Basic Information

Insect: Drosophila demipolita
Gene Symbol: L
Assembly: GCA_035042405.1
Location: JAWNLI010000025.1:4179815-4190430[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 9.7e-06 0.00068 19.9 2.9 1 23 171 193 171 193 0.98

2 17 0.34 23 5.6 6.2 1 23 199 221 199 221 0.97

3 17 1.6e-07 1.1e-05 25.5 3.2 1 23 227 249 227 249 0.99

4 17 1.2e-05 0.00083 19.6 0.4 1 23 255 277 255 277 0.99

5 17 0.11 8 7.1 0.1 2 23 352 377 351 377 0.92

6 17 0.00091 0.063 13.7 0.4 2 23 410 432 409 432 0.96

7 17 0.026 1.8 9.1 0.7 1 23 497 519 497 519 0.97

8 17 0.0049 0.34 11.4 0.1 2 23 527 548 526 548 0.91

9 17 0.00028 0.02 15.3 0.1 1 23 556 580 556 580 0.92

10 17 4.9 3.4e+02 1.9 1.6 2 23 616 638 615 638 0.95

11 17 0.0024 0.17 12.3 1.1 1 23 688 711 688 711 0.97

12 17 0.0061 0.43 11.1 1.6 2 23 885 907 884 907 0.96

13 17 0.11 7.7 7.1 0.1 1 23 913 935 913 935 0.92

14 17 0.53 37 5.0 0.4 2 23 943 964 942 964 0.93

15 17 0.61 43 4.8 0.6 2 23 1065 1086 1065 1086 0.94

16 17 0.046 3.2 8.3 0.0 1 23 1096 1118 1096 1118 0.94

17 17 0.00021 0.015 15.7 1.2 1 23 1123 1145 1123 1145 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	9.7e-06	0.00068	19.9	2.9	1	23	171	193	171	193	0.98
2	17	0.34	23	5.6	6.2	1	23	199	221	199	221	0.97
3	17	1.6e-07	1.1e-05	25.5	3.2	1	23	227	249	227	249	0.99
4	17	1.2e-05	0.00083	19.6	0.4	1	23	255	277	255	277	0.99
5	17	0.11	8	7.1	0.1	2	23	352	377	351	377	0.92
6	17	0.00091	0.063	13.7	0.4	2	23	410	432	409	432	0.96
7	17	0.026	1.8	9.1	0.7	1	23	497	519	497	519	0.97
8	17	0.0049	0.34	11.4	0.1	2	23	527	548	526	548	0.91
9	17	0.00028	0.02	15.3	0.1	1	23	556	580	556	580	0.92
10	17	4.9	3.4e+02	1.9	1.6	2	23	616	638	615	638	0.95
11	17	0.0024	0.17	12.3	1.1	1	23	688	711	688	711	0.97
12	17	0.0061	0.43	11.1	1.6	2	23	885	907	884	907	0.96
13	17	0.11	7.7	7.1	0.1	1	23	913	935	913	935	0.92
14	17	0.53	37	5.0	0.4	2	23	943	964	942	964	0.93
15	17	0.61	43	4.8	0.6	2	23	1065	1086	1065	1086	0.94
16	17	0.046	3.2	8.3	0.0	1	23	1096	1118	1096	1118	0.94
17	17	0.00021	0.015	15.7	1.2	1	23	1123	1145	1123	1145	0.97

