Basic Information

Gene Symbol
RREB1
Assembly
GCA_035042365.1
Location
JAWNLJ010000443.1:16318010-16324627[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.035 2.5 8.7 0.8 1 21 265 285 265 287 0.93
2 13 0.00033 0.023 15.1 0.2 1 23 297 319 297 319 0.98
3 13 0.00024 0.017 15.5 7.2 1 23 325 347 325 347 0.98
4 13 0.23 16 6.2 1.7 2 20 581 599 581 601 0.93
5 13 0.016 1.1 9.8 0.2 1 23 750 772 750 772 0.97
6 13 1.2e-05 0.00085 19.6 0.7 1 23 782 804 782 804 0.99
7 13 0.00081 0.057 13.9 2.0 1 23 810 833 810 833 0.97
8 13 0.0029 0.2 12.1 2.0 1 23 1102 1125 1102 1125 0.95
9 13 8.4e-05 0.0059 17.0 0.3 2 23 1519 1540 1518 1540 0.97
10 13 0.14 10 6.8 6.3 1 23 1546 1569 1546 1569 0.97
11 13 9.1 6.4e+02 1.1 3.4 1 23 1688 1711 1688 1711 0.78
12 13 0.0082 0.58 10.7 0.5 3 23 1769 1789 1767 1789 0.96
13 13 0.0013 0.092 13.2 4.8 1 23 1795 1817 1795 1817 0.99

Sequence Information

Coding Sequence
ATGCTcgccacacagcagcagcaacagcagcagcaacaacagcaacaatcgcacacagcagcagcagcaacacttgaGGATGCTCGCGATTTGGGCTTAATGGAGACGCGACAACGTCGCGATTCGAGTACATCTGAATCCTCGCTGGAGCATTTGGATTTGGGTCGCACGCCAAAAAagttaagcagcagcagcggcgcacCGCAGCCGACGTCGACGCCGCACGACACAGCAGTGACAGCGACGTCGTCGCGCAAGCGGAAACTGcgacagcaacaccagcagcagcaacagttgcggCTCTCCGATGAggatcagcatcagcatcagcagcaacagctgttggACTCTTCAGCGCAGCGACCGCGACACAAGCAGCGACGCAGCGCTGTTCCTGCTGCCACCAGCGCCAGCATCGTTGTTGACTACAGCGCCAGCGGAGACGCCAGCTCGCTGCGCAAAAAGTTTCGACTGAAtcgcagcagcgccagcagcaatgCTGCCAACGGTGATTTATCCGAGTCTGGCTTCGTTGATGGCAGCGCCCTCAGTGGCTATCTgcttggcaacaacaacaacaacaataacaacaacaacaacaacaataacaataataacaacaacaacaatattagtagtagtagcagcagcagcgcagtcgctcagtcagcagcatcagcagcagcgtcggcaGCGCAGCATGCGTCAAGCGTTAGCAGCTCGGGCGGCTCCTCGCCACAGGGCCTTTCGAGCGCCGAGTCGGGCATCGGCGCCGGTGATGAGCACATGAAATATCTGTGCCCCATCTGTGAGGTCGTCTCGGCCACGCCCCACGAATTCACCAATCACATTCGCTGCCACAACTACGCCAACGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTATCGTCGGCATCCTCGCTGGACCGGCATGTGCTGGTGCACACTGGAGAGCGTCCGTTCAACTGTCGCTATTGCCACTTGAACTTCACAACCAATGGGAACATGCATCGACACATGCGCACCCACAAGCAACATCAGgcatcgcagcagcagcagcagcaacagcagcagcaatcaagccaacagcagcagcagcaggcacagtcgcagtcgcaacagcagcaacagcgacgccAGCAACATGCGggtggagctggagcagctggcTCCGGATCGGGATCGGGATCGGCACAGTTGTTGACAACGCGAGCCGAGAGCTATGAGAGTGATGCCAGCTGCTCGACGGATGTTTCCAGTGAGCTGAACagtcacagcagcaacagcaatcaatccaaccacaacaacaatagccacaaaacgaacaacaataacaacaataagaacaacaacaacaacaacaacaatgaggaTGAGGtcgagctggagctggagctggaggatGAACAGTTAGTTTTGAGCAGCAAACAGCGACGTCTCAAGGCAGtccttaacaacaacaatattattagGGATGAGGAGCACGAGAATCGGGCAGATGATGATTCGGATGTGGACAGCGTTGATAGTGTTGCCCAGGTGATAACAAGCACACCAGATGTGGCCACGTTGCTCGCCTCGGGCGGCTCCTCGCCGAGCCACTCCCATTCGGAATCACATTCACCgcccctgctgctgcagagCTGCCCCGCCTGCAATTCGGGTGAATTTGAATCTGTGCCAGCGTTGTGCGCCCATCTGGATGCCGAGCATGCGGACATACCGGCCAAGTGTCGCGAGTGCGAGGTGATCTTTGCCACACATCGACAGCTGCAGGCGCACAGCTGCCGTGGATTGCCGCCGCTCCTTGGTGTCAGCTCATCGCCACTACACAAGCAGGAGGAGCACGaactggaggaggaggagcagcagcagcagcagcagcagcaccaggaGGACCATGaacagcagcacaagcaggaggaacaggaacaggctGAGCAGCGCGAATGTGAAGATTTCTTCCAGCAGCTGTATCTGAAGAATAAATCTTCAGCAGCGCTCCTCCCGTCTCCGATCAAACATGAGCCGGCGGATCAGCGACAGGATCTGGCCGACATTCAAAGCATACTCAATATGACCAGTTCCAGCTGCACCTCGAGTTTCCTGCGCAATTTTGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAATATAGCGTCGATGGACGCGATGGCGAGGAGGAGGCCCAGGATGCCTTCACCAATGAGTTCCGCAGAATGAAACTGCGCGGTGAGTTCCCCTGTAAGCTGTGCAGTGCCGTCTTTCCCAATCTTCGGGCACTCAAGGGCCACAACCGCTACCATCTGTCGGAGGTGGGCGCCGCTGGCCCATTCCGTTGCAACATGTGTCCCTATGCCGTCTGCGACAAGGCGGCACTCGTGCGGCACATGCGCACCCACAACGGCGATCGGCCCTACGAGTGTGCCGTCTGCAACTATGCCTTCACCACCAAGGCGAACTGTGAGCGCCATTTGCGCAATCGACATGGAAAGACCAGTCGGGATGATGTGAAACGTGCGATTGTCTACCATCCAGCCGAAGATGCCAGCTGCGAGGAGAACAAATCCCGCACCGATGCCGATATCCTAACCGAGCTGAGCGGCTATCGCTGTCCAACACCCACAGAGCACAGTTCCTCGGCCAGCTCCTCGTCACAGCTGAAGCACATGTTGCTGGCGGAGCCGACACCGGCCGTGAAGgttacagcaacagcagcagcagcaacatcgatGCCGCAACAACCGCTCAAGATTCAGGTGAAGAGCTTGGATCAGCTGGTGGATAAGCCGCTGCCTGCACTCGATCTCAGCATGGATGCGCTTGATTTGAGCAAGAAGCCCGCACAGCTGCTGGCCGAGCAAAGGGAGCAAAGGGAGCAGCTCGAAAGACACgaattgctgttgcagcagcagcagcaacaacagcagcagcaacaacaacagcagcagcagcagcaacaaatgtttgGGGCAGGCGATGCAGCTGCTCAGTATATGCAACAGCTGTTGCGCAGCTTCATGCTCCAGCAGTCACCCGGTTTTCCTTTCTTTGGTTTTATGGCGCCACCGCCAccaacagcggcagcggcagtagcaacatcagcagacaagtcaatgccaataaatccaacagcagcagcagcagcagccggcgcaacagcagcaacaattgctgcatTGCCACTGTCGTTGCCCGTGCCTCTGCCCGCTGGTGGTCCCGTCAAGATGGTCATCAAGAATGGTGTCCTGATGCCCAAGCAGAAACAGCGCCGCTATCGCACCGAGCGTCCCTTTGCCTGCGAGCATTGCTCGGCCCGCTTCACGCTCCGCTCCAACATGGAGCGGCACgtgaagcagcagcatccacagTTCTATGCGCATCGCCAGCGACACCGCAGCGGTCATCATGTGATGCGTGACCGGGCTGCATCCTCCAGTGCTGTCcaagcagcagccgctgctcaggcagcagcagcagccgcagctgccGCCGCAATGAGTAATctcagccagcagcaacagttgcagcattCACATCATGTCCATGCGCCAATTTCGGAGCAGGTCAAATATGCCATTTTAGCGCAGCAATTGAAGGCGCGCAAGGATACGGATTTGTTGCAACAGGCACTGGCACATGGCTCTAGCAGTGTGGTCACCAATCCGCTGCTGCATTttagctacaacaacaacagcatcggcaacaagcagcagcagcagcagcatcaacagttGAGCAACAACACTGGCAACTCTTTGGTGCTGGACGATGATGAGCCGCCCAAGCTGATTATTGACGAGGATGATGAGGATGTGGATGGTGAGGGTGAGGGCGAGGGCGAGGGCGAGTGCgaggacgatgatgatgaggaggaggagcatgAATTTAATGTCGATGACGAGGAGCAGGAGGATGAAGAGATGGAGTTGGACGAtgagcatcagcagcagcagcagcagctgccacacgaggaggatgatgatgatgatgataatgatgcagcagtcgcagcagcagcagcagcagaggcgtcgctgcaacaattgcaggCAACAAAGGACAAGCTGCAATCCAAGCCAATTGAGGCGGCCAAAAAGGCAGCGGAGATCATAATGGAGCAGGCAATCAAGGAGGGCGAGGAGAAGGCCTCCGAGAAGCAGCCGCGTTCCCAATCCCAGTCCAGAGGCGGCAATAAGCCGGCgacgccaacaacaatgaaaacaatgaTTGCACAAGCGGAATCGGTGGCCAAGTCCTTGAAGGAGGTGGCCAGTTCACCGTTCAAGGATGAATCTCAGGATCTGGTGCCTGTGGCCAAACTGGTGGACAATGCGACCAGCAATCAGGTGTCATTCAACAGCTATTTCCGTCCCAGCGACGTGGCCAATCACATGGAGCAGAGCGACGAGGAGGGTCTCGTCGCTAGCGGCAGCGCCAGCGAGAGCAACAATTCCGGCACCGAGGATgtgaccagcagcagcagcagctgcggcaacGACACCAAAAAGAAATCCGCCTACAGCCTGGCACCGAATCGTGTCAGCTGCCCGTATTGCCAGCGCATGTTCCCCTGGAGCAGCTCCCTGCGCCGCCACATCCTGACGCACACCGGCCAGAAGCCGTTCAAGTGCTCCCATTGCCCGCTGCTGTTCACCACGAAGAGCAACTGCGATCGCCATCTGCTGCGCAAGCATGGCAACGTTGAGTCCGCCATGTCTGTCTATGTGCCCACCGAGGATGTCAGCGAACCGATACCCGTGCCCAAGTCCGTTGAGGAGATTGAGCTCGAGGAGCAGCGACGTCGCCAGGCGGCCGAGGCCGAACAGGCCGAACGGGAGCAGCTCGAGCGCCAAAAGGAGCGCGAACGTGAACTGGAATTGGAACGGGAAAGGGAGcgggaacagcaacaattgatCCAACAGCTGCGCCAACAAAtggccgctgctgcagcggctgttgctgttgccgttgtcagTGCACCAGCGCATCCAACAGCACCACAGCCAGCCCAATCCCCACCGGGCCTGGAGGCGAGCAGTGATCTCCCCTACAAATGCCATCTGTGCGAATTCTCGTTTGGCGAGCGGCTGCAGTGTCTCGAGCACATCAAGCAGCTCCACTCGCACGAATTTGCACTGCTCCTGGCAAAGGGAGCCATCGAGACGGATACACAGCTGCAGCATCAACAGTTGCCAGTGGCGGCTGGTGGTGCCTCGCATTCGGATGATGAGGCTGCCGCTGTTGGCACCAGATCGGGCAAATATCCCGACTATAGCAATCGCAAAGTGATTTGCGCATTTTGCGTGCGTCGCTTCTGGTCAACGGAGGATCTGCGGCGACATATGCGCACCCATTCCGGTGAGCGTCCCTTCCAGTGCGAGATCTGCTTAAGGAAGTTCACATTGAAGCACAGCATGCTGCGGCACATGAAGAAGCACAGTGGACGCAGTCACAATGGTGGCGAACTCGATCATCAATCCGATTGCTCCGATGATGAGCAGATGTTGCCCTGCTCCCCACCCTCAACGCCAACGCCcactaacaataacaacaacaacaacacttgccagaacaacaacaacaacaacaacaacaatagcaacaacaacaacaacaatagcaacagcaagcaGGTGCTGCGCGAGCTGCTGGGCAAAGCCAACGAGTGGCGAGTGAGTCGCCTGGGTGAGCACAAGGAGAACATTGccgaggcaacaacaacaccctcagcagcaacagcagcagcggcagcaacagctgcagcagcagcagcagcagcggcagcagcagctgtggccAGTGGCGATCTAATTGGTAATCTGTTGGGGATCAGTGATCAGGGCATATTAAACAAGCTGCTCTCCTCACCAGACGAAGCTGCCAAGCTGCTAGGAGTGGAGAAGTAA
Protein Sequence
MLATQQQQQQQQQQQQSHTAAAATLEDARDLGLMETRQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHDTAVTATSSRKRKLRQQHQQQQQLRLSDEDQHQHQQQQLLDSSAQRPRHKQRRSAVPAATSASIVVDYSASGDASSLRKKFRLNRSSASSNAANGDLSESGFVDGSALSGYLLGNNNNNNNNNNNNNNNNNNNNNISSSSSSSAVAQSAASAAASAAQHASSVSSSGGSSPQGLSSAESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLNFTTNGNMHRHMRTHKQHQASQQQQQQQQQQSSQQQQQQAQSQSQQQQQRRQQHAGGAGAAGSGSGSGSAQLLTTRAESYESDASCSTDVSSELNSHSSNSNQSNHNNNSHKTNNNNNNKNNNNNNNNEDEVELELELEDEQLVLSSKQRRLKAVLNNNNIIRDEEHENRADDDSDVDSVDSVAQVITSTPDVATLLASGGSSPSHSHSESHSPPLLLQSCPACNSGEFESVPALCAHLDAEHADIPAKCRECEVIFATHRQLQAHSCRGLPPLLGVSSSPLHKQEEHELEEEEQQQQQQQHQEDHEQQHKQEEQEQAEQRECEDFFQQLYLKNKSSAALLPSPIKHEPADQRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSVDGRDGEEEAQDAFTNEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRYHLSEVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSRDDVKRAIVYHPAEDASCEENKSRTDADILTELSGYRCPTPTEHSSSASSSSQLKHMLLAEPTPAVKVTATAAAATSMPQQPLKIQVKSLDQLVDKPLPALDLSMDALDLSKKPAQLLAEQREQREQLERHELLLQQQQQQQQQQQQQQQQQQQMFGAGDAAAQYMQQLLRSFMLQQSPGFPFFGFMAPPPPTAAAAVATSADKSMPINPTAAAAAAGATAATIAALPLSLPVPLPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAHRQRHRSGHHVMRDRAASSSAVQAAAAAQAAAAAAAAAAMSNLSQQQQLQHSHHVHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVTNPLLHFSYNNNSIGNKQQQQQHQQLSNNTGNSLVLDDDEPPKLIIDEDDEDVDGEGEGEGEGECEDDDDEEEEHEFNVDDEEQEDEEMELDDEHQQQQQQLPHEEDDDDDDNDAAVAAAAAAEASLQQLQATKDKLQSKPIEAAKKAAEIIMEQAIKEGEEKASEKQPRSQSQSRGGNKPATPTTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSCGNDTKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQAAEAEQAEREQLERQKERERELELEREREREQQQLIQQLRQQMAAAAAAVAVAVVSAPAHPTAPQPAQSPPGLEASSDLPYKCHLCEFSFGERLQCLEHIKQLHSHEFALLLAKGAIETDTQLQHQQLPVAAGGASHSDDEAAAVGTRSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGGELDHQSDCSDDEQMLPCSPPSTPTPTNNNNNNNTCQNNNNNNNNNSNNNNNNSNSKQVLRELLGKANEWRVSRLGEHKENIAEATTTPSAATAAAAATAAAAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSPDEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00535518;
90% Identity
iTF_00525357;
80% Identity
-