Basic Information

Insect: Drosophila cyrtoloma
Gene Symbol: MBD-R2
Assembly: GCA_035042485.1
Location: JAWNLH010000666.1:9355465-9361129[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.2e-22 8.7e-19 66.8 0.1 4 76 454 524 451 525 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.2e-22	8.7e-19	66.8	0.1	4	76	454	524	451	525	0.93

Sequence Information

Coding Sequence: ATGGGGCGCCGCTGCTGCGTTTCTGAATGTCCGTCGACGTCGCGGCTCTTTGAGCACCACGGCGTCACTTACCACTCGTTCCCAATGGACCCCGTCATACGGGCCATTTGGATCAAAAACTCGCGCACAAGTCTCGATCGACCAATCACAAAGAGTGTGCTTGTCTGTTCACGTCACTTTCGACGGCTCGATTTTAATACCGTGCgcaatggaaaatatttgctaaagCCGCGCGTTTTTCCCACCGTCTTTCCGTGGGGCAAAATGGAACCCGCTGAGATCGAGGCGGATCAGCGTGCACTGCAACAGGCGACAGTGGATGGCGTTGGGGTCAGCGGTACCGCAAACAGTGCTACCAGCGAGGACTTGATCAGAGCAACTGTGGACCAAATTGTTGCCCAAATCCATGCCGAGACTGCCGAGCGGAATGCAGCCGCGGCCGCTGCAGCCGAGGCAGCAGCCAAAGTGGAAGCTGAAGTGCAAACAGAAGATGCTAAGGAAGTAAAAATCGAAGCAGAGacttcggctgctgctgctgagagtAAAATGGACGCAACTGCGTCAACTGCGGACGCCGTCGCTGCCGGCTCAGCTGAGTCCGCTAACGAAACGCTGCCAGATGCCAGCAGTGCCAATTCGCCCGTGTCTGCCACACCCCCCAAATATGGATCTCCCACAAACCTGACGATTGGCGCACGTCTCGAAGCGTTAAGCGCTGATGGCGCATGGCTGACCGCACGTATCGTCGAAGTCAACGATAAGGAGGAAACGCTTCTTATACGCTTCGAGCGGAACAGCAAGCTAAAAGTGTTGCCCTCAACGAACGGCAGTTACCAGGAATGGATGGGTTTCAAATCGGATCGTTTGCGTCAGCGCATCAGCTCGCGTGTGCTGCCTGTCTTTGAGCTGGAGGAGAAGTGCATGGCACGCTGGTCCGGACCTCGCAAATTTCCGGGCACCACCAAGAAGCTGCTGGGCAACGACACCTACGAGGTGCTCTTCGATGATGGCTACACAAAGAATGTGCGCGCCGTCCACATGACCAAGTTGCCGCGTCAGCTGCCCGCGGCGGGAACTGAGGCAGCCACTGAATCCCTAACCGCAGACCCAGCCAACGTTCCACttgcagttggagttggagttaaAAGACCAAGCACTGGTCCTACCAGCACCAGTAAGAAGAGCAAGACGACACCACAACGCAAGGACTGGCCATTACTGGATATGTCCAATTTGGATTTAGCTGCTTTGGGACTGCCGGACATACCGCACGATGGGGAATGGACCTGTCACTGGGTAAATGATCAGCCCATTGGCACCGAAGGTTTTCTCATTGTGGGTGAGCATCAGAAGCCAACGGTAATTGTACACGACTGGCGGCTGCCGGATGGTTGGATCAAGCACATGTATCAACGCTCCAATGTGCTGGGCAAGTGGGATGTCATCCTGGTGTCGCCCAGTGGCAAACGATTTCGCTCCAAGTCTGATCTCAAGGTGTTTCTGGAGTCGCAGGGCGAGGTCTACAATCCGGATGTGTACGATTTTAGCATTCATCGTCGACGCGCCAAGGACATCAATGcctatgtatatacacacgaCTACAGTCCGCAGCAGCCGGTCAAGCCAAAACCATTGGATGTCTCCCTGGACACTACTGCAACATTGCAAgagttgagcagcagcaaattatCGACTGTCACGCCCATATCGGCCATGGGTACGCGACGCAATGCAACCGACGAGAGTCAGTACATGGAAACACCAGTGGCCTCATTGGTGCCACCTGCGGAGCTGATGTCGCCTTCGCCACATGCCCAAGGAGTTGAGGCGCTGCCTCCCACAGCTGATGCAGCTGCATCCAGCTCTGCGCCTGGCATGGAAGAGCATGGCGCCGTTGTTGTGGAAGATGGTTATGCCTTTATTGGCggtttgaaaattcaaataaccGACAATTTGTTCGTTTGCCCCCGCGAGGGTTGCGGCAAAACCTTCCGAAAAGAAGATTTTCTACAAATACACATTCGTCATTACCACAAGGAACTTGCCGaACACGTCAGTCACTGTCCTAAGATGCAGGAGCTGGCCGTTAAGCGGACGCATCCCTCATCAATTGAGCAGAACGATCAGACGcccaaaaatcaaataccCAACCAGCAGTTCTTTGCCAAGCTGCACCAGCAGGACTTACAGCAATCGCGTTCCTTTCGACGTCACCCAGTGGGCACAGAAACATCGCCTTCGGCTCGGGATACATCTCCAAATATTTCACCTAGCAGTGCAggaatatcaataaaattacaacCGCCAACGACACCAGAATCTgtgtcagcaacagcagctgttggaCCAGTGACCGGTGAAGTAGCGACACCAACTCCATTAGAAACAAGCAAATCCGCAACACCAATCGCCACGACTTCGTCCAATCGATCCGTCAAACGTGCGCGTCCGTCATCTAGAAGACGTCAGTCTGGCTCACGTAAGAGCAGTCGTCAACGCACACAACGTCGTCCAGTGAATTCATCCCAAAGAAGAATTCCTGCTGCGGTCGCTAATTCGAGAAACTTGCCGGTCTCGGGGGTAGATAACGATGCCACTCAACTGTCGTATAATACACCCATTCCGGAGGCCCGTAACGATTCCAAGAAGCGACGCATAGCTACTTCGGGAACACCGGCTGGTTCTCCTGCCAACATCGCGTTGGTGCCGAGACCATCATCCAACGATCTGGTTGACATAAATGCGGctttgccgccgccgcctgcACTACCATTGGCCCCCCAGACGCCGCAGTACATCAAGGAGAACGGGGAATTAATCCGCATAGTACGCATGCGGCAGGAGGAAATCATTAACTGTACTTGCTACTATGGCGATGAGGATGGCCTGATGATACAGTGTGAACTATGCCTGTGCTGGCAGCACGGCCACTGTTATGGCATTTTCAAGGAGTCGGAAGTGCCTGAGAAGTATGTCTGCTATATTTGCCGCAATCCGCAACGCATGCGCGAATCAATGCGCTTTAAACATGATCAGGAGTGGCTATTCGAGGGCAAACTGCCAGTGGCTGGCTATCACACGCCTAATCAGCAGTCGTTCAAGAAGTTCGAGCTTTTGAAACACTCTCACACCCTGACCGGCAATTTGCTGGATGCTAAGCGTTTCATGCACTCGCTGCAGGTCAAAATCAATATAGCTCGGAATCGCTGCCACCCCAAGCTGTATTTGTGGGCCAAGAAGTGGGACGAGGATCAGACAGATGCCTCTGCTTCGCCCGTCAAGCGACCAAAGGTCGAACAGACCAATTGGCCACATGCGCCACAACCTGAGGCTGCCATCGATCCCGAGGAGTGTCAATACCGTTTAATTGAGCATGTCAAGGTACAACAATCATTATTGATGAATCGCCTTAACGACATTGAAGCTGAAATGGATGAACTTGAGAATGAGGACTACCTGACCGATCTTAAAGATTCAAACATTTCGACAACCAAAGAAGCCATGGCCACGTTTATTAAAGAGCTAGAGATAATGAAGCGTCTTGCAAAGCTCAACAATGTGGCCAACACGAAACAGTCTCTAAAGGACCAAGAATCGATCTTTAAGTTTTGTCGCGGGAAGTGTCACAAGGCGTTCAAACGCAAGAAGAACCCACGCAAGGTAGGATGGACAAAGGCACATCGCAAGTGGGCTGGCAAGGAGCTGACAATCGATCCCAGTTTCGAGTTTGAGATGCGTCGCAATGTGCCAATCAAATACAGTCGCGAGACCTGGCAGAAGGCCGCTGTGGCCATCAAGAAGGTCACTGAGATCAAGGAGCGCCGCGAGAGGCACTTTGTTATGGAGCGTCTGCGCAAGGGCCGCGAAGTTGAGATTCAAATGGATGTTAAGGATGTGCAACGGAATATGTCGCTTATACGTTCACCTGCCGCTGGCTTGAAGGAGCGTCGCGCAAAGGAAGAGGCCGAAGAGGCGGCGCTTATGGACGATGATCTGTCCGAAGAGAAGATCACATACGTCGATGCTCGCGAATTGGAAAAGAGACTCGAAGAGGGTCTGGGCGTGGAGGACATGGAGATGCTAGAAGCTTAA
