Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 6.2e-29 1.5e-26 92.9 0.2 6 107 3 103 1 106 0.95

2 4 0.047 11 6.4 0.1 78 109 106 137 103 138 0.87

3 4 1.5e-14 3.6e-12 46.5 0.1 32 107 141 209 140 212 0.93

4 4 0.061 15 6.0 0.0 81 107 215 241 209 244 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	6.2e-29	1.5e-26	92.9	0.2	6	107	3	103	1	106	0.95
2	4	0.047	11	6.4	0.1	78	109	106	137	103	138	0.87
3	4	1.5e-14	3.6e-12	46.5	0.1	32	107	141	209	140	212	0.93
4	4	0.061	15	6.0	0.0	81	107	215	241	209	244	0.86

Coding Sequence: ATGCTTGATACAAAGGAATTGGCAGATGTGACAATCGTCACAGCCGACGAACAAAAGATTCCAGTTCATAAGAATATATTATCAGCACGAAGTCCAGTCTTTGCAGCCATGTTTAAGCATCCAATGCAGGAAAATACTAAGAATTGTGTCGTCATTAAAGAATTCAATTCTGAAGTTGTCTCTGAGCTGATGCGATTCATATACTCAGGGGAAGCCCCGAATTTGAAAGAGATGAGTGGCCAACTTTTGGCGGCTGCTGATAAATATCAACTGGACAGACTGAAGATGATGTGTGCCAAGTTTATGGGTGACAATATAAACATAGATAATGCAGATGCAATCCTAAAGTCAGCCGACCTTTACAATTTGCGCGATCTTCAGTTGAAGACCAttcaatatattcaaaataacatGGAAAAAGCACAAAGCACAGTTTTTGCGGAAATGTTTGAGCATAGGAATAGCGTCGACATTAAGGACTTCAATTTTGATGTTGTCTCGGAACTAATTCGATTCATATACACAGGGGAAGTCCAGAAATTGAATGAGCTGAGTGGCGAACTTTTGGCAGCAGCTGATAAATATCAACTTGACGATCTGAAGATAATATGTGCCAAGTTTATGGGCGATAATCTGAGCATACATAATGCTGATGCAGTGCTAAAGTCAGCGAATCTTTACAATTTGCCGGATCTTAAGATCAAGACCAatcaatatattcaaattaaaaaagaaacttaCGAAGCAAATCccaatatcttaaatattttgctcgGTCTTCAGGAATTAAAACTAGATGATTCATCGAGCAgccaaaaaaatgattaa
Protein Sequence: MLDTKELADVTIVTADEQKIPVHKNILSARSPVFAAMFKHPMQENTKNCVVIKEFNSEVVSELMRFIYSGEAPNLKEMSGQLLAAADKYQLDRLKMMCAKFMGDNINIDNADAILKSADLYNLRDLQLKTIQYIQNNMEKAQSTVFAEMFEHRNSVDIKDFNFDVVSELIRFIYTGEVQKLNELSGELLAAADKYQLDDLKIICAKFMGDNLSIHNADAVLKSANLYNLPDLKIKTNQYIQIKKETYEANPNILNILLGLQELKLDDSSSSQKND

Sequence clustering based on sequence similarity using MMseqs2