Basic Information

Insect: Drosophila emarginata
Gene Symbol: egg
Assembly: GCA_037075365.1
Location: JBAMCD010000260.1:8474716-8479457[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.5e-14 9.2e-11 41.6 0.0 5 75 1012 1075 1009 1077 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.5e-14	9.2e-11	41.6	0.0	5	75	1012	1075	1009	1077	0.91

Sequence Information

Coding Sequence: ATGACCTCGGAAATGGCAGACATGGATTGCGGAGAAACTACAGAGAAATCGTTAACTGACATTTTAGTCACAAGTACCGGTGATGTGGAAGAAGAAAAGCCGGCTGAAAATTTGTTAGCCGAAACCACTGTACCGAAGGATGGAAAGGGGGAAACAACCGTGGATGCAAATCCAAATAAAGTAGAAATTATGGACTTACCACAAGAAGAGATTGCAATAAAATCGCAAGAGAACTCTAAAAAACTGGGCAATATGTCGCCTAATCAGACAATAAGTGAAGAGATTAATGAACCGCTGGTACTGGAGTTGGAAACTAAGCCAAAAGATTCCGAATCTATAGATGAAGCAGCAGTTGCTACTCCTGCCGAAAAAACATTAGATAAGAAGCAAGAGGGACAGGACATGGAGCTGGATCTAGACACCAGTGTCAAAGATTCAGAAGCAGATAATAGCATTGAGGTGATCAGTAGTCCGACACcaaatgaaactgaaatcaCAACCGTATCCAGCGTTGATGCCGAGGAATTGGAAGAGCCAGTTAAGGCCGGAGAAGATAATTTAGACAGCAGCATAGAAATAATTGAAAGTCCAAAAATTTCTATACGACAAGAAGAAGTTGAATTAGTCAATGAAGAGAAAGATCAGGGAGAAGCCAAGCTTAAGGAATCTGAATCAGATAGCAGCATTGAAGTTTTAGTATGCCCCgaaaaggaggaggaggaggatttGACAGAACCAAACACTAAAATTCAAGAAGAGGGCGAACCAAAATCGGAAAGCGACATAGCATTATTAGAAAAATCTTCGCCTCAAGAGCCAGAAAAGAATAAAGATCAGCCAAATGAAGTTGAGGAGTCGGAAAAAGAGCAAGCATCTTCTATAAATccttatataaaagaaaagcacaAAGCGGATGGGGTAGATAACAGGGTCGAGACAGaagacaaaaatataattgttacCGAAGCTACTCCCATGGAATTGGATGAAGCGGAGATAGAAATAAAACCTGTTCAAGAGCAAAGCTCAGTTGAGGAATCTtctaaagaagaaaatgaagctctgaatgcaaatacaaaagaGTCCACTGGTGAAAAGATCTGCTTGGAAACGGAAGATATTTCTGTAGTCAAATCAGAAGTAACACTAACTGAGTCTGATGAAGTTGCGATGGAGGTGGAGGTGGGTTTGGACACGGAAGAAGTTTTTGAATCCAAACCAGAAGTAATACCAACAGTGTCTAACGAAGCCACCTTGACAAAGAAGGAAGACGTTCTTGTAGCTAAACTAGAAGAGACCCAGAGCACACCAGATGTTAAATCGACTGAAGGAGAATCTGTCTCAGATGGAGAGATCTTCTATAACAAGGACTGCCTCAACTGCTACTGCCAACACCAGCATAAACAATTCATTCTGTCCAGTGCTGCAGTGTCAAATTATTTCAGAGTACCAAGGAAAGTGAATAAAAGACAATATATTTGCCTGGGATGTCATGATACGGCCATGGATATGTATGAGGATTGTGCAAGCCATCTGGTGGCCAAACAGCCGCTGCTTCTCAAAGAATTTAAGCAGGAACACACGGAATTTGTAGCTCTGGACAGTAGTGATGAAGAGGATAATGAAATTGAACCAGCCGAATCGGAATTTTCCACAAATGACTTGCAACTGATAGAGAATGAGCTGGAGGATGCCATACGTAGTGTATTTGATCGTGTTGATATTAAACAACAATTCGCCTGGTCTAAGACCATTTTGGAAGCCAAGTTCCAACAATTGGAGAGTGAATTTACTGTAGTCGGTTCGGAATTGGGTAGACTACAAAAAACCGCTGATCAAATGCATTTCGCTCTTTACAACTCCTGTCAGGTGGTGCAACAGCATAAGCCGCCATTAGATCTTTATCAGAGTATGGGTGATTATGTGCAAGTTCCTCCGGCCGGTGAGATTGAACGTCCGCCCATTAAACTCAACGAGACTTATTATGCGGTGAAAAACAAAGCCATTGCCAGTTGGGTATCCATCAAAGTGATTGAGTTTATGGAGAGCACCACTGTGGGTGGCAACTCAGTGCAGAGcttcaaaatcaaatatctGAATACCCCCTATCAGATGGTCAAGACAGTGACAGCCAAGCACATAGCTTACTTTGAGCCGCCTCCAGTGAGATTGACAATAGGAACTCGTGTCATTGCCTATTTTGATGGCAGTACCCTTATACGTGGCCGAGAGCGCAAGGAACGAGGCGTGGTCCAGAGCGCCTTTTATCCTGGTATCATAGCTGAACCCATGAAACAGGCGAACCGTTTTCGATATTTGATTTTCTACGATGATGGCTACACCCAATATGTTCAGCACAACGATGTGCGTTTGGTTTGTCAAGCCTCGGAGAAAGTTTGGGAGGATGTGCATCCGAATTCGCGGGATTTCATACAGAAATATGTGGAAAAATATTCAGTGGATAGGCCCATGGTGCAGTGCACTCGTGGACAGAGCATGAATACAGAATCTAATGGCACTTGGTTGTATGCCAGGGTCATTGATATAGACTGCAGCCTGGTGCTGATGCAGTTCGAGGGCGATAAGAACCACACAGAGTGGATTTATCGAGGATCTCTGCGCCTGGGTCCTGTATTCAAAGAGACGCAAAATTCCCTCaatagcatgcagcaacaaaCGCGAGTCCCAAGGcgcACGGAGCCCTTCATACGATACACTAAGGAGATGGAATCAAGTAGCCGGCAGGTGAATCAACAAATGCGGGCCATAGCCCGTAAAAGCAGTGCTGCACCACAACAGAATGTAGCCTCATCTTCATCAGCATCGCAGGTTCCTGCTGCCATTAGAACGAATACTAGTGCCAGCATTGTAAAGCATTTAAACAACTCCACCATCTATGTGGATGATGAGAATCGTCCCAAGGGGCATGTGGTTTATTTTACGGCCAAACGAAACCTACCCCCCAAAATCTACAAACATCACGAGTGCACACCAAATTGTCTCTTCAAAATTGTTCACCGCCTGGATAGCTATAGCCCTCTGGCCAAACCTCTGCTATCGGGTTGGGAGCGTCTAGTCCTGCGGCAGAAAGTCAAGCGTAGTGTAGTCTATCGTGGACCCTGCGGCAAAAGTTTTCGTAATTTGGCCGAAGTCCATCAGTATTTAAGGGCTACCGATAATGTTTTAAATGtggaaaattttgattttactcCCGATTTGAGATGCCTAGCTGAGTATTCCATTGATCCAACAATTGTAAAGGAAGCGGATATATCTAAGGGACAAGAGAAGATGGCCATACCGCTAGTCAACTACTATGACAACTCTTTGCCGCCACCCTGCACATACGCCAAGCAGCGCATACCCACTGAAGGAGTGCATCTGAATCTCGATGAGGAATTCCTAGTAGGCTGCGACTGTGAGGACGATTGTTCCGACAAATCCAAATGCTCATGCTGGCAGCTAACTGTGGCCGGGGTTAAGTATTGTAATCCCACAAAGCCTATCGAGGAAATTGGCTATCAATATAAGCGACTCCATGAACATGTACCAACTGGCATCTACGAATGCAATTCCCGTTGCAAGTGCAAAATGAATTGTCTAAATCGAGTTGTTCAGCACTCGTTGGAGATGAAATTGCAGGTGTTCAAGACCTCGAATCGTGGATGGGGTTTGCGATGTGTCAATGACATTCCCAAAGGGGCCTTCATCTGCATCTATGCCGGTCATCTATTGACCGAGACCAAGGCCAATGAGGGCGGTCAAGATGCAGGCGATGAATATTTTGCTGATTTGGATTACATTGAAGTGGCAGAGCAGCTTAAAGAAGGCTTTGAGTCGGATGTAGAGCACTCGGAGCAAGATCACGAGGAGGACAACGTTGGCCCTGATGGCGAAGATGGGGATGTTGATTTCAGACCAAATAATCACTATCAGCCAAGTAAGAGGGACACCAGGTTGCGTGTCTCACGCAGTAATTCCACACAGAACAATGAATTGGATTCGCAAGAGCGGGCCGTCATTAATTTCAATCCAAATGCGGATCTAGATGAAACAGTGCGTGAAAATTCTGTGCGTCGTTTGTTTGGCAAAGATGAAGCACCTTACATTATGGATGCCAAGACTACAGGCAATCTTGGGCGCTACTTTAATCACTCTTGTAATCCAAATTTATTCGTGCAGAATGTATTCGTGGACACCCATGACCTACGTTTCCCGTGGGTAGCCTTCTTTTCAGCCTCTCACATTCGGTCCGGCACTGAATTGACTTGGAATTATAATTATGAGGTTGGTGTCGTGCCGGGCAAGGTGCTGTACTGTCAATGTGGAGCCACTAATTGTCGCATAAGATTGCTTTAA
Protein Sequence: MTSEMADMDCGETTEKSLTDILVTSTGDVEEEKPAENLLAETTVPKDGKGETTVDANPNKVEIMDLPQEEIAIKSQENSKKLGNMSPNQTISEEINEPLVLELETKPKDSESIDEAAVATPAEKTLDKKQEGQDMELDLDTSVKDSEADNSIEVISSPTPNETEITTVSSVDAEELEEPVKAGEDNLDSSIEIIESPKISIRQEEVELVNEEKDQGEAKLKESESDSSIEVLVCPEKEEEEDLTEPNTKIQEEGEPKSESDIALLEKSSPQEPEKNKDQPNEVEESEKEQASSINPYIKEKHKADGVDNRVETEDKNIIVTEATPMELDEAEIEIKPVQEQSSVEESSKEENEALNANTKESTGEKICLETEDISVVKSEVTLTESDEVAMEVEVGLDTEEVFESKPEVIPTVSNEATLTKKEDVLVAKLEETQSTPDVKSTEGESVSDGEIFYNKDCLNCYCQHQHKQFILSSAAVSNYFRVPRKVNKRQYICLGCHDTAMDMYEDCASHLVAKQPLLLKEFKQEHTEFVALDSSDEEDNEIEPAESEFSTNDLQLIENELEDAIRSVFDRVDIKQQFAWSKTILEAKFQQLESEFTVVGSELGRLQKTADQMHFALYNSCQVVQQHKPPLDLYQSMGDYVQVPPAGEIERPPIKLNETYYAVKNKAIASWVSIKVIEFMESTTVGGNSVQSFKIKYLNTPYQMVKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGSTLIRGRERKERGVVQSAFYPGIIAEPMKQANRFRYLIFYDDGYTQYVQHNDVRLVCQASEKVWEDVHPNSRDFIQKYVEKYSVDRPMVQCTRGQSMNTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFKETQNSLNSMQQQTRVPRRTEPFIRYTKEMESSSRQVNQQMRAIARKSSAAPQQNVASSSSASQVPAAIRTNTSASIVKHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKIYKHHECTPNCLFKIVHRLDSYSPLAKPLLSGWERLVLRQKVKRSVVYRGPCGKSFRNLAEVHQYLRATDNVLNVENFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNSLPPPCTYAKQRIPTEGVHLNLDEEFLVGCDCEDDCSDKSKCSCWQLTVAGVKYCNPTKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKMNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETKANEGGQDAGDEYFADLDYIEVAEQLKEGFESDVEHSEQDHEEDNVGPDGEDGDVDFRPNNHYQPSKRDTRLRVSRSNSTQNNELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCNPNLFVQNVFVDTHDLRFPWVAFFSASHIRSGTELTWNYNYEVGVVPGKVLYCQCGATNCRIRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00483687; iTF_00590966; iTF_00577778; iTF_00577779; iTF_00600315;
90% Identity: -
80% Identity: -