Dfal016641.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila falleni
Gene Symbol
Runx1
Assembly
GCA_035045575.1
Location
JAWNOV010000185.1:5603834-5620477[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 5 2e+04 -12.6 9.5 58 71 30 43 16 49 0.48
2 3 2.9e-73 1.2e-69 232.0 0.0 3 129 97 223 95 223 0.98
3 3 2.7 1.1e+04 -3.9 0.0 68 91 592 616 588 619 0.74

Sequence Information

Coding Sequence
ATGCATTTGACAACCACCAGCAGCAACTCGACGGCATCTAatgccaataacaacaacaacaataataacaacaacaacaacacaactaacaacaacaataactcgagcagcagcaacaacaacaacacagcgaACACAAAtggcaccaacaacaacaacaacaacaactcgaacagcaacagcaacaacaacagcaccgaACAAAACACACCACCAACACCCGCCCAGCTGCTAAATGAGGCCTACACAAAGATGACCTCTGACATCCTGGCCGAACGAACACTGGGCGACTTCCTCACCGAACATCCGGGCGAGCTGATCAGGACGAGCAGTCCCCTCTTCGTCTGCACCGTCCTGCCACCGCATTGGCGCTCCAACAAGACGCTGCCGGTGGCCTTCAAGGTCGTCTCCCTGGGCGACATCATGGACGGCACCATGGTCACCGTCCGCGCCGGCAACGATGAGAACTATTGCGCCGAGCTGCGCAACTGTACCGCCGTCATGAAGAACCAGGTGGCCAAGTTCAATGACCTTCGGTTTGTCGGTCGCAGCGGCAGAGGGAAGAGCTTCACATTAACCATCACCGTGTCAACGAATCCACCGCACATAGCCACCTACAACAAGGCGATCAAAGTGACTGTCGATGGGCCACGTGAACCACGCTCCAAGACCAggcagcaacaacaattccaCTTCGCCTTTGGCCAGCGACCGTTCCATTTCTCCACGGATCCCCTCTCCGGCTTCCGCATGCCACCGATTGGCAATTGTCAGAGTGCCAGCAACACGCATTGGGGCTACGGATCGGCGGCCTCGGCCTATTCACCGTACTTGGCCAGCAGCGGATTATCCTCCTGCACCACGCCCACATCAGCTCAGTTCAACAATCCAGCGTTGGGCTTCACCTGCTCCTCCAACGACCAGAGCAACAATCAGGACTTTGGCGGCGCCACCAATCGCGATTGTGTGCCAATGCTGCCTGATTCGACGGCCAGTGATCTGGATCAGCATCTGAGCAGTCTGGTTGGCTCGACCAGTGGCCAGATGTCGCATCACAGTCTGTTGGGCGCCAGTGGCCAGACGTCGATCACGTCGACGGTGAATGGAGCGAGCACCGGGAGCGGAACAGCCGCTGGGAGTGCATCGGGCGCTGGCAGTGGGGCCGGAGCGAATTCGATATTGGTGCCACGTTATCATACCAATGCCAGCAACGAGTACAATGTGCATTCCAGCCAAAATGGGCCGCGCAGTCTGAGCGACAGCTCGCAGGCGGAGTCACCGGTGCAGGAGGATCTGCTGTCCACCAATACACCCAATTTGGGCGGCAGCGGCACTGGCGGTGGCGGTGCAACCAATGGCGGTGCCGCCAATGGTGGTGCCGGCAGTGCAGCGGGCGCGGGCAGCGGTGGCACAGCGGGTGCCTCAGCTGGCGCTGTCAATCCTGCCATGCTGGGCGCCAATCAAAACTTTCCGGGCATTGTCAACCAGGCACAGCATGCCTCCGCCTCCGCCTATGGCGGTGGTGTCGGTGTGGGCGTGGGCGTTGGTGTGGGCGGTGGTCATGGCGGTGGGGCTGGCGCCACAGCTGCCGGCTGCAATGGCTCACTGTATCCGGTGCTGCCCGCCAGTCTGCTCTACTCCCAGCTGTATACCGCTGCCAATCAGTCGGCCCATGGCTTCCATTCGCACACGTTGCCGTCGCACGCCTCGCCCAACTCCTCGGTGCATGGGGAGCTGCAGAGTGTGATGGATCACATTAGCAATGTGGGCGTGAGGCAGCAGCATAATATTATGACCGGCGGGGGCGTGGCACATCCGGGTGATCTGACGCTAATTGGCAACTGTGGGGCGTCGGTGAGGAACATCGAGGATGGCAACACAAATCGTCAGGTGGCCGCGCTCGCTGCCCATCGCGGCCACCACAACCCAACTGACAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence
MHLTTTSSNSTASNANNNNNNNNNNNNTTNNNNNSSSSNNNNTANTNGTNNNNNNNSNSNSNNNSTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASTGSGTAAGSASGAGSGAGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGGSGTGGGGATNGGAANGGAGSAAGAGSGGTAGASAGAVNPAMLGANQNFPGIVNQAQHASASAYGGGVGVGVGVGVGGGHGGGAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPSHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00916968; iTF_00901263; iTF_00522729; iTF_00568747; iTF_00803375; iTF_00528571; iTF_00547839; iTF_00565156; iTF_00605350; iTF_00349949;
90% Identity
iTF_00509592;
80% Identity
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