Sequence Information

Coding Sequence: ATGATGGCTTTAAAGATGTTATATCGCGGTCCCAGTTCGCGTTTGGAGAACTTGATTGAAAAGATTCAGGCAACAAAGGAAATTACAAATAACGACATGTACAGCACGCACACCTCGTCGAGCTACTCGCCCAGCATCTCGGATGGCACATTGACGCCCAACtcggtgcagcagcagcaactgctgcccaAGGCTGCCGCCGAGGATAATCACAGCGAAGAGTCGAAGGCAAATGGTGAGGGTCCTGGTGCGGAGCAACAGGATCTGGTCAAGCCGAAGCGACCCGCTCActtgcatcatcatcatcatcatcattatcatcatcagcaggcGCTGAAAATTGCCAACAAGCTGCGCAAAATCAATAAGGAAGCCAAGTTGGCAACCGCAGGAGCAGCACATGGCACAGGAGCAGCTGGCGCAGGAGctggaggcggaggcggaggagtTGCCGCCAGCAAGTTTGATAAGTTGACAGGCGAGGGAATTAAAAGTCGCGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGCTACTTGAAGCATCACGTCCAGAGCCATGCCGAACATTTGCCTTTCAAGTGCGAATACTGCGCCAAGCTGTTCAAGCACAAGCGATCCCGAGATCGCCACAAGAAGCTGCACACCAACGAGAGGAACTACAAATGTCCACATTGCGAGGCTGCTTTCTCCAGAAGCGATCATTTAAAGATTCACATGAAGACGCACGATATACAAAAGCCTTTCCAGTGCAGCATGTGCAATCGTGGCTATAATACTGCTGCCGCTTTGACCTCCCACATGCAGAAGCACAAGAAGAATGCCGCAATTCTGGCAGCTGGTGGCAATCCGAATGCCTTGAATTATAGTCCACGCTCGACGGGATCGGCGTCCATCTCGAGCAATGGCAGCTTGCACAAGCGACGCTATGCTTTGGCACTCGCCTCGGACAGCAGTCCAAGTCGCCTGGAGTTCCCCAAGCGGGCACGTGGAGTCACCACAGTGCCGACCACGCCCACTCCAACGCCCCTGCTCAGATGCAGCTACTGCAGTCCCAAGGTGACCGAGTTCAGCAGCCTGGAACAGTTGAATGCCCATCTGCAGGCGGCAcacgaacagcaacagcagccgggCGCCAGGAGCTCCACAGCCACCAGCAGAGAGACCGCCGTGGAGACAGTGGAGCCTGCCACGAATGGTTTCCAGCTGAGCTGCGAATATTGCACAATGAAATTCGGAAATATTGCTGCACTTTTCCAGCACATGCGCAGCACCCACTTGGATCGGCTGAGCAGTCCCAATTCGTATTATGAGCACTTTAATCGCTTGGCCACCGCGGGCACATTTAGTCCACGCTTGGAGATGCCCAAGATCAAGCAGGATTTGCCGAGTCCGCCGGCGGAGGAGCTGCCAACGGATCTGAGCAGCAATAAGCGACGAACGTTGACGCCGCCAGAGCCACCTGGCGTCTTCTTCTGCAACCAGTGCAACGCAGGGTTGCCAGACTTTGAGAGTTTCCGCAATCATCTCAAGACGCACATTGCGGAGGGCATGCAACTGATATGTCCACACTGCGGACTGAGTCTGCCGGAGCAGAGTGAATTCGAGCGACATGTTGTCGCCCATTTCCTGATCACCGGCTCCGAGTTCAACTGCGCCGCCAGCTGTGGCAAATCGTTTGCCAAGTCGGAGGAACTGCAACAGCATCTGATCAGCGAACATGTGCAGACGCTGCTCAAGTGTGCGATCTGCTCGGAGCTGTGCGAGAATCGCATGTCCATGCAGCTCCATCTGGCCTGTGCCCACAGCCAGGAGACGAAGCTCCTGCGTTGCAGCGCCTGCTTGGAACTCTTTCGCAACGACACCGATTTCCATGTGCATGTCAAGACGCGACATCAACTGGTGGGCGGCAGTGCTTCTGGCGGATCAGTTGGTGGACCACCCACTGCGCCACCTGCTAATCCCTTGCAGTGCATGTTTTGTCGCGCCGTTTGCTCGTCGGAGTTGGAAatgcatttccatttggcGGCGCATGCTCGCCAATTCCGTTGTCCCAGTTGCCCGGAAACGTTCCACGTCGAATTCCTGCTCGATCGGCATATGCAGAGCCAGCATGGCGGTGTCAAGGAGAgcaagcaggagcagcagggtGCCAACAATTCGATGGGCAGTCTTTATGTCAATGCCTTGTTGCCACCattggcggcagcggcagcggctgcggcagctgccacaaataacaacagtaaTCTGCACATTGATTACAATGTGGCATTCAAGGGTCTGTTTGGAGGCGgaaatgccacgcccaccaacACACAGCCAGCCAACAAGTTCTACAGTCCTTTGCAGGTCGATACAAGTGCGCTGAAGCCCCAACAGACGCCGCATCCCGCGCTGATGTACGGACTCAGTCAGCGGTATTTGATGGAGATGTATGCGGCAAAGGCCACATCGCCGGCGGCCAGTGCACCCGAGCTGCCGGCACAGGCAACCCAAGCGGCAAATGCGACGGCATCCAGCACGGGCAGCAGCTACAGTTGTGGCATGTGCGAGCGGCAGGATCTGCGGAGTGAGGCCGAGCTGCATTCACATCGCAAGTTGGCGCACAATCTGAAGACGGGTGTGAGTCTGAGATGTGCCTACTGCTCCGGTAACTACAAGTCGCGGgcggagctggagcagcacaTGAAGAGCTGCCACAATTCGAGTGGCAAGCACAAGTGTCTCATTTGCGACGAGATATTTCCCTCGCCGGCGATACTCGCCGAGCACAAGTTACAGCACTCGAAGGTGGGTCAGTCGGGCAAGTGTGCCCATTGTggacagcagctggagcaTGTCGCCGCATTCCGTGCCCATCTCGGCGAACATGGCAACGATGGCAATTTGCCCATGGCATGCATTTGTTGCCGCCAAACTTTGCATTCGGAATTCGAGTTGAGTTTGCATGCCAAATTCCACACAAAATCTCCAAGTTGTGGCAGCCTCCAGGAGCCGGTGTGTGCGCTGTGCCTGGAACCCTTGCCGGGTGCGGGTGAAACCGCCAAGCTGTGTGAGAAATGTTGTCGCAAGCATAACCTAAATGGCAAACGCAACAAGGATGCAGTGGTCCCCCCACCCGCACcaccacaagcagcagcagcaggaaacaCAGTGGGTTATCTCGAGAATCGTTGTAATCTGTGCAAGCTGATATTGCCACATGCCAAGAAACTGCAGGAGCACCTCGTGGAGCACACATTCGCCGGCACCGAGCAACGTGGTTTCAATTGCTACATTTGCTCGGCGGTTTTCACGGCGCCAGGTGGACTTTTGGCCCACATTGGGGAGCATGGTGCTCGACCCTATGACTGCAATTTGTGCCCGGAGAAGTTTTACTTTCGCGCCGAGCTCGAGCATCATCAGCGTGCCCACGAACTAAGGCAAATCCCAGCAGCCGCCGCTGCTCCAACACGGCCCACAACCAAACAGGAGACTCAGCTCAGCTCGTCGGCCAGTTCACCCATTCTCACGCTGAGTCCCAGTCATGTGAAGCAGGAGCTCTACGAATCGGAGGCGGCAAACTCACCACAACCCGACGAAGACGAATCACCCGCCCCAGAGGATGAGGAGTACATTGAGGTGGAGCAAATGCCGCATGAGACCCGCTCCAATGAACTGGTCTCCGCGGAACGATCCAGCAACAGCGCCTGA
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSVQQQQLLPKAAAEDNHSEESKANGEGPGAEQQDLVKPKRPAHLHHHHHHHYHHQQALKIANKLRKINKEAKLATAGAAHGTGAAGAGAGGGGGGVAASKFDKLTGEGIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLEFPKRARGVTTVPTTPTPTPLLRCSYCSPKVTEFSSLEQLNAHLQAAHEQQQQPGARSSTATSRETAVETVEPATNGFQLSCEYCTMKFGNIAALFQHMRSTHLDRLSSPNSYYEHFNRLATAGTFSPRLEMPKIKQDLPSPPAEELPTDLSSNKRRTLTPPEPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEQSEFERHVVAHFLITGSEFNCAASCGKSFAKSEELQQHLISEHVQTLLKCAICSELCENRMSMQLHLACAHSQETKLLRCSACLELFRNDTDFHVHVKTRHQLVGGSASGGSVGGPPTAPPANPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKESKQEQQGANNSMGSLYVNALLPPLAAAAAAAAAATNNNSNLHIDYNVAFKGLFGGGNATPTNTQPANKFYSPLQVDTSALKPQQTPHPALMYGLSQRYLMEMYAAKATSPAASAPELPAQATQAANATASSTGSSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGNLPMACICCRQTLHSEFELSLHAKFHTKSPSCGSLQEPVCALCLEPLPGAGETAKLCEKCCRKHNLNGKRNKDAVVPPPAPPQAAAAGNTVGYLENRCNLCKLILPHAKKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLAHIGEHGARPYDCNLCPEKFYFRAELEHHQRAHELRQIPAAAAAPTRPTTKQETQLSSSASSPILTLSPSHVKQELYESEAANSPQPDEDESPAPEDEEYIEVEQMPHETRSNELVSAERSSNSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538445;
90% Identity: iTF_00514332;
80% Identity: -