Dfic005815.1
Basic Information
- Insect
- Drosophila ficusphila
- Gene Symbol
- FOXP4
- Assembly
- GCA_018152265.1
- Location
- JAECXK010000775.1:11274167-11277848[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 3.6 3.4e+03 -1.9 0.0 11 30 22 41 14 52 0.68 2 3 0.92 8.7e+02 -0.0 0.0 7 34 153 180 150 191 0.89 3 3 7.2e-17 6.8e-14 51.6 0.2 2 49 327 373 326 382 0.93
Sequence Information
- Coding Sequence
- ATGCATCGGATACAAGATGACGAGTATTCCGAGGAAGTGAAGGAAACCGACTTTAAGGGTTCTATTCAAAAGGACATATCGGCGAAGGCGCGTCACCAACTTTCCATACCAGATATTTGCTCAGATGCCGTCAAGAACAACTGCTTTCCGCCGACGGGCTTCCTGAATAACTCGATAGCCTTTGCATCGCACGTCATTAAGTGCAGTTCCCCGGCATCGAGTATAGATGAGTCTTCATCGGCGGCTCAGCACGAAGCCAATCCCCACATGCACATACAGGGCCAGCACATGATGGCCCCCGTTCCCGATCTGGGCTTCTATAATGTCCCCGAGTTTATTTCAGAACAGGAGAAGCTCATGTTCTCCGACGCCGAGAGGTTCCTGAGGTCAAAGGACAACGAGGTGTGCGGCAATGATTTCAGCTACATGCACGACGAGTTCGCCATGCGAAAGTACTATCATCCTCTATTTGCTCATGGCATTTGCCGATGGCCCGGCTGCGAAATGGATCTGGAAGATATCACATCATTTGTAAAGCATCTTAACACTGAACACGGCCTGGATGATCGATCCACCGCTCAGGCTCGCGTTCAGATGCAAGTGGTCTCCCAACTGGAATCCCACCTTCAAAAGGAACGAGATCGCTTGCAGGCCATGATGCATCACTTGTATCTGTCCAAGCAGCTTTTGTCACCCACCAAAATTGACAGAAAGGACGTTTCCGGAAGAGAGGGAAAGTTTTGCAGAAGTCCACTCACAATCAACAGCATAGGTCGACCGATCCGACAAACGAGTTCTCCGAACTCTCTTAATCTTCCCATAGTTAATTCCAACAACTTGTGCTCGATCAAGAAAAGAAGTCACGACAAAAACTCTTTCTCTATAAATGGTGGTCTACCTTATATGCTTGAAAGAGCAGGTCTTGATGTCCAACAGGAAATTCATCGGAATAGGGAGTTTTACAAAAATGCTGATGTACGACCACCCTTCACCTATGCATCCCTCATCAGACAGGCTATAATAGACTCCCCGGACAAGCAGCTAACCCTTAATGAAATTTATAATTGGTTCCAAAACACCTTTTGTTACTTTCGGCGCAACGCAGCTACATGGAAGGTAAAAAAAAAATTTACTATTTCCATTACTTTTTGA
- Protein Sequence
- MHRIQDDEYSEEVKETDFKGSIQKDISAKARHQLSIPDICSDAVKNNCFPPTGFLNNSIAFASHVIKCSSPASSIDESSSAAQHEANPHMHIQGQHMMAPVPDLGFYNVPEFISEQEKLMFSDAERFLRSKDNEVCGNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVSGREGKFCRSPLTINSIGRPIRQTSSPNSLNLPIVNSNNLCSIKKRSHDKNSFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKVKKKFTISITF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00604652;
- 90% Identity
- iTF_00561562;
- 80% Identity
- -