Basic Information

Insect: Drosophila engyochracea
Gene Symbol: hb
Assembly: GCA_035042385.1
Location: JAWNLK010000101.1:11410353-11412905[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00021 0.013 15.8 0.2 1 23 283 305 283 305 0.99

2 6 0.011 0.7 10.4 3.6 2 23 313 334 312 334 0.97

3 6 0.0003 0.019 15.3 5.0 1 23 340 362 340 362 0.98

4 6 0.04 2.5 8.6 5.3 1 23 368 392 368 392 0.93

5 6 0.00024 0.015 15.6 0.4 1 23 797 819 797 819 0.96

6 6 0.0035 0.22 11.9 0.2 1 22 825 846 825 849 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00021	0.013	15.8	0.2	1	23	283	305	283	305	0.99
2	6	0.011	0.7	10.4	3.6	2	23	313	334	312	334	0.97
3	6	0.0003	0.019	15.3	5.0	1	23	340	362	340	362	0.98
4	6	0.04	2.5	8.6	5.3	1	23	368	392	368	392	0.93
5	6	0.00024	0.015	15.6	0.4	1	23	797	819	797	819	0.96
6	6	0.0035	0.22	11.9	0.2	1	22	825	846	825	849	0.91

Sequence Information

Coding Sequence: ATGCAGAACTGGGAGACGAGCACCGCAGCGCCCAATTATGAGCAGCACAATGCGTGGTACAGCAGCATGTTCGCCGCCAACATCAAGCAGGAGCCCATCTcgcatcaccatcaccatcatcatgcTCATCACagtcatcatcagcatccgcatgacagcaacagcaatagcaacgcAAGCAGTCCACACCAATCGCCGTTGCCCTCACCCAATCCGCCCAGCAACACCAATCTGCAACTGGAGCAATACctcaagcaacagcaacaacaacaacagcagcagcagcaacaacaacaacaacaacccatGGATACACTTTGTGCTGCTGCCATGACTCCATCGCCGAGCAACAATGATCAGAATAGCTTGCAACACTTTGATGCCAccctgcagcagcaactcttgcagcagcaacaatatcagCAACACTTTCaggcagcacaacaacaacaacaacaacagcagcaacatcatcatctgACACTGGGCGGTTTCAATCCGTTGACGCCGCCCGGTTTGCCCAATCCCATGCAGCACTATTATGCTAGCAATTTGCGTCCCAGttcaacagcaacgacaacaacaacaacacctgctgctgctccaacgacaacagcagcagcaattgcactGCAAGCCAATGACAAATTACAGGCACTAACTCCACCCATGGATGTGACGCCACCAAAGTCACCGGCCAAGTCCCAGCAATCCAGTGCGGAGCCAGAGAAGGAGCATGATCTAATGTCCAATTCAAGTGAGGATATGAAATATATGGCCGAGTCGGAGGATGATGACACCAACATACGGATGCCCATCTACAATTCGCATGGCAAGATGAAGAACTACAAGTGCAAAACGTGCGGCGTGGTGGCCATTACCAAGGTGGATTTCTGGGCGCATACACGCACCCACATGAAACCGGACAAGATACTGCAGTGCGCCAAGTGTCCGTTTGTCACCGAGTTCAAGCATCATCTGGAGTACCACATACGCAAGCACAAGAACCAGAAACCGTTCCAGTGCGACAAGTGCAGCTATACGTGTGTGAACAAATCGATGCTCAACTCGCATCGCAAGTCGCACAGTTCGGTGTATCAGTATCGGTGTGCCGATTGTGATTATGCCACTAAATATTGTCACAGCTTCAAGTTGCATCTGCGCAAGTATGGTCACAAGCCGGGCATGGTCCTGGACGAGGATGGCACACCCAATCCCTCACTGGTCATCGATGTCTATGGCACCCGACGTGGCCCCAAAAGCAAATCGCTCTCGGGCAACGGCAACTCCAGCAACTGTTCCAgttccagcagcaacaagcgcagcagtgcaacagctgcaacatctgtgcagcatcagcaaccaGTTATTCCACCAGCAGCCACATCTCAACTGTCGGCTGCTTTGCAAGGATTCCCAATGCCAGTGGCggctgcagcaactgcagttgcaacaactgtGCCGCCTGTGTCGCCACCGTCGCCAGCGAAGAGTGTTGCCAGCAGCGTTGAGCAGGCGCCCAGTTTGTCGAACGCATTACTCCCACCTTTGGCCAGTTTGTTGCAACAGAATCATCGCAACATGGCCTTCTTTCCCTACTGGAATCTCAATCTGCAAATGCTTGCCGCCCAGCAGCAGGCTGCAGTTCTTGCCCAGCTATCGCCGCGCATGCGTGaccagctgcaacaacagcagcagcagcaacagcaacagcagcagcaacatcagcaacagcagcagctgcaacgaTTGCCCGCACACAGCGAcaacgaggaggaggagcaggagcaggaaccggaggaggaggaggaagctGAGGATGATTTTGAGCGCAAGTCAGTGGATTCAGCCATGGATCTGTCCCAAGGCACTCCGATTAAGGAggagccacagcaacaacagcgaacacTGAACAATCACATGGCAATGAATTTAAAGATCAAGGACGAGGATACACCgctgatcagcagcagcagcgcctccCGACGCAAGGGCCGTGTGCTCAAGTTGGACAcgttgctgcagctgaagtCCGCTGCAATGTCCACGCCGGAGCAACAGCTCAAACTGCCATCGAGTGTGCTGCCCACAGCCTCATCTCCGATCTCTGGCAGCAGTGCCAATAAGCAGCTGGCTGATGATCCGTGCTCGGGTGCCAGCTCAGCGGATGAGTCCATGGAAACGATGGGTCATGTGCCACAGGTCAATACGAGTGCCAGTTCAACGGCCTCTAGCTCCGGCAATAGCTcgaatgccagcagcagcagcaatccgactccagctgcaacagttgccgccTCAACCTCAGCCTCTACGTCCGCgtctgcatctgcatccgcGTCCGTGTCCAGCTCAtcctcgagcagcagcagcagctcaccGGCCATTTATGAGTGCAAGTATTGTGATATTTATTTCAAGGACGCCGTGCTCTACACCATCCACATGGGCTATCACAGCTGCGACGATGTCTTCAAGTGCAACATGTGCGGCGAGAAATGCGATGGACCCGTCGGACTCTTCGTGCACATGGCACGCAATGCGCACTCCTAA
Protein Sequence: MQNWETSTAAPNYEQHNAWYSSMFAANIKQEPISHHHHHHHAHHSHHQHPHDSNSNSNASSPHQSPLPSPNPPSNTNLQLEQYLKQQQQQQQQQQQQQQQQPMDTLCAAAMTPSPSNNDQNSLQHFDATLQQQLLQQQQYQQHFQAAQQQQQQQQQHHHLTLGGFNPLTPPGLPNPMQHYYASNLRPSSTATTTTTTPAAAPTTTAAAIALQANDKLQALTPPMDVTPPKSPAKSQQSSAEPEKEHDLMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCAKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNPSLVIDVYGTRRGPKSKSLSGNGNSSNCSSSSSNKRSSATAATSVQHQQPVIPPAATSQLSAALQGFPMPVAAAATAVATTVPPVSPPSPAKSVASSVEQAPSLSNALLPPLASLLQQNHRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMRDQLQQQQQQQQQQQQQHQQQQQLQRLPAHSDNEEEEQEQEPEEEEEAEDDFERKSVDSAMDLSQGTPIKEEPQQQQRTLNNHMAMNLKIKDEDTPLISSSSASRRKGRVLKLDTLLQLKSAAMSTPEQQLKLPSSVLPTASSPISGSSANKQLADDPCSGASSADESMETMGHVPQVNTSASSTASSSGNSSNASSSSNPTPAATVAASTSASTSASASASASVSSSSSSSSSSSPAIYECKYCDIYFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00547606;
90% Identity: iTF_00570685;
80% Identity: -