Deug007133.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila eugracilis
Gene Symbol
Btbd7
Assembly
GCA_018153835.1
Location
NW:2214510-2220068[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 4.9e-13 1e-10 41.4 0.0 6 87 165 246 160 270 0.81
2 3 7.3e-06 0.0015 18.3 0.0 22 44 305 327 301 374 0.74
3 3 3.8 8.1e+02 -0.1 0.0 74 106 397 430 393 432 0.83

Sequence Information

Coding Sequence
ATGGGAGCCAATACgtcaagcagcagcagctatcCCACAGTCGCCTCATCGGGAAGTGGAGCTAATAACAATTCTAGCAACTCGAATGGAAATTTATCAGCATTGCCTATGGGCGGAATGGGCGAAATGTCTAGTGGTTCAGGTGCTTTTGGCATGAGTGGAAATAGTAGTAGCAGTTGTGGACCTAGTGGAAATGCTAGCGGAACTCCTGGTATTGTCATAAGTGGAGCACATTACCATCGGGATCAGAGGAGGAAACGTGCCACCGGCTTTGCCACACTTAAACGCAAGTTTATACGTCGACGGCGTTCTTCGAAAGCCTGTGATCACGCACGCGTCCTGCGAGACTTTGTATCTGATTGGGCACCCGTGGAACTAGCAGCTCTATGCGAGGAATTCGAGGCGTTGTCGGCTCTAAGGGATTTGTCGGTGCAAGCTGAATTGGCACGGCCGCCGGCAGCAACGTTTAAACAAGATCTTGCTGCCATATATGAGAAAAATTTGTGCACCGATTgtgatttggtttttcgtgGAACGATATTCTCAGTGCACCGTTCAATATTATCAGCACGTTGTGTATATTTTCGGGACCTGCTGGCAGGATGTCCTGGTTTCGGAGCGCGTATATGTCTCGAATTACCTACTTCCCCCATTGATGTCCAACTTTTCTCATCACTATTACGCTACCTATACACTGGTGATCTATGTCCCCATGATCCCAACATTGACATAAGCCTATTGCGGCAGCTAGGCAAAGATTTCGGTACACCGAATCCCCTAGAGCATGATCTGCGCTATTTGTTGGAAACAGGTGATTACGCTGATGCAGCTCTTGTCTTTACTGCAGATGGTACCAACGACTATCTAAGACAAGACTCAGGAACTTCGGAGTATGGATTTAGACCGAAGATCGAATTACCTTGCCATAAAGCGATATTAAGCGCGCGTTCACCTTTTTTTCGAAATCTAATTGCGCGCCGTACGCGTAATATTGACGAGTACGTTGAACGTTCATTACACGTACCCACACGCATTGTATTAGATGAAACTGTTATACCAAAAAGATATGCCCGTGTGTTGCTGCAAGCAATCTATCTGGACTCGGTGGACTTGACATTGATATTGCGTGGCGTAGGTTCTGGTACATCGGCTGGTTCACTTGGTGAAGTGCATGCATTAACCAATACGGGACGTGTGCGACCAACGACTCTCGAGGAGGCCATGGAGTTATATCAGATCGGTCGTTTTCTAGAGCTGGATATATTGGCTCAAGGCTGTGAGGATTTGATTCTTGAATGGTTATCCATCGAAACGTTACCCACAGTTCTGAAATGGGGTTGCCAGCCCCACGGATCCGCATGGGTCTTTCGCCAAGCTTGTCAGTATTTACGTGAGGAATTTGCAGCTGTAAGCTCCTCACCGGTGTTGCATCAACTCGATAAATCTCAGTTAATACATATTCTGCATAGTAACTTCTTGCAAGCATCCGAATTGGAAGTATTGCAAGCCGTTCTCAAGTGGGGTGAGCAGGAGCTCATTCGTCGCATGGAGGATCGTGAGCCCAACTTGTTGTCCCACACAGCCCACTCGGTAGCACGCAAGGGTGTCAAGAAACGCGACCTGAGCGACATAGAATTACGCGAGATACTCTCGGAACTATTGCCACTGGTACGTATGGATCATGTCCTGCCGCCACATTGTGAGGTCCTTTGCCAGGCCATTCGTCGAGGTCTCGTGAGCACACCACCATCGCACATGATCGGAGATGATCGAGAAAATTTGCGTATCAATGCCTGGATTCGTGGGGGTAAAAATCAAGGTCTATACGTTAGGCCTCGTCTATTTATGCCCTATTTTGAGGAGGTCAAAGCGCTCTTGGAAGATCGCATGTCATCGTCACATCATCAGGTTGAACTAATGCGTATGCGCCGATGTCGACATCCCCCAGATATACCAGATACCCTCTATATGGTATCACATATGAATTCAAAGGCGAATAGTGATCTTAGCACAGTAGAAAATCGTAGTACTGATGGTAATGTTGATATATTAGTAGGCGCCGCTGTTATTCCACCACCGGACAACCAAACGTTATTAGCAATGCGAAAGCGGGAGCACAAGCTTCGTCAATCGCCAATGTGTCAGAGGGCATTACTGTTGCCACTTTCATCAAAGAGTGAAATCGACCGGCAAATTCGTCTGCGGGTTGTGCGGGAATTTAATCTGCCCGACGAGGTATCTGACCTACTGGAAATCGCCCTACAAACCAATACAGGTCGAAATGAGAATCATGCCGAGGAGACAAGTGCATCGACATCACAGAAAGATGACTCGTTGCTTGAGGATGAGGATCAAAGCCCGCCGCCATCACCAGCAGCTACATGCTCAGTTTCGCGACACACCAATGTTGCATCATCGTTTTTATCGCCAATGGGCTCATCCGTGGCGTCTTGTGGCACCGACGCTGCTCATCCGTGCTACAGCCGAAATCTCACCTTCCCACGCCACCATTCGAATGGACTAATCGGTGTGGCCAATGCATTTGGTTCCAGCTCTGGTCCGACGCTTCAGTGTAGTTATTCGCGACTCTCATCATCGGTGCATCAACGCAACGATCTACCAGCCCTCATAACCGAGGGAGACTTTCGTTTCCCGCATGGAAATGGCCTCGGATTGGATATGGGCGCCGAGGGCGGTGCCTGTGGACTGGATTCGGCCAATAGCCATCTATCCGAAATGATGCCCGATGTGGCAATGGCCACAGCCTCATTGGGACAGCTTCATTTGACAAATAATGGAGCTGGATGCGCCAGTAATATTGGCGGACGCGCAGTAAGCAGTAATAACGACATGTCCGAGAGCTTGCAATTAGATTTAGGCGATGGACCTAGCCCTCATATAATTGGAAGTGCTGTCGGTTCAATGACTCTACGAAATATACAGcaccAACTGCCAACAAACAACTATCACCACTTTATGCAGCGTTCGAACTCGCCATTCGAAATCCTGCGGCAAGGACAACCATCGCCAACATCACATCCACAACATTCCGGGACATACAATTCTGGACCACCAAGGTTTTTATAG
Protein Sequence
MGANTSSSSSYPTVASSGSGANNNSSNSNGNLSALPMGGMGEMSSGSGAFGMSGNSSSSCGPSGNASGTPGIVISGAHYHRDQRRKRATGFATLKRKFIRRRRSSKACDHARVLRDFVSDWAPVELAALCEEFEALSALRDLSVQAELARPPAATFKQDLAAIYEKNLCTDCDLVFRGTIFSVHRSILSARCVYFRDLLAGCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHDPNIDISLLRQLGKDFGTPNPLEHDLRYLLETGDYADAALVFTADGTNDYLRQDSGTSEYGFRPKIELPCHKAILSARSPFFRNLIARRTRNIDEYVERSLHVPTRIVLDETVIPKRYARVLLQAIYLDSVDLTLILRGVGSGTSAGSLGEVHALTNTGRVRPTTLEEAMELYQIGRFLELDILAQGCEDLILEWLSIETLPTVLKWGCQPHGSAWVFRQACQYLREEFAAVSSSPVLHQLDKSQLIHILHSNFLQASELEVLQAVLKWGEQELIRRMEDREPNLLSHTAHSVARKGVKKRDLSDIELREILSELLPLVRMDHVLPPHCEVLCQAIRRGLVSTPPSHMIGDDRENLRINAWIRGGKNQGLYVRPRLFMPYFEEVKALLEDRMSSSHHQVELMRMRRCRHPPDIPDTLYMVSHMNSKANSDLSTVENRSTDGNVDILVGAAVIPPPDNQTLLAMRKREHKLRQSPMCQRALLLPLSSKSEIDRQIRLRVVREFNLPDEVSDLLEIALQTNTGRNENHAEETSASTSQKDDSLLEDEDQSPPPSPAATCSVSRHTNVASSFLSPMGSSVASCGTDAAHPCYSRNLTFPRHHSNGLIGVANAFGSSSGPTLQCSYSRLSSSVHQRNDLPALITEGDFRFPHGNGLGLDMGAEGGACGLDSANSHLSEMMPDVAMATASLGQLHLTNNGAGCASNIGGRAVSSNNDMSESLQLDLGDGPSPHIIGSAVGSMTLRNIQHQLPTNNYHHFMQRSNSPFEILRQGQPSPTSHPQHSGTYNSGPPRFL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00606425;
90% Identity
iTF_00592484; iTF_00539754; iTF_00619244; iTF_00591791; iTF_00596752; iTF_00504786; iTF_00607867; iTF_00494484; iTF_00588245; iTF_00512106; iTF_00529661; iTF_00486662; iTF_00581639; iTF_00602696; iTF_00536873; iTF_00548169; iTF_00605675; iTF_00604948; iTF_00507707;
80% Identity
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