Deug007037.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila eugracilis
Gene Symbol
Hr39
Assembly
GCA_018153835.1
Location
NW:61923-86441[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.18 1.3e+03 -1.9 4.8 52 175 261 380 154 388 0.62
2 2 1.2e-105 8.5e-102 341.3 2.1 1 408 451 818 451 818 0.93

Sequence Information

Coding Sequence
atgccaaacatGTCCAGCATTAAAGCGGAGCAGCAGAGTGCTCCTATTGGAGGAACTAGCGGCTATCAACTGCCGGTCAATATGTGCACCACCGCCGTGGCAAGTACGACGACAACTCTGGGAGCAGCCACCGTGGGGGCTACTGTCTCCCGGCACAACGTATCTGTGACGAACATTAAGTGCGAGCTAGACGAGCTGCCCACGCCCAACGGAAATCTTGTGCCGGTAATCGCAAACTATGGCCACGGTAGCCTGCGCATTCCGCTAAGTGGACAGCCGAATCATGAGGAGTCCGATTCGGAGGAGGAGCTGGCGAACATCGAGAACCTGAAGGTGCGACGAAGGACGGCGTCTGATAAAAACGGACCTCGACCGATGTCTTGGGAGGGCGAACTGAGCGATGCTGAGGCTAACGGCGGGGAGGAACTAATGGAAATGGAGCCGACAATCAAGAGCGAGGCGGTCGCGGCCGTTCCCACTTCCCTTCAGCCAACCTGCGCTCTGCAGCCGATCAAAGCTGAGCTAGAGAATATTGCCGGAGAGCTGCAACTTCAGGGGAAGTCTTACCCCATGTCCAACTCACAATGCCACGTTGTCACGAAAATGAAGCTGGCGCCGACGCAGAGCGATCCGATCAATCTCAAATTCGAGCCCTCTCTGGGAGACAATTCGCCGCTACTGGCTGCCCGTAGTAAGTCCAGTAGTGGAGGCCACTTGCCGCTACCCGCGAATCCCAGTCCCGACTCTGCAATACATTCCGTCTACACGCACAGCTCGCCCTCGCAGTCGCCGCTGACGTCGCGACATGCCCCCTACACTCCCTCGCTGAGCCGCAACAACAGCGACGCCTCGCACAGCAGCTGTTACAGCTATAGTTCCGAGTTCAGTCCAACCCACTCGCCCATCCAGGCTCGGCATGCCCCACCCGCTGGTACGCACTATGGCAACGGAGGAGTGCACCACCACAGTGTTCTGTACCGTCCGCTCAAAGTAGAAGCCTCATCCACGGTGCCATCCAATGGGCAGGAGGCTCAGAACCTAAGCATGGACTCTGCCTCAAGCGGTCTGGATGCAGTGGGTTCGGGATCATCACATCCTGCTTCCCCGGCGGGCATTTCGCGTCAGCAGCTAATTAACTCGCCGTGTCCCATATGCGGTGACAAAATCAGCGGCTTTCACTACGGAATCTTCTCCTGCGAGTCCTGCAAAGGCTTCTTCAAGCGCACTGTTCAGAACCGCAAGAACTACGTGTGTGTACGTGGCGGACCCTGCCAGGTGAGCATCTCCACACGCAAGAAGTGTCCGGCCTGCCGGTTTGAAAAGTGCCTTCAGAAGGGCATGAAGCTGGAGGCGATTCGGGAGGATCGAACCCGCGGTGGCCGCTCCACTTACCAGTGCTCCTATACGCTTCCCAACTCAATGCTCAGTCCCCTGCTCAGTCCGGAtcaggcggcagcagctgtTGCCGCCGCAGCGGTGGCAagtcagcagcaacaacagcaacagcgactCCATCAGTTAAATGGAGGATTTGGCGGCGTACCCATCCCGTGCTCGACCTCTCTTCCAGCCAGTCCCAGTTTGGGGGGAGCTTCCATAAAATCGGAGGATGCCGTGGAGTCTGGCAAGCACAGCCTGCGAACCGGAAGCGTACCACCACTACTGCAGGAAATCATGGATGTTGAGCATCTGTGGCAGTACACCGATGCGGAACTGGCCCGCATCAACCAACCTCTGTCCGCATTCGCATCTGGAAGCTCCTCTTCGTCGTGCTCATCAGCCGCGTCCTCGGGTGCCAACGCACAGCCCCAACTAACAAATCCACTACTGGCCAGTGCCGGACTCTCATCCAATGGCGAGAACGCCAACCCCGATCTAATCGCCCATCTCTGCAACGTGGCTGATCACCGCCTCTACAAGATTGTCAAATGGTGCAAGAGTTTGCCGCTCTTCAAGAATATCTCGATCGAtgaccaaatctgcttgctcATAAATTCATGGTGCGAACTGCTGCTCTTCTCCTGCTGTTTTAGATCAATTGATACTCCCGGCGAGATTAAAATGTCCCAAGGCAGGAAGATAACCCTTTCACAGGCAAAATCAAATGGATTGCAGACTTGTATTGAACGGATGCTCAATCTGACCGATCACCTGAGGCGATTACGCGTTGACCGCTACGAATATGTTGCCATGAAGGTGATTGTGTTGTTGCAGTCAGATACGACGGAGTTACAGGAGGCGGTAAAGGTACGAGAGTGCCAGGAAAAGGCGTTGCAAAGCTTGCAGGCTTACACCCTAGCCCATTATCCAGACACGCCGTCGAAGTTCGGGGAACTCCTGCTGCGCATTCCCGATTTGCAGCGAACGTGCCAGCTGGGCAAGGAGATGCTGACGATCAAGACTCGAGATGGAGCTGATTTCAACTTGCTAATGGAGCTCTTGCGCGGAGAGCATTGA
Protein Sequence
MPNMSSIKAEQQSAPIGGTSGYQLPVNMCTTAVASTTTTLGAATVGATVSRHNVSVTNIKCELDELPTPNGNLVPVIANYGHGSLRIPLSGQPNHEESDSEEELANIENLKVRRRTASDKNGPRPMSWEGELSDAEANGGEELMEMEPTIKSEAVAAVPTSLQPTCALQPIKAELENIAGELQLQGKSYPMSNSQCHVVTKMKLAPTQSDPINLKFEPSLGDNSPLLAARSKSSSGGHLPLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAGTHYGNGGVHHHSVLYRPLKVEASSTVPSNGQEAQNLSMDSASSGLDAVGSGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAVAAAAVASQQQQQQQRLHQLNGGFGGVPIPCSTSLPASPSLGGASIKSEDAVESGKHSLRTGSVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSCSSAASSGANAQPQLTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGRKITLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH