Basic Information

Gene Symbol
RREB1
Assembly
GCA_037043665.1
Location
JBAMAZ010000306.1:708800-715729[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.038 2.5 8.7 0.8 1 21 278 298 278 300 0.93
2 13 0.00035 0.023 15.1 0.2 1 23 310 332 310 332 0.98
3 13 0.00026 0.017 15.5 7.2 1 23 338 360 338 360 0.98
4 13 0.25 16 6.1 1.7 2 20 593 611 593 613 0.93
5 13 0.017 1.1 9.8 0.2 1 23 760 782 760 782 0.97
6 13 1.3e-05 0.00085 19.6 0.7 1 23 792 814 792 814 0.99
7 13 0.00088 0.057 13.9 2.0 1 23 820 843 820 843 0.97
8 13 0.0031 0.2 12.1 2.0 1 23 1124 1147 1124 1147 0.95
9 13 9.1e-05 0.0059 17.0 0.3 2 23 1539 1560 1538 1560 0.97
10 13 0.15 10 6.8 6.3 1 23 1566 1589 1566 1589 0.97
11 13 9.9 6.5e+02 1.1 3.4 1 23 1707 1730 1707 1730 0.78
12 13 0.0089 0.58 10.7 0.5 3 23 1792 1812 1790 1812 0.96
13 13 0.0014 0.092 13.2 4.8 1 23 1818 1840 1818 1840 0.99

Sequence Information

Coding Sequence
ATGCTcgccacacagcagcagcagcaacagcaacagcagcagcagcaacaacaacagcaacaatcgcaCACAGcatctgcaactgcagcagcagcagcagcagcagtagcagcaacacatGAAGATGCTCGGGATTTGGAGTTAATGGAGACGCGACAGCGTCGCGATTCGAGCACCTCAGAATCCTCGCTGGAGCATTTGGATTTGGGTCGCACGCCCAAaaagttgagcagcagcagcggcgcacCGCAGCCGACGTCGACGCCGCACGACACAGCAGTGACAGCGACGTCGCGCAAGCGCAAACTGCGacagcaacaccaccagcagcagcagcagcagcaacagtcgccgCTCTCCGatgaggagcaacagcagcaacagcagcagcagctgttggacTCATCAGCGCAGCGACCGCGTCACAAGCAGCGACGCAGCgccgttgctgccgctgccagcgcCAGCATCGTTGTCGACTACAGCGCCAGCGGCGACGCCAGCTCGCTGCGCAAAAAGTTTCGACTGAAtcgcagcagcgccagcagcaatgCCGCCAACGGTGATTTATCCGAATCGGGTTTCGTTGATGGCAGCGCCCTCAGTGGCTATCTgcttggcagcaacaacaacaacaacaacaataataataacaacaacaacaatatcagtaatagtagcagcagcagcagcgcagtcgctcagtcagcagcagcagcagcagcgtcggcaGCGCAGCATGCGTCAAGCGTTAGCAGCTCGGGCGGCTCCTCGCCACAGGGCCTCTCGAGCGCCGAGTCGGGCATCGGTGCCGGCGATGAGCACATGAAATATCTGTGCCCCATTTGCGAGGTCGTCTCGGCCACGCCCCACGAATTCACCAATCACATTCGCTGCCACAACTACGCCAACGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTCTCGTCGGCATCCTCGCTGGACCGGCATGTCCTGGTGCACACTGGAGAGCGTCCGTTCAACTGTCGCTATTGCCACTTGAACTTCACAACCAATGGGAACATGCACCGACACATGCGCACCCACAAGCAACATCAggcgtcgcagcagcagcagcaacagcagcagcagcactcgcaacagcagcaatccacacaacagcagcaacaggcacagtcgcagtcgcagcaacagcaacagcgacgccAGCAACATGCGggtggagcaggagcaactgGCTCGGTATCGGGATCAGCACAGTTGTTGACGACGCGAGCGGAGAGCTATGAGAGTGATGCCAGCTGCTCGACGGATGTGTCCAGTGAGCTGAAcagtcacagcagcaacagcaatcaatccaaccacaacaataacaacaacaacaacaatagccacaaaacgaacaacaataacaataacaacaacaacaacaatgaggaTGAGCTCGAGCTGGAGGATGAGCAGCTAGTGCTGAGCAGCAAACAGCGACGCCACAAGGCAGCcctgaacaacaacaatataattaGGGATGAGGAGCACGAGAATCGGCCGGATGATGATTCGGATGTGGACAGCGCTGATAGCGTTGCCCAGGTGATAACAAGCACACCGGATGTGGCCACGCTGCTCGCTTCGGGCGGCACCTCGCCCACCCACTCGCATTCGGAATCGCATTCACCgcccctgctgctgcagagctGCCCGGCCTGCAATTCGGGTGAATTTGAATCTGTGCCAGCGTTGTGCGCCCATCTGGATGCCGAGCATGCAGACATACCGGCCAAGTGTCGCGAGTGCGAGGTGATCTTTGCCACACATCGACAGCTGCAGGCGCATAGTTGTCGAGGATTGCCGCCGCTGCTTGGTGTGAGCTCATCGCCACTGCACAAGCAGGAGGAGAGTGAACTGGaggagcagcaccagcagcagcacgaggaggaggataacgaacagcagcagcacaagcaggaggaacaggagcaggcTGAGCAGCGCGAATGCGAAGATTTCTTCCAGCAGCTGTATCTGAAGAATAAATCGTCAGCAACGCTGCTTCCCTCACCGATCAAACATGAGCCGGCGGACCAGCGACAGGATCTGGCCGATATTCAAAGCATACTCAATATGACCAGTTCCAGCTGCACCTCGAGTTTCCTGCGCAATTTCGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAATATAGCGTCGATGGACGCGATGGCGAGGAGGAGGCCCAGGATGCCTTCACCAATGAATTCCGGCGAATGAAACTGCGCGGTGAGTTCCCCTGCAAGCTGTGCACCGCCGTCTTTCCCAATCTGCGTGCACTCAAGGGCCACAATCGCTACCATCTGTCGGAGGTGGGCGCCGCTGGTCCATTCCGTTGCAACATGTGTCCCTATGCCGTCTGCGACAAGGCCGCCCTCGTCCGGCACATGCGCACCCACAACGGCGATCGGCCTTACGAGTGCGCCGTCTGCAATTATGCGTTCACCACCAAGGCGAACTGTGAGCGTCATTTGCGCAATCGACATGGCAAGACCAGTCGCGAGGATGTGAAACGTGCGATTGTCTATCATCCGGCCGAGGATGCCAGCTGCGAGGAGAACAAATCGCGGACCGAAGCCGATATCCTAACGGAGCTGGGCGGCTATCGTTGTGCAACACCCACGGAGCACAGCTCCTCGGCTAGCTCCTCGTCACAGCTGAAGCACATGTTGCTGGCGGAGCCGACGCCGACCGTAAaggtagcagcaacaacagctgcagtagcagcagcagcagcagcaacaacaacatcgctGCCACAACAACCGCTCAAGATTCAGGTGAAGAGCTTGGATCAGCTGGTGGATAAGCCACTGCCAGCACTCGATCTCAGCATGGATGCGCTCGACCTGAGCAAGAAGCCCGCCCAGCTGCTGGCCGAGCAACGGGAGCAAAGGGAGCAGCTCGAAAGACACGAActggtgctgcagcagcagcaacagcagcagcagcaacaacagctgcagcagcagcagcaacagcagcagcagcaacaaatgtttGGGGCTGGCGATGCAGCTGCTCAGTATATGCAACAGCTGTTGCGCAACTTCATGCTCCAGCAATCACCCGGTTTTCCCTTCTTTGCGTTTAtggcgccaccgccaccaacagcggcagcagcagcagcaacagcagcagacaaatcaatgacaacaaatccagcagcagcagcagcagcagccggcgcaacagcagcaacaattgctgcaatGCCACTGTCACTGCCTGTGCCACTGCCCGCTGGTGGTCCCGTCAAGATGGTCATCAAGAATGGCGTCCTGATGcccaagcagaagcagcgccGCTATCGCACCGAGCGTCCCTTTGCCTGCGAGCATTGCTCGGCCCGCTTCACCCTCCGCTCCAACATGGAGCGCCATgtaaagcagcagcatccacagtTCTATGCGCAGCGCCAGCGACACCGCAGCGGTCATCATGTGATGCGTGAACGGGCTGCATCCTCGAGTGCTGTCCAAGCGGCAGCCGCTGCAcaggcagccgcagcagccgccgccgcagcaatGAGTAAtctcagccagcagcaacagttgcagcactCGCATTCACATCATGTCCATGCGCCAATCTCGGAGCAGgtgaaatatgcaattttgGCGCAGCAATTGAAGGCGCGCAAGGATACCGATTTGTTGCAACAGGCACTGGCACATGGCTCCAGCAGTGTTGTCGCCAATCCGCTGTTGCATTTTagctacaacaataacaacagcagcaacagcatcagcaacaagcagcagcaacaacagttgagCAACAACACTGGCAACTCTTTGGTGCTGGACGACGATGAGCCGCCCAAGCTGATCATTGACGAGGATGACGAGGATGTGGATGGCGaggacgatgaggatgaggaggaggagcaggaatttgatgttgatgaggaggagcaggaggatgAAGAGATGGACTTGGACGatgagcatcagcagcagctgcacgaggaggatgatgatgatgatattgatgatgatgatgcagcagcaacagcaacagcagcaacagcagcagcagctgcagctgcagcagaggcgtcacagcaacaattgcagccaaCCAAGGACAAGCTGCAAACCAAGCCAATTGAGGCGGCCAAAAAGGTAGCGGAAACCATATTGGAGCAGGCAATCAAAGAGCGCGAGGAGAAAGCGGCCGAGAAGCAGCCGCATCCTCAGTCGGAGTCCGTGGGCGGGAATAAGCCGGcggcgccaacaacaatgaaaacgaTGATTGCACAAGCGGAATCGGTGGCCAAGTCCTTGAAGGAGGTGGCCAGTTCACCGTTCAAGGATGAATCTCAGGATCTGGTGCCGGTGGCCAAACTGGTGGACAATGCGACCAGCAATCAGGTGTCGTTCAACAGCTATTTCCGTCCCAGCGACGTTGCCAATCACATGGAGCAGAGCGACGAGGAGGGTCTCGTTGCCAGCGGCAGCGCCAGCGAGAGCAACAATTCCGGCACCGAGGAtgtgaccagcagcagcagcagctgcggcaatGACACCAAAAAGAAATCCGCCTACAGCCTGGCACCGAATCGTGTCAGCTGCCCGTATTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGTCGCCACATCCTGACGCACACCGGCCAGAAGCCGTTCAAGTGCTCCCACTGCCCGCTGCTGTTCACCACGAAGAGCAACTGCGATCGCCATCTGTTGCGCAAGCATGGCAATGTTGAGTCCGCCATGTCCGTCTATGTGCCCACCGAGGATGTCAGCGAACCGATACCCGTGCCCAAGTCCGTCGAGGAGATTGAGCTCGAGGAGCAGCGACGTCGCCAGGCGGCCGAGGCCGAACAGGCCGAGCGTGAGCAGCGCGAGCGCCAAAAGGAGCGCGAACGTGAACTGGAAttggaacgggaacgggaacgggaacacCAACAGTTGATACACCAGTTGCGCCAACAAATGGCCGCTGCCGCAGcggctgctgtcgctgttgccgcCGTTGCTGCACCAACGCATCCACCACCGCCGGCCCAATCGCCGCCAGGCCTGGAGGCGAGCAGTGATCTGCCCTACAAATGCCATCTGTGCGAGTTCTCATTCGGCGAGCGGCTGCAGTGTCTCGAGCACATCAAGCAGCTGCACGCACACGAGTTCGccctgctgctggccaagggGGCCATCGAAACGGATGCACagctccagcaccagcagcagcagcagcaacaattgccagcGGCTGGTGGTGCTCCACATTCGGATGATGAGGCTGCCGCTGTCGGCACCAGATCGGGCAAATATCCCGACTATAGCAATCGTAAAGTGATTTGCGCATTTTGCGTGCGTCGCTTCTGGTCAACGGAGGATCTGCGGCGACATATGCGCACCCATTCCGGTGAGCGTCCGTTCCAGTGCGAGATCTGCTTGAGGAAGTTCACATTGAAGCACAGCATGCTGCGGCACATGAAGAAGCACAGTGGACGCAGTCACAATGGTGGCGAGCTCGATCATCAATCCGATTGCTCCGACGATGAGCAGCTGTTGCCCTGCTCCCCACCCTCAACGCCAACGcccactaacaacaacaacaacaacacttgccagaacaacaacaacaacaacaataacaacaacaatagcaatggcAAGCAGGTGCTGCGCGAGCTGCTGGGCAAGGCGAACGAGTGGCGAGTGAGTCGCCTGGGCGAGCACAAGGAGAACATTGccgaggcaacaacaacaccctcagcagcaacagcagcagcggcagcaacagctgcagcagcagcagcagcagcagctgttgccagtgGCGATCTAATTGGTAATCTGTTGGGGATCAGTGATCAGGGCATACTAAACAAGCTGCTCTCCTCACCAGACGAAGCTGCCAAGCTGCTGGGAGTGGAGAAGTAA
Protein Sequence
MLATQQQQQQQQQQQQQQQQQSHTASATAAAAAAAVAATHEDARDLELMETRQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHDTAVTATSRKRKLRQQHHQQQQQQQQSPLSDEEQQQQQQQQLLDSSAQRPRHKQRRSAVAAAASASIVVDYSASGDASSLRKKFRLNRSSASSNAANGDLSESGFVDGSALSGYLLGSNNNNNNNNNNNNNNISNSSSSSSAVAQSAAAAAASAAQHASSVSSSGGSSPQGLSSAESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLNFTTNGNMHRHMRTHKQHQASQQQQQQQQQHSQQQQSTQQQQQAQSQSQQQQQRRQQHAGGAGATGSVSGSAQLLTTRAESYESDASCSTDVSSELNSHSSNSNQSNHNNNNNNNNSHKTNNNNNNNNNNNEDELELEDEQLVLSSKQRRHKAALNNNNIIRDEEHENRPDDDSDVDSADSVAQVITSTPDVATLLASGGTSPTHSHSESHSPPLLLQSCPACNSGEFESVPALCAHLDAEHADIPAKCRECEVIFATHRQLQAHSCRGLPPLLGVSSSPLHKQEESELEEQHQQQHEEEDNEQQQHKQEEQEQAEQRECEDFFQQLYLKNKSSATLLPSPIKHEPADQRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSVDGRDGEEEAQDAFTNEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRYHLSEVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREDVKRAIVYHPAEDASCEENKSRTEADILTELGGYRCATPTEHSSSASSSSQLKHMLLAEPTPTVKVAATTAAVAAAAAATTTSLPQQPLKIQVKSLDQLVDKPLPALDLSMDALDLSKKPAQLLAEQREQREQLERHELVLQQQQQQQQQQQLQQQQQQQQQQQMFGAGDAAAQYMQQLLRNFMLQQSPGFPFFAFMAPPPPTAAAAAATAADKSMTTNPAAAAAAAGATAATIAAMPLSLPVPLPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRHRSGHHVMRERAASSSAVQAAAAAQAAAAAAAAAMSNLSQQQQLQHSHSHHVHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVANPLLHFSYNNNNSSNSISNKQQQQQLSNNTGNSLVLDDDEPPKLIIDEDDEDVDGEDDEDEEEEQEFDVDEEEQEDEEMDLDDEHQQQLHEEDDDDDIDDDDAAATATAATAAAAAAAAEASQQQLQPTKDKLQTKPIEAAKKVAETILEQAIKEREEKAAEKQPHPQSESVGGNKPAAPTTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSCGNDTKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQAAEAEQAEREQRERQKERERELELEREREREHQQLIHQLRQQMAAAAAAAVAVAAVAAPTHPPPPAQSPPGLEASSDLPYKCHLCEFSFGERLQCLEHIKQLHAHEFALLLAKGAIETDAQLQHQQQQQQQLPAAGGAPHSDDEAAAVGTRSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGGELDHQSDCSDDEQLLPCSPPSTPTPTNNNNNNTCQNNNNNNNNNNNSNGKQVLRELLGKANEWRVSRLGEHKENIAEATTTPSAATAAAAATAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSPDEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00535518;
90% Identity
iTF_00525357;
80% Identity
-