Deug009582.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila eugracilis
Gene Symbol
foxo
Assembly
GCA_018153835.1
Location
NW:558029-592656[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.8e-28 3.7e-25 87.5 0.2 4 84 98 180 96 183 0.92
2 2 5.9 4.6e+03 -2.5 0.2 55 72 540 557 529 572 0.53

Sequence Information

Coding Sequence
ATGATGGACGGCTTCGCGCAGGACTGGCCCACGCTGACCCACACAGACAATGGGCTGCCCATGGACCAGTTGGGTGGTGACCTGCCTCCGTTGGATGTAGGCTTCGAGCCACAGACCAGAGCCAGATCCAACACATGGCCATGTCCGCGCCCCGAGAACTTCGTGGAGCCCGCCGACGAGTTGGACAGTACAAAGGCCAGCAATCAGCAGTTGGCCCCAGGAGACTCACAGCAGGCTATACAAAATGCGAATGCAGCCAAGAAGAACTCATCGCGTCGCAATGCATGGGGAAATCTATCCTATGCGGATCTCATCACGCATGCCATTGGATCGGCCACCGACAAACGACTGACTCTGAGCCAGATTTACGAGTGGATGGTCCAGAATGTGCCATACTTCAAGGACAAGGGCGATTCGAATAGTAGTGCTGGATGGAAGAACTCCATACGTCACAATCTGTCGCTGCACAACCGCTTTATGAGGGTTCAAAACGAGGGCACCGGCAAGTCCTCCTGGTGGATGTTGAACCCGGAGGCCAAGCCTGGCAAATCCGTGCGTCGTCGTGCCGCTTCCATGGAGACATCGCGTTACGAGAAGCGACGTGGCAGGGCCAAGAAGCGTGTGGAGGCACTGCGTCAAGCGGGCGTTGTTGGTCTAAACGATGCCACGCCCTCGCCTAGCAGCAGCGTCAGCGAGGGGCTAGACCATTTCCCGGAGAGTCCGCTGCACAGTGGCGGTGGCTTCCAATTGTCGCCCGACTTCCGGCAGCGCGCCTCATCCAATGCCAGTTCCTGCGGGCGCCTGAGTCCCATTAGGGCGCAGGACTTAGAGCCCGATTGGGGCTTCCCTGTTGACTACCAGAATACGACGATGACGCAGGCCCATGCCCAGGCCCTCGAGGAGTTGACGGGTTCAATAGCGGATGAGCTGACGCTGTGcacccagcagcagcaaggATTCAGTGCCGCTTCGGGTATACCCACGCAGCCCCCGCCCCCGCCTTATCAGCCACCGCAGCATCAGCaggcgcagcagcaacagtccTATGCCCTCAACGGCCCCGCCACTGGCTACAACACACTGCAGCCGCAGTCGCAGTGCCTGCTGCACCGATCCCTCAACTGCAGTTGCCTGCACAATGCAAGAGACGGTCTCTCGCCGAACTCAGTAACCACAACAATGTCGCCCGCCTATCCAAACAGCGAGCCCTCTTCGGACTCACTGAACACGTACAGCAACGTGGTGCTCGATGGTCCCGCGGACACTGCCTCTTTGTTggtgcaacaacagcaacagcaacagcagcaacaattgtCCGGCAACTTGGAAGGACAATGCCTGGAGGTGCTGAACAACGAGGCCCAGCCGATTGACGAATTTAATCTGGAGAACTTTCCAGTGGGGAATCTGGAGTGCAATGTCGAGGAGTTGCTTCAGCAGGAGATGAGCTATGGCGGTCTGCTGGACATCAATATCCCCTTGGCCACGGTGAACACGAACTTggtcaacagcagcagtgcGCCCCTGaacatcagcagcatcagcaacatcagcaacatcagcaacatcagcaacctCAGCAACCTTAGTAACCTTAGCAGCAATTCCGGCAGTAGTCTCAGTCTAAATCAGCTGCAGGCtcagctgcaacagcaacagcagcagcagcaacaacagcagcaactgcaacagcagcagcaacagcaacatcagcaacaccagcaacaattGCTGctcaataataacaacaacagcaacagcagcttgGAATTGGCAACACAAACGGCTAGCACAAATCTGAATGCCCGAGTGCAATACTCGCAACCCAGTGTGGTGACCTCGCCACCATCTTGGGTCCACTAG
Protein Sequence
MMDGFAQDWPTLTHTDNGLPMDQLGGDLPPLDVGFEPQTRARSNTWPCPRPENFVEPADELDSTKASNQQLAPGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGSIADELTLCTQQQQGFSAASGIPTQPPPPPYQPPQHQQAQQQQSYALNGPATGYNTLQPQSQCLLHRSLNCSCLHNARDGLSPNSVTTTMSPAYPNSEPSSDSLNTYSNVVLDGPADTASLLVQQQQQQQQQQLSGNLEGQCLEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVNTNLVNSSSAPLNISSISNISNISNISNLSNLSNLSSNSGSSLSLNQLQAQLQQQQQQQQQQQQLQQQQQQQHQQHQQQLLLNNNNNSNSSLELATQTASTNLNARVQYSQPSVVTSPPSWVH