCAGTGCGCCCAgtcagagcagcagcagcaatcagtccaacaacaacaacagccacaaagcgaacaataataataacaataatgaggaggaggaggaggaggaggagctgcgaGTGGGCAGCAAGCAGCGACGCCTCAAGacaaacattaacaacaacaacataatcagagatgagcaggagcaggcgcaGGCGCAGGCGCGGGAGCAGGCTGAGGATCACGACTCCGATGTGGACAGCGTGGATGTGGCCCAGATGATCACGAGCACACCGGATGTGGCCACATTGTTGGCCTCCTCGGGCGCCAGCTCGCCCAGCCAGTCGCGATCGCCGCCAttgccgtcgctgctgctcctccagaGCTGTCCCGCCTGCCATCTGGGTGAGTTTGAATCGCTGCCGGCGCTGTGCGCCCATCTGGATGCGGACCACGCGGATATACCCGCCAAGTGTCGCGAATGCGATGTGATCTTTGCCACACATCGGCAGCTGCAGGCGCACAGCTGTCGAGgattgccgccgctgctgggCGTCAGCTCGTCGCCGCTGCACAAGCAGGAGGCGGAGGAGCTGGAcgaggaacagcagcaggatgagcagcgggagcgggagcaggagcaggagcaggaggaggagcgcCAGCAGGAGCGCGAGCGCGAAGACTTCTTTCAGCAGCTGTATCTGAAGGGTAAGTCGGGCCAGCTGCCGTCGCCGATCAAGCATGAGCCGGCGGATCAGCGCCAGGATCTGGCTGACATACAGAGCATCCTGAACAtgaccagctccagctgcacgTCCAGCTTCCTGCGCAACTTTGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAGTACAGCTTGGATGGGCGCGATGGCGAGGAGGAGGCCCAGGATGCCTTCACCAGCGAGTTCCGGCGCATGAAGCTGCGCGGCGAGTTCCCCTGCAAGCTCTGCAGCGCCGTCTTTCCCAATCTGAGGGCGCTCAAGGGCCACAATCGCTTCCACCTGGGCGCCGTGGGCGCGGCCGGACCCTTCCGCTGCAACATGTGTCCCTATGCCGTGTGCGACAAGGCGGCCCTGGTGCGCCACATGCGCACCCACAACGGCGACAGACCGTACGAGTGCGCCGTGTGCAACTACGCCTTCACCACGAAGGCCAACTGTGAGCGCCACTTGCGCAATCGGCATGGCAAGACCAGTCGCGAGGATGTCAAGCGGGCCATTGTCTATCATCCGGCCGAGGATGCCAGCTGTGAGGATGGCAAGTCGGTGCTGCCACGCAGCCAGCTGGCCAGCGCGGACGCGGAACTGGCCGAGCTGAGCTCTGGCTATCGGTGTGTAACGCCCACGGAGCACAGCTCGTCCGCTGCCTCCGCCTGCTCCTCGTCACAGCTGAAGCACATGCTGTTGGCGGATGCGCCCAAGATTCAAGTGAAAAGCCTCGATCAGCTGGTGGACAAGCCGCCGGCCCTCGATCTCAGCATGGATGTGCTGGACCTGAGCAAGAAGCCAACCGTGGcacaacagcaggagcagcagcgcgaGCAGCAACGCGAGCAGCAGCGCGAGCAGCGTGAACGACAcgaattgctgctgcaacagcagcaacagcagcagcagcaacaacagcagcagcaacagcagcagcagcagcagctctttgGTGGCGATGCTGCCACACAGtatatgcagcagctgctgcgcaacTTTATGTTCCAGCAGTCGCCGGGCTTTCCCTTCTTTGGCTTCATGgcgccaccgccgccagctgctgccgccgccgcagaGACAACACCGACGGCAGCAACACTTGCGCCCAGCGTGGCGACACCAACAGTTGCcgcgctgccgctgtcgctgcccgTGCCGCTGCCCGCTGCCGTCGGCGGCGGCCCAGTCAAGATGGTCATCAAGAACGGCGTGCTGATGCCCAAGCAGAAGCAGCGTCGCTATCGCACCGAGCGTCCATTTGCCTGCGAGCACTGCTCGGCCAGATTCACGCTGCGCTCGAACATGGAGCGCCATgtgaagcagcagcatccgcaGTTCTATGCCCAGCGGCAGCGCAGCGGGCACCATGTGATGCGTGGACGCGCTGCTGCCTCGAGTGCGGCAcaggcagccgctgccgctgctgctgctgctgctgcagccatgAGCAAttacagccagcagcagcagcagcagcaacagttgtcgTCGCCGCACTCGCATCATGTGCATGCGCCCATTTCGGAGCAGGTGAAGTATGCGATATTGGCGCAGCAGCTGAAGGCGCGCAAGGATACGGACTtgctgcagcaggcgctggCACACGGCTCCAGCAGTGTTGTCTCCAATCCGCTGCTGCATTTCggctacaacagcagcaagcagaccagcagcaacagcaacatcaacagcaatgGTGGCGTTGCCATGGTGCTGGATGATGATGAGCCGCCCAAGCTGATCATTGACGAGGACGATGAGctggacgaggaggaggaggagcaggaggatgatgatgatgaagaggaggaggagcaggactTTGATGCGGAGGAGGAAgtggacgaggaggaggaggacgatgaAGAGGTCGagctcgagcagcagcagcagcagcagcaggtggcagtggcagcagctgaggtgcagcaacagcagcaattggaGAAAGAAGTGCCAGCCGTTGAGGTGGCCCAGAAGGTAGCGGAAAGCATGCTCGAGCAGGCAATCAAAGCACAAGCGGAGCCCGTCGCCAAGTCGGAGGCCTGCATCCAGGCCGATACGATTACCAAGCCCGCCACACCGCCGCCCAGCAGCACAACCATGAAGTCCATGATTGCCCAAGCGGAGTCGGTGGCCAAGTCGCTCAAGGAGGTGGCCAGTTCGCCGTTCAAGGACGAGTCGCAAGATCTGGTGCCGGTGGCCAAGCTCGTCGACAATGCGACCAGCAACCAGGTGTCCTTCAACAGCTACTTCCGGCCCAGCGACGTGGCCAATCACATGGAGCAGAGCGACGAGGAGGGTCTCGTGGCCAGCGGCAGCGCCAGCGAGAGCAACAACTCCGGCACCGAGGAcgtcaccagcagcagcagcagcagcggcaacgagCCCAAGAAGAAGTCCGCCTACAGCCTGGCCCCGAATCGCGTCAGCTGCCCCTACTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGCCGCCACATCCTGACCCACACGGGCCAGAAGCCCTTCAAGTGCTCGCACTGCCCGCTGCTCTTCACCACGAAGAGCAACTGCGATCGGCATCTGTTGCGCAAGCATGGCAACGTCGAGtcggccatgtccgtctatgtGCCCACCGAGGATGTCAGCGAGCCCATCCCCGTGCCCAAGTCCGTCGAGGAAATCGAACTGGAGGAGCAGCGACGTCGCCAGGCAGCCGAGGCCGAGCAGGCGGAGCGCGAAAAGGAGCGCGAGCGTGAGCTGGAGCGCGAACGGGAGcgggaacagcagcagctcatgcagcagctgcggcaacAAATGgctgcagccgccgccgctgctgctgctgctgcggcagctgttgttgttgtcgcgcCACCATCAGCCGCGAGTCCCGGCGTCGAGCCGAGCAGCGAGCTGCCGTACAAGTGTCATCTGTGCGAGTTCTCCTTTGCGGAGCGGCTGCAGTGCCTCGAGCACATCAAGCAGCTGCATGCGCACGAGTTTGCGCTGCTCCTCTCCAAGGGCGCCATCGAAACggaggcacagcagcagcagcagcaacagttgcccgCTGTGCACTCCGATGATGAGACTACGGCCGGTGCCCGTTCCGGCAAATATCCGGACTATAGCAATCGCAAGGTGATTTGCGCCTTTTGCGTGCGTCGCTTCTGGTCCACTGAGGATCTGCGCCGCCACATGCGCACCCACTCGGGCGAGCGACCCTTTCAGTGCGAGATCTGCTTGCGCAAGTTCACGCTGAAGCACAGCATGCTGCGCCACATGAAGAAGCACAGTGGACGCAGTCACAATGGCGAGCTGGATCATCAGTCCGACTGCTCCGACGATGAGCAGCTGCCGTCGCCGCCCGCAACGCCCAcagtcagcaacaacaacaataacaacaacacttgccacaacaacaacaacaacaacaatagtaatactaataataataataataatagcaagcAATTGCAACGTTTGCCCAAGCTGCATGAACTGATGGACAAGGCCAACCAGTGGCACGTGAGTCGCCTCGGTGAGCACAAGGAGAACATTGCTGAGGCAACAGCCGCGGCAGCAACACcctcggcagcagcagcagcagcggcagcagcagcagctgttgccagcGGTGATCTCATTGGCAATCTGTTGGGCATCAGCGATCAGGGCATACTGAACAAGCTGCTCTCCTCGCCGGACGAAGCCGCCAAGCTGCTCGGCGTGGACAAGTAA
Protein Sequence
MLATQQQQQQHTTATQAAAATTTVRQEDAIMERQRRESSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHEATSRKRKLRQQQQQQQQQQQPLSDEEEQSLQQQQLQSQSQLEPSSLRARHKQRRSAVAVAVAASAAASASIVVDYSASGDASSLRKKFRLNRSSANSTNNNNNNNGDLSESGFVDGSAHSGYLLSSSSGSSSALALAQSASTAAAAAAQPASSSSSGGSSPQGLCLSSAESGLGAGDDHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQATPQQQSQQQSQQQQQQQSQQQHRRQQGSAGGSGSGSGSGSGSQSLPTRAESYESDASSSTDVSSAPSQSSSSNQSNNNNSHKANNNNNNNEEEEEEEELRVGSKQRRLKTNINNNNIIRDEQEQAQAQAREQAEDHDSDVDSVDVAQMITSTPDVATLLASSGASSPSQSRSPPLPSLLLLQSCPACHLGEFESLPALCAHLDADHADIPAKCRECDVIFATHRQLQAHSCRGLPPLLGVSSSPLHKQEAEELDEEQQQDEQREREQEQEQEEERQQEREREDFFQQLYLKGKSGQLPSPIKHEPADQRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSLDGRDGEEEAQDAFTSEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRFHLGAVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREDVKRAIVYHPAEDASCEDGKSVLPRSQLASADAELAELSSGYRCVTPTEHSSSAASACSSSQLKHMLLADAPKIQVKSLDQLVDKPPALDLSMDVLDLSKKPTVAQQQEQQREQQREQQREQRERHELLLQQQQQQQQQQQQQQQQQQQQLFGGDAATQYMQQLLRNFMFQQSPGFPFFGFMAPPPPAAAAAAETTPTAATLAPSVATPTVAALPLSLPVPLPAAVGGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRAAASSAAQAAAAAAAAAAAAMSNYSQQQQQQQQLSSPHSHHVHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVSNPLLHFGYNSSKQTSSNSNINSNGGVAMVLDDDEPPKLIIDEDDELDEEEEEQEDDDDEEEEEQDFDAEEEVDEEEEDDEEVELEQQQQQQQVAVAAAEVQQQQQLEKEVPAVEVAQKVAESMLEQAIKAQAEPVAKSEACIQADTITKPATPPPSSTTMKSMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSSGNEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQAAEAEQAEREKERERELEREREREQQQLMQQLRQQMAAAAAAAAAAAAAVVVVAPPSAASPGVEPSSELPYKCHLCEFSFAERLQCLEHIKQLHAHEFALLLSKGAIETEAQQQQQQQLPAVHSDDETTAGARSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGELDHQSDCSDDEQLPSPPATPTVSNNNNNNNTCHNNNNNNNSNTNNNNNNSKQLQRLPKLHELMDKANQWHVSRLGEHKENIAEATAAAATPSAAAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSPDEAAKLLGVDK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00538428;
90% Identity
-
80% Identity
-