Dezo005218.1
Basic Information
- Insect
- Drosophila ezoana
- Gene Symbol
- E2f1
- Assembly
- GCA_035045725.1
- Location
- JAWNOU010000051.1:1058631-1063554[+]
Transcription Factor Domain
- TF Family
- E2F
- Domain
- E2F_TDP domain
- PFAM
- PF02319
- TF Group
- Helix-turn-helix
- Description
- This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.95 6.3e+03 -2.9 0.1 18 42 156 185 152 186 0.69 2 2 2.8e-31 1.8e-27 95.0 0.0 2 65 250 313 249 313 0.98
Sequence Information
- Coding Sequence
- ATGTCGAATTTTTTGATAACCAGCGCCGcgcccaacagcaacacacagcgtcaacagcagcagctttatGGAGTTGGCGGCACACAGGTGGTACGCAAACTCAGCTATGAGCTgctgggcaacaacaataacaacaacaataataatattgtgatcaaaaatgaaaatctgcGGGACATTGATTATGAGCAcggcagcaacgacaacagcaacagcggcgtTAAcatcggcgtcggcgtcgcagCCCACCTGCAAGATCACGAATACATAAGTCTGAATAAGTCTGgcaacacaacagcaacaaccgtTATAGCAGAGGCAACAAGCAcacatcatcagcagcagcagcaacgaaatggaggaggagctgctggcAAAACGAATGATATCACACACTACTACAGGGTCAAGCGCCGGCCGAACGCAACCACCCACGAGATCCACCCGAAGAAACAGGCCAAGCAGAGCGCACAGCATCAAACGGTcacctacaacaacagcaagcagcagctgcgctaccatcagcagcagtcgcagtcgcagcagctgtACGACGTCGAGCACGACGAAGATGACGATGTGGAGACGAGCAAACCGGCCGGCAACGGTACTTTGCATTCGCATGCACAGTTTGCGAGGACAGcgtcgcagcagcagacgacgccgcagcagcagacggCGCTGGTGACATCCTCTTCGACGTCTTCAGCTgggggcggcggcggaggtGGCGATCGCAATCGGGCGGACACCTCGCTGGGCATACTGACCAAAAAGTTTGTGGATCTGCTGCAGGAGTCGCCGGACGGTGTGGTCGATCTGAACGATGCGTCCACCCGGCTGTCCGTGCAGAAGCGTCGCATCTACGACATTACGAACGTGCTGGAGGGCATTGGCATCCTGGAGAAGAAGTCCAAGAACAACATACAATGGCGAGGCGGTCAATCACTGGTCAGCAGCGAACGCTCCCGGCACATCGAGGCGGAGTGCGAGCGGCTGGAGCAGCGCGAGAACGAGCTCAACACGCTCATCGATCAGATGCGCGGCGAGCTGGCCGAGATATCGCAGGAGGTGGAGAATATTGGCGGCATGGCCTACGTGACGCAAAACGATCTGCTCAACGTGGATCTGTTCAAAGATCAGATTGTGATTGTGATCAAAGCGCCGCCAGAGGCCAAACTTGTGCTGCCCAACACAAAGCTACCGCGCGAAATATACGTGAAGGCGGAGAACAGCGGGGAGATAAATGTATTTCTGTGCCAAGATAATTCGCCGGAAAGTTCGCCAATTGCGCCTGCGTTGTGTGGCAACGGCATTCgcacggcgacgtcgacgcgACTGCATCACCTGACCAATCAGCGCACCGATCCCCTATTCAATAACATTGATGCCATGAGCACGAAGGGCCTAGGCCATCCACCATATCGCTTATCAGCTCAGCGCAACCTCAGCAAGTCGATTGAGGAGGCGGCCAAGCAATCCCAGCCTGAATATAATAACATTTGTGATATTGGCGGCGTCAAATATGAACTGACCtcgccacagcagcagctgcaacagtcGACGACGCAGGCGggcaatgatgatgatgatgatgatgatgacgacgacgacgacgacgtcgacgatgAGCTGAATCAGCTGGTGCCGACGCTAACCAGTCCCGTGGTCCGCAGCTATCACTATCACCAGCGGCATGGTCCCGCTATTCAGCACATTTTAAACAGCCTAACACAATCCTCGCCCACGAAGGCGGAGGGCGGACTTCGCTCTACGACGCAGCGGCTCTGGCGACGTGCGGCGAATCCCGTCGCCAATATCGCGGGCAACACAACTACGCTTAATAGtcataacagcagcagcagcagcaacaacaacaacaacaattcccaaccccacaacagcaacaacagcagcagcagcacagttAATTACAGCTATCAGCAGttgcagctacagcagcagcgacgcagcGATGTACCAATGTATAACTGTGCAATGGACGGCGCGACTGCGTCGTATGCTGTtagcaataacagcaacaataacagcagccacaactcCTCTGCCATAGGCTCGCTGCACATGCAGTTTGCGGCAGTAGCCGGCAACGAAACCGACAGCGGCCTTGGCGTTGGCTTGGCGGCGACATATAGCGACATCTCTGGCGCTGGCGCCAATGTtaatcagcaacagcaatacaacaacaacaagaataattATCGCAGCCTGCCGCCAGGCGTtggcgactgcgacgctgACAGTGACGGCAGCAATGTTGCTCTCCAAGGCCTCGATGCGTTGTTTGGCGACATTGATACAGACTACTTCAATAACGAAGCCTTTGTGTCCATCGATCCGCCGGATGACAATGATTATCCCTACGCGCTGAACGCCAACGAGGGCATCGATCGTCTGTTCGACTTTAGCTCCGATGCCTACGGGCCctaa
- Protein Sequence
- MSNFLITSAAPNSNTQRQQQQLYGVGGTQVVRKLSYELLGNNNNNNNNNIVIKNENLRDIDYEHGSNDNSNSGVNIGVGVAAHLQDHEYISLNKSGNTTATTVIAEATSTHHQQQQQRNGGGAAGKTNDITHYYRVKRRPNATTHEIHPKKQAKQSAQHQTVTYNNSKQQLRYHQQQSQSQQLYDVEHDEDDDVETSKPAGNGTLHSHAQFARTASQQQTTPQQQTALVTSSSTSSAGGGGGGGDRNRADTSLGILTKKFVDLLQESPDGVVDLNDASTRLSVQKRRIYDITNVLEGIGILEKKSKNNIQWRGGQSLVSSERSRHIEAECERLEQRENELNTLIDQMRGELAEISQEVENIGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVLPNTKLPREIYVKAENSGEINVFLCQDNSPESSPIAPALCGNGIRTATSTRLHHLTNQRTDPLFNNIDAMSTKGLGHPPYRLSAQRNLSKSIEEAAKQSQPEYNNICDIGGVKYELTSPQQQLQQSTTQAGNDDDDDDDDDDDDDVDDELNQLVPTLTSPVVRSYHYHQRHGPAIQHILNSLTQSSPTKAEGGLRSTTQRLWRRAANPVANIAGNTTTLNSHNSSSSSNNNNNNSQPHNSNNSSSSTVNYSYQQLQLQQQRRSDVPMYNCAMDGATASYAVSNNSNNNSSHNSSAIGSLHMQFAAVAGNETDSGLGVGLAATYSDISGAGANVNQQQQYNNNKNNYRSLPPGVGDCDADSDGSNVALQGLDALFGDIDTDYFNNEAFVSIDPPDDNDYPYALNANEGIDRLFDFSSDAYGP
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00490572;
- 90% Identity
- iTF_00490572; iTF_00530745; iTF_00550727; iTF_00616696; iTF_00562970; iTF_00526368;
- 80% Identity
- -