Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.3e-36 1.1e-32 113.5 7.6 1 95 30 127 30 142 0.95

2 3 7.2e-30 6.1e-26 91.3 0.4 216 299 149 228 131 229 0.92

3 3 0.045 3.8e+02 0.1 3.6 210 241 248 278 230 302 0.54

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.3e-36	1.1e-32	113.5	7.6	1	95	30	127	30	142	0.95
2	3	7.2e-30	6.1e-26	91.3	0.4	216	299	149	228	131	229	0.92
3	3	0.045	3.8e+02	0.1	3.6	210	241	248	278	230	302	0.54

Coding Sequence: ATGGACAACACAAGTGCCACTGGTCGGCGACGGAACAATATATGTGTTAATGCCGAGGATAATGCGCTCGATCAAATTACAAAGGAGGCGGAAGCGCGGTTAGCAGCTCGTCGACAAGCTCGTGCCGAAGCACGTGAGATACGCATGCGAGAGCTTGAGCGGCAACAGAAGGAGCAAGAACAAAATGCTGACCGCGCATTTGACATGCATAACACCAGTGGTGGTGTTATTATCGACACTGTCTCATCACACCCCACACGTAATACCTACGGCGGTCTAGTAAACTTAACGCGCGCAACAGCTTCGAGACGCAGTAGTGAGGATTCATTGGAGGACGAAGGTCGCAGTTTGCGTGATATTAAATACGAGCTTAAGGGCTTACTATTATTTTATCGTGAGATTCGTAACATAACTAGCCAAATCGATGTAGCCATGTTCCCCAGCTTTGCGGGTTCGCTTGATATAAGACTCAAAAAGTTGgcagaagaaaaacaacgaCTTTTGAGCGAAATGCAAAATCTTCGTGAACAATTGGATGCGTATAAGTGTGATGGTCGGGGTGGACGAGGCAGTTCATTGAATGGTCCCGTAGGCTATGATGATGATTACGAAGTTCAAAgagaagcaaataaaatcatatcAGATTACAAATACAAGCTACAAAAGGCTGAACAGGAAATCGCTAGTCTTCAGGCAAGCTTATCACGCTCGGAGACACAAGTTATACGATATAAAAGCACGGCAGAAGCAGCCGAAAAAGCAGAGGCAGAACTAAAAGTCGAACGACGTAAACTCCAACGTGAACACCGGGAGATTCTGGAACGTTTGGAAGAATCTGAAACCGCTAATAACCATCTACTAAAACGTCTTGATAAACTAAAAAATGCTAAGAGCACGATTTTAAAGGACTTATGA
Protein Sequence: MDNTSATGRRRNNICVNAEDNALDQITKEAEARLAARRQARAEAREIRMRELERQQKEQEQNADRAFDMHNTSGGVIIDTVSSHPTRNTYGGLVNLTRATASRRSSEDSLEDEGRSLRDIKYELKGLLLFYREIRNITSQIDVAMFPSFAGSLDIRLKKLAEEKQRLLSEMQNLREQLDAYKCDGRGGRGSSLNGPVGYDDDYEVQREANKIISDYKYKLQKAEQEIASLQASLSRSETQVIRYKSTAEAAEKAEAELKVERRKLQREHREILERLEESETANNHLLKRLDKLKNAKSTILKDL

Sequence clustering based on sequence similarity using MMseqs2