Dezo006068.1
Basic Information
- Insect
- Drosophila ezoana
- Gene Symbol
- egg
- Assembly
- GCA_035045725.1
- Location
- JAWNOU010000052.1:3671998-3676476[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.6e-13 4e-10 39.3 0.0 5 75 918 981 915 983 0.90
Sequence Information
- Coding Sequence
- ATGGATTCCTTGGAAAACGCGGATGCGGCACCAATTGACGCTTCAACTGAGGCAGCTGCAAGTGAAACACTTTTGCCGGCCAGTAAAACAACCACTGAGGAAGAATCTGAACCGTTGGTTGAGATGGAGAAGACGAAGGAGGAGGAACAAACTAGTGGAGAAAAGCCAATGACCTTGGATGACTTGCCGGGTGAGCCACCGATGGCTTCAACCGCTGAGCAAAGTGTCGAGCCTTCTGCCGCTGAACTAGAAGGAGACGAAACTAAAGTATCTGAAACCGACAACAGCAGCGGAACAAAAGCGGATACAACAGAACAAGACAAGAGCTTCAGCGAAATAACATCTAAAGAGGATACAGACTCCTCAATTGAACTAATCAGTAGCCCAACTACCGATCAGCCGGATAGTACAGACAAGGATAAAAGTTCTATTGAGGAAACTGACGGGACCACAACAAAGGAAGATGCTGGCCTAATAATTGATTCAACTGATGCGGCTAAGTCAATCGCAGATGATTTGGATAGCAGCGTTGAATTGATCGATAGCCCCGCAGTCGAAGAGCTGCCCGCCAAGGATAATTTACCGGATAGTAAGAttgacagcgacagcagcattGAACTGATCAGTAGTCCGGACAAAGACACTATTGAGTGTCTCAAACACGATTTATGCCCAGAGGAAGCAGCCTCTAAGCCAGAAGCTATGGAGGCATCAAATAGTGAAATGGGGGAAGAGCCTAAGCTAATTAGCAAGGATGACAGTACAGAGGAAGAAGATCCCAAGCCAATAACTGAGTCCGATATGGCTATGCCAACTGAAACTACAGTTGAAGAAACAGCGCCCACATCCGCCAGCCCAGATCCCCCCTTGCCAGATCAAAGTCCACGGCAAATTGATGATGTGCCCGATGCGATCAAATCTGTACCACAGGAGGAATCACAGCAAGTGGAGGCCATGGAAACGGAAACCTGCAAGGAAGACGTAGAAAACGGAGGTCTCGTCGAGCTGCCAAAAGAAACGTTAACTGAAGTTGACACAAAAGAATCCCTGGAATTTGAGGCGGATAATGAAATCTACTACAAGAAGGATTGcctcaattgcaattgcgagaAGACGCATAAGCAATACGTGCGTGCCAGCCTGGCAGCGCTCAACTACTACAAGGTGCCCAGAAAGGCGCACAAGCGGCAGTACATCTGCCTGGGTTGCTATGACACAGCCATGGACATGTACGAGGACTATGCGGGTCATTTGGTGGCCAAACAGCCGCTGTTGTTGCGCAGCTTTAACCAGGATCATGCGGACTTTGTGGCACTGGACAGCAGTGACGAGGAGGAAAACGATGAAGAGCAGGACAAGCCGGAGTTCTCGGCAAATGATTTGGAGCTAATTGAAGAAGAGCTCGAGGATGCGATTAGGACTGTAATTGACAGGGTAGATTTGGACGATCAAATGGCTTGGTCCAAGAGCATATTGCAAGCAAAATCTCAGCGCATAAGCCGTGCAATTGAGCTGGCCAACGACGAGCTGAGCAAGCTGCAAAATATGGCCGACAAAATGCACTTCGCTCTGTACAGCTCTTGTCAAGTGGTGCACAAACATTTGCCGCCGCTTGATCTATACCAGAACATGAGTGATTATGTGCAAGTGCCGCCAGCGGGTGAGATAGAGCGTCCGCCCATACAGCTCAATGAGACCTACTATGCGGTGAAGAATAAAGCAATCGCCAGCTGGGTTTCGGTCAAGGTGATTGAGTTCACGGAGAGCACTACTGTGGGCGGCAATCTGGTGAAGAGCTACAAGATAAAGTATCTGAATACTCCATATCAAATGGTTAAGACCGTAACAGCCAAACATCTAGCCTACTTTGAGCCGCCACCGGTGCGCCTGACCATAGGCACGCGTGTCATAGCCTATTTCAATGGCAGCACATTGTCGCGCGGCAAGGAAAAAGGCGTCGTACCCAGCGCCTTCTACCCAGGCATTATAGCCGAGCCCCTAAAGCAAGCCAATCGCTTTAGATACCTCATCTTCTATGATGACGGCTATACTCAGTATGTTCAGCATAACGATGTGCGTTTGGTTTGCCAGGCATCGGAAAAAGTGTGGGAGGATGTGCATCCCGGCTCGCGAGACTTTATACAAAAGTATGTGGAGAAATACTCAGTGGATCGGCCCATGGTGCAGTGCACCCGTGGCCAGAATATGAATACGGAGTCCAATGGCACCTGGTTATATGCGCGCGTGATCGATATTGATTGCAGTCTGGTGCAGATGCAGTTCGACGATGACAAGAATCACACCGAGTGGATCTATCGTGGCTCCCTGCGTCTGGGACCGGTGTTTAAGGAGACACAAAATGCGCTTAACAGCGCGAATGCCATGCAGCAGCATCGTGTGCCGCGCCGCACCGAACCCTTCATACGATACACCAAGGAGATGGAGACAAGCAGCAGACAGGTGAATCAACAAATGCGCGCCATTGCCCGTAAAAGCAGCGCGGCGCCTCAGAACGTCAATATGTCATCGTCATCCTCTGCTGCAGCGGCCGCTgccaatgctgctgctgctgcagcgcgcAACACTGTTCGCCATCTGAACAACTCCACAATCTACGTTGACGACGAGAATCGGCCAAAAGGTCATGTTGTCTACTTCACAGCCAAGCGGAATTTGCCGCCCAAAATGTACACACCACATGAGTGCACGCCGGCCTGTTTATTCAAGATAGTTCACCGCCTGGATAGCTACAGTCCGCTGGCCAAGCCACTGTTGTCTGGCTGGGAGCGTTTGGTGTTCAAGCAGAAGGCTAAGCGCAACGTTGTCTATCGGGGCCCTTGTGGCAAGAGCTTTCGCAATCTGGCCGAGGTGCACATTTATCTGCGTGCCACGGAGAATGTACTAAACGTGGAGAACTTTGATTTTACGCCTGATTTGCGGTGCCTGGCGGAATACTCTATTGATCCCACTATAGTTAAGGAAGCGGATATATCTAAGGGTCAAGAGAAAATGGCCATACCGCTTGTCAACTACTATGACAACACATTGCCACCGCCCTGCACTTACGCCAAACAGCGTATACCCACAGAGGGCGTGCATCTGAATCTGGACGAGGAGTTCCTGGTGGGCTGTGATTGTGAGGACGATTGCTCGGACAAATCAAAGTGCGCCTGCTGGCAGCTCACGGTTGCGGGTGTCCGATACTGTAATCCCAACAAGCCAATCGAGGAGATTGGGTATCAGTACAAGCGTCTACATGAGCAGGTGACAACCGGCATTTATGAATGCAATTCGCGCTGCAAGTGTAAAAAGAACTGCCTGAATCGTGTGGTGCAGCATTCGCTGGAAATGAAACTGCAGGTTTTCAAGACCTCGAATCGTGGTTGGGGCTTGCGCTGCGTGAACGATATACCCAAGGGTGCATTCATATGCATTTATGCCGGACACCTGCTGACCGAGACTATGGCCAACGAGGGTGGCTTGGATGCAGGCGATGAGTACTTTGCCGATTTGGACTACATTGAGGTTGCCGAGCAGCTAAAGGAGGGCTACGAATCGGATGTTGAGCACTCGGCAACGGAAGAGGAAGAAGACCCTAATGTGCCAGATCCAGAGGACGATGCTGACTTCACACCCGCCAAGTATTATCAACCGCGCAAGAAGGATAAACTGCGCGTCTCCCGTAGCCACTCGACCCAATCCAGTGAGCCGGACTCTCAGGAGCGCGCggtaataaattttaatccGAATGCAGATCTGGACGAAACGGTGCGCGAGAATTCAGTGCGACGACTCTTTGGCAAAGATGAGGCGCCCTACATAATGGACGCAAAGACAACTGGCAATTTGGGACGTTACTTTAATCATTCATGTGCACCCAATTTGTTTGTGCAGAACGTTTTTGTGGACACGCACGATCTGCGTTTTCCCTGGGTCGCTTTCTTTTCGGCCAACCACATACGCTCCGGCACCGAACTCACTTGGAATTATAACTATGAGGTGGGCGTGGTACCTGGCAAGGTTCTTTATTGTCAATGCGGCGCCACCAATTGTCGAATACGTTTACTTTAA
- Protein Sequence
- MDSLENADAAPIDASTEAAASETLLPASKTTTEEESEPLVEMEKTKEEEQTSGEKPMTLDDLPGEPPMASTAEQSVEPSAAELEGDETKVSETDNSSGTKADTTEQDKSFSEITSKEDTDSSIELISSPTTDQPDSTDKDKSSIEETDGTTTKEDAGLIIDSTDAAKSIADDLDSSVELIDSPAVEELPAKDNLPDSKIDSDSSIELISSPDKDTIECLKHDLCPEEAASKPEAMEASNSEMGEEPKLISKDDSTEEEDPKPITESDMAMPTETTVEETAPTSASPDPPLPDQSPRQIDDVPDAIKSVPQEESQQVEAMETETCKEDVENGGLVELPKETLTEVDTKESLEFEADNEIYYKKDCLNCNCEKTHKQYVRASLAALNYYKVPRKAHKRQYICLGCYDTAMDMYEDYAGHLVAKQPLLLRSFNQDHADFVALDSSDEEENDEEQDKPEFSANDLELIEEELEDAIRTVIDRVDLDDQMAWSKSILQAKSQRISRAIELANDELSKLQNMADKMHFALYSSCQVVHKHLPPLDLYQNMSDYVQVPPAGEIERPPIQLNETYYAVKNKAIASWVSVKVIEFTESTTVGGNLVKSYKIKYLNTPYQMVKTVTAKHLAYFEPPPVRLTIGTRVIAYFNGSTLSRGKEKGVVPSAFYPGIIAEPLKQANRFRYLIFYDDGYTQYVQHNDVRLVCQASEKVWEDVHPGSRDFIQKYVEKYSVDRPMVQCTRGQNMNTESNGTWLYARVIDIDCSLVQMQFDDDKNHTEWIYRGSLRLGPVFKETQNALNSANAMQQHRVPRRTEPFIRYTKEMETSSRQVNQQMRAIARKSSAAPQNVNMSSSSSAAAAAANAAAAAARNTVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYTPHECTPACLFKIVHRLDSYSPLAKPLLSGWERLVFKQKAKRNVVYRGPCGKSFRNLAEVHIYLRATENVLNVENFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLVGCDCEDDCSDKSKCACWQLTVAGVRYCNPNKPIEEIGYQYKRLHEQVTTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGLDAGDEYFADLDYIEVAEQLKEGYESDVEHSATEEEEDPNVPDPEDDADFTPAKYYQPRKKDKLRVSRSHSTQSSEPDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCAPNLFVQNVFVDTHDLRFPWVAFFSANHIRSGTELTWNYNYEVGVVPGKVLYCQCGATNCRIRLL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00588840;
- 90% Identity
- iTF_00550890; iTF_00530947; iTF_00475212; iTF_00616898; iTF_00563171; iTF_00526570; iTF_00490774;
- 80% Identity
- -