Basic Information

Insect: Drosophila erecta
Gene Symbol: foxp1
Assembly: GCA_000005135.1
Location: CH954181.1:16049973-16052029[+]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8.1 7.8e+03 -2.9 0.0 41 58 12 29 8 41 0.68

2 3 1.3 1.2e+03 -0.3 0.0 7 34 153 180 150 189 0.88

3 3 8.8e-31 8.5e-28 96.3 0.3 2 81 327 400 326 407 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8.1	7.8e+03	-2.9	0.0	41	58	12	29	8	41	0.68
2	3	1.3	1.2e+03	-0.3	0.0	7	34	153	180	150	189	0.88
3	3	8.8e-31	8.5e-28	96.3	0.3	2	81	327	400	326	407	0.94

Sequence Information

Coding Sequence: ATGCATCGGATACACGACGACGAGTATTCTGAGGATGCCAAGGAATCTGACTTCAAGGGCTCAATTCAGAAGGAGATATCAGTCAAGTCGCGACACCAAATTTCCATTCCAGATATATGCTCAGATGCTGTTAAGAACAACTGTTTTCCGCCGACGGGCTTTCTGAATAACTCGATCGCCTTTGCCTCACACGTGGTTAAGTGCAGTTCTCCGGCCTCGAGCATCGATGAATCCTCATCAACGGCCCAGCACGAGCCCAGTCCCCACATGCACATACAGGGTCAGCATATGATGGCACCCGTTCCCGATCTGGGCTTCTACAATGTTCCCGAGTTCATTTCCGAGCAGGAGAAACTCATGTTCTCCGACGCGGAAAGGTTCTTGAGGTCGAAAGATAATGAGGTGTGCAACAATGATTTCAGCTATATGCACGATGAGTTCGCCATGCGAAAGTACTATCATCCTCTATTTGCTCATGGCATATGCCGCTGGCCCGGTTGCGAAATGGATTTGGAGGATATCACATCGTTTGTCAAGCATCTGAATACTGAACATGGATTGGACGATCGATCAACAGCCCAGGCACGGGTTCAAATGCAAGTTGTCTCCCAGCTGGAATCCCACCTGCAAAAGGAAAGAGATCGCTTGCAGGCTATGATGCATCACTTGTATTTGTCCAAGCAGCTTTTATCACCCACTAAAATCGATAGGAAGGACGTGCCCGGTAGAGAAGGAAAGTTTTGCCGGAGTCCGCTTACAGTGAATAGCATAGGTCGACCCATCCGCCAAACAAATTCACCCAGTCCTCTAAATCTTCCAATGGTTAATTCCACTAACTTATGCTCGATCAAAAAGAGAAACCACgacaaaaatacattttcaataaatgGCGGTTTACCCTATATGCTGGAAAGAGCCGGGCTTGATGTGCAACAGGaGATCCACCGAAACAGAGAGTTTTATAAGAATGCTGATGTACGACCGCCTTTTACTTATGCTTCGCTCATACGACAGGCTATAATTGACTCCCCTGACAAGCAGCTAACCCTTAACGAAATCTACAACTGGTTCCAAAACACATTTTGCTACTTCCGTCGCAACGCAGCTACGTGGAAGAACGCAGTTCGGCACAATCTGTCCCTTCATAAATGCTTTATGCGGGTTGAGAATGTGAAAGGAGCAGTTTGGACTGTCGATGAGATTGAGTTTTACAAAAGACGACCGCAGCGCACTGCTGGCATTGGTAACAACCTGACTGGTGCTACCAATTCGCCGGACACTAACTATTTTGTAGCCATGAACATTGGGTATGTGGGTCTCAAATag
Protein Sequence: MHRIHDDEYSEDAKESDFKGSIQKEISVKSRHQISIPDICSDAVKNNCFPPTGFLNNSIAFASHVVKCSSPASSIDESSSTAQHEPSPHMHIQGQHMMAPVPDLGFYNVPEFISEQEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNSIGRPIRQTNSPSPLNLPMVNSTNLCSIKKRNHDKNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEIEFYKRRPQRTAGIGNNLTGATNSPDTNYFVAMNIGYVGLK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00596470;
90% Identity: iTF_00592207;
80% Identity: -