Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 9.8 1.2e+04 -3.4 0.6 59 65 13 19 10 24 0.55

2 3 1.2e-15 1.5e-12 47.6 14.5 5 69 145 209 141 210 0.96

3 3 0.52 6.7e+02 0.6 1.6 5 14 231 240 222 245 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	9.8	1.2e+04	-3.4	0.6	59	65	13	19	10	24	0.55
2	3	1.2e-15	1.5e-12	47.6	14.5	5	69	145	209	141	210	0.96
3	3	0.52	6.7e+02	0.6	1.6	5	14	231	240	222	245	0.72

Coding Sequence: ATGTCGGCAGTGCCGTGCGATGAGCCATTTGTGCGTTGCTTGAAGTGTCTTAAGGTCATTAACTGCTCACGCTATGATACCGATCATATGCTGCAGCATGTCGCTCAGGATCATCCGGAAGTTATAGAAGAAACGAAGGAGAAGATCGAAAACCTATATAAATTAGCTGCCGCCCATGGCATTAGTCAGGAAAGGCTATCCCAGATTAGCAAAAAGACTGGCATGTCCGAAGAGCGAATGGCCGATGAGGCAGAAAAGTATATGGCCAAGAAGAAGAAAAGTGGAAGCAACTTGTCGATTGCAGCTTCTGGTCAGAATGTTACCGAAGGACTGGCCTTTAGACCCAATCGTGCCAAGGCCTGCGATTCGAGAGATCTCAGTCGTCGTCAATATTATCGCTCTTCCATTGAACGTTGGACAGCCACAGATGGGGCCATATATTGCCCTTCTTGCGGCTGTTGTCGTCGCCCAGTGATCCAATCGAAAGCGGAATTTTACAAGAGTACTGGATGCTGTGCAGCCTGTTTGATTAGTTGTTGGCCCTTTTGCTTTCTACCTTGCCTCATTTCACCTGAGAATCGTGAATATCTACATTGCCCCAATTGCAACACCTTTCTGGGCCTCTACGATCGGGAGAATAATTGCATTAAACCAAATCGTAATTTTGTTGTTTGTCCTTTGCCTTCTAAGCCCTGTTCCTGTCCCAGTTGTAGCGCCCGCCCCAGTTCAAAAAAAATGTCAATAACTTTTTAA
Protein Sequence: MSAVPCDEPFVRCLKCLKVINCSRYDTDHMLQHVAQDHPEVIEETKEKIENLYKLAAAHGISQERLSQISKKTGMSEERMADEAEKYMAKKKKSGSNLSIAASGQNVTEGLAFRPNRAKACDSRDLSRRQYYRSSIERWTATDGAIYCPSCGCCRRPVIQSKAEFYKSTGCCAACLISCWPFCFLPCLISPENREYLHCPNCNTFLGLYDRENNCIKPNRNFVVCPLPSKPCSCPSCSARPSSKKMSITF

Sequence clustering based on sequence similarity using MMseqs2