Protein Sequence: MGRRCCVSECPSTSRLFEHHGVTYHSFPMDPVIRAIWIKNSRTSLDRPITKSVLVCSRHFRRLDFNTVRNGKYLLKPRVFPTVFPWGKMEPAEIEADQRALQQATVDGVGVSGTANSATSEDLIRATVDQIVAQIHAETAERNAAAAAAAEAAAKVEAEVQTEDAKEVKIEAETSAAAAESKMDATASTADAVAAGSAESANETLPDASSANSPVSATPPKYGSPTNLTIGARLEALSADGAWLTARIVEVNDKEETLLIRFERNSKLKVLPSTNGSYQEWMGFKSDRLRQRISSRVLPVFELEEKCMARWSGPRKFPGTTKKLLGNDTYEVLFDDGYTKNVRAVHMTKLPRQLPAAGTEAATESLTADPANVPLAVGVGVKRPSTGPTSTSKKSKTTPQRKDWPLLDMSNLDLAALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVHDWRLPDGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQGEVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPLDVSLDTTATLQELSSSKLSTVTPISAMGTRRNATDESQYMETPVASLVPPAELMSPSPHAQGVEALPPTADAAASSSAPGMEEHGAVVVEDGYAFIGGLKIQITDNLFVCPREGCGKTFRKEDFLQIHIRHYHKELAEHVSHCPKMQELAVKRTHPSSIEQNDQTPKNQIPNQQFFAKLHQQDLQQSRSFRRHPVGTETSPSARDTSPNISPSSAGISIKLQPPTTPESVSATAAVGPVTGEVATPTPLETSKSATPIATTSSNRSVKRARPSSRRRQSGSRKSSRQRTQRRPVNSSQRRIPAAVANSRNLPVSGVDNDATQLSYNTPIPEARNDSKKRRIATSGTPAGSPANIALVPRPSSNDLVDINAALPPPPALPLAPQTPQYIKENGELIRIVRMRQEEIINCTCYYGDEDGLMIQCELCLCWQHGHCYGIFKESEVPEKYVCYICRNPQRMRESMRFKHDQEWLFEGKLPVAGYHTPNQQSFKKFELLKHSHTLTGNLLDAKRFMHSLQVKINIARNRCHPKLYLWAKKWDEDQTDASASPVKRPKVEQTNWPHAPQPEAAIDPEECQYRLIEHVKVQQSLLMNRLNDIEAEMDELENEDYLTDLKDSNISTTKEAMATFIKELEIMKRLAKLNNVANTKQSLKDQESIFKFCRGKCHKAFKRKKNPRKVGWTKAHRKWAGKELTIDPSFEFEMRRNVPIKYSRETWQKAAVAIKKVTEIKERRERHFVMERLRKGREVEIQMDVKDVQRNMSLIRSPAAGLKERRAKEEAEEAALMDDDLSEEKITYVDARELEKRLEEGLGVEDMEMLEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00535349;
90% Identity: iTF_00595937; iTF_00499618; iTF_00595973; iTF_00498186; iTF_00542475; iTF_00557204; iTF_00557240; iTF_00499578; iTF_00542432; iTF_00514212; iTF_00582951; iTF_00513451; iTF_00582995; iTF_00514170; iTF_00513499; iTF_00598916; iTF_00553030; iTF_00616231; iTF_00553071; iTF_00598875; iTF_00616189; iTF_00518474; iTF_00518433; iTF_00501839; iTF_00501797; iTF_00564687; iTF_00564643; iTF_00485852; iTF_00485894; iTF_00577054; iTF_00577095; iTF_00570431; iTF_00570387; iTF_00576384; iTF_00576339; iTF_00522164; iTF_00522209; iTF_00548796; iTF_00548840; iTF_00517024; iTF_00516982; iTF_00525120; iTF_00525164;
80% Identity: iTF_00498186;