Basic Information

Insect: Drosophila differens
Gene Symbol: Hr39
Assembly: GCA_037043665.1
Location: JBAMAZ010000197.1:849127-852568[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.3 1.2e+04 -4.7 17.0 22 204 40 220 23 225 0.41

2 3 2 1.7e+04 -11.0 28.9 32 144 212 337 200 375 0.34

3 3 2.2e-99 1.9e-95 320.7 19.8 1 408 511 912 511 912 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.3	1.2e+04	-4.7	17.0	22	204	40	220	23	225	0.41
2	3	2	1.7e+04	-11.0	28.9	32	144	212	337	200	375	0.34
3	3	2.2e-99	1.9e-95	320.7	19.8	1	408	511	912	511	912	0.85

Sequence Information

Coding Sequence: ATGCCAAATATGTCGAGCATTAAGACGGAGCAGAGTGTTTCACCCGGTGCCAGTGGCAGCTATCAGCTGCCCGTTAACATGTCGACGGCGACAGTGACGCCagcgtcgcagcagcagcagcagcatcagcaacagcagcagcagcagcagcagcgccacaaTGTCTCCGTGACGAATATCAAATGTGAACTGGACGAGCTGGCGACGCCAACGAATGGCAACCTGGTGCCGGTCATAGCCAactataataatcataatcacaatcacaatcacaatcacagcGGCAGCCTGTGCATACCCCTCGGCGGCAATGGGGATGAGTCCGATTCGGATGCGGAGCTGGCCAACATTGAGAATCTGAAGGTGCGACGACGTGCGTCAGACAAGAATGGTCCGCGTCCCATGTCCTGGGAGGGTGAGCTGAGCGAGAACGAAACGAATGGCGGCGCCGTCGGTGACGAGGAGGAGCTCATGGAAACGGAAACGGTGATCAAGAGCGAggtgagcagcagcaccagcaccagcagcagcagcagtgccacaACAATGGCCAGCAGTCAAGTGAACGCCATGCTGCAGCCCATCAAAACCGAACTGGAGAACATAGCCGGCgagatgcaacagcagcagcagcagcagcaacaacagcagcagcagcaacaacaacagcagcagcagcagcaacaacaacaacagcagcagcagcaacagcagcagcaacaactccagctgcaacaacaacaacaacaattgctgccaCTGAAGCAACAGAGCTTTGCACCGaacaacaaactgaaattGGCGCCGACGCAAAGTGATCccatcaatttgaaatatgagccaacgacaacgacaacatcgtCGCTGCTCTGCGACAGGAGCAAGTCGAATAGTGGCGGCcatttgccgctgctgcccgCCAATCCCAGTCCCGATTCTGCCATACATTCCGTCTATACGCACAGCAGCCCCTCCCAATCGCCGCTGACGTCCCGCCACGCCCCCTATACGCCCTCGCTGAGCAGGAACAACAGCGATGCGTCGCACAGTAGctgctacagctacagctccGAATTCAGTCCCACCCACTCACCCATTCAGGCGCGTCATGCGCCACTCGCTGGCGTCGCCGCCTTGTTCACGGGCAATGCAAATGGCGGTGCACTGCATCATCATAGTGTGCTCTATCGGCCACTCAATGTGGATGCCGCACAGGAGGCACAAAATCTGAGCATGGACGCGGGTGGTGCATCATTGGATGCCAGTGCCACGTTGGCTGCCTCGCCGGCGGGCATCTCGCGCCAGCAGCTGATCAATTCGCCGTGTCCGATTTGTGGGGATAAGATCAGTGGCTTCCACTATGGCATCTTTTCGTGCGAGTCGTGCAAGGGCTTCTTCAAGCGCACCGTCCAGAATCGCAAgaactatgtgtgtgtgcgaggcgGTCCCTGCCAGGTGAGCATCTCGACGCGCAAAAAGTGCCCCGCCTGCCGTTTCGAGAAGTGCCTGCAGAAGGGCATGAAATTGGAGGCGATACGCGAGGATCGCACCCGTGGCGGTCGCTCCACCTATCAGTGCTCCTACACGCTGCCCAATTCGATGCTCAGTCCGCTGCTCAGTCCCGATCAGGCGgcagccgctgcagccgccgccgccgttgtcaatcaacagcagcagcagcagcatcagcaccagcatcagcagcagcatcagcaacaccaacagcagcgacttcaacagcatcagcagcagcaacaacaacagcaacatcagcagcagcagcaacatggtCCACTCAATGGCTTTGGTGGTGGCGGCTCCAATTCGCTGCCAGCTAGTCCCAGTCTCGGCGGGGCATCCATCAAGACGGAGCAATCGGAGCAGCTAAATCATCATACGTCATCATCAACGCGAGCCTCAAGCATTCCAGCCCTGCTGCAGGAAATCATGGATGTTGAACATCTCTGGCAATATACCGATGCGGAATTGGCACGCATTAATCAGCCGCTGTCCTCATTTGCAACGGGTGGCTCATCGTCGAGCAGCACGGGCGGTTCAAGTTCCGCCGGACAGCATACGGGCAATGCACAACAGATGACCAATCCACTGCTGGCCAGTGCTGGTCTCGCATCCAACGGCGAGAACGCCAATCCCGATCTGATTGCACACCTCTGCAACGTGGCCGATCATCGCCTCTACAAGATCGTCAAATGGTGCAAGAGTTTGCCGCTCTTCAAGAACATCTCGATTGACGATCAGATCTGCCTGCTCATCAACTCGTGGTGTGAACTGTTGCTCTTCTCCTGCTGTTTTCGTTCCGTCGACACGCCCGGCGAGATCAAGATGTCACAGGGCAGAAAGATTACGCTGGCACAGGCTAAAACCAATGGCTTGCAGGCGTGCATTGAGCGCATGTTGAATCTGACCGATCATTTGCGTCGCCTGCGCGTTGATCGCTACGAATATGTTGCCATGAAGGTAATCGTGCTGCTGCAGTCCGACACAACGGAACTGCACGAGGCAGTCAAGGTGCGCGAGTGCCAGGAGAAGGCGCTGCAGGGTTTGCAGGCCTACACGTTGGCCCATTACCCCGAGACGCCGTCCAAGTTTGGTGAGCTGCTCCTGCGCATACCCGATCTGCAGCGCACGTGTCAGCTGGGCAAGGAAATGCTGACGATCAAAACGCGCGATGGTgcagattttaatttgctaatGGAACTGCTGCGCGGAGAACATTGA
Protein Sequence: MPNMSSIKTEQSVSPGASGSYQLPVNMSTATVTPASQQQQQHQQQQQQQQQRHNVSVTNIKCELDELATPTNGNLVPVIANYNNHNHNHNHNHSGSLCIPLGGNGDESDSDAELANIENLKVRRRASDKNGPRPMSWEGELSENETNGGAVGDEEELMETETVIKSEVSSSTSTSSSSSATTMASSQVNAMLQPIKTELENIAGEMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQQQQLLPLKQQSFAPNNKLKLAPTQSDPINLKYEPTTTTTSSLLCDRSKSNSGGHLPLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPLAGVAALFTGNANGGALHHHSVLYRPLNVDAAQEAQNLSMDAGGASLDASATLAASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVVNQQQQQQHQHQHQQQHQQHQQQRLQQHQQQQQQQQHQQQQQHGPLNGFGGGGSNSLPASPSLGGASIKTEQSEQLNHHTSSSTRASSIPALLQEIMDVEHLWQYTDAELARINQPLSSFATGGSSSSSTGGSSSAGQHTGNAQQMTNPLLASAGLASNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSVDTPGEIKMSQGRKITLAQAKTNGLQACIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELHEAVKVRECQEKALQGLQAYTLAHYPETPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00575636;
90% Identity: iTF_00595983;
80% Identity: iTF_00499630;